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AJ Simon

@ayejaysimon.bsky.social
183 followers 286 following 20 posts

Neuroscience PhD candidate at Yale Brain networks, cognition, psychiatry Constable Lab NSF GRFP fellow @Neuroscapeucsf alum Twitter: @ayejaysimon

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Reposted by AJ Simon
Alex Fornito @alexfornito.bsky.social · 19/08/2026
Not sure how to visualise your connectome data? Check our latest led by @m-gajwani.bsky.social & C Adamson on NeuroMarvl: an open source web-based platform for visualising and sharing connectomes! Paper: tinyurl.com/2t7ftu9d Software: tinyurl.com/yrv3xja3 @nsb-lab.bsky.social
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AJ Simon @ayejaysimon.bsky.social · 19/08/2026
Excited to announce that my paper on modeling individualized disordered circuit patterns and linking them to clinical phenotypes is now up on Biorxiv! www.biorxiv.org/content/10.6...
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Biological Psychiatry @biologicalpsych.bsky.social · 20/06/2026
Running therapy is linked to the reorganization of large-scale brain dynamics in individuals with affective disorders, and this reorganization is linked to symptom improvement.
biologicalpsychiatrycnni.org
Running therapy reorganizes dynamic brain networks linked to symptom improvement in affective disorders
Exercise therapy reduces depressive and anxiety symptoms, but its neural mechanisms remain unclear. We examined whether running therapy reorganizes dynamic brain functional connectivity in affective…
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AJ Simon @ayejaysimon.bsky.social · 20/06/2026
Had a great time presenting some of my work on modeling individual specific disordered brain circuits at #OHBM2026! It was great to see everyone and I’m looking forward to next time already
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AJ Simon @ayejaysimon.bsky.social · 20/06/2026
Thoroughly enjoyed participating in the French-American doctoral exchange program in precision psychiatry hosted by the INSERM a couple weeks ago. Looking forward to staying in touch with everyone I met and forming new collaborations
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Reposted by AJ Simon
Russ Poldrack @russpoldrack.org · 20/04/2026
"AI amplifies whatever is already there. Good discipline becomes great output. No discipline becomes technical debt at machine speed. Anthropic chose a direction. Go faster. Have Claude check Claude. And when it breaks, go faster still." substack.com/home/post/p-...
substack.com
Claude Code's Source: 3,167-Line Function, Regex Sentiment
Anthropic claimed 100% of Claude Code is AI-written. A source leak exposed a 3,167-line function, regex sentiment analysis, and 250K wasted API calls daily
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Martin Gell @martingell.bsky.social · 11/03/2026
🚨 New preprint alert! 🚨 Transdiagnostic latent factor models of psychopathology are widely assumed to improve brain-behaviour associations. So we decided to test this directly and found that they don't. A short 🧵 Link: www.biorxiv.org/content/10.6... 1/10
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Alessandro Gozzi @gozziale.bsky.social · 05/03/2026
fMRI connectivity is dominated by recurring high-amplitude BOLD events (CAPs, QPPs) But what originates these events? Many think neuromodulation is the culprit. Our new work offers a simpler take: cortico-cortical dynamics alone can generate CAP-like events! doi.org/10.1371/journal.pcbi.1013995 🧵1/n
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Marc L Seal @parkvillegeek.bsky.social · 03/03/2026
Music Ensemble: a large dataset on musicianship, cognition, and personality in musicians and nonmusicians | Scientific Data www.nature.com/articles/s41...
nature.com
Music Ensemble: a large dataset on musicianship, cognition, and personality in musicians and nonmusicians - Scientific Data
Scientific Data - Music Ensemble: a large dataset on musicianship, cognition, and personality in musicians and nonmusicians
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Reposted by AJ Simon
Todd Constable @toddc.bsky.social · 23/02/2026
It's important to note that when discussing brain structure-function relationships across scales, that the definition of function changes with scale. Keep it straight! @sbe.bsky.social link.springer.com/article/10.1...
link.springer.com
Anatomic & functional brain atlases: connecting functional flexibility with fixed infrastructure - Brain Structure and Function
Brain Structure and Function - Recent advancements in imaging across scales has propelled the development of anatomic brain atlases reflecting a wide range of cellular properties. It’s...
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AJ Simon @ayejaysimon.bsky.social · 17/02/2026
Very cool!
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Reposted by AJ Simon
Todd Constable @toddc.bsky.social · 09/02/2026
I wrote an perspectives piece relevant to the structural atlasing endeavors. Structural atlases are not the end of the story. This perspective calls for models that take into account the flexible functional organization within this fixed architecture. www.frontiersin.org/journals/neu...
frontiersin.org
Frontiers | Structure–function relationships across scales: implications for atlases
Neuroscience aims to understand how the structural and functional organization of the brain relates to behavior. Structural studies at the cellular level est...
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AJ Simon @ayejaysimon.bsky.social · 18/12/2025
This is cool and useful!
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AJ Simon @ayejaysimon.bsky.social · 09/12/2025
Great talk/conversation!
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AJ Simon @ayejaysimon.bsky.social · 06/12/2025
The correct way to settle academic conflicts
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Reposted by AJ Simon
Ziv Ben-Zion, PhD @zivbenzion.bsky.social · 06/12/2025
The Two Faces of #PTSD: Fear vs. Emotional Pain. Our new research in Biological Psychiatry @biologicalpsych.bsky.social identifies distinct clinical & neural profiles. AI says no one reads long papers, so we made an infographic!👇 Full Paper (for the insistents😉): doi.org/10.1016/j.bi...
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AJ Simon @ayejaysimon.bsky.social · 05/12/2025
Excited to attend this!
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Alessandro Gozzi @gozziale.bsky.social · 05/12/2025
As we chase whole-brain signatures of cognition with fMRI, this fascinating perspective argues that cognitive signals are broadly distributed...but far from everywhere! For those of us using whole-brain neuroimaging lots to think about.. 👇 www.nature.com/articles/s41...
nature.com
How distributed is the brain-wide network that is recruited for cognition? - Nature Reviews Neuroscience
Both localized and distributed views on the functional organization of the brain have been put forward. In this Perspective, Rosen and Freedman examine the degree to which these two views account for ...
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AJ Simon @ayejaysimon.bsky.social · 02/12/2025
Congrats on getting this published in Biomedical Signal Processing and Control @tifenpan.bsky.social! Here, we showed that signals from frontal EEG channels predicted emotional states while listening to music, but other channels and peripheral physiological sensors did not improve model performance.
sciencedirect.com
When more is not better: Predicting human emotional states with brain and bodily biosensors
Recent technological advances have made wearable biosensors increasingly accessible, affordable, and sensitive, driving their widespread adoption for …
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AJ Simon @ayejaysimon.bsky.social · 02/12/2025
Excited to see this paper out in Biological Psychiatry! It highlights that emotional pain and fear represent distinct PTSD dimensions, leading us closer to identifying PTSD subtypes with dissociable biological underpinnings. Congrats on leading the charge on this cool study @zivbenzion.bsky.social
sciencedirect.com
Dissecting Fear and Emotional Pain in PTSD: From Symptom Networks to Neural Signatures
Posttraumatic stress disorder (PTSD) is a heterogeneous condition with diverse symptom presentations and emotional experiences. While fear is traditio…
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Reposted by AJ Simon
Marc L Seal @parkvillegeek.bsky.social · 16/11/2025
Multivariate environmental exposures are reflected in whole-brain functional connectivity and cognition in youth | bioRxiv www.biorxiv.org/content/10.1...
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PessoaBrain @pessoabrain.bsky.social · 29/10/2025
Congrats, great choices for Cogneuro research:
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Russ Poldrack @russpoldrack.org · 25/10/2025
Great piece by @natolambert.bsky.social on the current state of human exhaustion in the AI world. Makes this important point:
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Marc L Seal @parkvillegeek.bsky.social · 22/10/2025
BOLD signal changes can oppose oxygen metabolism across the human cortex | bioRxiv www.biorxiv.org/content/10.1...
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Jordyn R. Ricard @jordynricard.bsky.social · 20/10/2025
Excited to share our new preprint! We conducted a spatial meta-analysis of community violence and mental health, synthesizing 155 articles (k = 769) to test how exposure to community violence is associated with mental health problems, and how state social service investments moderate the link. 💵
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AJ Simon @ayejaysimon.bsky.social · 20/10/2025
Really cool interdisciplinary study! www.researchsquare.com/article/rs-7...
researchsquare.com
Cross-species mapping of psychedelic gene expression reveals links to the 5HT2A receptor, cortical layers, and human accelerated regions
Psychedelic drugs exert rapid and profound effects on human consciousness and are increasingly explored for their clinical potential. Yet, the genetic programs through which psychedelics reshape brain...
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Reposted by AJ Simon
Jivesh Ramduny @jivr.bsky.social · 16/10/2025
Excited to share our new paper entitled Multisystem Environmental Factors Elucidate Shared and Distinct Associations With Brain and Behavior in Adolescents. Link: www.jaacap.org/article/S089.... @kavliatyale.bsky.social
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Omri Raccah @omriraccah.bsky.social · 16/10/2025
thrilled to share our preprint on false memories in naturalistic recollection! Distinct paths to false memory revealed in hundreds of narrative recalls paper: doi.org/10.31234/osf... w/ phoebehc.bsky.social (co-first) Vy A. Vo @davidpoeppel.bsky.social @toddgureckis.bsky.social thread below 👇
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Caterina Gratton @caterinagratton.bsky.social · 16/10/2025
Why do brain networks vary? Do these differences shape behavior? If every 🧠 is unique, how can we detect common features of brain organization? @rodbraga.bsky.social and I dig in, in @annualreviews.bsky.social (ahead of print): go.illinois.edu/Gratton2025-... #neuroskyence #psychscisky #MedSky 🧵👇
go.illinois.edu
Dense Phenotyping of Human Brain Network Organization Using Precision fMRI
The advent of noninvasive imaging methods like functional magnetic resonance imaging (fMRI) transformed cognitive neuroscience, providing insights into large-scale brain networks and their link to cog...
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AJ Simon @ayejaysimon.bsky.social · 15/10/2025
Couldn’t agree more. It’s easy to blame the “other” side for not trusting scientists, but to begin to repair these fractures it’s our responsibility to step up and be leaders and engage with the community
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Reposted by AJ Simon
Tim Lawn @timlawn.bsky.social · 13/10/2025
Beautiful example of fMRI-based stratification for precision psychiatry! www.nature.com/articles/s44...
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AJ Simon @ayejaysimon.bsky.social · 10/10/2025
Go do more creative stuff! www.nature.com/articles/s41...
nature.com
Creative experiences and brain clocks - Nature Communications
Creative experiences such as dance, music, drawing, and strategy video games might preserve brain health. The authors show that regular practice or short training in these activities is linked to brains that look younger and work more efficiently.
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Reposted by AJ Simon
Sydney E. Smith @syd-smith.bsky.social · 09/10/2025
This is a fascinating study dissecting the degree to which functional connectivity in EEG is driven by aperiodic activity instead of oscillations -- how robust are connectivity findings in a frequency band (theta, alpha) when oscillations are not omni-present? www.jneurosci.org/content/earl...
jneurosci.org
Functional connectivity is dominated by aperiodic, rather than oscillatory, coupling
Functional connectivity (FC) has attracted significant interest in the identification of specific circuits underlying brain (dys-)function. Classical analyses to estimate FC ( i.e ., filtering electro...
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Reposted by AJ Simon
Todd Constable @toddc.bsky.social · 09/10/2025
Great to have @timlawn.bsky.social visiting today and presenting some really interesting findings. Cool stuff.
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AJ Simon @ayejaysimon.bsky.social · 06/10/2025
New preprint alert! We used connectome-based predictive modeling in a transdiagnostic sample to identify brain network correlates of wide array of behavioral measures. We also identify where networks supporting cognition overlap with those linked to diagnostically related clinical symptomatology.
biorxiv.org
Transdiagnostic connectome-based predictive modeling of many behavioral phenotypes reveals brain network mediators of clinical-cognitive relationships
Connectome-based predictive modeling (CPM) applied to functional MRI connectivity data can identify brain networks that vary with behavioral measures across subjects. The prediction strength also prov...
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Reposted by AJ Simon
Sydney E. Smith @syd-smith.bsky.social · 23/07/2025
Theo Kertesz, a brilliant intern here in the B&C lab, wrote a fantastic piece about my PhD research. Read it on Medium! medium.com/p/listening-...
medium.com
Listening to the Brain’s Hidden Rhythms: How Aperiodic Activity is Changing EEG and Depression…
Rates of depression have been rising steadily over the past few decades, affecting more than 280 million people worldwide (World Health…
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Reposted by AJ Simon
Sydney E. Smith @syd-smith.bsky.social · 07/07/2025
Started a new postdoc at Yale in @brognition.bsky.social Lab with Kia Nobre! Studying adaptive cognition in humans using brain recordings—both on and in the head. New lab, new city, new chapter!
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AJ Simon @ayejaysimon.bsky.social · 26/06/2025
If you’re at OHBM this year, come check out my poster titled “Brain networks that mediate clinical-cognitive relationships” on Friday and Saturday at location number 1150
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AJ Simon @ayejaysimon.bsky.social · 19/03/2025
Excited to get this collaborative paper out from my rotation with @dscheinost.bsky.social
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AJ Simon @ayejaysimon.bsky.social · 02/03/2025
Had a great time discussing network neuroscience (and skiing) at #whistlerbrain2025! Thanks for organizing @toddc.bsky.social and @anjasamardzija.bsky.social!
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Todd Constable @toddc.bsky.social · 21/01/2025
Last week to register! (registration closes Jan 26) #whistlerbrain Register here: web.cvent.com/event/34b0c2...
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Michael W. Cole @mwcole.bsky.social · 03/12/2024
“Cognitive flexibility as the shifting of brain network flows by flexible neural representations”, a solo paper by yours truly, making the case that brain activity flow shifts are essential to mental flexibility (and quite interesting too!) Open access: www.sciencedirect.com/science/arti...
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