Dan Auclair @auclairdan.bsky.social · 27/05/2026oncodaily.com/voices/danie... #Hemesky #myelomasky @oncodaily.bsky.socialoncodaily.comDaniel Auclair: Annual ASCO26 List of 10 Interesting Myeloma Abstracts - OncoDailyDaniel Auclair: Annual ASCO26 List of 10 Interesting Myeloma Abstracts / ASCO26, cancer, Daniel Auclair, Myeloma, OncoDaily, Oncology 010
Reposted by Dan AuclairWaggoner Lab @labwaggoner.bsky.social · 02/09/2025PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1... 083
Dan Auclair @auclairdan.bsky.social · 28/08/2025#IMS25 full abstracts are out! #myelomasky #hemesky 041
Reposted by Dan AuclairAmerican Society of Clinical Oncology @ascocancer.bsky.social · 30/05/2025For breaking news and expert analysis during #ASCO25, turn to #ASCODailyNews! During and after the Meeting, ASCO Daily News has coverage of all the practice-changing research being presented. Bookmark us now: dailynews.ascopubs.org/meetings/asc... #oncsky 094
Dan Auclair @auclairdan.bsky.social · 25/05/2025Now that the final #ASCO25 abstracts are out, here are my top #myelomasky ones Etentamig meetings.asco.org/abstracts-pr... IberVd meetings.asco.org/abstracts-pr... 5-Year Follow-up on CARTITUDE-1 meetings.asco.org/abstracts-pr... 150
Dan Auclair @auclairdan.bsky.social · 25/05/2025The US has world-class scientific talent. The rest of the world is hoping to lure that away www.yahoo.com/news/us-worl...yahoo.comThe US has world-class scientific talent. The rest of the world is hoping to lure that awayAs the Trump administration cut billions of dollars in federal funding to scientific research, thousands of scientists in the U.S. lost their jobs or grants — and governments and universities around t... 020
Dan Auclair @auclairdan.bsky.social · 23/05/2025Roche taps Broad Institute to test SBX sequencing in the clinic www.fiercebiotech.com/medtech/roch...fiercebiotech.comRoche taps Broad Institute to test SBX sequencing in the clinicRoche raised the curtain on its novel approach to DNA sequencing earlier this year, and now it's working with the Broad Institute to explore its use cases, ahead of a full public launch s | Roche tapp... 020
Dan Auclair @auclairdan.bsky.social · 18/04/2025An ultrasensitive method gor detection of cell-free RNA www.nature.com/articles/s41...nature.comAn ultrasensitive method for detection of cell-free RNA - NatureA method, RARE-seq, for sensitive detection of cell-free RNAs in blood is demonstrated to have diverse clinical applications including diagnosing and characterizing human cancers, and tracking respons... 030
Reposted by Dan AuclairWafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 01/04/2025Challenging times. Harvard at risk of losing $9 billion in federal funds as US launches review www.reuters.com/world/us/us-...reuters.comUS reviewing federal contracts, grants to Harvard over antisemitism allegationsThe administration of Republican President Donald Trump announced a review on Monday of federal contracts and grants at Harvard University over allegations of antisemitism. 002
Reposted by Dan AuclairCell Press @cellpress.bsky.social · 19/03/2025Check out our #50ScientistsThatInspire interviews with Drs. Madhukar Pai, Johanna Joyce, Juan-Pablo Correa-Baena, & Hanna Kokko threaded below🧵 @madhupai.bsky.social @johannajoyce.bsky.social @jpcorreabaena.bsky.social @kokkonut.bsky.social 11812
Reposted by Dan AuclairEric Topol @erictopol.bsky.social · 18/03/2025Quite an essay on the basis of cancer entitled "The End of the Genetic Paradigm of Cancer" @plosbiology.org arguing against the primacy of somatic mutations (traditional model) and cells, invoking gene regulatory networks and tissue journals.plos.org/plosbiology/... 521764
Dan Auclair @auclairdan.bsky.social · 18/03/2025BCMA-directed CAR T-cell therapy in patients with multiple myeloma and CNS involvement #MyelomaSky ashpublications.org/bloodadvance... 171
Dan Auclair @auclairdan.bsky.social · 18/03/2025Advantages of a NGS assay for detection of mutant NPM1 MRD in AML #HemeSky - Detection of mNPM1 MRD by NGS overcomes several limitations of RT-qPCR - Prognostic significance of mNPM1 MRD appears greatest in patients with AML with a concomitant FLT3-ITD ashpublications.org/bloodadvance... 030
Dan Auclair @auclairdan.bsky.social · 13/03/2025Large-scale dependency and drug screens characterize the therapeutic vulnerabilities of Multiple Myeloma with 1q+ @ireneghobrial.bsky.social #MyelomaSky ashpublications.org/blood/articl... 230
Dan Auclair @auclairdan.bsky.social · 11/03/2025Nice review: Hallmarks of AI contributions to precision oncology www.nature.com/articles/s43...nature.comHallmarks of artificial intelligence contributions to precision oncology - Nature CancerRuppin and colleagues overview recent research on the use of AI frameworks in precision oncology, describe ten hallmarks of their contributions across cancer detection, therapy optimization and treatm... 010
Dan Auclair @auclairdan.bsky.social · 03/03/2025New SEC filings reveal potential further impact of federal cuts www.wired.com/story/trump-...wired.comTrump's FDA Cuts Are Putting Drug Development at RiskNew SEC filings from pharmaceutical companies reveal Donald Trump and Elon Musk's cost-cutting measures could slow drug research and delay FDA approvals. 021
Dan Auclair @auclairdan.bsky.social · 03/03/2025Dissecting tumor cell programs through biology estimation in clinic single-cell transcriptomics www.nature.com/articles/s41...nature.comDissecting tumor cell programs through group biology estimation in clinical single-cell transcriptomics - Nature CommunicationsExisting methods for identifying differential gene expression signatures for clinical case/control analyses with high throughput sequencing data present various challenges. Here, the authors develop B... 010
Dan Auclair @auclairdan.bsky.social · 01/03/2025Francis Collins retires from NIH www.npr.org/sections/sho...npr.orgLegendary former NIH director retires from embattled agencyDr. Francis Collins is leaving the National Institutes of Health, where he served as director from 2009 to 2021. The agency is facing cutbacks and restrictions under the Trump administration. 020
Dan Auclair @auclairdan.bsky.social · 27/02/2025Coming together for sciences www.science.org/doi/10.1126/...science.orgCome together, right nowThe chaos, conflicting information, firings, and hurtful rhetoric of the Trump administration’s approach to science over the past month are causing anxiety, grief, and concern for the scientific commu... 000
Dan Auclair @auclairdan.bsky.social · 24/02/2025Lung-MAP 3.0. Adding NGS screening options for patient recruitment ascopost.com/issues/febru...ascopost.comLung-MAP 3.0: Simplifying the Process to Meet Patients’ NeedsThe Lung Cancer Master Protocol (Lung-MAP) is an innovative clinical trial designed to efficiently address the unmet needs of patients with advanced non–small cell lung cancer (NSCLC) following front-... 010
Reposted by Dan AuclairEric Topol @erictopol.bsky.social · 24/02/2025The time relegated to being data clerks among US physicians is increasing jamanetwork.com/journals/jam...jamanetwork.comTrends in Physician Electronic Health Record Time and Message VolumeThis cohort study uses national electronic health record data to assess patient medical advice request message volume and the time physicians spend in the records. 109328
Reposted by Dan AuclairRajini Rao @madamescientist.bsky.social · 22/02/2025Pitt to pause PhD admissions, following Vanderbilt and USC, because of uncertainty of NIH funding to academic universities. Who will teach and train US scientists for pharma and biotech? Should we import them from countries that do? www.wesa.fm/health-scien...wesa.fmThe University of Pittsburgh pauses its Ph.D. admissions process amid research funding uncertaintyA spokesperson for the University told WESA Friday that the school has "temporarily paused additional Ph.D. offers of admission," while Pitt works to understand how proposed federal funding cuts could... 89648
Dan Auclair @auclairdan.bsky.social · 22/02/2025One of many similar stories to come out in the last week. A sad state of affairs. 020
Dan Auclair @auclairdan.bsky.social · 20/02/2025Turmoil at FDA and fears it might impact new drug approvals www.biospace.com/fda/fda-reel...biospace.comFDA Reels From ‘Indiscriminate’ Job Cuts Under Trump as Biopharma Appeals for ClarityMorale is low at the FDA, which was hit with layoffs this week following RFK Jr.’s confirmation. Biopharma leaders and agency insiders fear further workforce cuts could delay new medicines. 011
Dan Auclair @auclairdan.bsky.social · 20/02/2025Illumina unveils its novel spatial transcriptomics platform www.illumina.com/company/news...illumina.comIllumina unveils first-of-its-kind spatial transcriptomics technology 010
Dan Auclair @auclairdan.bsky.social · 20/02/2025US researchers are in shock. What to expect next. www.nature.com/articles/d41...nature.comTrump’s siege of science: how the first 30 days unfolded and what’s nextThe breakneck pace and devastating impact of the administration’s policy changes has researchers shocked. 112
Dan Auclair @auclairdan.bsky.social · 18/02/2025Genetic disruption of Blimp-1 drastically augments the antitumor efficacy of BCMA-targeting CAR T cells #MyelomaSky ashpublications.org/bloodadvance...ashpublications.orgGenetic disruption of Blimp-1 drastically augments the antitumor efficacy of BCMA-targeting CAR T cellsKey PointsAblation of Blimp-1 in anti-BCMA CAR T cells improves efficacy, representing a promising novel therapeutic product for MM.Transcriptomic analysis 041
Reposted by Dan AuclairWafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 14/02/2025NIH reportedly loses two top leaders in two days www.qcnews.com/nexstar-medi...qcnews.comNIH reportedly loses two top leaders in two daysTwo key staff members at the National Institutes of Health (NIH) are reportedly leaving the agency amid ongoing efforts by the Trump administration and Department of Government Efficiency head Elon… 001
Dan Auclair @auclairdan.bsky.social · 13/02/2025Congrats, and happy to see your labor of love coming to fruitions Jonathan @pedalheadphx.bsky.social #MyelomaSky 010
Reposted by Dan AuclairJonathan Keats, PhD 🇨🇦 @pedalheadphx.bsky.social · 09/02/2025go.bsky.app/BtBs6xj Still slowly building a myeloma research oriented starter pack, let me know if you are missing. 2193
Dan Auclair @auclairdan.bsky.social · 11/02/2025Characterization of plasma cell-free DNA variants as of tumor- or clonal hematopoiesis-origin in 16,812 advanced cancer patients aacrjournals.org/clincancerre... 000
Reposted by Dan AuclairSTAT @statnews.com · 10/02/2025Mass General Brigham announces largest layoff in its history amid ongoing restructuring - via @bostonglobe.com www.statnews.com/2025/02/10/m...statnews.comMass General Brigham announces largest layoff in its history amid ongoing restructuringMass General Brigham said Monday it will let go of hundreds of employees in the next two months, the largest layoff in the organization’s history. 3297
Reposted by Dan AuclairSTAT @statnews.com · 11/02/2025A federal judge issued a nationwide temporary pause on plans by the NIH to substantially slash research overhead payments www.statnews.com/2025/02/11/j...statnews.comHalt on Trump administration’s cuts to NIH research payments expanded nationwideA federal judge issued a nationwide temporary pause on plans by the NIH to substantially slash research overhead payments. 02413
Dan Auclair @auclairdan.bsky.social · 08/02/2025Bold editorial by the Lancet today American chaos: standing up for health and medicine 083
Dan Auclair @auclairdan.bsky.social · 08/02/2025This STAT article hits the nail on the head www.statnews.com/2025/02/08/n...statnews.comThe NIH’s drastic cut to indirect cost rates is a critical threat to U.S. research infrastructureThe drastic reduction in indirect costs is not a path to innovation or cost savings — it’s a threat to U.S.’s position as global leader in medical research. 075
Dan Auclair @auclairdan.bsky.social · 08/02/2025Congrats for this important work. CEPHEUS study of Dara+VRd vs. VRd: MRD-negativity 60.9% for quad vs. 39.4% w/ VRd; ≥CR rates 81.2% vs. 61.6%; sustained MRD negativity (≥12 mos) 48.7% vs. 26.3%, 43% lower progression or death risk #MyelomaSky @szusmani.bsky.social pubmed.ncbi.nlm.nih.gov/39910273/pubmed.ncbi.nlm.nih.govDaratumumab plus bortezomib, lenalidomide and dexamethasone for transplant-ineligible or transplant-deferred newly diagnosed multiple myeloma: the randomized phase 3 CEPHEUS study - PubMedFrontline daratumumab-based triplet and quadruplet standard-of-care regimens have demonstrated improved survival outcomes in newly diagnosed multiple myeloma (NDMM). For patients with transplant-ineli... 111
Reposted by Dan AuclairSTAT @statnews.com · 08/02/2025#BREAKING - NIH plans to slash support for indirect research costs, sending shockwaves through sciencebuff.lyNIH plans to slash support for indirect research costs, sending shockwaves through scienceThe NIH said Friday night that it would slash support for indirect costs on all existing and future grants to 15% 44331
Dan Auclair @auclairdan.bsky.social · 08/02/2025This is big, and not a good way, for academic research and labs. 000
Reposted by Dan AuclairWaggoner Lab @labwaggoner.bsky.social · 05/02/2025IL-27 elicits a cytotoxic CD8+ T cell program to enforce tumor control @nature.com nature.com/articles/s41... 093
Reposted by Dan AuclairEric Topol @erictopol.bsky.social · 05/02/2025The promise of a personalized (neoantigen) vaccine for treating cancer, as seen by immune response bolstering against renal cell carcinoma in a Phase 1 trial nature.com/articles/d41... nature.com/articles/s41...nature.comA neoantigen vaccine generates antitumour immunity in renal cell carcinoma - NatureA phase I trial of a neoantigen-targeting personalized cancer vaccine led to durable and polyfunctional T cell responses and antitumour recognition, and was associated with no recurrence in patie... 732461
Reposted by Dan AuclairNPR @npr.org · 04/02/2025There's widespread confusion and fear among scientists and doctors on the sprawling National Institutes of Health campus and at institutions dependent on the agency's funding.npr.orgA sense of foreboding hangs over the National Institutes of HealthThere's widespread confusion and fear among scientists and doctors on the sprawling National Institutes of Health campus and at institutions dependent on the agency's funding. 482119435
Dan Auclair @auclairdan.bsky.social · 04/02/2025NIH resumes grant reviews after 2 weeks pause www.statnews.com/2025/02/04/t...statnews.comNIH resumes grant reviews after two-week pause, along with some communications and travelNational Institutes of Health holds first grant review meetings since first days of the Trump administration 010
Dan Auclair @auclairdan.bsky.social · 04/02/2025T-cell immune cluster analysis using CyTOF identifies unique subgroups of patients with acute myeloid leukemia #HemeSky ashpublications.org/bloodadvance... 050
Dan Auclair @auclairdan.bsky.social · 04/02/2025#WorldCancerDay coincides with my dad’s birthday whom I lost to DLBCL. Great hope with new tools (immune & cell therapies, degraders, molecular glues, etc.). Cancer cells are smart, we still have lot to learn about biology & get better at early #detection #interception Keep fighting and innovating! 050
Dan Auclair @auclairdan.bsky.social · 04/02/2025Agree with @scaltritilab.bsky.social on the importance of reverse translation medicine. We need to learn from what is happening in patients in order to better accelerate new cancer discoveries and therapies #HemeSky #MedSky www.nature.com/articles/s43...nature.comBreaking frontiers with multidisciplinary cancer research - Nature CancerFive experts share their thoughts on key areas of focus in multidisciplinary cancer research for the upcoming years. They discuss the research approaches, tools, technologies, collaborations and way o... 141
Reposted by Dan AuclairScience Magazine @science.org · 31/01/2025A long-awaited nonopioid pain drug has won approval from the U.S. Food and Drug Administration (FDA) to treat moderate to severe short-term pain.scim.agNonopioid drug for acute pain wins FDA approvalOngoing trials will reveal whether suzetrigine is also effective against chronic pain 18921
Dan Auclair @auclairdan.bsky.social · 03/02/2025On #NationalWomenPhysiciansDay remembering Dr. Elizabeth Blackwell, US first female doctor. After dozens of rejections, she finally got into GMCNY in 1847, her acceptance having been put to vote before the medical class. Legend has it they thought it was a joke healthmatters.nyp.org/happened-dr-... 010
Reposted by Dan AuclairWaggoner Lab @labwaggoner.bsky.social · 31/01/2025CAR trogocytosis transfers antitumor immunity between T cells and is dictated by their transmembrane domain @sciimmunology.bsky.social www.science.org/doi/10.1126/... 0134
Dan Auclair @auclairdan.bsky.social · 31/01/2025The current landscape and emerging challenges of benchmarking single-cell methods www.biorxiv.org/content/10.1... 000