Sign in

Brian Sweis

@brianmsweis.bsky.social
443 followers 250 following 51 posts

MD, PhD | psychiatry | neuroscience | neuroeconomics | neuromodulation | assistant professor | residency program training director @MountSinaiPsych @SinaiBrain 🧠

PostsRepliesMedia
Reposted by Brian Sweis
Nicole Rust @nicolecrust.bsky.social · 26/09/2026
2. @brianmsweis.bsky.social ++ are building up insights into the neural circuits responsible for *regret* and seeing it through to their implications for psychiatric conditions. www.science.org/doi/10.1126/...
science.org
Distinct forms of regret linked to resilience versus susceptibility to stress are regulated by region-specific CREB function in mice
Resilience versus susceptibility to stress confers sensitivity to distinct types of regret mediated by different brain regions.
1123
Reposted by Brian Sweis
Zach Pennington @zachtpennington.bsky.social · 24/09/2026
I'm honoured to be among this incredible group of scientists and immensely grateful for the support of @braincanada.bsky.social, which will allow my lab to address fundamental questions about how reward memories can be so long-lasting, influencing mental health conditions like addiction.
4283
Reposted by Brian Sweis
The Friedman Brain Institute @sinaibrain.bsky.social · 17/09/2026
ONE WEEK AWAY! On Thursday, September 24, 1pm, the #FBISeminarSeries and host Dr. @bshev.bsky.social welcome @upenn.edu's Dr. @nicolecrust.bsky.social. Dr. Rust will present "From Subjective Feelings to Brain Mechanisms: Advancing the Science of Mood through Epistemic Iteration". ✨NOT TO MISS!
094
Reposted by Brian Sweis
Blair Shevlin @bshev.bsky.social · 17/09/2026
Incredibly excited to host this event next week! Dr. Rust's work is both rigorous and inspiring
021
Reposted by Brian Sweis
The Friedman Brain Institute @sinaibrain.bsky.social · 16/09/2026
TOMORROW! Not To Miss! On Thurs, Sept. 17th, 1pm, the #FBISeminarSeries & host Dr. @brianmsweis.bsky.social welcome @medschool.umaryland.edu's Dr. Marco Venniro: “From isolation to connection: a journey through addiction neuroscience”. Learn More about the Venniro Lab's work 🐁 www.vennirolab.org
021
Reposted by Brian Sweis
The Friedman Brain Institute @sinaibrain.bsky.social · 14/09/2026
COMING UP! Not To Miss! On Thurs, Sept. 17th, 1pm, the #FBISeminarSeries & host Dr. @brianmsweis.bsky.social welcome @medschool.umaryland.edu's Dr. Marco Venniro: “From isolation to connection: a journey through addiction neuroscience”. Learn More about the Venniro Lab's work: 🐁 www.vennirolab.org
021
Reposted by Brian Sweis
Herbert Wu @herbertwu.bsky.social · 20/08/2026
First study out! Using a new cooperative paradigm and multi-agent inverse RL, we show that mice spontaneously adopt leader/follower roles, and the prefrontal cortex encodes these role dynamics and an egocentric social value map of the partner’s position. (1/3) www.nature.com/articles/s41...
nature.com
Asymmetric prefrontal representations for leader–follower dynamics - Nature
Mice spontaneously form leader and follower roles during cooperation, and the medial prefrontal cortex encodes these role dynamics and an egocentric social value map of the partner’s position.
48124
Reposted by Brian Sweis
Jennifer Bussell PhD @jenbussell.bsky.social · 30/07/2026
How does the brain represent the value of knowledge? In our paper--out now at Nature Neuroscience--we identify a representation of intrinsic information value within neural population structures in the orbitofrontal cortex in mice. www.nature.com/articles/s41593-026-02377-y #neuroskyence 🧠🧪 (1/8)
nature.com
Representations of the intrinsic value of information in mouse orbitofrontal cortex - Nature Neuroscience
Mice are motivated to seek information of no extrinsic value. Recording neural activity in orbitofrontal cortex reveals a representation of the value of information that is distinct from the value of ...
917965
Brian Sweis @brianmsweis.bsky.social · 16/07/2026
Congrats Lorenzo and team! 👏 excited to collaborate with you in the near future!
110
Reposted by Brian Sweis
Ben Hayden @benhayden.bsky.social · 16/07/2026
Hard to overstate the importance of this paper. Acategoricality and mixed selectivity together kill a lot of sacred cows. For starters, place cells aren't real, in that they are not a meaningful category. They are just a thing we scrape out of the data. Scientists focus on them because...
26818
Reposted by Brian Sweis
Kurt Fraser @kurtfraser.bsky.social · 11/07/2026
Our labs first paper! Some 😳 surprising effects. Turns out everything comes back to context 🤓
148824
Reposted by Brian Sweis
Lex Kravitz @kravitzlab.com · 09/07/2026
I am happy to share our latest manuscript, led by newly-minted PhD Justin Wang, identifying a neural population that selectively controls hedonic, but not homeostatic, feeding. www.biorxiv.org/content/10.6...
biorxiv.org
Ventral pallidal GABAergic neurons control hedonic feeding and obesity
Food intake is governed by two interacting drives. The homeostatic hunger drive regulates food intake to fulfill caloric needs while the hedonic drive promotes intake of palatable foods outside of cal...
25620
Reposted by Brian Sweis
The Friedman Brain Institute @sinaibrain.bsky.social · 25/06/2026
EXCITING PAPER! In this review, Drs. Parul Jain & Daniela Schiller synthesize research across various domains to trace how relationships develop from initial impressions through repeated interactions to stable social bonds & networks. Neuron l @cellpress.bsky.social 👉 www.cell.com/neuron/abstr...
031
Brian Sweis @brianmsweis.bsky.social · 23/06/2026
Thank you! I’m honored to receive this award! A special thank you to Mount Sinai, my mentors, mentees, colleagues, and family!
000
Reposted by Brian Sweis
Kate Nussenbaum @katenuss.bsky.social · 17/06/2026
📝 New preprint (co-led with Hannah Hamling as her NYU honors thesis!) 📝 🧠 Do adolescents learn differently in volatile versus stable environments? 🧠 Yes, and they seem to adapt their learning computations to a greater extent than adults! 😮 🤔 Preprint for deets (+ 👁️ data) osf.io/preprints/ps...
osf.io
OSF
04114
Reposted by Brian Sweis
Rudebeck Lab @rudebecklab.bsky.social · 01/06/2026
A few years back we started a collaboration to try to work out the mechanisms engaged by DBS for depression. Published today we found that it changes functional networks (expected) but also remodels specific white matter tracts (unexpected). Read more here: www.nature.com/articles/s41...
nature.com
Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks - Nature Neuroscience
In a nonhuman primate model, Fujimoto et al. show that deep brain stimulation promotes white matter remodeling and reorganizes brain-wide functional networks, detailing a mechanism through which this ...
26628
Reposted by Brian Sweis
Decision & Aging @srndna.bsky.social · 15/04/2026
📣 Call for Applications: 2026 SRNDNA Pilot Grant We’re excited to announce the final round of SRNDNA pilot funding supporting research at the intersection of decision neuroscience & aging. 🗓️ Applications due June 1, 2026 🧠 Priority: ADRD-related projects #DecisionNeuroscience #AgingResearch #ADRD
146
Reposted by Brian Sweis
Decision & Aging @srndna.bsky.social · 26/05/2026
Less than a week left! Apply now!
011
Reposted by Brian Sweis
The Friedman Brain Institute @sinaibrain.bsky.social · 06/04/2026
✨ April is #GraduateStudentAppreciation Month! 🏐 Highlighted here, Emma Andraka. Mentored by Daniela Schiller & @brianmsweis.bsky.social, Emma is developing a cross-species task for elucidating decision-making processes & neurophysiology underlying social interactions in rodents & humans. AMAZING!
012
Reposted by Brian Sweis
Rudebeck Lab @rudebecklab.bsky.social · 04/04/2026
Want a dataset to test ideas on neural basis of decision making or how areas interact as we make choices? Check out our data published today @rudebecklab.bsky.social. >16,000 single neurons from 22 anatomically confirmed areas in macaques performing a decision task. www.nature.com/articles/s41...
nature.com
Dataset of cortical and subcortical single neuron activity during value-based tasks in macaque monkey - Scientific Data
Scientific Data - Dataset of cortical and subcortical single neuron activity during value-based tasks in macaque monkey
210534
Reposted by Brian Sweis
Constantinople lab @constantinoplelab.bsky.social · 03/04/2026
Excited to share our recent review, which highlights algorithmic and implementational degeneracy in studies of cognition: www.sciencedirect.com/science/arti...
sciencedirect.com
Addressing degeneracy in rodent studies of cognition
In order to relate neural dynamics to cognitive computations, it is critical to determine whether subjects are employing behavioral strategies that ac…
03913
Brian Sweis @brianmsweis.bsky.social · 30/03/2026
Thank you @drnancypadilla.bsky.social for hosting me! I hope this can be a helpful resource for students considering if the MD/PhD path is right for them!
011
Brian Sweis @brianmsweis.bsky.social · 30/03/2026
Thank you @drnancypadilla.bsky.social for hosting me! I hope this can be a helpful resource for students considering if the MD/PhD path is right for them!
010
Reposted by Brian Sweis
Constantinople lab @constantinoplelab.bsky.social · 25/03/2026
Thrilled to share our new paper, which shows that the relative timing of cholinergic and dopamine release dynamically gates whether dopamine acts as an RPE for in vivo plasticity and reinforcement learning. www.nature.com/articles/s41...
nature.com
Acetylcholine demixes heterogeneous dopamine signals for learning and moving
Nature Neuroscience - Jang et al. measured dopamine and acetylcholine release in the striatum of rats performing a decision-making task and found that the relative timing of cholinergic and...
215767
Brian Sweis @brianmsweis.bsky.social · 24/03/2026
🚨The Sweis Lab for Translational Neuroeconomics at Mount Sinai is searching for a postdoctoral research fellow! If you or someone you know is searching for a position, please share! 📄 📌Link to job flyer here: tinyurl.com/3vapfpn5 🧠 🐁 🔬🏙️🌆🧪🧬💊🧫💡🏥 @sinaibrain.bsky.social @mountsinai.bsky.social
01115
Reposted by Brian Sweis
Nature Portfolio @natureportfolio.nature.com · 11/03/2026
For Pokémon’s 30th anniversary, Nature spoke to scientists from around the world about how their work has been shaped by playing Pokémon games, watching animated TV series and films and trading cards in school playgrounds. 🧪
go.nature.com
Pokémon turns 30 — how the fictional pocket monsters shaped science
The Japanese media sensation has inspired generations of researchers in fields as diverse as evolution, biodiversity and research integrity.
15420
Reposted by Brian Sweis
Paul Kenny @paulkennyphd.bsky.social · 19/02/2026
Congratulations to our 2026 Scholars! This year’s projects span molecules to circuits to behavior and reflect the highly collaborative environment that defines neuroscience at Mount Sinai. Sincere thanks to the donors whose support makes this type of curiosity-driven science possible.
042
Reposted by Brian Sweis
Esther Krook-Magnuson @kmlab.bsky.social · 21/02/2026
The KM Lab is hiring! We're looking for both a new technician (makes a great post-bac like experience) and a post-doc. Come do fun science. Come join an amazing community. Learn more: sites.google.com/site/krookma...
0119
Reposted by Brian Sweis
Patricia Lockwood @thepsychologist.bsky.social · 20/02/2026
We are recruiting! Postdoctoral research fellow at www.sdn-lab.org, studying the computational & neural basis of social decision-making. Birmingham is a fantastic & affordable place to live, with one of the youngest populations in Europe & over 600 parks. Please share! www.jobs.ac.uk/job/DQO275/p...
jobs.ac.uk
Postdoctoral Research Fellow in Social Decision Neuroscience at University of Birmingham
Explore an exciting academic career as a Postdoctoral Research Fellow in Social Decision Neuroscience. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
13645
Reposted by Brian Sweis
The Transmitter @thetransmitter.bsky.social · 16/02/2026
If neuroscience is serious about building general principles of brain function, cross-species dialogue must become a core organizing principle rather than an afterthought, writes @suthanalab.bsky.social. #neuroskyence www.thetransmitter.org/animal-model...
thetransmitter.org
Neuroscience has a species problem
If neuroscience is serious about building general principles of brain function, cross-species dialogue must become a core organizing principle.
38732
Reposted by Brian Sweis
Keri Martinowich @martinowk.bsky.social · 16/02/2026
Really important insight from @suthanalab.bsky.social. There seems to be lots of general agreement about the importance for cross-species analysis. But, in practice and in the trenches - there's a real divide on how to do it and how to implement it. Appreciate these conversations being raised!
0214
Reposted by Brian Sweis
Denise J. Cai, Ph.D. @denisejcai.bsky.social · 06/02/2026
How does neuronal gene expression evolve over time in response to experience? CytoTape will help us find out - a major milestone for neuroscience, providing new ways to study memory & aging 🧠 Congrats to the whole team! Looking forward to our continued collaboration on this work 🎉
2219
Reposted by Brian Sweis
allen institute @alleninstitute.org · 05/12/2025
🧠📢 New preprint alert Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧵 #neuroskyence #compneurosky
37231
Reposted by Brian Sweis
Nancy Padilla-Coreano @drnancypadilla.bsky.social · 03/12/2025
(1/6) We have a new paper out in #eNeuro! How does the brain’s reward processing change across social contexts? We mapped brain activity (cFos) & found that social context reshapes how reward circuits are coordinated🐭🏆 Read more: www.eneuro.org/content/12/1...
24011
Reposted by Brian Sweis
Kenneth Harris @kenneth-harris.bsky.social · 14/11/2025
1. New preprint resolving a conundrum in systems neuroscience with an AI scientist, and humans Reilly Tilbury, Dabin Kwon, @haydari.bsky.social, @jacobmratliff.bsky.social, @bio-emergent.bsky.social, @carandinilab.net, @kevinjmiller.bsky.social, @neurokim.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Characterizing neuronal population geometry with AI equation discovery
The visual cortex contains millions of neurons, whose combined activity forms a population code representing visual stimuli. There is, however, a discrepancy between our understanding of this code at ...
19526
Reposted by Brian Sweis
Optogenetics Gordon Research Conference @optogrc.bsky.social · 26/11/2025
🚨 Reminder: Applications for #OptoGRC2026 are now OPEN! Don’t miss your chance to join an incredible week of science, discovery, and connection with the brightest minds in optogenetics 💡🧠 Apply now for the best chance of acceptance: www.grc.org/optogenetic-...
0128
Reposted by Brian Sweis
The Friedman Brain Institute @sinaibrain.bsky.social · 25/11/2025
NOT TO MISS! In @mountsinainyc.bsky.social's 2025 issue of Science & Medicine magazine, Dean @ericjnestler.bsky.social discusses his vision for Icahn Mount Sinai, and how his distinguished academic career & research expertise have prepared him. 👉 scienceandmedicine.mountsinai.org/article/2025...
053
Reposted by Brian Sweis
The Friedman Brain Institute @sinaibrain.bsky.social · 14/11/2025
A Special Congratulations to @ericjnestler.bsky.social on receiving the 2025 Synapsy Prize. This prestigious award celebrates lifelong dedication to translating fundamental neuroscience discoveries into tangible clinical advancements in mental health. Learn More 👉 www.eurekalert.org/news-release...
0234
Brian Sweis @brianmsweis.bsky.social · 14/11/2025
Stop by our posters tomorrow afternoon at #SFN25!! #sfn2025 @sfn.org #neuroscience
052
Reposted by Brian Sweis
adrinnenberg.bsky.social @adrinnenberg.bsky.social · 13/11/2025
✨ New preprint ✨ What if we could watch AND control thousands of individual neurons in behaving mice—with stable access over months? 🧠⚡ Our work introduces transgenic all-optical tools that make this possible - and a resulting surprising discovery! 🔭💡 www.biorxiv.org/content/10.1... 1/13 🧵
biorxiv.org
Large-scale cellular-resolution read/write of activity enables discovery of cell types defined by complex circuit properties
The complexity of the mammalian brain’s vast population of interconnected neurons poses a formidable challenge to elucidate its underlying mechanisms of coordination and computation. A key step forwar...
14914
Reposted by Brian Sweis
Markus Wöhr @markuswohr.bsky.social · 06/11/2025
Our Behavioural Brain Research special issue on Ultrasonic Communication in Rodents is growing, rapidly – and actually a lot faster than I manage to post about it. Nine new manuscripts got accepted since my last post. Quite impressive work. Check it out: www.sciencedirect.com/special-issu...
02413
Reposted by Brian Sweis
Abha Karki Rajbhandari, PhD @brainbodylab.bsky.social · 29/10/2025
📣We are hiring! 📣 
Join us as a Postdoctoral Researcher to study brain–body interactions uncovering how neural and physiological systems regulate behavior and energy metabolism under stress! Details are below: 📩 abha.rajbhandari@mssm.edu
🔗 careers.mountsinai.org/jobs/3032214
careers.mountsinai.org
Postdoctoral Fellow-MSH-13400-363 in New York, NY | Mount Sinai Health Systems
Mount Sinai is hiring a Postdoctoral Fellow-MSH-13400-363 in New York, NY. Review all of the job details and apply today!
197
Brian Sweis @brianmsweis.bsky.social · 29/10/2025
For those heading to #SfN25, come check out our posters on Saturday Afternoon! The lab is growing & expanding in several new directions & collabs #neuroeconomics 🧠🐭🧠 @sinaibrain.bsky.social @sinaiccp.bsky.social @sfn.org @socforneuroecon.bsky.social @bwfund.bsky.social @animalsocaging.bsky.social
11712
Reposted by Brian Sweis
The Friedman Brain Institute @sinaibrain.bsky.social · 23/10/2025
"The way forward has become very clear"- Dr. Brendan G. Carr A HUGE CONGRATULATIONS to @ericjnestler.bsky.social named Anne & Joel Ehrenkranz Dean of the Icahn School of Medicine. We’re thrilled about the exciting new direction Icahn Mount Sinai will take under Dr. Nestler's visionary leadership!
0135
Reposted by Brian Sweis
Sarah Heilbronner @srheilbronner.bsky.social · 21/10/2025
When I moved to BCM, an extremely talented movement disorders neurologist, Nora Vanegas Arroyave, reached out to discuss brain circuits responsible for non-motor deficits in Parkinson's Disease. I have learned so much from her and from this collaboration. One paper out, more to come!
academic.oup.com
Apathy, effort-based decisions and brain integrity in Alzheimer’s and Parkinson’s diseases
Morris et al. identify a common behavioural signature of apathy in Alzheimer’s and Parkinson’s disease: a decision bias towards rejecting the option to exe
1308
Reposted by Brian Sweis
Shawn Rhoads @shawnrhoadsphd.com · 22/09/2025
We are also considering applications from undergraduate students and Master's students in the local New York City area! Please check out our website for more information on how to become involved: sinclaboratory.com/apply
sinclaboratory.com
Apply
SOCIAL INTERACTION &<br>NEURAL COMPUTATION LAB. The SINC Lab examines the neural and computational basis of social cognition and interaction. We are particularly interested in understanding how social...
123
Reposted by Brian Sweis
Armin Lak @laklab.bsky.social · 16/10/2025
Out today at Neuron, our experiments show that frontal cortical representation of economic variables is jointly determined by spatial organization and downstream connectivity of neurons, revealing a structured, multi-scale code for economic variables. www.cell.com/neuron/fullt...
69827
Reposted by Brian Sweis
Jonah Padawer-Curry, PhD @jonahpadawercurry.bsky.social · 15/10/2025
🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging. 👇🧵 nature.com/articles/s41... #Neuroscience #Psychedelics #BrainImaging
nature.com
Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function
Nature Neuroscience - Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI...
14825