iiinova — where your digital self keeps evolving

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Bind Research @bindresearch.org · 22/09/2026

This Sudoku-like puzzle is called assignment, and for gnarly IDPs, it can take weeks to solve. Our recent work, led by James Eaton & Gogulan Karunanithy, combines data from the BMRB with predictions from AlphaFold2 to generate probabilistic assignments for IDPs, streamlining this process.

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Bind Research @bindresearch.org · 22/09/2026

We tested SpinForecast against independently determined assignments for IDPs (NUPR1 and JPT2) of increasing size and complexity. Across fully disordered proteins, it assigned approximately 40–75% of signals with 100% confidence, and those assignments were more than 99% accurate.

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Bind Research @bindresearch.org · 22/09/2026

For the remaining signals, it returned a ranked shortlist of likely candidates, with the correct residue appearing on that shortlist more than 97% of the time.

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