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Bernhard Bein

@bernhardbein.bsky.social
55 followers 101 following 20 posts

PhD student in comparative genomics @ Senckenberg and Goethe University Frankfurt

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Reposted by Bernhard Bein
Michael Hiller @hillermich.bsky.social · 23/09/2026
Happy to share results of the @bat1kgenomes.bsky.social phase 1, providing reference genomes covering 21 bat families. New insights into bat phylogeny, ancestral genome reconstruction, European origin & ancestral echolocation. Great work by a team of 100+ colleagues www.nature.com/articles/s41...
nature.com
Reference genomes and fossils revise bat family phylogeny and biogeography - Nature
An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families.
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Dimitris Kontopoulos @dgkontopoulos.io · 11/09/2026
Thrilled to share our new Genome Biology and Evolution paper! Here, we study the associations between evolutionary shifts in #torpor across placental mammals and changes in individual protein-coding #genes. 1/7 doi.org/10.1093/gbe/evag216
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Sergei Pond @sergeilkp.bsky.social · 11/09/2026
I've spent ~30 years writing HyPhy to study selection & evolution. That era is coming to a close. HyPhy is passing the torch to HyphAeon: a ~2M parameter geometric transformer running in the browser that does things we never built it to do. @nclark.bsky.social @brcanalytics.bsky.social 🧵👇
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Adam Phillippy @aphillippy.bsky.social · 06/08/2026
For the past 30 years, “whole-genome sequencing” has been a misnomer. Today the T2T Consortium publishes a dozen papers heralding a future of truly complete genomes for humans and nearly any vertebrate 👨‍🔬🐒🐦🐀🦒🐎🫏🐹🐟 (sorry, no salamanders): www.cell.com/consortium/t... 🧵[1/15]
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Springer Nature @springernature.com · 04/08/2026
A flowering plant has been confirmed as a new carnivorous lineage, says research in Nature Communications. Findings show Saxifraga candelabrum can attract, trap, & digest insects, and absorb nitrogen from them, supporting prediction made by Charles Darwin: spklr.io/63323EuqgT #Biology 🌾 🧪
spklr.io
Identification of carnivory in the flowering plant Saxifraga via multidisciplinary evidence - Nature Communications
Carnivorous plants capture and digest insects for nutrients, an adaptive strategy typically found in wetlands. This study identifies carnivory in the alpine Saxifraga plant lineage, supporting Darwin's hypothesis of carnivory in this genus.
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Bernhard Bein @bernhardbein.bsky.social · 09/07/2026
Absolute tour de force led by @ymalovichko.bsky.social, with contributions from many in the lab @leonhilgers.bsky.social @xuelingyi.bsky.social @mich-albertini.bsky.social Alejandro Gonzales-Irribarren, Evgeny Leushkin and many others Check #TOGA2 out: github.com/hillerlab/TO...
github.com
GitHub - hillerlab/TOGA2: TOGA2: A faster, more versatile successor of Tool to infer Orthologs from Genome Alignments
TOGA2: A faster, more versatile successor of Tool to infer Orthologs from Genome Alignments - hillerlab/TOGA2
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Yanis Chrysostomakis @yanischrysost.bsky.social · 05/07/2026
Had such a good time at @official-smbe.bsky.social talking about museum samples and comparative genomics. Many thanks to everyone who reached out to me and my supervisor for all her support @astridboehne.bsky.social. Special thanks to the Alexander-Koenig-Gesellschaft for funding my trip. #SMBE2026
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Adam Ameur @adameur.bsky.social · 03/07/2026
For those interested in PacBio's SPRQ-Nx chemistry and reusable SMRT Cells: in the Genome of Sweden project, we moved from 2 to 3 acquisitions per SMRT Cell in June. The results are impressive—we’re now approaching 400 Gb HiFi yield from a single SMRT Cell!
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Adria LeBoeuf @adriatica.bsky.social · 01/07/2026
Excellent dive into the bizarre world of turtles and how they completely reworked their bodyplan through gene loss by @leonhilgers.bsky.social #SMBE2026 Especially great detective work on the genes of interest!
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Bernhard Bein @bernhardbein.bsky.social · 29/06/2026
If you are interested in #PacBio #HiFi sequencing of challenging specimens through long range #PCR amplification, check out my poster (Board 038, Blomster Salen) this evening between 6-8pm! #SMBE2026
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Michael Hiller @hillermich.bsky.social · 23/05/2026
Happy to announce the release of TOGA2 data for 68 turtle genomes, generated with a cryptodiran and a pleurodiran turtle reference. The combined TOGA2 annotation consistently improves annotation completeness compared with RefSeq. All data at genome.senckenberg.de/download/TOGA2. Genome browsers ...
genome.senckenberg.de
Index of /download/TOGA2
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Iliana Bista @ilianabista.bsky.social · 30/04/2026
Drivers of cold adaptation and genome evolution in Antarctic fish, and a haplotype resolved assembly for an important model notothenioid species 🐟 🧬 Our new paper available on BioRxiv #BiodiversityGenomics #ColdAdaptation www.biorxiv.org/content/10.6...
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Senckenberg Ocean Species Alliance (SOSA) @oceanspecies.bsky.social · 29/04/2026
And the winner is… Your 2026 International Mollusc of the Year is 𝘾𝙪𝙢𝙞𝙖 𝙞𝙣𝙩𝙚𝙧𝙩𝙚𝙭𝙩𝙖, the Vampire Snail! It will be the first blood-feeding mollusc to ever have its genome sequenced. Huge thanks to the nominators & @sgn.one for unlocking its DNA secrets! 🧬🩸 #IMOY26
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Michael Hiller @hillermich.bsky.social · 08/05/2026
We now have genome browsers on our UCSC mirror at genome.senckenberg.de for the 1033 mammal and 866 bird assemblies, showing spliceAi, reference-based and ref-integrated TOGA2 tracks. Tables with links to all browsers are genome.senckenberg.de/TOGA2Mammali... & genome.senckenberg.de/TOGA2Aves.html
genome.senckenberg.de
Hiller Lab UCSC Genome Browser
Senckenberg Genome Browser
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The American Genetic Association @theaga.bsky.social · 25/04/2026
Here's a genome from the Vertebrate Genomes Project (vertebrategenomespro...): a chromosome-level assembly for the false killer whale (Pseudorca crassidens)! 🐋 This resource advances cetacean research and conservation. Photo: Stefan Thiesen Buntrabe 1/2
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Emilio Mármol Sánchez @marmole6.bsky.social · 23/04/2026
New preprint out!!📜 We show that decades-old FFPE brain tissue archived in the unique Danish Brain Collection (up to 73 years old) can yield biologically informative genomes and transcriptomes. Read the full manuscript at: www.biorxiv.org/content/10.6... #RNA #DNA #FFPE #Brain
biorxiv.org
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Senckenberg Gesellschaft für Naturforschung @sgn.one · 14/04/2026
Lernt den Spitzenprädator Triplofusus giganteus kennen! 👹 Die Florida-Pferdemuschel ist mit einer Länge von bis zu 60 cm eine der größten fleischfressenden Schnecken der Welt. Sie nutzt ihren massiven Fuß, um ihre Beute zu „ersticken“. 🌊 Stimmt für den Atlantikriesen 👉 sgn.one/moty2026 🐚
Riesige rote Meeresschnecke Triplofusus giganteus verschlingt eine Muschel am MeeresstrandGroße rote Meeresschnecke Triplofusus giganteus liegt in ihrem Gehäuse am StrandDie riesige rote Meeresschnecke Triplofusus giganteus verschlingt eine Krabbe im seichten WasserDie große rote Meeresschnecke Triplofusus giganteus kriecht aus ihrem Gehäuse heraus frontal auf die Kamera zu
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Bernhard Bein @bernhardbein.bsky.social · 17/03/2026
I've always been fascinated with biodiversity, dreaming of discovering new species. That dream has finally come true: We found two new crab species tugged away in small streamlets in Guangdong! This journey started 7 years ago, huge thanks to Chao for taking me along! 🦀 🦀 🦀 doi.org/10.6620/ZS.2...
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Michael Hiller @hillermich.bsky.social · 12/03/2026
I wrote a short Nature Methods News & Views piece on deep learning based gene finders such as ANNEVO. www.nature.com/articles/s41...
nature.com
Learning genes deeply - Nature Methods
Annevo uses deep learning to achieve unprecedented accuracy in eukaryotic gene annotation, approaching the performance of evidence-based methods.
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Leon Hilgers @leonhilgers.bsky.social · 10/03/2026
I hear you want novelty🦎->🐢, chromosome evolution 🧬, sex determination🩷, link population history📈 & climate🌏🌡️? Or you share my love for wonderfully weird animals? Side-necked turtle genomes reveal chromosomal dynamics, skeletal innovation and cancer resistance www.biorxiv.org/content/10.6... A 🧵
Chelodina longicollis, Eastern Long-necked Turtle. Melbourne Museum. 
Photographer: David Paul, Source: Museums Victoria
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Bernhard Bein @bernhardbein.bsky.social · 07/03/2026
Truly breathtaking work here, building on the concept of targeted sequencing and turning it dynamic. Remains to be seen how QV will scale beyond human/mammalian data, but the future of routine T2T assemblies might be around the corner: www.nature.com/articles/s41...
nature.com
Targeted sequencing and iterative assembly of near-complete genomes - Nature Communications
Long-read sequencing enables high-quality genome assemblies, but challenges remain. Here, the authors introduce Cornetto, a method that improves assembly quality, enables genome sequencing from saliva...
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Michael Hiller @hillermich.bsky.social · 28/02/2026
Happy to share that our work with Ekaterina Osipova, @maggiemcko.bsky.social, Tim Sackton, Maude Baldwin & fantastic collaborators on convergent and lineage-specific genomic adaptations in sugar-feeding birds is published in Science www.science.org/doi/10.1126/.... While high sugar intake ...
science.org
Convergent and lineage-specific genomic changes shape adaptations in sugar-consuming birds
High-sugar diets cause human metabolic diseases, yet several bird lineages convergently adapted to feeding on sugar-rich nectar or fruits. We investigated the underlying molecular mechanisms in hummin...
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jakobheinz.bsky.social @jakobheinz.bsky.social · 24/02/2026
Our paper on foldback artifacts in long-read sequencing is now published in BMC Genomics! We introduce Breakinator to flag foldback and chimeric artifacts across library types, sequencers, and chemistries. Paper: link.springer.com/article/10.1... With Matthew Meyerson and @lh3lh3.bsky.social
link.springer.com
Detecting foldback artifacts in long-reads - BMC Genomics
Long-read sequencing data is useful for detecting large and complex structural variations; however, technical artifacts can lead to false structural variant calls. In our analyses, we became aware of ...
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Adam Ameur @adameur.bsky.social · 20/02/2026
Say hello to Nallo - our Nextflow pipeline for long-read WGS analysis!👋 It handles both ONT and PacBio data and we’re using this for rare disease and population projects in Sweden. A big team effort by Felix Lenner, Anders Jemt et al.🧬💻 academic.oup.com/bioinformati...
academic.oup.com
Nallo: a Nextflow pipeline for comprehensive human long-read genome analysis
AbstractMotivation. Long-read sequencing (LRS) is increasingly used for human medical research and clinical diagnostics, due to its capacity to generate co
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Diana Aguilar-Gómez @dianaguilr.bsky.social · 18/02/2026
The last chapter of my PhD is finally out !!!! In the same species, on neighboring islands, we see radically different warning colors emerge. Evolution in action: Selection-driven color variation in the aposematic strawberry poison frog, Oophaga pumilio: Current Biology www.cell.com/current-biol...
cell.com
Selection-driven color variation in the aposematic strawberry poison frog, Oophaga pumilio
Aguilar-Gómez et al. use exome sequencing of 347 strawberry poison frogs to uncover the genetic basis of color variation. They identify that kit, ttc39b, and bco1 underlie blue-red, yellow-red, and gr...
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Bernhard Bein @bernhardbein.bsky.social · 16/02/2026
Amazing to see read N50 in the 100s of kb: www.sciencedirect.com/science/arti... Also, optimizing the protocol for long-fragment DNA extraction must have been a mighty effort!
sciencedirect.com
Nanopore ultra-long sequencing and adaptive sampling spur plant complete telomere-to-telomere genome assembly
The pursuit of complete telomere-to-telomere (T2T) genome assembly in plants, challenged by genomic complexity, has been advanced by Oxford Nanopore T…
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Schneeberger Lab @labschneeberger.bsky.social · 05/02/2026
Just in time for Karneval, we present coelsch ! 🎭🥳 A platform-agnostic framework for single-cell recombination analysis. We study crossover variation in mutants & natural lines, identifying the largest natural inversion in A. thaliana to date! 📄 doi.org/10.64898/202... 🐱 github.com/schneeberger...
doi.org
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David Enard @denard.bsky.social · 30/01/2026
That looks great! To avoid errors due to starting with spotty gene annotations (gene loss vs. not annotated), I would suggest re-annotating every genome used with TOGA2 from the Hiller lab: github.com/hillerlab/TO... Many annotations out there are not optimal and TOGA2 has great power and accuracy.
github.com
GitHub - hillerlab/TOGA2: TOGA2: A faster, more versatile successor of Tool to infer Orthologs from Genome Alignments
TOGA2: A faster, more versatile successor of Tool to infer Orthologs from Genome Alignments - hillerlab/TOGA2
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Senckenberg Gesellschaft für Naturforschung @sgn.one · 28/01/2026
📣 #Forschungsnews: Feine Unterschiede – 5 neue Krebsarten in der Nordsee entdeckt 🌊🦐 In der Deutschen Bucht, einem der weltweit bestuntersuchten Meeresgebiete, hat ein Senckenberg-Forschungsteam 5 neue Arten winziger Krebstiere nachgewiesen. Unbekannte Vielfalt vor der Haustür! 👉 sgn.one/1df
Vergrößerte Aufnahme der fünf neu entdeckten Krebstiere eingefärbt in Rot, Orange, Gelb, Türkis und Blau vor schwarzem Hintergrund.Vergrößerte Aufnahme eines der neu entdeckten, blass-weißen Krebstiere, einmal von oben, einmal von der Seite vor schwarzem Hintergrund.
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Megan Dennis @mydennis.bsky.social · 08/12/2025
Excited to share our final accepted version of the CiFi method out today: www.nature.com/articles/s41...
nature.com
CiFi: accurate long-read chromosome conformation capture with low-input requirements - Nature Communications
Hi-C methods for studying 3D genome structure typically require millions of cells and struggle with repetitive regions. Here, authors develop CiFi, combining 3C with PacBio HiFi sequencing, enabling c...
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BatProtect @batprotect.bsky.social · 02/12/2025
Day 2: bringing the consortium researchers & experts together is on the theme of Functional & comparative genomics Keynote #StefanMundlos: Functional Genomics of Bat Limb Development With Genome Chalk team talks #LucasCanesin, #YuryMalovichko, #AlejandroGonzales, #BernhardBein & #MicheleAlbertini
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Vertebrate Genomes Project @vertebrategenomes.bsky.social · 25/11/2025
⚡ We've released a new version of rdeval! v0.0.8 includes full support for @pacbio.bsky.social CiFi read preprocessing, visualization report improvements, and upgrades to performance and parallelization! 🔗 Release notes and source code: github.com/vgl-hub/rdev...
github.com
Release rdeval v0.0.8 · vgl-hub/rdeval
Changes in this Release New Features Added full support for PacBio CiFi read preprocessing, including CiFi-specific metrics, biologically precise cut-site handling, examples, and test datasets. Re...
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Michael Hiller @hillermich.bsky.social · 23/11/2025
Happy to present TOGA2, developed by Yury Malovichko @ymalovichko.bsky.social, the faster, memory-efficient & more accurate TOGA1 successor (github.com/hillerlab/TO...). And annotations, orthologs & gene loss/dup data generated with 4 references for 883 placental mammal and with 5 refs for 676 ...
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Dimitris Kontopoulos @dgkontopoulos.io · 19/11/2025
📢 New #preprint alert 📢 www.biorxiv.org/content/10.1101/202… Several lineages of #birds and #mammals appear to have independently gained or lost the ability to enter #torpor. 🧵1/4
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Marcela Uliano-Silva @marcelauliano.bsky.social · 02/10/2025
Preprint Alert! 🦥 We produced complete genomes for 2 Xenarthra and placed them in a mammalian comparative framework. We found that Xenarthra harbour the largest number of retrocopies in mammals! www.biorxiv.org/content/10.1...
biorxiv.org
Retrocopy formation and domestication shape genome evolution in sloths and other xenarthrans
Xenarthrans, comprising sloths, anteaters, and armadillos, represent one of the most morphologically and physiologically specialised mammalian clades, yet the genomic basis of their adaptations remain...
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Adam Phillippy @aphillippy.bsky.social · 22/09/2025
Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]
biorxiv.org
A complete diploid human genome benchmark for personalized genomics
Human genome resequencing typically involves mapping reads to a reference genome to call variants; however, this approach suffers from both technical and reference biases, leaving many duplicated and ...
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Adam Ameur @adameur.bsky.social · 10/09/2025
New preprint! With PureTarget we achieved >1000× coverage of targets with ~5kb PacBio reads at QV39. This enabled high-resolution analysis of CRISPR-Cas9 outcomes Key finding: Some CRISPR-mutations may only emerge in the second generation, due to germ cell mosaicism www.biorxiv.org/content/10.1...
biorxiv.org
Accurate characterization of CRISPR-Cas9 genome editing outcomes and mosaicism with near-perfect long reads
Background: Genetic mosaicism is a consequence of CRISPR-Cas9 genome editing that is difficult to study, especially when it involves structural variants occurring at low frequency. A comprehensive ana...
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Nature @nature.com · 03/09/2025
A common type of ant in Europe breaks a fundamental rule in biology: its queens can produce male offspring that are a whole different species go.nature.com/4mOb5T9
go.nature.com
‘Almost unimaginable’: these ants are different species but share a mother
Ant queens of one species clone ants of another to create hybrid workers that do their bidding.
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Bernhard Bein @bernhardbein.bsky.social · 03/09/2025
#PacBio #ULI #HiFi sequencing goes clinical: Really cool paper showing that Ultra-low input (ULI) HiFi sequencing can help cancer diagnostics. Only emphasizes how interdisciplinary the ULI field is ( #museomics, #single-cell #sequencing, #diagnostics etc) www.medrxiv.org/content/10.1...
medrxiv.org
Whole-genome variant detection in long-read sequencing data from ultra-low input patient samples
Long-read sequencing provides a more complete view of the genome than short-read sequencing, with advantages in the detection of structural variants, tandem repeats, and small variants (single nucleot...
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Xueling (Ling) Yi @xuelingyi.bsky.social · 19/08/2025
The poster session was really great and lots of fun @eseb2025.bsky.social! Many interesting discussions and ideas! Thanks to everyone who stopped by at my poster! Looking forward to more interesting talks and posters in the following days!
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Vertebrate Genomes Project @vertebrategenomes.bsky.social · 30/07/2025
🔗 doi.org/10.1093/bioinformatics/btaf… 💻️ rdeval code: github.com/vgl-hub/rdeval (3/3)
github.com
GitHub - vgl-hub/rdeval: Multithreaded read analysis
Multithreaded read analysis. Contribute to vgl-hub/rdeval development by creating an account on GitHub.
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Leon Hilgers @leonhilgers.bsky.social · 24/07/2025
You link #phenotype 🦜 to #genotype 🧬 with #comparative #genomics 💻? This #review is for you 📜: authors.elsevier.com/sd/article/S... We review new #methods, remaining #challenges and #future directions and highlight recent key studies. Thanks @hillermich.bsky.social! Please share! 🙂
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mara lawniczak @marakat.bsky.social · 07/07/2025
new from the lab -- we investigate 100% ethanol, DMSO salt solution (DESS), EDTA, RNAlater, and AllProtect as possible approaches for short term room temperature preservation of mosquito HMW DNA, nuclei for Hi-C, and RNA towards high quality reference genome creation. the key findings/tips are ....
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Bernhard Bein @bernhardbein.bsky.social · 06/07/2025
6 years ago, a dream came true when Chao took me along on a field trip to look for freshwater crabs in Guangdong. Now, the new species we found is formally described (𝘔𝘦𝘨𝘢𝘱𝘭𝘦𝘰𝘯𝘶𝘮 𝘺𝘢𝘯𝘨𝘥𝘰𝘯𝘨𝘦𝘯𝘴𝘦 in the article). Congrats!! zookeys.pensoft.net/articles.php... #FreshwaterCrab #Biodiversity #Potamidae
zookeys.pensoft.net
Four new freshwater crab species of the genus Megapleonum Huang, Shih & Ahyong, 2018 (Crustacea, Decapoda, Potamidae) from Guangdong, China
Four new species of the poorly known genus Megapleonum Huang, Shih & Ahyong, 2018, are described from Guangdong Province, China: Megapleonum falx sp. nov. from Huizhou City, M. yangdongense sp. no...
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Phil Morin @philmor1964.bsky.social · 03/07/2025
The Cetacean Genomes Project is happy to share a milestone publication, presenting the first 18 reference-quality, chromosome-resolved genomes of whales, dolphins and porpoises across the cetacean tree of life. www.frontiersin.org/journals/mar...
frontiersin.org
Frontiers | Genomic infrastructure for cetacean research and conservation: reference genomes for eight families spanning the cetacean tree of life
Reference genomes from representative species across families provide the critical infrastructure for research and conservation. The Cetacean Genomes Project...
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Bernhard Bein @bernhardbein.bsky.social · 20/05/2025
Exciting news! Good to see that findings from our study on ethanol-preserved specimens are now applied to formalin-fixed cancer samples. Looking forward to more of these interdisciplinary applications regarding amplification-aided sequencing (i. e. scWGA). #PCRAmplification #LongReadSequencing
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ERGA - European Reference Genome Atlas @ergabiodiv.bsky.social · 23/04/2025
#ERGAReads | Thinking of sequencing a genome in your lab? 🧬 This review offers practical guidance on how to start a #genome project for non-model species - covering DNA extraction, sequencing tech, costs, and more! 🔗 rdcu.be/eiHRG @sgn.one @leibnizlib.bsky.social #biodiversity #genomics
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Carola Greve @cgreve.bsky.social · 17/04/2025
Still no reading material for the Easter break🌞🌻🐰? Then I have a suggestion: "Establishing genome sequencing and assembly for non-model and emerging model organisms: a brief guide" (lnkd.in/dsRmSBDE). It was a pleasure to work on this new publication with TilmanSchell & @lpodsiadlowski.bsky.social🙏!
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Bernhard Bein @bernhardbein.bsky.social · 21/03/2025
Research about ultra-low input DNA seq and MDA I recently found: 1. MDA on pg input DNA for ONT rapid seq of pathogens + Tool to detect concatemers doi.org/10.1111/1755... 2. MDA for metagenomics of low biomass samples doi.org/10.1093/isme... Exciting Stuff, small inputs + ampli. going strong!
onlinelibrary.wiley.com
Evaluating the Benefits and Limits of Multiple Displacement Amplification With Whole‐Genome Oxford Nanopore Sequencing
Multiple displacement amplification (MDA) outperforms conventional PCR in long fragment and whole-genome amplification, making it attractive to couple MDA with long-read sequencing of samples with li...
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Senckenberg Gesellschaft für Naturforschung @sgn.one · 03/03/2025
🐙 Jetzt abstimmen: Molluske des Jahres 2025! 🐌 5 beeindruckende Weichtiere stehen im Finale. Dem Gewinner-Weichtier winkt die Entschlüsselung seines kompletten Genoms! 🧬🏆 Erfahrt mehr über die Kandidaten und stimmt bis zum 31.3. für euren Favoriten ab 👉 moty.senckenberg.science
Ein Kraken der Gattung Muusoctopus schwimmt am MeeresgrundEin Blauer Drache (Glaucus atlanticus), eine leuchtend blaue Meeresnacktschnecke, schwebt in dunklem Wasser. Seine fingerartigen Fortsätze erstrecken sich symmetrisch vom Körper. Darunter ist eine blau-weiße, kreisförmige Kolonie einer Staatsqualle zu sehen.Eine Hawaiische Schwarzfuß-Napfschnecke (Cellana exarata) guckt mit ausgestreckten Fühlern aus ihrer Muschelschale heraus, die auf sandigem Boden nahe einer dunklen Felswand liegt.
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