This Perspective promotes the use of external validation using independent datasets for human neuroimaging studies.

This Perspective promotes the use of external validation using independent datasets for human neuroimaging studies.

This Perspective promotes the use of external validation using independent datasets for human neuroimaging studies.

Nature Human Behaviour, Published online: 15 April 2026; doi:10.1038/s41562-026-02447-yAcross more than 12,000 MRI scans, the authors show that features discarded during feature selection can rival top-ranked ones in predicting behaviour yet imply different brain circuits, warning that focusing only on top features can mislead neurobiology.

ALT: a black cat is using an apple laptop with the words deadline is coming written below it

Fluctuations in brain activity increase until mid-adolescence. Deviations from this trajectory are linked to worse executive functioning.

Individuals with opioid use disorder were less able to flexibly engage different patterns of brain activity, Yale researchers found.

Fetal, infant, and toddler (FIT) neuroimaging researchers study early brain development to gain insights into neurodevelopmental processes and identif…

This case-control study compares functional magnetic resonance imaging data from individuals with opioid use disorder (OUD) and healthy control participants to examine whether individuals with OUD hav...

This case-control study compares functional magnetic resonance imaging data from individuals with opioid use disorder (OUD) and healthy control participants to examine whether individuals with OUD hav...