iiinova — where your digital self keeps evolving

thanks! it was great to meet you too, see you at the next conference!

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... but before leaving Vienna, I couldn't resist some local #patisserie 🍰 Just... glorious.

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thanks @iuisjuniorcomm.bsky.social for inviting us to their career fair where I had a chance to talk about how I got started with my #sci_comm gig! I loved the discussion afterwards

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So long, Vienna! I'm back home in Amsterdam after a great week of #immunology at #IUIS2025! I had an amazing time! Check out @immunologypodcast.com for daily episodes covering our favorite talks & recording of the live episode! Thanks @iuis-online.bsky.social! See you all in Toronto #IUIS2028

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Cool abstract talks from Charlotte Zajc @meduniwien.ac.at about engineering CARs with ON- and OFF-switches modulated by small molecules & Carolina Mangana @cemm.oeaw.ac.at about changes in tumor-draining LNs brought up by increased myeloid (Mo/Mac) infiltration and loss of T cell zone #IUIS2025

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Gabriel is opening a new lab in #Barcelona with support of @caixaresearch.bsky.social - and they are hiring!

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Next in the session: Gabriel Rabinovich (@University of Buenos Aires)☝️ Galectin 1 promotes tumor growth in many ways, such interaction w/ VEGFR2 to promote angiogenesis (resistant to anti-VEGF therapy) & enhancement of myeloid suppressor cells 💡GAL1-neutralizing mAb could help. #IUIS2025

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The band was awesome! Looking forward to their next tour date #IUIS2028 🎶 @iuis-online.bsky.social make sure to book them well in advance, I am sure these musicians are in high demand 🤣

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British Society for Immunology @britsocimm.bsky.social · 22/08/2025

Another daily episode is out! Our highlights from yesterday's sessions @immunologypodcast.com @iuis-online.bsky.social #IUIS2025

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🔬 Struggling to design multiparametric #flow #cytometry experiments? Learn how to cut through the complexity and build experiments that work in our training course with @ddcytometry.bsky.social, taking place on 17 & 24 September. ⏳ Just weeks away! Secure your spot today: bit.ly/43N86mG

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... 2️⃣ Logic-gating: IF-BETTER gates target 2 antigens-> enhanced activity when primary Ag expression low 3️⃣ inactivating mutation of 2/3 of CD3 ITAM domains improves CAR-T cell persistence w/o affecting function - only 25M dose sufficient for protective response in B cell lymphoma

#IUIS2025 Day 5! Time flies when having fun! Started the day w/ excellent talk from Michael Sadelain @columbiacancer.bsky.social about the current state of CAR T cell therapy and exciting approaches 1️⃣ HLA-independent TCRs interact with CD3 molecules for increased sensitivity and work in low Ag...

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Immunology Podcast @immunologypodcast.com · 21/08/2025

Also in the #neuroimmunology session: David Hafler @yaleschoolofmed.bsky.social - IFNg+CD4 cells in brain: come from gut, similar to WAT T cells, affect behavior / increased infiltration in early Parkinson's brain precedes symptoms - could targeting this inflammation be key to prevent progression?

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A huge thank-you to Dr. Zwi Berneman for joining us for this special show at #IUIS2025, and thanks to everyone who came to listen! If you missed it, the episode will be published on podcast platforms next week!

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Immunology Podcast @immunologypodcast.com · 20/08/2025

You can see how happy we were to see Dr. James Allison in person at #IUIS2025! 😁 We had the pleasure of speaking with Dr. Allison in 2024. Listen to the conversation here: bit.ly/47EUFYm

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just look at those little buddies interacting in vitro! #neuroimmunology

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@iuis-online.bsky.social #IUIS2025 Day 4! reporting for the @immunologypodcast.com Started the day w/ neuro immunology session - cool story from Ulrich von Andrian @harvardmed.bsky.social -> close interaction of dermal DCs and nociceptive neurons in dermatitis & myeloid suppressor cells in cancer

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Also on #IUIS2025 Day 3: keynote by Ruslan Medzhitov. Pet shop mice have pre-existing immunity (look at the size of those LNs!) and a crowded "antigenic space" with Th1/17/reg immunity. Allergic sensitization in SPF mice is possible because the antigenic space is available for full blown Th2

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Next up: BRAIN EATING AMOEBA 😱 - Ashley Moseman from @duke-university.bsky.social: N. fowleri infection starts through olfactory nerves 👃 and because complement proteins: ❌ can't cross blood-olfactory barrier ❌ can't mark amoeba for neutrophil attack, pathogen 🦠 reaches brain ahead of immune cells 😵

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Later on: @victora.bsky.social at RockefellerU used brainbow mice to study BCR evolution in individual GCs - tl;dr: GCs mostly do mutations that are easy, not most enhancing/ GCs are intolerant to loss of affinity / clonal bursts are not main drivers: rather slow evolution biased to higher affinity

Brenda Raud @brendaraud.bsky.social · 20/08/2025

I loved seeing the story from @iannaconelab.bsky.social presented live! HBV-infected hepatocytes can prime CD8 cells directly but CD4 help -> Kupffer cells (not DCs) -> CD27 is needed to prevent dysfunction (check episode #109 of @immunologypodcast.com for the full story!)

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Day 3 #IUIS2025 @immunologypodcast.com Lost a pair of pants and was late to the 1st session of today 🥲 - but enjoyed a masterclass on immune suppression after severe illness from Laura Cook @Peter Doherty Institute - finished strong w/cute organoid-derived pineapple shaped cilliated cells

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#IUIS2025 Rising Stars: Thomas Krausgruber (@cemm.oeaw.ac.at ) w/ role of structural cells in response to acute/chronic LCMV infecions, Thomas Vogl (@meduniwien.ac.at) dramatic changes in Ab repertoires in 1y of life & @kedmiranit.bsky.social on interacting Rorgt+ APC and pTregs in oral tolerance.

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Very cool plenary talk from Dan Littman from NYU on 20 years of RORgt history. Latest news: identity of RORgt+ tolerogenic APCs driving the development of pTreg populations in response to microbes & oral antigens! Cells are DC lineage (TolDCs) and RORgt + PRDM16 are key TFs. #IUIS2025

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Next up: grat talk from Willfred Ellmeier from @univie.ac.at about the effect of inhibiting HDAC1 in autoimmunity! Would be a great target for therapy but HDAC1-specific inhibitors are hard to come by... @immunologypodcast.com #immunosky #IUIS2025

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#IUIS2025 Day 2! Jochen Hühn(@helmholtzhzi.bsky.social): Tissue-resident Tregs show unique methylation vs. splenic Tregs. Residency depends on stromal cell conditioning 👉 Microbiome-derived tryptophan metabolites tune adipose stromal cells → IL-33 → support of ST2⁺ Tregs in fat tissue.

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Brenda Raud @brendaraud.bsky.social · 23/07/2025

I'm at #IUIS2025 in #Vienna! On the ground reporting for the @immunologypodcast.com🎤 with by buddy Jason (@drsifujg.bsky.social) Looking forward to a few days awesome talks, and to our LIVE PODCAST EPISODE on Thursday! #immunosky

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congratulations on your publication! it was a great read :)

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Brenda Raud @brendaraud.bsky.social · 06/05/2025

Our latest #IMMUNOLOGY2025 episode is available to download! Tune in to hear our highlights from day 2 #immunosky #AAI2025

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Brenda Raud @brendaraud.bsky.social · 05/05/2025

Aloha! The first episode of our live coverage of #IMMUNOLOGY2025 is ready to download. Jason and I share the highlights of the sessions of Day 1 #immunosky #AAI2025

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Brenda Raud @brendaraud.bsky.social · 04/05/2025

enjoy guys! I hope to bump into one of you at some point! :)

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Brenda Raud @brendaraud.bsky.social · 04/05/2025

I'm in Honolulu for #IMMUNOLOGY2025! Stay tuned for live coverage of the conference, and if you are around, you can: - JOIN OUR LIVE SHOW on Monday! 🤩 - Join our special podcast episode featuring attendees 🎙️ - Say hi to me if you'd like 🤗 More info? come over to the @immunologypodcast.com booth!

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Immunology Podcast @immunologypodcast.com · 23/04/2025

We have a new episode out! Dr. Henrique Veiga-Fernandes from the @champalimaudf.bsky.social joins us to talk about crosstalk between #neurons and the immune system. Listen now: bit.ly/3Y9fPbF

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Immunology Podcast @immunologypodcast.com · 08/04/2025

Our next episode features Dr. Monika Wolkers (@monikawolkers.bsky.social) from @uva.nl! Check out her lab's work on RNA-binding proteins and their effects on #Tcell effector function in this @cp-cellreports.bsky.social paper: bit.ly/3XOARMw

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Brenda Raud @brendaraud.bsky.social · 16/03/2025

The 100th episode of the @immunologypodcast.com is out! Don't miss out on our conversation with Nobel prize laureate Peter Doherty about his research on T cell immunity, his 50+year career in immunology and the joy of doing science! www.immunologypodcast.com/ep-100-viral...

immunologypodcast.com

Ep. 100: "Viral Immunity" Featuring Dr. Peter Doherty - The Immunology Podcast

Dr. Peter Doherty is Laureate Professor at the University of Melbourne. He and Dr. Rolf Zinkernagel, the co-recipient of the 1996 Nobel Prize in Physiology or Medicine, discovered how T cells recogniz...

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Institute of Molecular Biology (IMB) @imbmainz.bsky.social · 17/02/2025

The summer call of our International PhD programme is open! 📢 Ready to advance your scientific career? If you're passionate about #RNAbiology, #Bioinformatics, or #Immunology, apply to our open calls and join our global community of over 200 #PhD students! 🌍 www.imb.de/phd

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EFIS_Immunology @efis-immunology.bsky.social · 10/03/2025

EFIS, together with its official journal, EJI, and its partner, the Fondation ACTERIA, will be awarding up to 100 travel grants for early career researchers to attend the 19th International Congress of Immunology - IUIS 2025. Read more and apply 👉 www.efis.org/news/efis-tr... #immunology #IUIS2025

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Serendipity brought this opportunity to my inbox almost five years ago ❤️ Hard (fun) work and the support from everyone in the team made it the experience of a lifetime. 𝗛𝗲𝗿𝗲 𝗶𝘀 𝗮 𝘁𝗼𝗮𝘀𝘁 𝘁𝗼 𝘁𝗵𝗲 𝗻𝗲𝘅𝘁 𝟭𝟬𝟬 𝗲𝗽𝗶𝘀𝗼𝗱𝗲𝘀! 🥂

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I am full of gratitude to the 100+ scientists that we interviewed throughout the years, Nicole and Kristina who trusted me with bringing their project to life, Patricia who makes the whole thing work behind the scenes, and @stemcell.com for sponsoring our work.

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On top of that, we collaborate with @aai.org and @iuis-online.bsky.social to bring our podcast live to their conferences. Washington DC, Cape Town, Chicago… next up Honolulu and Vienna!

A bunch of people as it turns out! The podcast feed has 1000s of monthly downloads,with encouraging feedback from listeners in academia and industry. Fellow immunologists have reached out with kind words and reciprocal enthusiasm, which always makes my day!

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I have had the pleasure of having extended, unscripted conversations with so many of my scientific role models, of attending conferences and making friends along the way. But sometimes impostor syndrome creeps in: “𝘸𝘩𝘰 𝘸𝘰𝘶𝘭𝘥 𝘱𝘰𝘴𝘴𝘪𝘣𝘭𝘺 𝘸𝘢𝘯𝘵 𝘵𝘰 𝘩𝘦𝘢𝘳 𝘺𝘰𝘶 𝘺𝘢𝘱 𝘢𝘣𝘰𝘶𝘵 𝘪𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺 𝘧𝘰𝘳 𝘢 𝘧𝘶𝘭𝘭 𝘩𝘰𝘶𝘳?"

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Anyone who knows me can tell that I am quick to chat, and that I have a bit of an urge to share my enthusiasm for science with anyone willing to listen. These qualities are an integral part of who I am, and I like to think that they are assets to my work.

What felt a crazy idea turned out to be one of the most satisfying things I have ever done: after years of listening to podcasts I started co-hosting a podcast myself! Every other week, we talk about the latest immunology research and we record a conversation with an accomplished scientist.

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