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Angel Goñi-Moreno

@angelgm.eurosky.social
1.2K followers 172 following 141 posts

Computing with living systems | Synthetic biology. Head of the Biocomputation Lab at the CNB-CSIC @cnb-csic.bsky.social www.biocomputationlab.com

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Reposted by Angel Goñi-Moreno
Centro Nacional de Biotecnología (CNB) @cnb-csic.bsky.social · 17/10/2026
NEWTON Biotwins, liderado por @angelgm.eurosky.social, es uno de seleccionados en la convocatoria #CaixaImpulse de Innovación de Fundación ”la Caixa” El proyecto desarrolla una plataforma de gemelos digitales para agilizar análisis y reducir experimentos ℹ️https://f.mtr.cool/qb98mv4gxd
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Reposted by Angel Goñi-Moreno
El Salto @elsaltodiario.com · 16/10/2026
Decenas de miles de personas demandan que Ayuso deje de maltratar a la educación pública para favorecer a la privada en el tercer día de huelga indefinida. Fotos de Diego Vitores www.elsaltodiario.com/madrid/multit…
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Angel Goñi-Moreno @angelgm.eurosky.social · 16/10/2026
Muy contento con esta oportunidad. Seguimos avanzando en el uso de gemelos digitales para análisis celular con la iniciativa NEWTON Biotwins newtonbiotwins.com cofundada junto a @mirobueno.bsky.social
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Reposted by Angel Goñi-Moreno
El Salto @elsaltodiario.com · 15/10/2026
🟢El profesorado madrileño mantiene el pulso en el segundo día de huelga educativa en todos los niveles no universitarios en la Comunidad de Madrid. Cientos de profesores y profesoras han formado una cadena humana frente a la Consejería de Educación. Vídeo @davidfsabadell.bsky.social
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Angel Goñi-Moreno @angelgm.eurosky.social · 07/10/2026
Lab retreat 2026 at the Geological and Mining Institute of Spain (IGME-CSIC). Fascinating discussions in an impressive environment. To the next academic year!
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Angel Goñi-Moreno @angelgm.eurosky.social · 11/09/2026
You remember our #ALife paper from 2023? doi.org/10.1162/isal.... One of my favourites! Experimental results are in, finally. You will most definitely enjoy reading about them. Coming soon! @lewisgrozinger.bsky.social @pglekas.eurosky.social
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Reposted by Angel Goñi-Moreno
Alejandro Requena-Menéndez @redquena.bsky.social · 09/09/2026
This week I’m in Berlin for the International Symposium on Plasmid Biology @plasmidsociety.bsky.social! Much learnings on plasmid biology, new colleagues and, most important, valuable feedback of our project on bacterial conjugation control! If you are around and want to chat, feel free ☺️
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Angel Goñi-Moreno @angelgm.eurosky.social · 07/09/2026
Also next in Lab's conference agenda: the IEEE International Conference on Digital Twin swc-ieee-2026.github.io/digitaltwin/. Jesús @mirobueno.bsky.social will give a talk about our digital twins in microbiology and #synbio.
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Angel Goñi-Moreno @angelgm.eurosky.social · 07/09/2026
Next in Lab's conference agenda: International Symposium on Plasmid Biology plasmid-biology-2026.de. Alejandro @redquena.bsky.social will be presenting poster CM-05 on the engineering of conjugation dynamics. Go talk to him!
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Angel Goñi-Moreno @angelgm.eurosky.social · 03/09/2026
Back to Madrid now. It's been great to engage with this community: computability, completeness, complexity... This conference was dedicated to Mario de Jesús Pérez Jiménez, a true titan of science, who passed away a year ago.
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Angel Goñi-Moreno @angelgm.eurosky.social · 03/09/2026
Just scheduled a meeting for the 14th September... 2027! Not a mistake. We're gonna need a bigger agenda.
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Angel Goñi-Moreno @angelgm.eurosky.social · 31/08/2026
Next in Lab's (busy!) conference agenda: International Conference on Membrane Computing (Sevilla, 1-4 Sep, icmc2026.org). I've always been very close to this community, but never really collaborated. See what happens! I'll be talking about the host cell as an Operating System.
icmc2026.org
ICMC2026
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Angel Goñi-Moreno @angelgm.eurosky.social · 28/08/2026
Next in Lab's conference agenda: the EPIA Conference on AI, next week in Madeira. @lewisgrozinger.bsky.social will talk about the computational evolution of genetic circuits (within the Theory and Methods track). A collaboration with our Brazilian colleagues at Universidade Federal do Maranhão.
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Angel Goñi-Moreno @angelgm.eurosky.social · 13/08/2026
La puesta de sol ayer me pilló desprevenido y fue una maravilla. En Gallegos (Segovia) se vio igual que en la foto de Ángel Bravo.
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Angel Goñi-Moreno @angelgm.eurosky.social · 02/07/2026
Una maravilla esto que edita @principiamagazine.bsky.social sobre María Teresa Toral.
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Angel Goñi-Moreno @angelgm.eurosky.social · 02/07/2026
Happy to be part of this brilliant #synbio network across 22 EU institutions. 40 postdoc positions will be announced soon. www.biochem.mpg.de/syncell-nexu...
biochem.mpg.de
SynCell-nExUs: Training Europe's Next Generation of Leaders in Synthetic Cell Research
On 1 August 2026, the Max Planck Society will launch the SynCell nExUs postdoctoral programme. The five-year programme, coordinated by the Max Planck Institute (MPI) of Biochemistry and the MPI for T...
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Angel Goñi-Moreno @angelgm.eurosky.social · 16/06/2026
The 2026 Systems Biology Department's retreat. What a brilliant crowd! The t-shirt (artist: Marina de la Fuente) has a logo of every lab in the Dept. Our Lab is The logic Doors :-) Kudos to organizers: @angeles-hg.bsky.social, @pglekas.eurosky.social, @lewisgrozinger.bsky.social & Guillermo Gomez.
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Reposted by Angel Goñi-Moreno
Alejandro Requena-Menéndez @redquena.bsky.social · 16/06/2026
This week I’m in Oxford for the EECI International Graduate Course on Biological Control Systems. Previous to the course beggining I could sightsee a bit of the city and, in the afternoon, we started with basic model math & theory control for biologists! A tope for today!
Oxford
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Angel Goñi-Moreno @angelgm.eurosky.social · 08/06/2026
Next conference in the Lab's agenda: the #SynBYSS conference that starts today in Barcelona. The agenda is absolutely spectacular: www.jcvi.org/events/synbyss. If you are around, go visit Crislaine Rocha at poster 17. Her research, on coupling sensors to gates is truly brilliant. #synbio
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Reposted by Angel Goñi-Moreno
Ricard Solé @ricardsole.bsky.social · 04/06/2026
What if living cells compute in ways that silicon never can? Rather than mimicking computers, the future of biocomputation may lie in harnessing the unique information-processing strategies of evolution. Check this paper by @angelgm.eurosky.social and co. www.sciencedirect.com/science/arti....
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Reposted by Angel Goñi-Moreno
Ángeles Hueso-Gil @angeles-hg.bsky.social · 29/05/2026
Paper out!! 🥳 We controlled bacterial growth by tuning native RNAP availability. Then, we studied the impact of growth and this RNAP availability over different NOT gates present in that strain. Great work with @mirobueno.bsky.social and @angelgm.eurosky.social 😀. link.springer.com/article/10.1...
link.springer.com
Growth control as a central regulator for tuning the cellular context - Journal of Biological Engineering
The cellular context decisively shapes genetic circuit performance, but the interplay between host and circuit remains difficult to control rationally. To address this challenge, we replaced the nativ...
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Angel Goñi-Moreno @angelgm.eurosky.social · 22/05/2026
📣 Latest paper out! I'll write a thread about it next week: growth control, cellular context, genetic circuits... A fascinating story by @angeles-hg.bsky.social & @mirobueno.bsky.social #synbio #biocomputation link.springer.com/article/10.1...
link.springer.com
Growth control as a central regulator for tuning the cellular context - Journal of Biological Engineering
The cellular context decisively shapes genetic circuit performance, but the interplay between host and circuit remains difficult to control rationally. To address this challenge, we replaced the nativ...
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Reposted by Angel Goñi-Moreno
Alejandro Requena-Menéndez @redquena.bsky.social · 19/05/2026
Este miércoles, a las 19h, estaré en el Moe’s Club (Madrid) en el @pintofscience.es de Madrid 😄. Representando al @cnb-csic.bsky.social, hablaré de si los ordenadores pueden estar vivos y cómo podemos crearlos en el laboratorio. ¡Nos vemos allí!
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Angel Goñi-Moreno @angelgm.eurosky.social · 16/05/2026
Yes! We cannot assume variability = noise.
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Angel Goñi-Moreno @angelgm.eurosky.social · 14/05/2026
Gene expression noise is not always noise. If expression comes from stable rates and events (blue lines) it is noiseless information (yet stochastic & probabilistic!). If there are sudden perturbations on the channel (green), then there is noise. I find that word particularly misleading 🤔
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Angel Goñi-Moreno @angelgm.eurosky.social · 21/04/2026
This paper is most interesting for us. It'll take us some time to digest; the amount of information in it is near infinite! doi.org/10.1021/acs....
doi.org
Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications
Agriculture is under pressure to provide food for a growing population and the feedstock required to drive the bioeconomy. Methods to breed and genetically modify plants are inadequate to keep pace. W...
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Reposted by Angel Goñi-Moreno
Yolanda Schaerli @yschaerli.bsky.social · 12/04/2026
Interested in synthetic biology & microbiomes? 🧬🧫 We are recruiting a PhD student to develop biosensors to study microbe–microbe & microbe–host interactions. In beautiful Lausanne, Switzerland🏔️⛵ @dmf-unil.bsky.social @fbm-unil.bsky.social Apply by 24.05.2026 👇 shorturl.at/6X7M4 Boosts appreciated!
shorturl.at
Career Opportunities: PhD position in microbial synthetic biology (22753)
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Angel Goñi-Moreno @angelgm.eurosky.social · 07/04/2026
It's all about the Moon now, but here is the Sun from my office window this morning.
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Reposted by Angel Goñi-Moreno
Alex Fedorec @ajfedorec.bsky.social · 20/03/2026
Our special issue "Biology computes: Information processing across biological scales" Editorial - authors.elsevier.com/a/1moUK3si8Q... Contributions from @drmichaellevin.bsky.social, Chris Barnes, Matthias Függer, Thomas Nowak, @angelgm.eurosky.social - www.sciencedirect.com/special-issu...
sciencedirect.com
Seminars in Cell & Developmental Biology | Biology computes: information processing across biological scales | ScienceDirect.com by Elsevier
Over half a century ago, in a time of rapid advances in digital computing, Jacob and Monod’s seminal work on the lac operon was destined to be framed as biological computation. But the history of cell...
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Reposted by Angel Goñi-Moreno
CSIC @csic.es · 13/03/2026
🦠Un equipo del #CSIC ‘domestica’ mediante ‘computación viva’ una bacteria clave para el control de patógenos vegetales  🌱Este conocimiento es clave para la utilización de esta especie bacteriana como herramienta biotecnológica en suelos ➡️ tinyurl.com/yf7nus3r
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Reposted by Angel Goñi-Moreno
Centro Nacional de Biotecnología (CNB) @cnb-csic.bsky.social · 13/03/2026
El equipo de @angelgm.eurosky.social en el CNB-CSIC domestica P protegens, una bacteria clave para controlar patógenos vegetales con gran valor medioambiental  Más información: f.mtr.cool/ugejpdzuir Artículo en Cell Systems: f.mtr.cool/dwxrylxwkm
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Angel Goñi-Moreno @angelgm.eurosky.social · 06/03/2026
Just migrated to @eurosky.social. I guess all my data is in EU servers now. Everything else looks the same: network, apps, etc.
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Reposted by Angel Goñi-Moreno
Ricard Solé @ricardsole.bsky.social · 05/03/2026
Can we engineer the resilience of fragile ecosystems? In this paper with @vmaull.bsky.social @lizashpilkina.bsky.social & @vdlorenzo.bsky.social, we discuss "Emergent Bioengineering" bringing together complexity, #synbio and ecology across scales www.preprints.org/manuscript/2...
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Angel Goñi-Moreno @angelgm.eurosky.social · 05/03/2026
(5/5) Based on our knowledge of NOT gates, can we design a larger circuit? Oh, yes! We designed a YES gate by coupling two NOT functions. We designed the best gate that would work in Pf-5. The model also said that gate would not work in KT2440 Guess what? That is what happened (fourth result).
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Angel Goñi-Moreno @angelgm.eurosky.social · 05/03/2026
(4/5) A good example is parameter g. This is in charge of digital performance i.e. how clear the two states (on/off) are defined. We tested gates that only differed in the RBS (that is basically g in the model). Third result: Pf-5 is more digital tan KT2440. Let that sink in :-)
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Angel Goñi-Moreno @angelgm.eurosky.social · 05/03/2026
(3/5) Each of the four new parameters had a very specific impact on NOT gate performance (arrows in figure). This is the core of the comparison. Second result: the four parameters that explained each NOT gate in a chassis built a fingerprint. Their value told as a lot.
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Angel Goñi-Moreno @angelgm.eurosky.social · 05/03/2026
(2/5) We compared NOT gates against the (also soil!) chassis Pseudomonas putida KT2440. But hey, we needed math models to run this comparison. Overfitting enters the game. First result: we turned full mechanistic models (A) into models with clustered rates (B). Bye, bye overfitting!
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Angel Goñi-Moreno @angelgm.eurosky.social · 05/03/2026
(1/5) As promised, here a short thread about this work. Why Pseudomonas protegens Pf-5? It is a key environmental host with unique interactions with soil’s biotic and abiotic compounds. Thus great for our Lab’s goal: ecosystems computing. We needed to know how this host interacts with circuits.
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Angel Goñi-Moreno @angelgm.eurosky.social · 04/03/2026
Good luck! We'll miss you. Amazing years indeed.
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Angel Goñi-Moreno @angelgm.eurosky.social · 27/02/2026
Thanks!
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Angel Goñi-Moreno @angelgm.eurosky.social · 27/02/2026
Latest paper out! This piece was a challenge: logic, predictability, decidability, non-model organisms, design... Kudos to @juanricomol.bsky.social & Pablo Japón #syntheticbiology #synbio #biocomputation (I'll post more on this next week) www.sciencedirect.com/science/arti...
sciencedirect.com
Dynamics of genetic circuits in Pseudomonas protegens
Genetic circuit engineering enables new cellular functions, yet most circuits are developed in the model host Escherichia coli, limiting their availab…
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Angel Goñi-Moreno @angelgm.eurosky.social · 09/02/2026
Back at the lab after a week in Copenhagen for @aliceworkshop.org! A brilliant week—full of ideas and enthusiastic colleagues. So many things to discuss with the lab now. Kudos to the organizers, and thanks for bringing this energy to #ALIFE topics.
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Angel Goñi-Moreno @angelgm.eurosky.social · 01/02/2026
On my way to Copenhagen for the ALICE workhsop @aliceworkshop.org! Discussions around #ALIFE topics for a full week — looking forward. I'll be talking about cellular computing (what else? :-)
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Angel Goñi-Moreno @angelgm.eurosky.social · 19/01/2026
New tech adventure: co-founded Newton Biotwins together with @mirobueno.bsky.social. We're building #DigitalTwins for the lab — starting with a flow cytometry twin. Turning #biology into an information science! newtonbiotwins.com/en/home_en/
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Angel Goñi-Moreno @angelgm.eurosky.social · 15/01/2026
Next in Lab's conference agenda: AI, Engineering Biology and beyond. It starts today in Bristol hosted by @chofski.bsky.social. Looks great: aiebab.github.io. From our side, @lewisgrozinger.bsky.social will be talking about our approach to the use of evolutionary algorithms for biocomputation.
aiebab.github.io
AIEBaB-2026
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Angel Goñi-Moreno @angelgm.eurosky.social · 12/01/2026
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Angel Goñi-Moreno @angelgm.eurosky.social · 12/01/2026
Just published our workflow for genotyping transposon libraries. All methods, files, scripts... are open source and publicly available. 🔗 link.springer.com/article/10.1...
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Angel Goñi-Moreno @angelgm.eurosky.social · 08/01/2026
The biological messiness, as the quantum weirdness, as a source of (unconventional) computing.
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Angel Goñi-Moreno @angelgm.eurosky.social · 08/01/2026
The team: @crislaineksr.bsky.social, @angeles-hg.bsky.social, @loraleja.bsky.social, @juanricomol.bsky.social and Paula Múgica.
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Angel Goñi-Moreno @angelgm.eurosky.social · 08/01/2026
New paper out!📢 Exploring the computing power of microbes that shapes the environment. In this short review we talk about the "complexity gap", the distance between bottom-up genetic circuits and microbial information processes. Key questions to improve #biocomputation. 🔗 doi.org/10.1016/j.mi...
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