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Ayman Aljishi

@aymanaljishi.bsky.social
84 followers 174 following 0 posts

PhD student in neuroscience at Vanderbilt University - laboratory of Kari Hoffman, PhD. NHP electrophysiology, hippocampus, and sleep 🧠💤🐒

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Reposted by Ayman Aljishi
Kari Hoffman @karihoffman.bsky.social · 30/07/2026
📣New paper! How does the sleeping brain help us to integrate new experiences while managing memories from the past? For his PhD work, @sabbaspoor.bsky.social recorded hippocampal ensembles in freely moving monkeys and found something unexpected. 🧵1/n www.nature.com/articles/s41... 🧪🧠📈👩‍🔬#OpenAccess
nature.com
Experience reorganizes content-specific memory traces in macaques - Nature Neuroscience
In macaques, old memories, relative to new ones, are supported by more stable and interconnected cell assemblies. New-biased and old-biased assemblies reactivate during overnight sleep and can sometim...
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Trends in Neurosciences @cp-trendsneuro.bsky.social · 09/12/2025
Check out the December 2025 issue of Trends in Neurosciences! www.cell.com/issue/S0166-... Featured content & more: cell.com/trends/neuro... Cover article: ‘Cracking the complexity of REM sleep’, by Yufan Dong & Danqian Liu www.cell.com/trends/neuro...
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Nature Neuroscience @natneuro.nature.com · 03/12/2025
Don't sleep on our December issue! www.nature.com/neuro/volume...
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Kari Hoffman @karihoffman.bsky.social · 17/11/2025
Happening now ss3 ss4 dentate spikes, beta, category learning in freely moving 🐒
Poster presentation
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Kari Hoffman @karihoffman.bsky.social · 16/11/2025
Rm 25a @10:45 to hear about first full cell assembly reactivation in sleep in primates (human or nonhuman), comparing rvn for newly-learned and old memoranda. Implications for memory linking, integration. @sabbaspoor.bsky.social and I would love your feedback! #sfn25 🧠🧪
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Kari Hoffman @karihoffman.bsky.social · 14/11/2025
Here are our contributions for #SFN2025 #SFN25, Sunday and Monday morning. Hope to see you there!
List of SFN presentations from the Hoffman lab
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Liz Siefert @lizsiefert.bsky.social · 16/11/2025
At SfN and interested in 'neuronal dynamics underlying memory'?? Come check out the nanosymposium (NANO011) that @catrinahacker.bsky.social and I are chairing tomorrow (Sunday) from 8-11:30am. So many awesome folks sharing their research, spanning work in rodents, NHPs, and humans!!
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The Transmitter @thetransmitter.bsky.social · 10/11/2025
Research in primate brains has been essential for the development of brain-computer interfaces and artificial neural networks. New funding and policy changes put future such advances at risk, write Cory Miller, @movshon.bsky.social and Doris Tsao. #neuroskyence bit.ly/47MXYLH
bit.ly
Without monkeys, neuroscience has no future
Research in primate brains has been essential for the development of BCIs, ANNs. New funding and policy changes put future such advances at risk.
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 28/09/2025
Beta bursts mediate amygdala gating of hippocampal emotional encoding www.biorxiv.org/content/10.1101/202…
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Science Magazine @science.org · 16/09/2025
The hippocampus is one of the most studied brain areas because of its major role in fundamental brain functions including learning, memory, and spatial navigation. In a new #ScienceReview, researchers focus on the role of overlooked areas and circuits within the hippocampus. scim.ag/3VKRbMM
scim.ag
Noncanonical circuits, states, and computations of the hippocampus
Traditional views of hippocampal function are largely based on the canonical flow of information from the entorhinal cortex through the trisynaptic loop—comprising the dentate gyrus and cornu ammonis ...
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Cell - a Cell Press journal @cp-cell.bsky.social · 10/07/2025
The new issue is out 👉https://www.cell.com/cell/current On the cover, three articles from the Mesoscopic Brain Mapping Consortium published with Neuron and Developmental Cell shed light on the cell type diversity and their connectivity in mouse and primate brains.
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Vinny Costa @vincentcostaphd.bsky.social · 17/04/2025
This is an epic experiment and set of results bsky.app/profile/kari...
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Kari Hoffman @karihoffman.bsky.social · 15/04/2025
= massive labor of love, built over yrs of foundational work, made possible with the laudable contributions from international students @sabbaspoor.bsky.social (lead, now w/ @jordan-farrell.bsky.social) and @aymanaljishi.bsky.social, and with BRAIN Initiative NINDS + Whitehall Foundation funding.
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Kari Hoffman @karihoffman.bsky.social · 15/04/2025
The NEW assemblies showed greater drift during the task, associated with several ensemble/graph theoretic markers of isolatedness, as in @denisejcai.bsky.social . Again, day-old “RECENT” assemblies look like OLD. Even within CA1, laminar diffs a la Abbaspoor et al., 2024 drop with assembly age.
biorxiv.org
Ensemble remodeling supports memory-updating
Memory-updating is critical in dynamic environments because updating memories with new information promotes versatility. However, little is known about how memories are updated with new information. T...
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Kari Hoffman @karihoffman.bsky.social · 15/04/2025
YES, both groups reactivated, and yes, during sharp-wave-ripples. But the OLD group had stronger reactivation, and actually, that was evident even after 1 day, in the RECENT group. That proved to be a theme.
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Kari Hoffman @karihoffman.bsky.social · 15/04/2025
After careful curation of single units from CA1 and connected structures, we identified cell assemblies - repeated patterns of synchronous firing (typically N~100, some approaching 300). Some assemblies were more active in NEW trials, others OLD. But did either or both groups reactivate in sleep?
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Kari Hoffman @karihoffman.bsky.social · 15/04/2025
We recorded wirelessly from high-density probes in freely-moving macaques as they learned item-context sequences. In the same session, they had to remember an OLD sequence, learned weeks earlier, and a NEW sequence learned that day. We came back the next day, too, calling the NEW sequence RECENT).
treehouse enclosure and spike waveforms
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Kari Hoffman @karihoffman.bsky.social · 15/04/2025
How does the brain integrate information from new experiences while preserving established memories? Have a look at our latest preprint, "Experience reorganizes content-specific memory traces in macaques" 🧵 🧪🧠🤖👩‍🔬 www.biorxiv.org/content/10.1...
biorxiv.org
Experience reorganizes content-specific memory traces in macaques
Memory formation requires neural activity reorganization during experience that persists in sleep. How these processes promote learning while preserving established memories remains unclear. We record...
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