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Brian Sweis

@brianmsweis.bsky.social
445 followers 250 following 52 posts

MD, PhD | psychiatry | neuroscience | neuroeconomics | neuromodulation | assistant professor | residency program training director @MountSinaiPsych @SinaiBrain 🧠

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Reposted by Brian Sweis
Zachary Zeidler @brainofzedzed.bsky.social · 05/10/2026
I'm on the 2026-27 faculty job market! My lab will study how prefrontal circuits build and coordinate the brain-wide networks behind lasting memories, and how psychedelics & related compounds reshape those networks and behavior. Interested? Get in touch: brainofzedzed.github.io
brainofzedzed.github.io
Zachary Zeidler, PhD | Prefrontal circuits & memory
How prefrontal circuits build lasting memories and shape the ways experience guides behavior.
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Brian Sweis @brianmsweis.bsky.social · 05/10/2026
Congratulations @deisseroth.bsky.social!! 🧠 An inspiration to all, especially the physician-scientist community in psychiatry 👏
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Nobel Prize @nobelprize.org · 05/10/2026
BREAKING NEWS The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
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Zach Pennington @zachtpennington.bsky.social · 01/10/2026
I'm SO excited to have this out in the world!!!! Check out our latest work on the contribution of the anterior hypothalamic nucleus to stress sensitivity and valence processing.
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Denise J. Cai, Ph.D. @denisejcai.bsky.social · 30/09/2026
NEW: The anterior hypothalamic nucleus acts like a volume knob for stress, scaling the brain’s response to threatening events 🧠 Read the Cai Lab's latest paper, led by @zachtpennington.bsky.social, in @nature.com 🎉 www.nature.com/articles/s41... More: bsky.app/profile/did:...
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Nicole Rust @nicolecrust.bsky.social · 26/09/2026
2. @brianmsweis.bsky.social ++ are building up insights into the neural circuits responsible for *regret* and seeing it through to their implications for psychiatric conditions. www.science.org/doi/10.1126/...
science.org
Distinct forms of regret linked to resilience versus susceptibility to stress are regulated by region-specific CREB function in mice
Resilience versus susceptibility to stress confers sensitivity to distinct types of regret mediated by different brain regions.
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Zach Pennington @zachtpennington.bsky.social · 24/09/2026
I'm honoured to be among this incredible group of scientists and immensely grateful for the support of @braincanada.bsky.social, which will allow my lab to address fundamental questions about how reward memories can be so long-lasting, influencing mental health conditions like addiction.
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The Friedman Brain Institute @sinaibrain.bsky.social · 17/09/2026
ONE WEEK AWAY! On Thursday, September 24, 1pm, the #FBISeminarSeries and host Dr. @bshev.bsky.social welcome @upenn.edu's Dr. @nicolecrust.bsky.social. Dr. Rust will present "From Subjective Feelings to Brain Mechanisms: Advancing the Science of Mood through Epistemic Iteration". ✨NOT TO MISS!
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Blair Shevlin @bshev.bsky.social · 17/09/2026
Incredibly excited to host this event next week! Dr. Rust's work is both rigorous and inspiring
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The Friedman Brain Institute @sinaibrain.bsky.social · 16/09/2026
TOMORROW! Not To Miss! On Thurs, Sept. 17th, 1pm, the #FBISeminarSeries & host Dr. @brianmsweis.bsky.social welcome @medschool.umaryland.edu's Dr. Marco Venniro: “From isolation to connection: a journey through addiction neuroscience”. Learn More about the Venniro Lab's work 🐁 www.vennirolab.org
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The Friedman Brain Institute @sinaibrain.bsky.social · 14/09/2026
COMING UP! Not To Miss! On Thurs, Sept. 17th, 1pm, the #FBISeminarSeries & host Dr. @brianmsweis.bsky.social welcome @medschool.umaryland.edu's Dr. Marco Venniro: “From isolation to connection: a journey through addiction neuroscience”. Learn More about the Venniro Lab's work: 🐁 www.vennirolab.org
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Brian Sweis @brianmsweis.bsky.social · 27/08/2026
Congrats!!!!
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Herbert Wu @herbertwu.bsky.social · 20/08/2026
First study out! Using a new cooperative paradigm and multi-agent inverse RL, we show that mice spontaneously adopt leader/follower roles, and the prefrontal cortex encodes these role dynamics and an egocentric social value map of the partner’s position. (1/3) www.nature.com/articles/s41...
nature.com
Asymmetric prefrontal representations for leader–follower dynamics - Nature
Mice spontaneously form leader and follower roles during cooperation, and the medial prefrontal cortex encodes these role dynamics and an egocentric social value map of the partner’s position.
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Jennifer Bussell PhD @jenbussell.bsky.social · 30/07/2026
How does the brain represent the value of knowledge? In our paper--out now at Nature Neuroscience--we identify a representation of intrinsic information value within neural population structures in the orbitofrontal cortex in mice. www.nature.com/articles/s41593-026-02377-y #neuroskyence 🧠🧪 (1/8)
nature.com
Representations of the intrinsic value of information in mouse orbitofrontal cortex - Nature Neuroscience
Mice are motivated to seek information of no extrinsic value. Recording neural activity in orbitofrontal cortex reveals a representation of the value of information that is distinct from the value of ...
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Brian Sweis @brianmsweis.bsky.social · 24/07/2026
Welcome to NYC!
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Brian Sweis @brianmsweis.bsky.social · 16/07/2026
Congrats Lorenzo and team! 👏 excited to collaborate with you in the near future!
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Ben Hayden @benhayden.bsky.social · 16/07/2026
Hard to overstate the importance of this paper. Acategoricality and mixed selectivity together kill a lot of sacred cows. For starters, place cells aren't real, in that they are not a meaningful category. They are just a thing we scrape out of the data. Scientists focus on them because...
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Kurt Fraser @kurtfraser.bsky.social · 11/07/2026
Our labs first paper! Some 😳 surprising effects. Turns out everything comes back to context 🤓
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Lex Kravitz @kravitzlab.com · 09/07/2026
I am happy to share our latest manuscript, led by newly-minted PhD Justin Wang, identifying a neural population that selectively controls hedonic, but not homeostatic, feeding. www.biorxiv.org/content/10.6...
biorxiv.org
Ventral pallidal GABAergic neurons control hedonic feeding and obesity
Food intake is governed by two interacting drives. The homeostatic hunger drive regulates food intake to fulfill caloric needs while the hedonic drive promotes intake of palatable foods outside of cal...
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The Friedman Brain Institute @sinaibrain.bsky.social · 25/06/2026
EXCITING PAPER! In this review, Drs. Parul Jain & Daniela Schiller synthesize research across various domains to trace how relationships develop from initial impressions through repeated interactions to stable social bonds & networks. Neuron l @cellpress.bsky.social 👉 www.cell.com/neuron/abstr...
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Brian Sweis @brianmsweis.bsky.social · 23/06/2026
Thank you! I’m honored to receive this award! A special thank you to Mount Sinai, my mentors, mentees, colleagues, and family!
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Kate Nussenbaum @katenuss.bsky.social · 17/06/2026
📝 New preprint (co-led with Hannah Hamling as her NYU honors thesis!) 📝 🧠 Do adolescents learn differently in volatile versus stable environments? 🧠 Yes, and they seem to adapt their learning computations to a greater extent than adults! 😮 🤔 Preprint for deets (+ 👁️ data) osf.io/preprints/ps...
osf.io
OSF
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Rudebeck Lab @rudebecklab.bsky.social · 01/06/2026
A few years back we started a collaboration to try to work out the mechanisms engaged by DBS for depression. Published today we found that it changes functional networks (expected) but also remodels specific white matter tracts (unexpected). Read more here: www.nature.com/articles/s41...
nature.com
Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks - Nature Neuroscience
In a nonhuman primate model, Fujimoto et al. show that deep brain stimulation promotes white matter remodeling and reorganizes brain-wide functional networks, detailing a mechanism through which this ...
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Decision & Aging @srndna.bsky.social · 15/04/2026
📣 Call for Applications: 2026 SRNDNA Pilot Grant We’re excited to announce the final round of SRNDNA pilot funding supporting research at the intersection of decision neuroscience & aging. 🗓️ Applications due June 1, 2026 🧠 Priority: ADRD-related projects #DecisionNeuroscience #AgingResearch #ADRD
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Decision & Aging @srndna.bsky.social · 26/05/2026
Less than a week left! Apply now!
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The Friedman Brain Institute @sinaibrain.bsky.social · 06/04/2026
✨ April is #GraduateStudentAppreciation Month! 🏐 Highlighted here, Emma Andraka. Mentored by Daniela Schiller & @brianmsweis.bsky.social, Emma is developing a cross-species task for elucidating decision-making processes & neurophysiology underlying social interactions in rodents & humans. AMAZING!
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Rudebeck Lab @rudebecklab.bsky.social · 04/04/2026
Want a dataset to test ideas on neural basis of decision making or how areas interact as we make choices? Check out our data published today @rudebecklab.bsky.social. >16,000 single neurons from 22 anatomically confirmed areas in macaques performing a decision task. www.nature.com/articles/s41...
nature.com
Dataset of cortical and subcortical single neuron activity during value-based tasks in macaque monkey - Scientific Data
Scientific Data - Dataset of cortical and subcortical single neuron activity during value-based tasks in macaque monkey
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Constantinople lab @constantinoplelab.bsky.social · 03/04/2026
Excited to share our recent review, which highlights algorithmic and implementational degeneracy in studies of cognition: www.sciencedirect.com/science/arti...
sciencedirect.com
Addressing degeneracy in rodent studies of cognition
In order to relate neural dynamics to cognitive computations, it is critical to determine whether subjects are employing behavioral strategies that ac…
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Brian Sweis @brianmsweis.bsky.social · 30/03/2026
Thank you @drnancypadilla.bsky.social for hosting me! I hope this can be a helpful resource for students considering if the MD/PhD path is right for them!
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Brian Sweis @brianmsweis.bsky.social · 30/03/2026
Thank you @drnancypadilla.bsky.social for hosting me! I hope this can be a helpful resource for students considering if the MD/PhD path is right for them!
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Brian Sweis @brianmsweis.bsky.social · 26/03/2026
Congrats!
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Constantinople lab @constantinoplelab.bsky.social · 25/03/2026
Thrilled to share our new paper, which shows that the relative timing of cholinergic and dopamine release dynamically gates whether dopamine acts as an RPE for in vivo plasticity and reinforcement learning. www.nature.com/articles/s41...
nature.com
Acetylcholine demixes heterogeneous dopamine signals for learning and moving
Nature Neuroscience - Jang et al. measured dopamine and acetylcholine release in the striatum of rats performing a decision-making task and found that the relative timing of cholinergic and...
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Brian Sweis @brianmsweis.bsky.social · 24/03/2026
🚨The Sweis Lab for Translational Neuroeconomics at Mount Sinai is searching for a postdoctoral research fellow! If you or someone you know is searching for a position, please share! 📄 📌Link to job flyer here: tinyurl.com/3vapfpn5 🧠 🐁 🔬🏙️🌆🧪🧬💊🧫💡🏥 @sinaibrain.bsky.social @mountsinai.bsky.social
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Brian Sweis @brianmsweis.bsky.social · 17/03/2026
Very cool! Quick naive question - I’d imagine these effects could not be accounted for / are not driven by simpler changes in imaging due to a disturbance in the liquid compartments affecting the sensor optics themselves, changes in the z plane, etc?
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Nature Portfolio @natureportfolio.nature.com · 11/03/2026
For Pokémon’s 30th anniversary, Nature spoke to scientists from around the world about how their work has been shaped by playing Pokémon games, watching animated TV series and films and trading cards in school playgrounds. 🧪
go.nature.com
Pokémon turns 30 — how the fictional pocket monsters shaped science
The Japanese media sensation has inspired generations of researchers in fields as diverse as evolution, biodiversity and research integrity.
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Paul Kenny @paulkennyphd.bsky.social · 19/02/2026
Congratulations to our 2026 Scholars! This year’s projects span molecules to circuits to behavior and reflect the highly collaborative environment that defines neuroscience at Mount Sinai. Sincere thanks to the donors whose support makes this type of curiosity-driven science possible.
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Esther Krook-Magnuson @kmlab.bsky.social · 21/02/2026
The KM Lab is hiring! We're looking for both a new technician (makes a great post-bac like experience) and a post-doc. Come do fun science. Come join an amazing community. Learn more: sites.google.com/site/krookma...
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Patricia Lockwood @thepsychologist.bsky.social · 20/02/2026
We are recruiting! Postdoctoral research fellow at www.sdn-lab.org, studying the computational & neural basis of social decision-making. Birmingham is a fantastic & affordable place to live, with one of the youngest populations in Europe & over 600 parks. Please share! www.jobs.ac.uk/job/DQO275/p...
jobs.ac.uk
Postdoctoral Research Fellow in Social Decision Neuroscience at University of Birmingham
Explore an exciting academic career as a Postdoctoral Research Fellow in Social Decision Neuroscience. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
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Brian Sweis @brianmsweis.bsky.social · 19/02/2026
Congrats all!
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The Transmitter @thetransmitter.bsky.social · 16/02/2026
If neuroscience is serious about building general principles of brain function, cross-species dialogue must become a core organizing principle rather than an afterthought, writes @suthanalab.bsky.social. #neuroskyence www.thetransmitter.org/animal-model...
thetransmitter.org
Neuroscience has a species problem
If neuroscience is serious about building general principles of brain function, cross-species dialogue must become a core organizing principle.
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Keri Martinowich @martinowk.bsky.social · 16/02/2026
Really important insight from @suthanalab.bsky.social. There seems to be lots of general agreement about the importance for cross-species analysis. But, in practice and in the trenches - there's a real divide on how to do it and how to implement it. Appreciate these conversations being raised!
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Brian Sweis @brianmsweis.bsky.social · 07/02/2026
Congrats!!
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Denise J. Cai, Ph.D. @denisejcai.bsky.social · 06/02/2026
How does neuronal gene expression evolve over time in response to experience? CytoTape will help us find out - a major milestone for neuroscience, providing new ways to study memory & aging 🧠 Congrats to the whole team! Looking forward to our continued collaboration on this work 🎉
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allen institute @alleninstitute.org · 05/12/2025
🧠📢 New preprint alert Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧵 #neuroskyence #compneurosky
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Nancy Padilla-Coreano @drnancypadilla.bsky.social · 03/12/2025
(1/6) We have a new paper out in #eNeuro! How does the brain’s reward processing change across social contexts? We mapped brain activity (cFos) & found that social context reshapes how reward circuits are coordinated🐭🏆 Read more: www.eneuro.org/content/12/1...
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Kenneth Harris @kenneth-harris.bsky.social · 14/11/2025
1. New preprint resolving a conundrum in systems neuroscience with an AI scientist, and humans Reilly Tilbury, Dabin Kwon, @haydari.bsky.social, @jacobmratliff.bsky.social, @bio-emergent.bsky.social, @carandinilab.net, @kevinjmiller.bsky.social, @neurokim.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Characterizing neuronal population geometry with AI equation discovery
The visual cortex contains millions of neurons, whose combined activity forms a population code representing visual stimuli. There is, however, a discrepancy between our understanding of this code at ...
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Optogenetics Gordon Research Conference @optogrc.bsky.social · 26/11/2025
🚨 Reminder: Applications for #OptoGRC2026 are now OPEN! Don’t miss your chance to join an incredible week of science, discovery, and connection with the brightest minds in optogenetics 💡🧠 Apply now for the best chance of acceptance: www.grc.org/optogenetic-...
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The Friedman Brain Institute @sinaibrain.bsky.social · 25/11/2025
NOT TO MISS! In @mountsinainyc.bsky.social's 2025 issue of Science & Medicine magazine, Dean @ericjnestler.bsky.social discusses his vision for Icahn Mount Sinai, and how his distinguished academic career & research expertise have prepared him. 👉 scienceandmedicine.mountsinai.org/article/2025...
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Brian Sweis @brianmsweis.bsky.social · 14/11/2025
It’s giving Dr. T.J. Eckleburg
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