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Dan Auclair

@auclairdan.bsky.social
789 followers 832 following 87 posts

Blood cancer translational scientist with a special love for #myeloma, animals and nature friend | Opinions are my own #MyelomaSky #HemeSky

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Dan Auclair @auclairdan.bsky.social · 27/05/2026
oncodaily.com/voices/danie... #Hemesky #myelomasky @oncodaily.bsky.social
oncodaily.com
Daniel Auclair: Annual ASCO26 List of 10 Interesting Myeloma Abstracts - OncoDaily
Daniel Auclair: Annual ASCO26 List of 10 Interesting Myeloma Abstracts / ASCO26, cancer, Daniel Auclair, Myeloma, OncoDaily, Oncology
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Waggoner Lab @labwaggoner.bsky.social · 02/09/2025
PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
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Dan Auclair @auclairdan.bsky.social · 28/08/2025
#IMS25 full abstracts are out! #myelomasky #hemesky
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American Society of Clinical Oncology @ascocancer.bsky.social · 30/05/2025
For breaking news and expert analysis during #ASCO25, turn to #ASCODailyNews! During and after the Meeting, ASCO Daily News has coverage of all the practice-changing research being presented. Bookmark us now: dailynews.ascopubs.org/meetings/asc... #oncsky
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Dan Auclair @auclairdan.bsky.social · 25/05/2025
Now that the final #ASCO25 abstracts are out, here are my top #myelomasky ones Etentamig meetings.asco.org/abstracts-pr... IberVd meetings.asco.org/abstracts-pr... 5-Year Follow-up on CARTITUDE-1 meetings.asco.org/abstracts-pr...
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Dan Auclair @auclairdan.bsky.social · 25/05/2025
The US has world-class scientific talent. The rest of the world is hoping to lure that away www.yahoo.com/news/us-worl...
yahoo.com
The US has world-class scientific talent. The rest of the world is hoping to lure that away
As the Trump administration cut billions of dollars in federal funding to scientific research, thousands of scientists in the U.S. lost their jobs or grants — and governments and universities around t...
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Dan Auclair @auclairdan.bsky.social · 23/05/2025
Roche taps Broad Institute to test SBX sequencing in the clinic www.fiercebiotech.com/medtech/roch...
fiercebiotech.com
Roche taps Broad Institute to test SBX sequencing in the clinic
Roche raised the curtain on its novel approach to DNA sequencing earlier this year, and now it's working with the Broad Institute to explore its use cases, ahead of a full public launch s | Roche tapp...
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Dan Auclair @auclairdan.bsky.social · 18/04/2025
An ultrasensitive method gor detection of cell-free RNA www.nature.com/articles/s41...
nature.com
An ultrasensitive method for detection of cell-free RNA - Nature
A method, RARE-seq, for sensitive detection of cell-free RNAs in blood is demonstrated to have diverse clinical applications including diagnosing and characterizing human cancers, and tracking respons...
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Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 01/04/2025
Challenging times. Harvard at risk of losing $9 billion in federal funds as US launches review www.reuters.com/world/us/us-...
reuters.com
US reviewing federal contracts, grants to Harvard over antisemitism allegations
The administration of Republican President Donald Trump announced a review on Monday of federal contracts and grants at Harvard University over allegations of antisemitism.
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Cell Press @cellpress.bsky.social · 19/03/2025
Check out our #50ScientistsThatInspire interviews with Drs. Madhukar Pai, Johanna Joyce, Juan-Pablo Correa-Baena, & Hanna Kokko threaded below🧵 @madhupai.bsky.social @johannajoyce.bsky.social @jpcorreabaena.bsky.social @kokkonut.bsky.social
Cell Press banner that reads "50 Scientists that Inspire: Putting a spotlight on researchers who drive innovation" The headshots of Drs. Madhukar Pai, Johanna Joyce, Juan-Pablo Correa-Baena, & Hanna Kokko are illuminated under a spotlight.
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Eric Topol @erictopol.bsky.social · 18/03/2025
Quite an essay on the basis of cancer entitled "The End of the Genetic Paradigm of Cancer" @plosbiology.org arguing against the primacy of somatic mutations (traditional model) and cells, invoking gene regulatory networks and tissue journals.plos.org/plosbiology/...
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Dan Auclair @auclairdan.bsky.social · 18/03/2025
BCMA-directed CAR T-cell therapy in patients with multiple myeloma and CNS involvement ⁦‪⁦‪#MyelomaSky ashpublications.org/bloodadvance...
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Dan Auclair @auclairdan.bsky.social · 18/03/2025
Advantages of a NGS assay for detection of mutant NPM1 MRD in AML #HemeSky - Detection of mNPM1 MRD by NGS overcomes several limitations of RT-qPCR - Prognostic significance of mNPM1 MRD appears greatest in patients with AML with a concomitant FLT3-ITD ashpublications.org/bloodadvance...
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Dan Auclair @auclairdan.bsky.social · 13/03/2025
Large-scale dependency and drug screens characterize the therapeutic vulnerabilities of Multiple Myeloma with 1q+ @ireneghobrial.bsky.social #MyelomaSky ashpublications.org/blood/articl...
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Dan Auclair @auclairdan.bsky.social · 11/03/2025
Nice review: Hallmarks of AI contributions to precision oncology www.nature.com/articles/s43...
nature.com
Hallmarks of artificial intelligence contributions to precision oncology - Nature Cancer
Ruppin and colleagues overview recent research on the use of AI frameworks in precision oncology, describe ten hallmarks of their contributions across cancer detection, therapy optimization and treatm...
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Dan Auclair @auclairdan.bsky.social · 03/03/2025
New SEC filings reveal potential further impact of federal cuts www.wired.com/story/trump-...
wired.com
Trump's FDA Cuts Are Putting Drug Development at Risk
New SEC filings from pharmaceutical companies reveal Donald Trump and Elon Musk's cost-cutting measures could slow drug research and delay FDA approvals.
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Dan Auclair @auclairdan.bsky.social · 03/03/2025
Dissecting tumor cell programs through biology estimation in clinic single-cell transcriptomics www.nature.com/articles/s41...
nature.com
Dissecting tumor cell programs through group biology estimation in clinical single-cell transcriptomics - Nature Communications
Existing methods for identifying differential gene expression signatures for clinical case/control analyses with high throughput sequencing data present various challenges. Here, the authors develop B...
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Dan Auclair @auclairdan.bsky.social · 01/03/2025
Francis Collins retires from NIH www.npr.org/sections/sho...
npr.org
Legendary former NIH director retires from embattled agency
Dr. Francis Collins is leaving the National Institutes of Health, where he served as director from 2009 to 2021. The agency is facing cutbacks and restrictions under the Trump administration.
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Dan Auclair @auclairdan.bsky.social · 27/02/2025
Coming together for sciences www.science.org/doi/10.1126/...
science.org
Come together, right now
The chaos, conflicting information, firings, and hurtful rhetoric of the Trump administration’s approach to science over the past month are causing anxiety, grief, and concern for the scientific commu...
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Dan Auclair @auclairdan.bsky.social · 24/02/2025
Lung-MAP 3.0. Adding NGS screening options for patient recruitment ascopost.com/issues/febru...
ascopost.com
Lung-MAP 3.0: Simplifying the Process to Meet Patients’ Needs
The Lung Cancer Master Protocol (Lung-MAP) is an innovative clinical trial designed to efficiently address the unmet needs of patients with advanced non–small cell lung cancer (NSCLC) following front-...
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Eric Topol @erictopol.bsky.social · 24/02/2025
The time relegated to being data clerks among US physicians is increasing jamanetwork.com/journals/jam...
jamanetwork.com
Trends in Physician Electronic Health Record Time and Message Volume
This cohort study uses national electronic health record data to assess patient medical advice request message volume and the time physicians spend in the records.
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Rajini Rao @madamescientist.bsky.social · 22/02/2025
Pitt to pause PhD admissions, following Vanderbilt and USC, because of uncertainty of NIH funding to academic universities. Who will teach and train US scientists for pharma and biotech? Should we import them from countries that do? www.wesa.fm/health-scien...
wesa.fm
The University of Pittsburgh pauses its Ph.D. admissions process amid research funding uncertainty
A spokesperson for the University told WESA Friday that the school has "temporarily paused additional Ph.D. offers of admission," while Pitt works to understand how proposed federal funding cuts could...
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Dan Auclair @auclairdan.bsky.social · 22/02/2025
One of many similar stories to come out in the last week. A sad state of affairs.
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Dan Auclair @auclairdan.bsky.social · 20/02/2025
Turmoil at FDA and fears it might impact new drug approvals www.biospace.com/fda/fda-reel...
biospace.com
FDA Reels From ‘Indiscriminate’ Job Cuts Under Trump as Biopharma Appeals for Clarity
Morale is low at the FDA, which was hit with layoffs this week following RFK Jr.’s confirmation. Biopharma leaders and agency insiders fear further workforce cuts could delay new medicines.
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Dan Auclair @auclairdan.bsky.social · 20/02/2025
Illumina unveils its novel spatial transcriptomics platform www.illumina.com/company/news...
illumina.com
Illumina unveils first-of-its-kind spatial transcriptomics technology
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Dan Auclair @auclairdan.bsky.social · 20/02/2025
US researchers are in shock. What to expect next. www.nature.com/articles/d41...
nature.com
Trump’s siege of science: how the first 30 days unfolded and what’s next
The breakneck pace and devastating impact of the administration’s policy changes has researchers shocked.
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Dan Auclair @auclairdan.bsky.social · 18/02/2025
Genetic disruption of Blimp-1 drastically augments the antitumor efficacy of BCMA-targeting CAR T cells #MyelomaSky ashpublications.org/bloodadvance...
ashpublications.org
Genetic disruption of Blimp-1 drastically augments the antitumor efficacy of BCMA-targeting CAR T cells
Key PointsAblation of Blimp-1 in anti-BCMA CAR T cells improves efficacy, representing a promising novel therapeutic product for MM.Transcriptomic analysis
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Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 14/02/2025
NIH reportedly loses two top leaders in two days www.qcnews.com/nexstar-medi...
qcnews.com
NIH reportedly loses two top leaders in two days
Two key staff members at the National Institutes of Health (NIH) are reportedly leaving the agency amid ongoing efforts by the Trump administration and Department of Government Efficiency head Elon…
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Dan Auclair @auclairdan.bsky.social · 13/02/2025
Congrats, and happy to see your labor of love coming to fruitions Jonathan @pedalheadphx.bsky.social #MyelomaSky
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Jonathan Keats, PhD 🇨🇦 @pedalheadphx.bsky.social · 09/02/2025
go.bsky.app/BtBs6xj Still slowly building a myeloma research oriented starter pack, let me know if you are missing.
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Dan Auclair @auclairdan.bsky.social · 11/02/2025
Characterization of plasma cell-free DNA variants as of tumor- or clonal hematopoiesis-origin in 16,812 advanced cancer patients aacrjournals.org/clincancerre...
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STAT @statnews.com · 10/02/2025
Mass General Brigham announces largest layoff in its history amid ongoing restructuring - via @bostonglobe.com www.statnews.com/2025/02/10/m...
statnews.com
Mass General Brigham announces largest layoff in its history amid ongoing restructuring
Mass General Brigham said Monday it will let go of hundreds of employees in the next two months, the largest layoff in the organization’s history.
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STAT @statnews.com · 11/02/2025
A federal judge issued a nationwide temporary pause on plans by the NIH to substantially slash research overhead payments www.statnews.com/2025/02/11/j...
statnews.com
Halt on Trump administration’s cuts to NIH research payments expanded nationwide
A federal judge issued a nationwide temporary pause on plans by the NIH to substantially slash research overhead payments.
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Dan Auclair @auclairdan.bsky.social · 08/02/2025
Bold editorial by the Lancet today American chaos: standing up for health and medicine
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Dan Auclair @auclairdan.bsky.social · 08/02/2025
This STAT article hits the nail on the head www.statnews.com/2025/02/08/n...
statnews.com
The NIH’s drastic cut to indirect cost rates is a critical threat to U.S. research infrastructure
The drastic reduction in indirect costs is not a path to innovation or cost savings — it’s a threat to U.S.’s position as global leader in medical research.
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Dan Auclair @auclairdan.bsky.social · 08/02/2025
#MyelomaSky #HemeSky
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Dan Auclair @auclairdan.bsky.social · 08/02/2025
Congrats for this important work. CEPHEUS study of Dara+VRd vs. VRd: MRD-negativity 60.9% for quad vs. 39.4% w/ VRd; ≥CR rates 81.2% vs. 61.6%; sustained MRD negativity (≥12 mos) 48.7% vs. 26.3%, 43% lower progression or death risk #MyelomaSky @szusmani.bsky.social pubmed.ncbi.nlm.nih.gov/39910273/
pubmed.ncbi.nlm.nih.gov
Daratumumab plus bortezomib, lenalidomide and dexamethasone for transplant-ineligible or transplant-deferred newly diagnosed multiple myeloma: the randomized phase 3 CEPHEUS study - PubMed
Frontline daratumumab-based triplet and quadruplet standard-of-care regimens have demonstrated improved survival outcomes in newly diagnosed multiple myeloma (NDMM). For patients with transplant-ineli...
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STAT @statnews.com · 08/02/2025
#BREAKING - NIH plans to slash support for indirect research costs, sending shockwaves through science
buff.ly
NIH plans to slash support for indirect research costs, sending shockwaves through science
The NIH said Friday night that it would slash support for indirect costs on all existing and future grants to 15%
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Dan Auclair @auclairdan.bsky.social · 08/02/2025
This is big, and not a good way, for academic research and labs.
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Waggoner Lab @labwaggoner.bsky.social · 05/02/2025
IL-27 elicits a cytotoxic CD8+ T cell program to enforce tumor control @nature.com nature.com/articles/s41...
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Eric Topol @erictopol.bsky.social · 05/02/2025
The promise of a personalized (neoantigen) vaccine for treating cancer, as seen by immune response bolstering against renal cell carcinoma in a Phase 1 trial nature.com/articles/d41... nature.com/articles/s41...
nature.com
A neoantigen vaccine generates antitumour immunity in renal cell carcinoma - Nature
A phase I trial of a neoantigen-targeting personalized cancer vaccine led to durable and polyfunctional T cell responses and antitumour recognition, and was associated with no recurrence in patie...
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NPR @npr.org · 04/02/2025
There's widespread confusion and fear among scientists and doctors on the sprawling National Institutes of Health campus and at institutions dependent on the agency's funding.
npr.org
A sense of foreboding hangs over the National Institutes of Health
There's widespread confusion and fear among scientists and doctors on the sprawling National Institutes of Health campus and at institutions dependent on the agency's funding.
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Dan Auclair @auclairdan.bsky.social · 04/02/2025
NIH resumes grant reviews after 2 weeks pause www.statnews.com/2025/02/04/t...
statnews.com
NIH resumes grant reviews after two-week pause, along with some communications and travel
National Institutes of Health holds first grant review meetings since first days of the Trump administration
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Dan Auclair @auclairdan.bsky.social · 04/02/2025
T-cell immune cluster analysis using CyTOF identifies unique subgroups of patients with acute myeloid leukemia #HemeSky ashpublications.org/bloodadvance...
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Dan Auclair @auclairdan.bsky.social · 04/02/2025
#WorldCancerDay coincides with my dad’s birthday whom I lost to DLBCL. Great hope with new tools (immune & cell therapies, degraders, molecular glues, etc.). Cancer cells are smart, we still have lot to learn about biology & get better at early #detection #interception Keep fighting and innovating!
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Dan Auclair @auclairdan.bsky.social · 04/02/2025
Agree with @scaltritilab.bsky.social on the importance of reverse translation medicine. We need to learn from what is happening in patients in order to better accelerate new cancer discoveries and therapies #HemeSky #MedSky www.nature.com/articles/s43...
nature.com
Breaking frontiers with multidisciplinary cancer research - Nature Cancer
Five experts share their thoughts on key areas of focus in multidisciplinary cancer research for the upcoming years. They discuss the research approaches, tools, technologies, collaborations and way o...
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Science Magazine @science.org · 31/01/2025
A long-awaited nonopioid pain drug has won approval from the U.S. Food and Drug Administration (FDA) to treat moderate to severe short-term pain.
scim.ag
Nonopioid drug for acute pain wins FDA approval
Ongoing trials will reveal whether suzetrigine is also effective against chronic pain
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Dan Auclair @auclairdan.bsky.social · 03/02/2025
On #NationalWomenPhysiciansDay remembering Dr. Elizabeth Blackwell, US first female doctor. After dozens of rejections, she finally got into GMCNY in 1847, her acceptance having been put to vote before the medical class. Legend has it they thought it was a joke healthmatters.nyp.org/happened-dr-...
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Waggoner Lab @labwaggoner.bsky.social · 31/01/2025
CAR trogocytosis transfers antitumor immunity between T cells and is dictated by their transmembrane domain @sciimmunology.bsky.social www.science.org/doi/10.1126/...
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Dan Auclair @auclairdan.bsky.social · 31/01/2025
The current landscape and emerging challenges of benchmarking single-cell methods www.biorxiv.org/content/10.1...
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