Mendelian randomization (MR) enables the estimation of causal effects while controlling for unmeasured confounding factors, but MR estimators often rely on strong parametric assumptions. We propose an...

This mass spectrometry-based proteomic study profiles the plasma proteome in 2,147 children and adolescents and reveals its association with age, sex, puberty, body mass index and genetics.

Any variant associated with either numerator or denominator will associate with the ratio in GWAS of sufficient size. Associations with ratio traits are thus not specific to the ratio. Instead, we rec...