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Peter van Galen

@vangalenlab.bsky.social
765 followers 221 following 49 posts

We study how blood ages & how to improve leukemia treatment, using cell biology + bioinformatics — @mgbresearch @harvardmed @broadinstitute — vangalenlab.org

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Reposted by Peter van Galen
Sandra McAllister, PhD @sandramcallister.bsky.social · 15/12/2025
🎀 Age influences breast cancer cell and molecular features 🎀 Congrats to our international team for the work featured in the December @nataging.nature.com issue! @vangalenlab.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social
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Peter van Galen @vangalenlab.bsky.social · 15/12/2025
🟣🟣🟣 Check out this straightforward method of improving human hematopoietic stem cell expansion by inhibiting ferroptosis 🟣🟣🟣 thanks for including me @bloodgenes.bsky.social #hemesky 🧬🔬🧪
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Peter van Galen @vangalenlab.bsky.social · 06/11/2025
Exciting to see our latest story out in print — with @sandramcallister.bsky.social — on how breast cancer differs between younger and older patients, leading the way to tailored management to improve outcomes 💻🔬🧬🧪
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Reposted by Peter van Galen
Peter van Galen @vangalenlab.bsky.social · 28/09/2025
Congratulations! * Rapid epigenomic classification of acute leukemia* — the most innovative and impactful application of long-read sequencing and machine learning I know. Happy to be included!! #hemesky 🩸🧬💻🔬
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Peter van Galen @vangalenlab.bsky.social · 07/09/2025
This new way of looking at cellular diversity in single-cell sequencing is transformative imo, which is why we've taken a similar approach to study aging blood stem cells. Congratulations @dkotliar.bsky.social and @soumya-boston.bsky.social! 🩸🧪🧬 #hemesky
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Peter van Galen @vangalenlab.bsky.social · 06/09/2025
Excited to share our latest work on blood aging! To find out why the blood system changes as people age, we started at the source: hematopoietic stem cells (HSCs) #hemesky 🩸🧬 doi.org/10.1101/2025... 🧵 1/5
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Peter van Galen @vangalenlab.bsky.social · 15/08/2025
New insights into the Unfolded Protein Response in hematopoietic stem cells in @bloodjournal.bsky.social this week + commentary from @basitsalik.bsky.social and me🩸🐁 #hemesky doi.org/10.1182/bloo...
doi.org
The PERKs of ER homeostasis for hematopoietic stem cells
In this issue of Blood, Zheng et al1 show that the unfolded protein response (UPR) sensor PERK (protein kinase R-like endoplasmic reticulum kinase) is disp
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Peter van Galen @vangalenlab.bsky.social · 15/08/2025
Online today! *Aging, Immune Fitness and Cancer* 🔬 Learn the latest about the intersection between these processes in @natrevcancer.nature.com 🧬 Great to work with @sandramcallister.bsky.social lab again 😁 doi.org/10.1038/s415...
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Peter van Galen @vangalenlab.bsky.social · 05/08/2025
This may be my favorite paper of the year so far: integrating single-cell leukemia datasets to reveal how differentiation and mutations interact to drive disease, along with a tool that speeds up bone marrow cell annotation from ~4 weeks to ~4 hours..! aacrjournals.org/bloodcancerd... 🔬🩸🧬 #hemesky
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Peter van Galen @vangalenlab.bsky.social · 04/08/2025
Whenever the team @posit.co brings out a new feature, it’s exactly how I wished it would be. AI integration done right 🧠 positron.posit.co/assistant @anthropic.com
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Reposted by Peter van Galen
Vikram Paralkar @paralkarlab.bsky.social · 02/08/2025
📣 New preprint 📣 We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation. Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
biorxiv.org
Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis
Transcription of ribosomal RNAs (rRNAs) from rDNA repeats is the first step of ribosome biogenesis, accounting for a major portion of all cellular transcription. Often regarded as a housekeeping proce...
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Peter van Galen @vangalenlab.bsky.social · 02/08/2025
Had a great time catching up with friends and learning new science at FASEB Hematologic Malignancies! #hemesky @faseborg.bsky.social #HEMSRC
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Reposted by Peter van Galen
Vikram Paralkar @paralkarlab.bsky.social · 30/07/2025
At the FASEB Heme Malignancies meeting with old friends and new - Pam Sung, Peter Van Galen (@vangalenlab.bsky.social), Julia Maxson (@juliamaxson.bsky.social), Johnathon Shafer. Trying out ales at the @treehousebrewing.bsky.social! #HEMSRC
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Peter van Galen @vangalenlab.bsky.social · 22/02/2025
#positron is rapidly replacing programs and websites I used with a customizable multilingual coding environment for data science (local+cluster+virtual machines) #bash #rstats #python @posit.co
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Reposted by Peter van Galen
Ann Mullally @mullallylab.bsky.social · 10/01/2025
Delighted to share our #hematology review article on mutant calreticulin in #MPN Congrats to co-authors Drs. Mifra Faiz, Merle Riedemann & Jonas Jutzi. We hope it’s a useful resource, link below! @stanforddeptmed.bsky.social link.springer.com/article/10.1...
link.springer.com
Mutant Calreticulin in MPN: Mechanistic Insights and Therapeutic Implications - Current Hematologic Malignancy Reports
Purpose of Review More than a decade following the discovery of Calreticulin (CALR) mutations as drivers of myeloproliferative neoplasms (MPN), advances in the understanding of CALR-mutant MPN continu...
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Peter van Galen @vangalenlab.bsky.social · 11/01/2025
Erasmus MC Hematology Lecture speaker lineup never fails to impress! #hemesky 🧪🩸 mcusercontent.com/71bcc0f3bb8a...
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Peter van Galen @vangalenlab.bsky.social · 04/01/2025
Just a reminder of what is easily in my top 5 of favorite papers from 2023 www.cell.com/iscience/ful... @bailee-kain.bsky.social @thekinglab.bsky.social
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Peter van Galen @vangalenlab.bsky.social · 23/12/2024
Our latest work is now available to read on bioRxiv! Very proud of this and its potential implications for patients with acute myeloid leukemia 🩸 🧪 🔬💊 **eIF4A-mediated translation initiation as an AML cell vulnerability that can be co-targeted with BCL-2 inhibition** www.biorxiv.org/content/10.1...
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Peter van Galen @vangalenlab.bsky.social · 22/12/2024
Boston’s North End ❄️
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Peter van Galen @vangalenlab.bsky.social · 16/12/2024
Our new review “Insights into Leukemia from Single-Cell Genomics” is out! Great work by Nurefsan Sariipek @nursariipek.bsky.social 📝 www.annualreviews.org/content/jour... #hemesky 🩸🧬
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Peter van Galen @vangalenlab.bsky.social · 05/12/2024
Office plants are watered, almost ready to hit the road #ASH24 🩸🧬 #HemeSky
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Peter van Galen @vangalenlab.bsky.social · 04/12/2024
www.exphem.org/article/S030...
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Peter van Galen @vangalenlab.bsky.social · 04/12/2024
Interesting BMC Genomics paper filters "nucleus-free" low-quality cells using the number of intronic reads. MALAT1 expression may provide a shortcut, but I would be wary of filtering out meaningful data 1/3 🩸🧬 @tmontsay.bsky.social @annaesteveco.bsky.social www.ncbi.nlm.nih.gov/pubmed/39574...
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Peter van Galen @vangalenlab.bsky.social · 28/11/2024
On Thanksgiving day, what is the effect of frequent blood donations? Donors may have a higher prevalence of EPO-responsive clonal hematopoiesis, but there is no increased risk for malignant clones, underscoring safety of repetitive blood donations. www.medrxiv.org/content/10.1... 🩸🧪 #hemesky
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Reposted by Peter van Galen
Fabian Theis @fabiantheis.bsky.social · 20/11/2024
1/ 🧬 Single-cell genomics reveals biological variations beyond cell types. Unveiling these in separate latent dim’s is known as disentanglement. Led by @AmirAliMoinfar, we develop DRVI to learn nonlinear, disentangled & interpretable latent spaces. biorxiv.org/content/10.1101/2024.11.06.622266v1
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Peter van Galen @vangalenlab.bsky.social · 18/11/2024
Bad use case 🫠 (and reminder to carefully check everything ChatGPT generates)
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Reposted by Peter van Galen
Kellie Machlus @kmachlus.bsky.social · 17/11/2024
Finally- the starter pack we have all been waiting for is here … Hematopoiesis 🎉❤️🩸🦴 So excited to have reached a critical mass of this community on here. 🙌🏻 Let me know if you want to be added!! go.bsky.app/KWdX5w7
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Peter van Galen @vangalenlab.bsky.social · 16/11/2024
Not many papers change the way I think about AML, but this exceptional work shows how cell states and genetics intertwine to mediate venetoclax resistance, unifying previous studies by identifying RAS-mutated LSCs that are primed to produce myeloid cells #hemesky 🩸🧪 www.nature.com/articles/s41...
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Peter van Galen @vangalenlab.bsky.social · 15/11/2024
Ok let’s give social media another try. I’ll share advances in blood/cancer/aging/bioinformatics research and pictures of my daily commute along Boston’s Esplanade like this one
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Peter van Galen @vangalenlab.bsky.social · 24/02/2024
Python ≠ my forte, but with the help of ChatGPT I created this nice little script to count files stored in Google Cloud Storage (GCS) buckets, categorized by their storage class (e.g., STANDARD, NEARLINE, COLDLINE, ARCHIVE). I hope it helps someone like it does me! 🐍 github.com/petervangale...
github.com
GitHub - petervangalen/count_storage_classes: Count the number of files in Google Cloud Storage (GCS) buckets categorized by their storage class
Count the number of files in Google Cloud Storage (GCS) buckets categorized by their storage class - petervangalen/count_storage_classes
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Reposted by Peter van Galen
ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · 23/02/2024
Special seminars! @bloodsky.bsky.social www.iseh.org/page/isehweb...
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Peter van Galen @vangalenlab.bsky.social · 12/02/2024
Briefly went on X to look something up and on top of my feed was a video making fun of someone’s medical condition. Such a relief to be here 😇
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Peter van Galen @vangalenlab.bsky.social · 23/01/2024
Proud to be part of the innovative work on blood stem cell dynamics published with Vijay Sankaran @bloodgenes.bsky.social, Chen Weng and Jonathan Weissman out in Nature today titled “Deciphering cell states and genealogies of human hematopoiesis” doi.org/10.1038/s415...
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Peter van Galen @vangalenlab.bsky.social · 08/01/2024
When you paste something from ChatGPT and Grammarly tries to correct it
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Peter van Galen @vangalenlab.bsky.social · 05/01/2024
Analysis of somatic mutations from single-cell RNA-sequencing libraries is crucial to understand (pre) cancer biology @livius.bsky.social www.nature.com/articles/s41...
nature.com
Integrative genotyping of cancer and immune phenotypes by long-read sequencing - Nature Communicatio...
Single-cell transcriptomics excel in cell subset classification and can be augmented by suitable genotype information. Here the authors devise a long-read sequencing workflow, termed nanoranger, for d...
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Peter van Galen @vangalenlab.bsky.social · 22/12/2023
Another great line up at one of my favorite (publicly accessible) seminar series 📺 Mondays 4 PM CET / 10 AM EST us06web.zoom.us/j/83009472100
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Peter van Galen @vangalenlab.bsky.social · 20/12/2023
So happy with the CURE Mentor Appreciation Award! Getting a mentor award is really something different 😊 and thanks to my trainees who are the real reason we gave the students a good experience! www.dfhcc.harvard.edu/news-archive...
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Peter van Galen @vangalenlab.bsky.social · 20/12/2023
Thanks @paralkarlab.bsky.social for the invite! Let's hope this will be a more benign environment. We just have to get the community to join!
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