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Astri Kusumawardhani

@astrikusuma.bsky.social
68 followers 90 following 0 posts

Mom of 2, Loves tinkering with bacteria! 🧬🧫 Postdoc at the Schaerli lab, UNIL🇨🇭

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Reposted by Astri Kusumawardhani
Howard Salis @hsalis.bsky.social · 02/12/2024
NEW paper 🚨! We engineered TNT sensors in soil bacteria for long-term detection of explosive in natural soil, enabling geospatial detection of contaminated soil. This work (led by Erin Essington) included new sensors, circuits, modeling, & a 28-day testing workflow. 1/ www.nature.com/articles/s41...
nature.com
An autonomous microbial sensor enables long-term detection of TNT explosive in natural soil - Nature Communications
Engineered microbes can detect harmful chemicals, but may not work well in complex environments. Here, the authors built microbial sensors for detection of TNT explosive and tested their response over...
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Reposted by Astri Kusumawardhani
Alex Crits-Christoph @acritschristoph.bsky.social · 12/06/2024
Going viral: The role of mobile genetic elements in bacterial immunity www.cell.com/cell-host-mi...
cell.com
Going viral: The role of mobile genetic elements in bacterial immunity
Bacteria deploy a broad range of defense systems to protect themselves against viruses and other mobile genetic elements. Here, we review recent work that reveals how most defense systems are carried ...
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Reposted by Astri Kusumawardhani
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 13/06/2024
Genetic encoding and expression of RNA origami cytoskeletons in synthetic cells www.biorxiv.org/content/10.1101/202…
biorxiv.org
Genetic encoding and expression of RNA origami cytoskeletons in synthetic cells https://www.biorxiv.org/content/10.1101/2024.06.12.598448v1
The central dogma at the core of molecular biology states that information flows from DNA to RNA and
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Reposted by Astri Kusumawardhani
Cameron Thrash @jcamthrash.bsky.social · 12/04/2024
PyCoMo: a python package for community metabolic model creation and analysis academic.oup.com/bioinformati... #jcampubs
academic.oup.com
PyCoMo: a python package for community metabolic model creation and analysis
AbstractSummary. PyCoMo is a python package for quick and easy generation of genome-scale compartmentalized community metabolic models that are compliant w
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Reposted by Astri Kusumawardhani
Yolanda Schaerli @yschaerli.bsky.social · 02/04/2024
Very happy to share our latest preprint DMF UNIL: Jung and Gábor controlled the ring patterns in E. coli colonies generated by a synthetic oscillator with optogenetics. We observed synchronisation, resonance, entrainment, undertone, period doubling and even chaos! Feedback welcome.
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Reposted by Astri Kusumawardhani
Yolanda Schaerli @yschaerli.bsky.social · 26/03/2024
www.advancedsciencenews.com/a-living-bio... Nice news article in “Advanced Science News” covering our recent publication (result of a collaboration with @pengellab.bsky.social as part of the NCCR Microbiomes).
advancedsciencenews.com
A living biosensor helps track honeybee health - Advanced Science News
First living biosensor developed to study honeybee gut microbiome, providing insights into health and conservation.
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Reposted by Astri Kusumawardhani
STCmicrobeblog @stcmicrobeblog.bsky.social · 21/03/2024
Filamentous Phage Shields by Roberto — Elaborate mechanisms that protect bacteria against phage are well known, with CRISPR leading the way. Less familiar but equally fascinating is the fact that, somewhat unexpectedly, phages themselves sometimes offer... Read more > tinyurl.com/yktjj3z7 #MicroSky
Detail from Fig. 1. Schematic model of the mechanism of Pf4 phage-mediated antibiotic tolerance. [Source: https://www.pnas.org/doi/full/10.1073/pnas.1917726117]
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Reposted by Astri Kusumawardhani
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 17/03/2024
Bottlenecks in the Implementation of Genome Scale Metabolic Model Based Designs for Bioproduction from Aromatic Carbon Sources www.biorxiv.org/content/10.1101/202…
biorxiv.org
Bottlenecks in the Implementation of Genome Scale Metabolic Model Based Designs for Bioproduction from Aromatic Carbon Sources https://www.biorxiv.org/content/10.1101/2024.03.15.585139v1
Genome scale metabolic models (GSMM) are commonly used to identify gene deletion sets that result in
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Reposted by Astri Kusumawardhani
Sara Mitri @saramitri.bsky.social · 06/02/2024
Amazing to see this finally out!!From competition to collaboration: we show how 2 bacterial species that compete for a carbon source can interact positively in a toxic environment, with one species removing ROS to the benefit of the other plos.io/3SOvRnZ congrats Aurore Picot & Rita Di Martino
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Reposted by Astri Kusumawardhani
Will Ratcliff @wcratcliff.bsky.social · 25/01/2024
Our paper engineering yeast to be phototrophic (gaining energy from light) by chucking a rhodopsin into the vacuole is out in Current Biology. www.cell.com/current-biol...
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Reposted by Astri Kusumawardhani
Michael Baym @baym.lol · 26/01/2024
How stable are bacterial genomes as they adapt to an environment? My collaboration with Anurag Limdi, Alex Couce, @relenski.bsky.social, and Olivier Tenaillon exploring this over 50,000 generations of evolution is out today! 1/ (cross-post from the other place) www.science.org/doi/10.1126/...
science.org
Changing fitness effects of mutations through long-term bacterial evolution
Predictable and parallel changes occur in the fitness effects of mutations in Escherichia coli over 50,000 generations.
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Reposted by Astri Kusumawardhani
Stephen Heard @stephenbheard.bsky.social · 23/01/2024
why most of my scientific papers aren't really all that exciting - and why that's perfectly OK and a normal part of how science advances. With bonus architecture analogy... scientistseessquirrel.wordpress.com/2024/01/23/w...
scientistseessquirrel.wordpress.com
Why most of my papers just aren’t that exciting
I’ve published about 95* papers in my career so far, and most of them aren’t very exciting. I don’t mean that they’re boring to read, as written texts. Well, most of them are boring to read, t...
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Reposted by Astri Kusumawardhani
Jose A Escudero @jaescudero.bsky.social · 15/01/2024
And its out! New paper for #integron aficionados. We found gene-less cassettes in superintegrons that express/silence other cassettes in the array. Here is a 🧵(if I know how to do this in Bluesky...😆) academic.oup.com/nar/advance-...
academic.oup.com
Identification of promoter activity in gene-less cassettes from Vibrionaceae superintegrons
Abstract. Integrons are genetic platforms that acquire new genes encoded in integron cassettes (ICs), building arrays of adaptive functions. ICs generally encod
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Reposted by Astri Kusumawardhani
Teppo Hiltunen @teppo-h.bsky.social · 17/01/2024
Application deadline has been extended until Feb 5th!
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Reposted by Astri Kusumawardhani
Philipp Engel @pengellab.bsky.social · 15/01/2024
Finally published! We show that host metabolites facilitate gutcolonization of a symbiont of social bees. Huge congrats to co-lead authors @andrewhq9.bsky.social & Yassine El Chazli. Super collabo with NanoSIMS expert Anders Meibom EPFL and our Electron Microscopy Facility FBM_UNIL 🐝 🧪
nature.com
Host-derived organic acids enable gut colonization of the honey bee symbiont Snodgrassella alvi - Na...
Comparative metabolomics and NanoSIMs reveal that the honey bee symbiont Snodgrassella alvi uses host-derived metabolites to colonize the gut, indicating adaptation to a specific metabolic niche in it...
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Reposted by Astri Kusumawardhani
Pablo Ivan Nikel @pabnik.bsky.social · 15/01/2024
#Pseudomonas enthusiasts! Join us at the international #conference Sept 1-5 · Dive into the latest research on #microbiology, clinical #infection & #biotechnology · Abstract submission opens later this week · #Pseudomonas2024 · Please spread the word! microbiologysociety.org/event/full-e...
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Reposted by Astri Kusumawardhani
eLife @elife.bsky.social · 10/01/2024
When researchers tried to evolve a yeast population to stick to plastic, they accidentally increased it’s ability to cause infection. What more can we learn about ‘accidental virulence’? elifesciences.org/articles/945...
black and white microscopy image of budding yeast
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Reposted by Astri Kusumawardhani
Cameron Thrash @jcamthrash.bsky.social · 03/01/2024
Integron cassettes integrate into bacterial genomes via widespread non-classical attG sites www.nature.com/articles/s41... #jcampubs
nature.com
Integron cassettes integrate into bacterial genomes via widespread non-classical attG sites - Nature...
Computational analyses and molecular genetics reveal that integron cassettes integrate into bacterial genomes at widespread non-classical attG sites, enabling acquisition of genetic material and disru...
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