🧠 What if Alzheimer’s risk starts at the synapse?
In our new study led by Mariana Barata, we show that BIN1, a key AD risk gene, regulates inhibitory synapses—loss of BIN1 → hyperexcitability before Aβ.
www.cell.com/cell-reports...
cell.com
Alzheimer’s genetic risk factor Bin1 controls synapse vesicle exo-endocytosis in inhibitory synapses
Barata et al. show that the Alzheimer’s risk gene BIN1 is critical for the stability
of inhibitory synapses. BIN1 deficiency accelerates the synaptic vesicle endocytic
cycle, leading to synapse loss a...
