Reposted by Artemy KolchinskyThomas F. Varley @thosvarley.bsky.social · 24/09/2026Opus 5.5 can solve basically any information-theory question I want it to. I can get the answer to every puzzle that's ever bugged me throughout my career, with zero effort or friction. Turns out...that kind of sucks. Faust was totally right. 372
Reposted by Artemy KolchinskyPhysical Review Letters @physrevlett.aps.org · 28/09/2026To simplify multiscale systems, scientists often average out fast variables and focus on slow ones. New work shows how this method neglects complex, narrow pathways, or “singular funnels,” and misrepresents systems’ resilience to perturbations. More: go.aps.org/3Tp3dxZ 013
Reposted by Artemy KolchinskyLuís M. Rocha @lmrocha.bsky.social · 20/08/2026Some words about Howard Pattee, expanding a bit my comments last night @alifeconf.bsky.social . heycityzen.substack.com/p/howard-h-p... #ComplexSystems #TheoreticalBiology #ArtificalLifeheycityzen.substack.comHoward H. Pattee (1926-2026)It is with a lot of emotion that I applaud the International Society for Artificial Life for honoring the lifetime achievement of Howard Pattee to the field. 0104
Reposted by Artemy KolchinskyKate Nave @kathrynnave.eurosky.social · 29/07/2026My postdoc is coming to an end, so I'm looking for work! Let me know if you, or anyone you know, wants to hire a philosopher of biology/cognition with a knack for cross-disciplinary work, a focus on autonomy + agency, and experience writing for the broader public (10+ yrs in sci/tech journalism). 35032
Artemy Kolchinsky @artemyte.bsky.social · 28/07/2026See also: Santolin and Falasco, Dissipation Bounds the Coherence of Stochastic Limit Cycles, PRL journals.aps.org/prl/abstrac... Nagayama and Ito, Duality between dissipation-coherence trade-off and thermodynamic speed limit arxiv.org/abs/2509.06421arxiv.orgDuality between dissipation-coherence trade-off and thermodynamic...We derive two fundamental trade-offs for general stochastic limit cycles in the weak-noise limit. The first is the dissipation-coherence trade-off, which was discovered and proved under additional... 010
Artemy Kolchinsky @artemyte.bsky.social · 28/07/2026What is the fundamental cost of stochastic oscillators? In a recent PRE, I provide an elementary derivation of a fundamental "dissipation-coherence bound". Builds on work on thermodynamics of limit-cycle oscillators by Santolin-Falasco and Nagayama-Ito journals.aps.org/pre/abstrac... 170
Artemy Kolchinsky @artemyte.bsky.social · 13/07/2026Open postdoc position. Interested in complex systems, dynamical systems, and computational mechanics? With Alexandra Jurgens at INRIA (Bordeaux) recrutement.inria.fr/public/clas...jobs.inria.frPost-Doctoral Research Visit F/M Inferring structure in complex systemsOffre d'emploi Inria 063
Artemy Kolchinsky @artemyte.bsky.social · 25/06/2026I just learned Peter Schuster passed away recently. Peter Schuster was a theoretician who did incredible work on the origin of life, evolutionary dynamics, genotype-phenotype maps, and other topics in theoretical biology. A huge loss. 0101
Reposted by Artemy KolchinskyMelanie Mitchell @melaniemitchell.bsky.social · 08/06/2026I wrote a piece for the Yale Review on AI and "jagged intelligence". (Note: headline was not written by me.) yalereview.org/article/mela...yalereview.orgMelanie Mitchell: What We Get Wrong About AIMelanie Mitchell probes the jagged landscape of AI and its uncertain future. 812737
Reposted by Artemy KolchinskyTim Taylor @drtimt.bsky.social · 09/06/2026I'm so very sad to hear of the passing of Inman Harvey. He was my PhD examiner in 1999 (I'm glad to say he passed it!), and was a mentor, inspiration and friend not just to me but to a whole generation (and more) of Artificial Life researchers. He will be very sorely missed, but his legacy lives on. 021
Artemy Kolchinsky @artemyte.bsky.social · 05/05/2026This was a very fun collaboration with Giacomo and Jonathan, and my first chance to dive deep into the thermodynamics and dynamics of phase separation. 020
Artemy Kolchinsky @artemyte.bsky.social · 05/05/2026We find that phase separation can slow down, speed up, damped or amplify oscillations, depending on alignment b/w interaction energies & nonlinear kinetics. In spatial systems with phase separation + reaction + diffusion, rich traveling patterns of concentration & phase emerge 110
Artemy Kolchinsky @artemyte.bsky.social · 05/05/2026How does phase separation, a key mechanism of equilibrium self-organization, interact with nonlinear nonequilibrium dynamics? In our paper with Jonathan Bauermann and Giacomo Bartolucci @gbart.bsky.social, we look at phase separation in chemical oscillators journals.aps.org/prl/abstrac... 1112
Artemy Kolchinsky @artemyte.bsky.social · 01/05/2026Open postdoc with the amazing Sarah Marzen (Scripps College, Claremont, California). Intersection of information theory, biophysics, neuroscience, and machine learning. Please RT theclaremontcolleges.wd1.myworkdayjobs.com/en-US/SCR_C...theclaremontcolleges.wd1.myworkdayjobs.comPost-Doctoral ResearcherClaremont, CA Job Posting Title: Post-Doctoral Researcher Job Description: PRIMARY PURPOSE/GENERAL DESCRIPTION: Working with Professor Sarah Marzen, the Post-Doctoral Researcher will serve in an advanced professional research capacity to conduct original scholarly and scientific research relating to the engineering of hybrid adaptive networks. The Researcher will routinely need to apply advanced knowledge in physics, applied mathematics, biophysics, scientific computing, and related fields. DESCRIPTION OF DUTIES AND RESPONSIBILITIES: ESSENTIAL FUNCTIONS: This information is intended to be descriptive of the key responsibilities of the position. The incumbent will primarily be engaged in advanced intellectual and creative professional work requiring specialized academic training and the exercise of discretion and independent judgment. Additional duties may be assigned; any such additional duties will primarily be consistent with the professional nature of the position. Independently des 084
Artemy Kolchinsky @artemyte.bsky.social · 30/04/2026We discuss research on non-Markovian systems, active matter, and optimal transport, as well as challenges in scaling up stochastic thermo to complex systems beyond the microscopic scale. 000
Artemy Kolchinsky @artemyte.bsky.social · 30/04/2026We wrote a perspective piece on future directions & challenges for stochastic thermodynamics. Great collaboration with Jan Korbel, Sarah Loos, Gonzalo Manzano, Rosalba Garcia-Millan, Olga Movilla Miangolarra, Edgar Roldan arxiv.org/abs/2604.26601arxiv.orgQuo vadis, stochastic thermodynamics?Stochastic thermodynamics is a framework for describing non-equilibrium processes at the level of fluctuating trajectories, where the state of a system evolves as a stochastic time series,... 1102
Reposted by Artemy Kolchinskydavidasivak.bsky.social @davidasivak.bsky.social · 27/04/2026Reminder: online Workshop on Stochastic Thermodynamics May 18-22 Registration deadline May 17 Detailed schedule now available: wostmeeting.org/programme/wostmeeting.orgProgrammeWorkshop programme is available here: wost7detailedDownload The workshop runs from approximately 3pm to 6:30pm on each day (CEST, or UTC+2). 032
Reposted by Artemy KolchinskyPaolo De Los Rios @paolodelosrios.bsky.social · 21/03/2026Postdoc opening with us at EPFL! Experimental project on how ATP driven chaperone cycles keep proteins out of equilibrium. We will quantify energy use, kinetics, and functional outcomes, including clients whose native-like functional state is stable only by sustained chaperone action. 2811
Artemy Kolchinsky @artemyte.bsky.social · 14/04/2026This work has been a long but very illuminating journey. Very happy to finally have it out and for the great collaboration! 010
Artemy Kolchinsky @artemyte.bsky.social · 14/04/2026The paper builds on our earlier work (journals.aps.org/prresearch/...) on decompositions of entropy production based on Euclidean geometry, which works best for near-equilibrium and diffusive systems. As we show here, info-geometry emerges naturally in the far-from-equilibrium regime 110
Artemy Kolchinsky @artemyte.bsky.social · 14/04/2026Our work unifies several theoretical ideas (thermodynamic speed limits, optimal transport, large deviations, and information geometry) in the setting of nonequilibrium and nonlinear systems. As an example application, we prove a novel speed limit for open metabolic networks 110
Artemy Kolchinsky @artemyte.bsky.social · 14/04/2026Our paper with Andreas Dechant, Kohei Yoshimura and @ito_sosuke is out in Phys Review Research (journals.aps.org/prresearch/...). We propose a "generalized free energy" for nonequilibrium systems, plus an information-geometric decomposition of dissipation into excess & housekeeping terms 190
Reposted by Artemy KolchinskyEckfordLab @eckfordlab.bsky.social · 09/03/2026I was at the IZS in Zurich last week, a spectacular conference in a beautiful location. I used my invited paper as an opportunity to explain what biological information theory is, and why I think it is important [PDF link]: www.research-collection.ethz.ch/server/api/c...research-collection.ethz.ch 121
Artemy Kolchinsky @artemyte.bsky.social · 07/03/2026Great post on rationalism versus empiricism in the history of optimal control. 050
Reposted by Artemy KolchinskyQuanta Magazine @quantamagazine.org · 25/02/2026In 1874, Georg Cantor published one of the most important papers in math’s 4,000-year history. The ideas in it were stolen. 🧵 33011
Artemy Kolchinsky @artemyte.bsky.social · 23/02/2026Fascinating paper — molecular error correction might not incur an accuracy/speed tradeoff. In fact, it may be favored by evolution simply due to increased speed www.science.org/doi/10.1126/...science.orgEvolution of error correction through a need for speedKinetic proofreading is a class of error-correcting mechanisms in biology that expend energy to avoid mistakes during replication, transcription, and translation. Proofreading is typically assumed to ... 041
Reposted by Artemy KolchinskyJohn C. Baez @johncarlosbaez.bsky.social · 22/02/2026Which of these shapes looks like the sound "bouba", and which looks like the sound "kiki"? People of all cultures agree on this, and now it's been found that baby chicks do too: phys.org/news/2026-02... It's called the bouba/kiki effect, and I think it follows from physics! (1/2) 2153
Artemy Kolchinsky @artemyte.bsky.social · 19/02/2026Our paper w/ @maguilera.net & Sosuke Ito is out in PRL. We combine ideas from stochastic thermodynamics & nonequilibrium Maximum Entropy to quantify forces + dissipation in high-dimensional nonequilibrium systems, including spin glasses and neural data link: journals.aps.org/prl/abstract... 0112
Reposted by Artemy KolchinskyLance Fortnow @lance.fortnow.com · 16/02/2026Joe Halpern passed away Friday at the age of 72. He was a leader in mathematically reasoning about knowledge. www.linkedin.com/pos... 082
Reposted by Artemy KolchinskyInstitut Natura e Teoria ※ Pireneus (INTP) @intp-science.bsky.social · 28/01/2026☀️ 2026 Summer School in the Pyrenees - Unifying Mathematical Models of Biodiversity Applications are now open! This school offers a state-of-the-art overview for interdisciplinary theoreticians. 🗓️ July 5-11 🎯 PhD students to senior researchers ℹ️ intp.science/en/summer26.... 📭 contact@intp.science 🌐🧪 02110
Reposted by Artemy KolchinskyRicard Solé @ricardsole.bsky.social · 10/02/2026Can we engineer cognition in aneural systems? What are the challenges and implications? Can synthetic biology be used to interrogate basal cognition? Our new paper with @jordiplam.bsky.social explores these questions using models of minimal gene circuits. Available here pubs.acs.org/doi/pdf/10.1... 2276
Reposted by Artemy KolchinskyManlio De Domenico @manlius.bsky.social · 28/01/2026"In other words, European taxpayers will have spent more on the funding process than on the funding itself, and the scientific ecosystem has been drained" The situation is rapidly becoming unsustainable: the current research funding scheme does not work. www.nature.com/articles/d41...nature.comPoint of no returns: researchers are crossing a threshold in the fight for fundingWith so little money to go round, the costs of competing for grants can exceed what the grants are worth. When that happens, nobody wins. 2159
Artemy Kolchinsky @artemyte.bsky.social · 26/01/2026A remarkable preprint that shows emergence of active protocells from simple starting conditions 041
Reposted by Artemy KolchinskyOrigin of Life Early-Career Network @oolen.bsky.social · 12/01/2026If you work on the origins of life / prebiotic chemistry, consider joining OoLEN 🧬🌍 We’re an early-career community for connecting across disciplines, sharing opportunities, and building momentum together. Join: oolen.org/join (And feel free to reply with what you work on!) #OriginOfLife 0116
Reposted by Artemy Kolchinskydavidasivak.bsky.social @davidasivak.bsky.social · 06/01/2026Interested in the intersection of nonequilibrium thermodynamics and biophysics? Think Canada might be a nice place for your PhD/postdoc? Talk to me! Brand-new funding opportunity has quick deadline (so likely undersubscribed). nserc-crsng.canada.ca/en/news/laun... SFU internal deadline Feb 11nserc-crsng.canada.caLaunch of new Canada Impact+ Research Training AwardsAs announced in Budget 2025 - 164
Artemy Kolchinsky @artemyte.bsky.social · 06/01/2026Yes, its possible to have local maxima of entropy. Supercooled water is one example, as are other phase transitions that require a "nucleation" event. en.wikipedia.org/wiki/Nucleat...en.wikipedia.orgNucleation - Wikipedia 031
Reposted by Artemy KolchinskyItai Yanai @itaiyanai.bsky.social · 05/01/2026"Choosing problems is the primary determinant of what one accomplishes in science." 'Now What?' by Nobel Laureate John Hopfield should be required reading for aspiring scientists. pni.princeton.edu/document/1136 03711
Artemy Kolchinsky @artemyte.bsky.social · 20/12/2025New paper in PRL on the relationship between thermodynamic driving and eigenvalues in Markovian master equations. We prove a weaker version of a beautiful conjecture proposed by Uhl and Seifert. Led by Guo-Hua Xu, with Jean-Charles Delvenne and Sosuke Ito journals.aps.org/prl/abstract...journals.aps.orgThermodynamic Geometric Constraint on the Spectrum of Markov Rate MatricesA thermodynamic constraint is placed on the spectrum of Markov rate matrices, allowing for a better understanding of the dynamics of biochemical clocks. 0123
Reposted by Artemy KolchinskyRicard Solé @ricardsole.bsky.social · 19/12/2025Cooperation is a universal feature of complex systems, from the origins of life and microbiomes to societies. What universal patterns can be found in these systems? Here's our new @pnas.org paper. @jordipinero.bsky.social @artemyte.bsky.social @sfiscience.bsky.social www.pnas.org/doi/epdf/10.... 47630
Reposted by Artemy KolchinskyComplexity Cat 🐱 @amahury.bsky.social · 17/10/2025The characterization of life as a thermodynamic phenomenon out of equilibrium is usually attributed to Schrödinger. What if I told you that he wasn't the first (not even the second😶🌫️) to reach that famous and influential conclusion?/1 #complexitycat🐈⬛ amahury.github.io/posts/reinve...amahury.github.ioWhen Schrödinger Reinvented the WheelErwin Schrödinger’s “What is Life?” is perhaps one of the most influential works in theoretical biology, but what if I told you that one of the key ideas discussed in it was nothing new? 2186
Artemy Kolchinsky @artemyte.bsky.social · 07/10/2025It's part of a great special issue on fundamental constraints on the origins of life, organized by @ricardsole.bsky.social and Chris Kempes royalsocietypublishing.org/toc/rstb/202...royalsocietypublishing.orgPhilosophical Transactions of the Royal Society B: Biological Sciences: Vol 380, No 1936 1121
Artemy Kolchinsky @artemyte.bsky.social · 07/10/2025After a long time in the making, my paper on nonequilibrium thermodynamics of Darwinian evolution has been published in Philosophical Transactions B. Updated version: arxiv.org/abs/2112.02809 36017
Reposted by Artemy KolchinskyRicard Solé @ricardsole.bsky.social · 02/10/2025How dit life originate in our planet? How can we create it in the lab?Our @royalsocietypublishing.org Theme Issue "Origins of Life: the possible and the actual", coedited with @sfiscience.bsky.social C Kempes and Susan Stepney is out! royalsocietypublishing.org/toc/rstb/202... @manlius.bsky.socialroyalsocietypublishing.orgPhilosophical Transactions of the Royal Society B: Biological Sciences: Vol 380, No 1936 17331
Artemy Kolchinsky @artemyte.bsky.social · 15/09/2025Possible biosignatures detected on Mars www.nature.com/articles/d41...nature.comDid Mars harbour life? One of the strongest signs yet is spotted in a peculiar rockThe intriguing chemistry of a rock collected by the Perseverance rover could trace to microbial activity — or not. 070
Artemy Kolchinsky @artemyte.bsky.social · 15/09/2025Reading this beautiful review of the "cutoff timescale" in Markov chains, the timescale over which a system relaxes from nonequilibrium to equilibrium behavior arxiv.org/abs/2508.21055arxiv.orgModern aspects of Markov chains: entropy, curvature and the cutoff phenomenonThe cutoff phenomenon is an abrupt transition from out of equilibrium to equilibrium undergone by certain Markov processes in the limit where the size of the state space tends to infinity: instead of ... 040
Reposted by Artemy KolchinskyBen Recht @beenwrekt.bsky.social · 11/09/2025This new center strikes the right tone in approaching the AI alignment problem. alignmentalignment.aialignmentalignment.aiCenter for the Alignment of AI Alignment CentersWe align the aligners 35914
Reposted by Artemy KolchinskyRicard Solé @ricardsole.bsky.social · 10/09/2025Can a single cell learn? Even without a brain, some microbes show simple forms of cognition. Can this basal cognition be engineered? Check our new paper with @jordiplam.bsky.social on the minimal synthetic circuits & their cognitive limits. @drmichaellevin.bsky.social www.biorxiv.org/content/10.1... 510942
Artemy Kolchinsky @artemyte.bsky.social · 05/09/2025Helping to organize this workshop on quantum and stochastic thermodynamics in Kyoto, Japan, Dec 8-12. Resource theory, optimal transport, and more. Submissions open! indico.yukawa.kyoto-u.ac.jp/event/68/indico.yukawa.kyoto-u.ac.jpKyoto Workshop on Quantum Thermodynamics and Stochastic Thermodynamics 2025Schedule and VenueDecember 8-12, 2025 Panasonic Auditorium, Yukawa Hall, YITP, Kyoto University, JapanScopeRecent advances in physics have increasingly highlighted the need to understand energy conver... 041