As the impact of art on better health outcomes is being studied more and more, some hospital systems are now focusing on even the youngest of patients. Special correspondent Mike Cerre took a look at ...

Hundreds of boreholes form the underground part of a geothermal heating and cooling network beneath Colorado Mesa University’s campus in Grand Junction, Colorado. The system currently connects 16 buil...

Grandparents taking care of their grandkids is nothing new. But the surging cost of childcare in the U.S. has made familial support even more critical for some parents who struggle to afford it.

MRI surveillance for brain metastases helps preserve cognition in small cell lung cancer, and an AACR report calls for sustained research funding.

Health systems are rethinking physician surveys to measure burnout, build trust and turn feedback into action.

As families begin back-to-school shopping, here's how to know if your child's backpack is too heavy, and how to lighten their load.

Introduction This simulation-based curriculum aimed to improve emergency medicine residents’ confidence and knowledge in applying palliative care principles in end-of-life scenarios in the emergency d...

Understanding how human pancreatic α and β cell electrical activities mature is critical for building fully functional stem cell–derived (SC-) pancreatic organoids for research and therapeutics. We im...

Worldwide, the estimated 5-year prevalence for all cancers is 50·5 million. The number of cancer survivors is growing due to aging populations and improved early detection and treatment. Yet current m...

The CDC said Thursday that the mutations, detected in a sample taken from a Louisiana patient, may help bind the virus to the upper airways in people.

Using an AI tool, researchers at Karolinska Institutet have analysed brain images from 70-year-olds and estimated their brains’ biological age. They found that factors detrimental to vascular health, ...

Systemic delivery of large nucleic acids, such as mRNA, to the brain remains challenging in part due to the blood-brain barrier (BBB) and the tendency of delivery vehicles to accumulate in the liver. Here, we design a peptide-functionalized lipid nanoparticle (LNP) platform for targeted mRNA delivery to the brain. We utilize click chemistry to functionalize LNPs with peptides that target receptors overexpressed on brain endothelial cells and neurons, namely the RVG29, T7, AP2, and mApoE peptides. We evaluate the effect of LNP targeting on brain endothelial and neuronal cell transfection in vitro, investigating factors such as serum protein adsorption, intracellular trafficking, endothelial transcytosis, and exosome secretion. Finally, we show that LNP peptide functionalization enhances mRNA transfection in the mouse brain and reduces hepatic delivery after systemic administration. Specifically, RVG29 LNPs improved neuronal transfection in vivo, establishing its potential as a nonviral platform for delivering mRNA to the brain.

Weekly statistics from the National Notifiable Diseases Surveillance System (NNDSS)..