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Bind Research @bindresearch.org · 22/09/2026

Want more? Try the tool yourself: tools.bindresearch.org/bindbox/SpinForecast You can play with the underlying NMR data here: tools.bindresearch.org/bindbox/BMRB_Chemical_Shifts Check out the source code: github.com/bindresearch/BindBox

tools.bindresearch.org

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Bind Research @bindresearch.org · 22/09/2026

New to #NMR? Our blog post explains the science behind SpinForecast and why assignment matters: bindresearch.org/news/solving... #NMRchat #ChemSky

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Bind Research @bindresearch.org · 22/09/2026

For the remaining signals, it returned a ranked shortlist of likely candidates, with the correct residue appearing on that shortlist more than 97% of the time.

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Bind Research @bindresearch.org · 22/09/2026

We tested SpinForecast against independently determined assignments for IDPs of increasing size and complexity. Across fully disordered proteins, it assigned approximately 40–75% of signals with 100% confidence, and those assignments were more than 99% accurate. #NMRchat #NMR #ChemSky

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Bind Research @bindresearch.org · 22/09/2026

This Sudoku-like puzzle is called assignment, and for gnarly IDPs, it can take weeks to solve. Our recent work combines data from the BMRB with predictions from AlphaFold2 to generate probabilistic assignments for IDPs, streamlining this process.

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Bind Research @bindresearch.org · 22/09/2026

Check out the first tool from Bind Research: SpinForecast. #NMR is one of the most powerful tools for probing the atomic behaviour of IDPs. But the data can look like a Jackson Pollock painting: a sea of peaks that we must painstakingly match to positions along the protein backbone.

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Bind Research @bindresearch.org · 22/09/2026

You can play with the underlying NMR data here: tools.bindresearch.org/bindbox/BMRB_Chemical_Shifts and check out the source code: github.com/bindresearch/BindBox

tools.bindresearch.org

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Bind Research @bindresearch.org · 22/09/2026

Want more? Try the tool yourself: tools.bindresearch.org/bindbox/SpinForecast

tools.bindresearch.org

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Bind Research @bindresearch.org · 22/09/2026

New to NMR? Our blog post explains the science behind SpinForecast and why assignment matters: bindresearch.org/news/solving...

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Bind Research @bindresearch.org · 22/09/2026

For the remaining signals, it returned a ranked shortlist of likely candidates, with the correct residue appearing on that shortlist more than 97% of the time.

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Bind Research @bindresearch.org · 22/09/2026

We tested SpinForecast against independently determined assignments for IDPs (NUPR1 and JPT2) of increasing size and complexity. Across fully disordered proteins, it assigned approximately 40–75% of signals with 100% confidence, and those assignments were more than 99% accurate.

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Bind Research @bindresearch.org · 22/09/2026

This Sudoku-like puzzle is called assignment, and for gnarly IDPs, it can take weeks to solve. Our recent work, led by James Eaton & Gogulan Karunanithy, combines data from the BMRB with predictions from AlphaFold2 to generate probabilistic assignments for IDPs, streamlining this process.

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Bind Research @bindresearch.org · 22/09/2026

For the remaining signals, it returned a ranked shortlist of likely candidates, with the correct residue appearing on that shortlist more than 97% of the time. (4/10)

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Bind Research @bindresearch.org · 22/09/2026

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Bind Research @bindresearch.org · 22/09/2026

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Bind Research @bindresearch.org · 18/03/2026

Accompanying Current Opinion in Structural Biology: doi.org/10.1016/j.sb...

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Bind Research @bindresearch.org · 18/03/2026

Disordered proteins play key roles in disease but remain largely out of reach for drug discovery. The prevailing assumption is that they are undruggable. At Bind, we ask what it would take to make them druggable at scale. See our white paper and accompanying COSB below.

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Reposted by Bind Research

Gabi Heller @g-heller.bsky.social · 24/03/2025

We’re looking for fellow nerds to help us make disordered proteins druggable. Love #IDPs, #MD, #NMR, #AI, #DrugDiscovery, or #MassSpec? Let’s talk. @bindresearch.org is hiring across the board: bindresearch.org/careers/ #compchem #compbio #NMRChat #TeamMassSpec #chemjobs @chemjobber.bsky.social

bindresearch.org

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Bind Research @bindresearch.org · 11/02/2025

We are building high-throughput tools and public datasets to make disordered proteins druggable for everyone. Want to drug the undruggable with us? We’d love to hear from you! Reach out at bindresearch.org.

bindresearch.org

Bind

Bind is a non-profit research organization dedicated to making disordered proteins druggable

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Bind Research @bindresearch.org · 11/02/2025

We’re thrilled to announce the launch of Bind Research, the UK’s first not-for-profit Focused Research Organisation, with long-term support from the Department for Science, Innovation and Technology’s Research Ventures Catalyst Programme, industry, and charities.

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