Cleveland Clinic pediatric hospitalist Moises Auron, MD, addresses common misconceptions in perioperative management and provides strategies to improve care for children with medical complexity.

By José Manuel Moreno-Mirón, Juan de Dios Alfonso & 3 more. A case of thrombotic microangiopathy and hypertensive emergency following cocaine use

Hereditary haemolytic anaemias represent the most prevalent group of genetic disorders worldwide and have a substantial impact on global health. Current treatments are few and primarily supportive. Re...

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of chronic kidney disease, resulting in substantial morbidity and mortality globally. Advances in molecular geneti...

Sepsis is defined as a dysregulated host response to infection that leads to life-threatening organ dysfunction. The infectious insult triggers a dysregulated immune response that variably activates a...

Atrial fibrillation affects approximately 37·6 million people worldwide, with the prevalence predicted to double over the next 35 years. The ubiquitous use of wearable devices and other technologies w...

AIM The “2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults” is a de novo guideline that provides comprehensive recomme...

Pediatricians play a key role in preparing patients and families for anesthesia and surgery by primarily addressing 2 major areas of concern. The first involves preparation and ensures that the patien...

Leprosy, also known as Hansen's disease, is a curable granulomatous condition caused by Mycobacterium leprae or Mycobacterium lepromatosis, disproportionately affecting impoverished communities across...

Tetanus, although preventable by a highly effective vaccine, continues to cause 30 000–50 000 deaths annually. Global mortality has fallen substantially since the 1980s due to widespread vaccination e...

Prostate cancer poses a substantial clinical challenge and accounts for a large proportion of cancer-related deaths worldwide. The therapeutic landscape has undergone a large transformation in the pas...

Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is a monogenic disease of adulthood characterised by treatment-refractory systemic inflammation and progressive bone marrow fa...

Heart failure is a complex clinical syndrome affecting around 70 million individuals globally. It has a prevalence of 2% in Europe and North America and approximately 1% in Asia and South America. Acc...

Renin-angiotensin-aldosterone system (RAAS) antagonists are essential in managing heart failure, hypertension, chronic kidney disease, and atherosclerotic cardiovascular disease. However, their perioperative use remains controversial due to concerns about intraoperative hypotension and vasoplegia. T …

Background: Direct thrombin inhibitors are recommended in confirmed or suspected heparin-induced thrombocytopenia. False elevation of the international normaliz...

Abstract. Valve disease and heart failure are intricately linked in a bidirectional relationship. Heart failure is both a frequent cause and a common conse

Platelet transfusion is a cornerstone of modern supportive care, yet its application is characterized by significant practice variation and uncertainty regarding optimal strategies. This comprehensive...

The triglyceride-glucose (TyG) index is one of the parameters that have been used in assessing insulin resistance. Triglycerides and fasting blood glucose are two low-cost, common laboratory indicators that are used to compute the TyG index. This ...

We hypothesise that amylin receptor agonists (eg, pramlintide) and dual amylin and calcitonin-receptor agonists (eg, cagrilintide), which are emerging treatments for obesity and type 2 diabetes, can a...

Abstract. Rickets remains one of the most common nontransmissible pediatric diseases, especially in low- to middle-income countries. Rickets is characterized by impaired mineralization of growing bone...

A podcast about professional burnout in medicine for real people

The healthcare landscape is evolving rapidly due to escalating costs from the traditional fee-for-service model. Value-based care has emerged as a viable solution, and initiatives focus on areas prone...

The rise of multi-resistant infections and complications associated with the overuse of antibiotics has led to the implementation of antibiotic stewardship strategies as a marker of patient safety and quality. Using biomarkers that can accurately ...

Background and Objectives A plasma transfusion dose should be weight-based (10–20 mL/kg), which equates to three to four units in an average-sized adult; therefore, the transfusion of single units u...

Implementing and complying with a maximum surgical blood ordering schedule (MSBOS) is challenging but essential to avoid waste and reduce costs. MSBOS helps manage blood product scarcity and healthcare expenditure by avoiding unnecessary ...

The United States may be heading into its second severe flu season in a row, driven by a mutated strain called subclade K that’s behind early surges in the United Kingdom, Canada and Japan.

A new type of seasonal flu virus is raising concerns among health officials as winter approaches. Here's what to know about subclade K.

A new H3N2 flu variant could bypass vaccine immunity, raising concerns for a rougher flu season as holiday travel begins and vaccination rates drop.

Cleveland Clinic currently performs more than 10,000 tests for respiratory viruses per week across Northeast Ohio.

Certain students may no longer receive the same loan for their studies as what counts as "professional" will determine how much they get.

This randomized clinical trial tests whether a liberal compared with a restrictive transfusion strategy lowers the risk of a cardiac event 90 days after major vascular or general surgery among patient...

A new way for doctors to learn from each other—fast. Roon for Doctors offers perspectives from medical experts on relevant questions in medicine.

Finally understood TMLE's "doubly robust" property through simulation. Works well when either outcome OR treatment model is correct. XGBoost + TMLE captured complex relationships without manual specif...