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Brian Sweis

@brianmsweis.bsky.social

450 followers 251 following 55 posts

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Brian Sweis @brianmsweis.bsky.social · 09/10/2026

As a field, do we think Prof Schultz’s own #dopamine neurons are spiking, dipping, or staying the same right now? 🖼️ 🧠 #SNE2026 @socforneuroecon.bsky.social

Prof Wolfram Schultz sitting in the audience at the 2026 Society for Neuroeconomics annual meeting seeing his famous figure of classic dopamine reward prediction error firing being presented during a talk. The figure is framed on the slide. (posted with his permission)

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Brian Sweis @brianmsweis.bsky.social · 24/03/2026

🚨The Sweis Lab for Translational Neuroeconomics at Mount Sinai is searching for a postdoctoral research fellow! If you or someone you know is searching for a position, please share! 📄 📌Link to job flyer here: tinyurl.com/3vapfpn5 🧠 🐁 🔬🏙️🌆🧪🧬💊🧫💡🏥 @sinaibrain.bsky.social @mountsinai.bsky.social

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Brian Sweis @brianmsweis.bsky.social · 14/11/2025

It’s giving Dr. T.J. Eckleburg

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Brian Sweis @brianmsweis.bsky.social · 14/11/2025

Stop by our posters tomorrow afternoon at #SFN25!! #sfn2025 @sfn.org #neuroscience

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Brian Sweis @brianmsweis.bsky.social · 29/10/2025

For those heading to #SfN25, come check out our posters on Saturday Afternoon! The lab is growing & expanding in several new directions & collabs #neuroeconomics 🧠🐭🧠 @sinaibrain.bsky.social @sinaiccp.bsky.social @sfn.org @socforneuroecon.bsky.social @bwfund.bsky.social @animalsocaging.bsky.social

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Brian Sweis @brianmsweis.bsky.social · 13/09/2025

#FluorescentFriday The lab’s 1st slice physiology recordings! Timelapse recording of striatal neurons ex vivo using a Thy1-GCaMP mouse 🐭 🧠 + glutamate in the bath. Thanks @neuromanonyc.bsky.social! Shout out to @keyenceusa.bsky.social who has been great to work with customizing the BZ-X800🔬

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Brian Sweis @brianmsweis.bsky.social · 15/07/2025

This speaks to the importance of cross-species research that is constantly forward- & back-translated between the clinic & lab. The importance of animal models leading to unanticipated discoveries - even in the realm of human psychology - is invaluable, especially in psychiatry🧠 tinyurl.com/yur3j2n8

From the linked press release: “Neuroscientists discover that a non-coding RNA molecule in the prefrontal cortex, which promotes resilience to depression only in women, alters how the female brain ruminates on the past when making certain types of decisions in a mouse model. The single-stranded RNA molecule LINC00473 is depicted in the center. Image generated by OpenAI.”

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Brian Sweis @brianmsweis.bsky.social · 15/07/2025

Here, we discovered LINC00473 in mPFC specifically altered change-of-mind decisions in female mice only. This was driven by enhanced sensitivity to sunk costs and how much re-evaluating recent mistakes influenced future choices. This is the 1st demo of non-coding RNA playing a role in cognition 5/6

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Brian Sweis @brianmsweis.bsky.social · 15/07/2025

A recent study led by @ornaissler.bsky.social found levels of the non-coding RNA LINC00473 were reduced specifically in mPFC 🧠 of women but not men diagnosed with MDD, based on post-mortem human 🧠 tissue studies. Expressing LINC00473 in mPFC promotes resilience to stress in female mice only. 4/6 🐭

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Brian Sweis @brianmsweis.bsky.social · 15/07/2025

Women are 2x as likely to develop depression than men. Major depressive disorder can manifest w different symptoms b/t sexes, including alterations in negative rumination on the past. Combining clinical questions, behavioral neuroscience, & translational #neuroeconomics, we dove into this deeper 3/6

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Brian Sweis @brianmsweis.bsky.social · 15/07/2025

We found striking sex differences in only change-of-mind choices, and not initial value-based judgements, in mice 🐭 working for food rewards of varying costs (delays ⏰) & preferences (flavors 🧀🍌🍫🍇) on our #neuroeconomic foraging task, Restaurant Row, while on a limited daily time budget. 2/6

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Brian Sweis @brianmsweis.bsky.social · 06/04/2025

From my graduate lab - single units in OFC & NAc as well as population decoding. Firing / representations of missed rewards into the next trial but only when encountering a worse offer on the next trial following an economic violation. Counterfactual / regret signals. www.nature.com/articles/nn....

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Brian Sweis @brianmsweis.bsky.social · 07/12/2024

Hi #ACNP2024 6th conference for me! I’m a physician-scientist Asst Prof in Psychiatry & Neuroscience studying decision-making across species. Come to our poster T185 on REGRET in humans. Huge collaboration across multiple labs - we want your help as a field to define this construct!🧠 #neuroeconomics

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Brian Sweis @brianmsweis.bsky.social · 11/11/2023

Excited for #SfN23 this year! 🧠 🐭🧠🐭🧠🐭🧠 Come by our linked posters Sunday Morning OO21-24 to see some of the new collaborations in #NeuroEconomics that have been developing at Mount Sinai!

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