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Amanda Ali

@amandality.bsky.social
74 followers 99 following 22 posts

At the helm of the Ali Lab, studying all things osteoarthritis | Assistant Scientist/Professor @HFH+MSU | Postdoc @UHN | Postdoc @UWO | PhD @UofT | Guyanese-Canadian | Mama

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Reposted by Amanda Ali
Nature Reviews Rheumatology @natrevrheum.nature.com · 05/05/2026
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The complexity of pain in osteoarthritis
Nature Reviews Rheumatology, Published online: 30 April 2026; doi:10.1038/s41584-026-01372-8Managing pain in osteoarthritis (OA) remains a major clinical challenge. The authors of this Review explore the spectrum of pain complexity in OA and highlight how integrating multiple mechanistic domains could be used to predict outcomes and improve management of OA pain.
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Amanda Ali @amandality.bsky.social · 26/04/2026
I am honored to be the recipient of the 2026 OARSI Rising Star Award (Basic Research) for exceptional early career researchers in the osteoarthritis field. I gave brief remarks at the World Congress in West Palm Beach, FL this week, with a key message: if I can be a Rising Star, so can you.
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Reposted by Amanda Ali
OARSI Early Career Investigators @oarsi-eci.bsky.social · 18/03/2026
This month’s featured #OARSI ECI publications highlight 2025 year-in-review papers across key areas: 🧬 Genetics, genomics & epigenetics 📊 Epidemiology & therapy 🔬 Biology A great snapshot of where the field is headed!
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Amanda Ali @amandality.bsky.social · 11/02/2026
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Amanda Ali @amandality.bsky.social · 10/02/2026
Special seminar today at @hfhs-bjc.bsky.social by Dr. Nathaly Villacis, who will be visiting from the University of Michigan. The title of her talk is “Towards Rotator Cuff Tendon Digital Twins: A Three-Dimensional Experimental and Computational Approach”.
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Amanda Ali @amandality.bsky.social · 06/02/2026
"Don't ignore the problem, but keep it light. Take action with a smile. Adding tension won't solve your troubles faster. Even when the problem is hard, it doesn't need to harden you. Unknot yourself. Body loose, head clear, and then take the first step. Be happy in the doing." James Clear
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Reposted by Amanda Ali
Osteoarthritis and Cartilage Journal @oacjournal.bsky.social · 12/01/2026
As we usher in the new year, we also wanted to celebrate the achievements of a giant in the hashtag#osteoarthritis community. Read more about Frank's legacy and the Frank Beier Graduate Opportunity Scholarship in this month's issue here: www.oarsijournal.com/article/S106...
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Reposted by Amanda Ali
Joel Boerckel @jboerckel.bsky.social · 11/01/2026
Defending PhD student, looking over their thesis: “If I knew then what I know now, I could’ve done all of this in like 9 months.” A thread about my favorite pioneering cave explorers and why I don’t think AI will ever “solve” biology.
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Timothy Caulfield @caulfieldtim.bsky.social · 06/01/2026
Solid advice.👇 There. Is. No. Magic. Move. Eat real food. Sleep. Don't smoke. Drink less (or not at all). Prevention (yep, vaccines). Community!! ♥️ Trying to improve your health and wellness in 2026? Keep it simple apnews.com/article/well...
apnews.com
Trying to improve your health and wellness in 2026? Keep it simple
If you want to improve your health in 2026, experts say keep it simple. Be cautious of health and wellness fads. There are no magic fixes.
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Reposted by Amanda Ali
Kelsey H. Collins @kelseyhcollins.bsky.social · 03/12/2025
Honored to share our new paper, Osteoarthritis as a Systemic Disease, in @natrevrheum.nature.com, out today: rdcu.be/eSXLW - thanks to Ida Haugen, @tuhinaneogi.bsky.social and @farsh-g.bsky.social for your input on gaps and opportunities.
rdcu.be
Osteoarthritis as a systemic disease
Nature Reviews Rheumatology - Emerging evidence suggests a paradigm shift in viewing osteoarthritis (OA) as a systemic, bidirectional disease. This Review examines the current data supporting this...
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Amanda Ali @amandality.bsky.social · 26/11/2025
"...former ANRF scholar Dr. Shabana Amanda Ali has published groundbreaking research that could detect osteoarthritis and rheumatoid arthritis before joint damage occurs..." www.nature.com/articles/s41... Donate to the Arthritis National Research Foundation: secure.everyaction.com/DpkWeOy9n0ii...
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Reposted by Amanda Ali
Jerry Chen @jcsalterego.bsky.social · 11/11/2025
welcome to bluesky. if the word "mapquest" means anything to you and/or you used it as a verb, you're in the right place
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Reposted by Amanda Ali
Timothy Caulfield @caulfieldtim.bsky.social · 10/11/2025
Ridiculous. So maddening. Yes, complex. But there is NO doubt that antivaxx misinformation big part of problem. Canada loses measles elimination status after three decades, health agency says www.reuters.com/business/hea...
reuters.com
Canada loses measles elimination status after three decades, health agency says
Canada has lost its measles elimination status after nearly three decades due to its failure to curb a year-long outbreak, the country's public health agency said on Monday.
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Reposted by Amanda Ali
OARSI Early Career Investigators @oarsi-eci.bsky.social · 26/10/2025
Monthly #OARSI ECI Publication: @amandality.bsky.social and her team identified miR-126-3p as a promising biomarker for knee #OA. It reduces angiogenesis and mitigates disease severity, supporting its potential as a therapeutic target.
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Reposted by Amanda Ali
Henry Ford Bone & Joint Center @hfhs-bjc.bsky.social · 20/09/2025
🚨🚨 New Publication Alert: The Ali Lab published a review on advancements in genomics, genetics, and epigenetics of #osteoarthritis. Fantastic work Thomas Wilson, Madhu Baghel and @amandality.bsky.social! www.oarsijournal.com/article/S106...
oarsijournal.com
Osteoarthritis year in review 2025: Genetics, genomics, and epigenetics
This review provides an overview of the work performed in the realms of genetics, genomics and epigenetics in osteoarthritis (OA) research over the past year.
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Reposted by Amanda Ali
Kevin Baker @orthoengineer.bsky.social · 20/09/2025
Another great publication from @amandality.bsky.social and team! Sure does make one reconsider the old "wear and tear" hypothesis about #osteoarthritis. Exciting times in OA research!
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Amanda Ali @amandality.bsky.social · 20/09/2025
Truly an honor to be invited by #OARSI and @oacjournal.bsky.social to summarize all the amazing work in the genetics, genomics, and epigenetics of #osteoarthritis over the last year. A tough job with many great papers not included, but our review is now online: www.oarsijournal.com/article/S106...
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Amanda Ali @amandality.bsky.social · 28/08/2025
All the right pieces in all the wrong places (also how I write grants). Wordle 1,530 2/6 🟨🟨🟨🟨🟨 🟩🟩🟩🟩🟩
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Amanda Ali @amandality.bsky.social · 09/08/2025
Kudos to Postdoc Madhu Baghel who led this project applying a custom sequencing analysis pipeline that included discovery of novel microRNAs in early-stage osteoarthritis and rheumatoid arthritis, laying a foundation for future biomarker studies. Read our paper here: www.nature.com/articles/s41...
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Reposted by Amanda Ali
Kevin Baker @orthoengineer.bsky.social · 31/07/2025
More miR-awesomeness from @amandality.bsky.social and team in the @hfhs-bjc.bsky.social! Great diagnostic potential for miR's in both #Osteoarthritis and #RheumatoidArthritis.
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Reposted by Amanda Ali
Henry Ford Bone & Joint Center @hfhs-bjc.bsky.social · 31/07/2025
🚨🚨New publication alert! The Ali Lab @amandality.bsky.social ‬ in the @hfhs-bjc.bsky.social uses sequencing to profile microRNAs in early-stages of both osteoarthritis and rheumatoid arthritis! Now published in Scientific Reports ‪@natureportfolio.nature.com‬, read it here: rdcu.be/eylic
rdcu.be
Circulating microRNA profiles in early-stage osteoarthritis and rheumatoid arthritis
Scientific Reports - Circulating microRNA profiles in early-stage osteoarthritis and rheumatoid arthritis
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Reposted by Amanda Ali
Henry Ford Bone & Joint Center @hfhs-bjc.bsky.social · 26/07/2025
The Henry Ford Health Bone & Joint Center has a storied history with microCT imaging of MSK tissues, thanks primarily to Dr. Yeni's group. Today we took a large leap forward with the installation of a brand new Scanco MicroCT-90 system! #orthopaedics #imaging #bone #cartilage
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Amanda Ali @amandality.bsky.social · 25/07/2025
My gratitude to the Beier family for allowing us to join his celebration of life memorial. Frank will be deeply missed by the scientific community and will not be forgotten. I am so grateful for his mentorship in shaping my career in osteoarthritis research. We love you Frank. @beierlab.bsky.social
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Reposted by Amanda Ali
Frank Beier @beierlab.bsky.social · 24/07/2025
In his memory, Western has opened an equity-based graduate scholarship. Please consider supporting his final initiative if you are able: www.westernconnect.ca/beier ; thank you for all the time you spent and laughs you shared with him. We love and miss him so much already. - The Beiers
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Melina R. Bellini @mrbel.bsky.social · 23/07/2025
Thank you, @beierlab.bsky.social , for your remarkable impact you will be deeply missed ❤️ The Frank Beier Graduate Opportunity Scholarship is one way your legacy of generosity and mentorship will live on. I miss you! www.giving.westernu.ca/giving/frank...
giving.westernu.ca
The Frank Beier Graduate Opportunity Scholarship
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Amanda Ali @amandality.bsky.social · 21/07/2025
Nothing. Nothing. Something. Wordle 1,492 3/6 ⬛⬛⬛⬛⬛ ⬛⬛⬛⬛⬛ 🟩🟩🟩🟩🟩
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Reposted by Amanda Ali
Nature Reviews Rheumatology @natrevrheum.nature.com · 12/07/2025
ICYMI: New content online:
bit.ly
Synovial fluid as a complex molecular pool contributing to knee osteoarthritis
Nature Reviews Rheumatology, Published online: 07 July 2025; doi:10.1038/s41584-025-01271-4The synovial fluid lubricates joints while also collecting molecular mediators from surrounding tissues. This Review highlights how molecular analyses of the synovial fluid might provide information on the progression of knee osteoarthritis and treatment efficacy, and identify potential therapeutic strategies targeting synovial fluid mediators in knee osteoarthritis.
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Amanda Ali @amandality.bsky.social · 15/07/2025
Appreciate the feature of our recent publication in @natcomms.nature.com, thank you @henryfordhealth.bsky.social Ortho in Motion! www.henryford.com/-/media/file...
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Amanda Ali @amandality.bsky.social · 12/07/2025
Congrats to the newest cohort of Arthritis National Research Foundation (ANRF) awardees! This is a fantastic career development opportunity as ANRF provides support for its funded scientists in so many ways. Happy to be alum. curearthritis.org/arthritis-re...
curearthritis.org
Scientists - Arthritis National Research Foundation | Funding Research To Cure Arthritis
Education & Resources Scientists We invite you to meet the talented and dedicated scientists who are at the forefront of arthritis research. Each year, our esteemed Scientific Advisory Board carefully...
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Reposted by Amanda Ali
André Picard @picardonhealth @picardonhealth.bsky.social · 26/06/2025
A new hospital in Mississauga will be the first in Ontario to serve just women and children. Shah Family Hospital will focus on prenatal and postnatal care, childhood and adolescence, as well as the health needs of women, by Kristin Rushowy www.thestar.com/politics/pro... via @thestar.com
thestar.com
New hospital will be Ontario’s first to serve just women and children
A new Mississauga hospital will be Ontario’s first to focus on prenatal and postnatal care, childhood and adolescence, and the health needs of women throughout their lives.
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Reposted by Amanda Ali
Henry Ford Bone & Joint Center @hfhs-bjc.bsky.social · 23/06/2025
Members of the Bone & Joint Center had a great time sharing and learning about musculoskeletal research at @michiganstateu.bsky.social and @henryfordhealth.bsky.social during the HFH+MSU Musculoskeletal Research Retreat. Our Chairman @shouldergeek.bsky.social delivered inspiring opening remarks!
Jonathan Braman, MD (Chair, Orthopaedic Surgery at Henry Ford Health) delivers opening remarks at the Henry Ford + Michigan State University Musculoskeletal Research Retreat held in East Lansing, MI on 06/17/2025.
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Amanda Ali @amandality.bsky.social · 18/06/2025
Yesterday was a great day for musculoskeletal researchers and clinicians from Henry Ford and MSU attending the inaugural partnership event aimed at bridging gaps and fostering collaboration to advance translational research. Happy to have co-chaired this retreat with @mattharkeyphd.bsky.social.
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Reposted by Amanda Ali
The Lancet @thelancet.com · 04/06/2025
Musculoskeletal diseases have risen sharply with global ageing, affecting over 121 million people in the USA. In ‪The Lancet Healthy Longevity, authors discuss the need for personalised, multidisciplinary approaches to address these diseases: tinyurl.com/4ybej569
Figure showing cumulative prevalence of major musculoskeletal diseases in the USA by age group (2021).Copyright: The Author(s). Published by Elsevier Ltd. CC BY-NC-ND 4.0 license.
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Amanda Ali @amandality.bsky.social · 30/05/2025
Excellent presentation by Research Associate Thomas Wilson from the Ali Lab @hfhs-bjc.bsky.social at the 9th annual Musculoskeletal Health Symposium @uofmichigan.bsky.social! Grateful for the opportunity to share our research on the podium and to connect with fantastic MSK Twitter colleagues IRL.
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Amanda Ali @amandality.bsky.social · 14/05/2025
New publication alert! A summary of the research discussed at the 3rd Workshop on the Epigenetics of OA held in Toronto last September. From mechanism to medicine: The progress and potential of epigenetics in osteoarthritis - Osteoarthritis and Cartilage Open www.oarsiopenjournal.com/article/S266...
oarsiopenjournal.com
From mechanism to medicine: The progress and potential of epigenetics in osteoarthritis
Osteoarthritis (OA) is a chronic, degenerative disease of the articular joints. The disease presents an enormous clinical and economic burden globally, due in part to the lack of disease modifying the...
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Amanda Ali @amandality.bsky.social · 12/05/2025
A privilege having Dr. Joakim Lundeberg (pioneer of spatial omics) as our keynote speaker for the @henryfordhealth.bsky.social 22nd Annual Research Symposium last week and a pleasure for the Ali lab to join him for dinner on Friday at La Lanterna in Detroit!
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Reposted by Amanda Ali
André Picard @picardonhealth @picardonhealth.bsky.social · 11/05/2025
More alternatives to knee replacement surgery are emerging. Physicians caution that the treatment aren’t permanent fixes, but they may work well for some, especially those not eligible for surgery, by Rebecca Theim www.washingtonpost.com/health/2025/... via @washingtonpost.com
washingtonpost.com
More alternatives to knee replacement surgery are emerging
Many people aren’t eligible for knee replacement surgery because of health issues.
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Amanda Ali @amandality.bsky.social · 09/05/2025
Today: Co-chairing for my 3rd and final year the 22nd annual HFH @henryfordhealth.bsky.social Research Symposium!
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Reposted by Amanda Ali
Sarah Rice @grainofscience.bsky.social · 03/05/2025
For the 3rd #EpigeneticsOA workshop, 77 attendees united to discuss progress and potential of our field. Delighted to see the meeting report in print! Whether you made it, or missed out, catch up w/ the outcomes here --> bit.ly/42YeWnT #orthosky @oacjournal.bsky.social @versusarthritis.bsky.social
bit.ly
From mechanism to medicine: the progress and potential of epigenetics in osteoarthritis
Osteoarthritis (OA) is a chronic, degenerative disease of the articular joints. The disease presents an enormous clinical and economic burden globally…
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Reposted by Amanda Ali
Jamie Collins @colljamie.bsky.social · 24/04/2025
Congratulations to paper of the year winners! #OARSI2025
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Amanda Ali @amandality.bsky.social · 24/04/2025
Getting real-time updates certainly helps offset the FOMO from not being able to attend OARSI this year! Congratulations to our team on the Basic Science Publication of the Year award from @oacjournal.bsky.social!
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Henry Ford Bone & Joint Center @hfhs-bjc.bsky.social · 27/02/2025
Check out the latest Nature Communications manuscript from Dr. Ali in the Bone & Joint Center! Establishing circulating microRNA-126-3p as a biomarker in human knee #osteoarthritis and demonstrating an angiogenesis-driven protective effect in an animal model. Small RNAs with big implications!
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Kevin Baker @orthoengineer.bsky.social · 27/02/2025
Grateful to be a (very) small part of such an amazing study! All credit to the awesome @amandality.bsky.social and her team for this important #osteoarthritis discovery just published in @naturecomms.bsky.social. The miR-evolution is now!
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Amanda Ali @amandality.bsky.social · 27/02/2025
Excited to share our work on the small but mighty microRNA-126-3p in @naturecomms.bsky.social! We found this microRNA is elevated in four knee osteoarthritis cohorts and show in an animal model that it reduces the severity of knee osteoarthritis - at least in part via angiogenesis. rdcu.be/ebycj
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Sarah Rice @grainofscience.bsky.social · 22/02/2025
The list is growing! If you’re new to Bluesky and ate interested in ortho/MSK research, this is a great place to start (re)building your network. Recent additions: @daniellerux.bsky.social @rmraftery.bsky.social @mcalinden-lab.bsky.social @amandality.bsky.social go.bsky.app/DJVukXR
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