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Synovial fluid as a complex molecular pool contributing to knee osteoarthritis
Nature Reviews Rheumatology, Published online: 07 July 2025; doi:10.1038/s41584-025-01271-4The synovial fluid lubricates joints while also collecting molecular mediators from surrounding tissues. This Review highlights how molecular analyses of the synovial fluid might provide information on the progression of knee osteoarthritis and treatment efficacy, and identify potential therapeutic strategies targeting synovial fluid mediators in knee osteoarthritis.