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Farshid Guilak

@farsh-g.bsky.social
368 followers 390 following 30 posts

@ShrinersStLouis @wustlortho @washubme @washudevbio @wustlCRM @theNAMedicine @theNAEng @AcadofInventors @cytexortho @MyAOCConnect #racquetball

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Farshid Guilak @farsh-g.bsky.social · 23/01/2026
Sleep matters for joint health! In our new paper led by Dr Liz Rowlands, we studied sleep habits of 500,000 people. Osteoarthritis risk was highest with <6 hours of nightly sleep and significantly increased by shift work. acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
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Reposted by Farshid Guilak
Kelsey H. Collins @kelseyhcollins.bsky.social · 03/12/2025
Honored to share our new paper, Osteoarthritis as a Systemic Disease, in @natrevrheum.nature.com, out today: rdcu.be/eSXLW - thanks to Ida Haugen, @tuhinaneogi.bsky.social and @farsh-g.bsky.social for your input on gaps and opportunities.
rdcu.be
Osteoarthritis as a systemic disease
Nature Reviews Rheumatology - Emerging evidence suggests a paradigm shift in viewing osteoarthritis (OA) as a systemic, bidirectional disease. This Review examines the current data supporting this...
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Reposted by Farshid Guilak
Ardem Patapoutian @ardemp.bskyverified.social · 21/07/2025
Exciting new study on the role of PIEZOs in Chondrocytes! Relevance to arthritis and pain. From: @farsh-g.bsky.social & @kelseyhcollins.bsky.social arthritis-research.biomedcentral.com/articles/10....
arthritis-research.biomedcentral.com
Chondrocyte-specific knockout of Piezo1 and Piezo2 protects against post-traumatic osteoarthritis structural damage and pain in mice - Arthritis Research & Therapy
Background Osteoarthritis (OA) is a debilitating joint disease characterized by cartilage degeneration, synovial inflammation, and bone remodeling, with limited therapeutic options targeting the under...
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Farshid Guilak @farsh-g.bsky.social · 23/06/2025
Congrats to Amanda Cimino and team on her latest paper in @JCRnEDITORS - she developed new synthetic chronogenetic gene circuits that allow controlled drug delivery at precise times day using various elements of the circadian clock! doi.org/10.1016/j.jc...
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Farshid Guilak @farsh-g.bsky.social · 11/06/2025
Huge congrats to Dr. Amanda Cimino for an outstanding presentation and defense - her committee said it was time for a "PhD+" degree. Amazing work!
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Farshid Guilak @farsh-g.bsky.social · 03/06/2025
Chronotherapy in Rheumatoid Arthritis Treatment: Tantalizing but Understudied www.medscape.com/viewarticle/...
medscape.com
Chronotherapy in RA Treatment: Tantalizing but Understudied
Research is evaluating chronotherapy to target drugs to reduce morning stiffness and flares in rheumatoid arthritis, but it has a long way to go before it reaches the clinic.
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Reposted by Farshid Guilak
Stand Up for Science! @standupforscience.net · 22/05/2025
We don’t always know what questions will change the world. But public science has a way of answering them anyway. Federal science funding isn’t just lines in a budget. It’s a vote for progress, for possibility. www.nytimes.com/2025/05/16/s...
nytimes.com
9 Federally Funded Scientific Breakthroughs That Changed Everything
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Farshid Guilak @farsh-g.bsky.social · 22/05/2025
Most studies of cartilage mechanobiology study the upregulation of chondrocyte gene expression and biosynthesis with mechanical loading. Check out our recent paper where Daniel Palmer studied the down-regulated "mechanome" with Piezo1 or TRPV4 activation. www.tandfonline.com/doi/full/10....
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Reposted by Farshid Guilak
FASEB @faseborg.bsky.social · 22/05/2025
Your research on Ion Channel Regulation might be the next watershed discovery! Join FASEB for the latest findings at #ICRSRC with keynote speaker @farsh-g.bsky.social and organizers @roseedixon.bsky.social and Jonathan Silva. Submit your abstract by June 8 and save your space now! buff.ly/A3wmAbp
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Farshid Guilak @farsh-g.bsky.social · 20/05/2025
Congrats to Amanda Cimino for her latest paper creating a chronogenetic gene circuit that automatically delivers anti-inflammatory biologic drugs in response to inflammation or circadian signal! jbioleng.biomedcentral.com/articles/10....
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Farshid Guilak @farsh-g.bsky.social · 13/05/2025
Lots of celebrations this month in the Guilak Lab! Congrats to Xinyi Melissa Li and Katelyn Lipa for passing their qualifying exams with flying colors!
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Reposted by Farshid Guilak
Satanik Mukherjee @satanikm.bsky.social · 08/05/2025
🚨 Big updates! ✅ Successfully defended my PhD thesis: “Multiscale Modeling of Chondrocyte Mechanobiology: Insights into Degeneration and Regeneration” ✅ Joined the lab of @farsh-g.bsky.social at WashU St Louis as a Rita Levi-Montalcini Postdoc Fellow in regenerative medicine! Grateful & excited !
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Reposted by Farshid Guilak
American Institute for Medical & Biological Engineering (AIMBE) @aimbe-official.bsky.social · 05/05/2025
Please widely share these 3 new advocacy letter templates with your colleagues. @lolauic.bsky.social @orssociety.bsky.social @bmes-cmbe.bsky.social @aapmhq.bsky.social @acadrad.bsky.social @ceschmidt2024.bsky.social @settonlab.bsky.social @tejaladesai.bsky.social @farsh-g.bsky.social
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Reposted by Farshid Guilak
Anne-Marie Malfait @jointsintheworld.bsky.social · 02/05/2025
Join us for our quarterly C-COMP journal club, featuring this exciting new paper by the team of @kelseyhcollins.bsky.social and @farsh-g.bsky.social Monday May 12th 10 am CST- ask us how to register! www.science.org/doi/full/10....
science.org
Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain
Osteoarthritis and knee joint pain are driven by systemic leptin and complement factor D secreted by adipose tissue.
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Farshid Guilak @farsh-g.bsky.social · 01/05/2025
Congrats to Sophie Paradi on a fantastic Master's thesis and defense! Amazing work and collaboration with Erica Ely and many others in the Guilak Lab
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Reposted by Farshid Guilak
FASEB @faseborg.bsky.social · 28/04/2025
Ion channel research can have major consequences for cancer and cardiovascular disease treatments. Join FASEB at #ICRSRC for the latest findings with keynote speaker @farsh-g.bsky.social and organizer @roseedixon.bsky.social. Check out the full program and save your space: buff.ly/d213NE1
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Farshid Guilak @farsh-g.bsky.social · 25/04/2025
Congrats ‪@kelseyhcollins.bsky.social‬ on another tour de force, shedding further light into the relationship between obesity and OA! The more we learn, the more complex it gets... Fantastic collaboration with the June lab and WashU Rheumatology!
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Farshid Guilak @farsh-g.bsky.social · 24/04/2025
put me in, coach...
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Farshid Guilak @farsh-g.bsky.social · 24/04/2025
Join us today for our AOC Thought Leaders Webinar: Managing the Research Enterprise — for anyone navigating the evolving landscape of academic orthopaedics. April 24 | 4:00 PM ET Register Here: lnkd.in/eTrzEem6 Joint the AOC at myaocconnect.com!
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Farshid Guilak @farsh-g.bsky.social · 10/04/2025
Congrats Dr. Jackie Garcia on an amazing dissertation on defense "Characterizing PIEZO1 Mechanotransduction in Articular Chondrocytes"!
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Farshid Guilak @farsh-g.bsky.social · 07/04/2025
Excited for our most recent publication mapping macrophage populations in the synovium with knee injury and obesity! Great work by @nharasymowicz.bsky.social and team!
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Farshid Guilak @farsh-g.bsky.social · 18/03/2025
www.menshealth.com/health/a6375...
menshealth.com
A Definitive Guide to Racquet Sports, From Tennis to Pickleball to Padel
There are so many racquet sports with varying levels of difficulty, benefits, and #vibes. Find the one that's right for you here.
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Reposted by Farshid Guilak
American Institute for Medical & Biological Engineering (AIMBE) @aimbe-official.bsky.social · 11/03/2025
The 3/14 deadline to finalize the FY2025 budget is fast approaching! ⌛ AIMBE has developed a new advocacy letter (<1 min to send) for the scientific community to urge Congress to support our federal science agencies, including NIH, NSF, FDA, ARPA-H, CDMRP, and more 👇 takeaction.io/aimbe/suppor...
takeaction.io
Support Strong FY25 Funding for Biomedical Research by March 14
Use AIMBE's letter template below, edit as needed, or create your own message to your Members of Congress on issues that matter. Enter your contact information on the left, and your letter will be rou...
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Farshid Guilak @farsh-g.bsky.social · 07/03/2025
Engineered stem cells automatically deliver arthritis drugs at prescribed times of day apnews.com/press-releas... www.nature.com/articles/s41...
apnews.com
Engineered stem cells automatically deliver arthritis drugs at prescribed times of day
“This technology has the potential to change a lot of lives.
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Farshid Guilak @farsh-g.bsky.social · 05/03/2025
We’ve created a new field called “chronogenetics”: controlling gene expression with the cell’s internal clock! Lara Pferdehirt & Anna Damato made living implants that sync to the body & automatically deliver biological drugs on a 24 hr cycle. www.nature.com/articles/s41...
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Farshid Guilak @farsh-g.bsky.social · 28/02/2025
On #RareDiseaseDay, we are excited to publish Zainab Harissa's paper showing that rare, dysplasia-causing mutations in the ion channel TRPV4 alter the response of chondrocytes to mechanical loading. journals.physiology.org/doi/abs/10.1...
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Farshid Guilak @farsh-g.bsky.social · 20/02/2025
Check out the latest insights on what controls pericellular matrix properties (measured by atomic force microscopy) as it is degraded in OA. fantastic collaboration with Marina Danalache. Congrats to Jule Nieuwstraten for leading this study!
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Farshid Guilak @farsh-g.bsky.social · 11/02/2025
Congrats to all the new members of the National Academy of Engineering, especially our many biomedical engineering colleagues Kyriacos Athanasiou, Sam Achilefu, Lisa Brannon-Peppas, Lydia Kavraki, and many others! www.nae.edu/331605/NAENe...
nae.edu
National Academy of Engineering Elects 128 Members and 22 International Members
National Academy of Engineering Elects 128 Members and 22 International Members to the Class of 2025
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Reposted by Farshid Guilak
American Institute for Medical & Biological Engineering (AIMBE) @aimbe-official.bsky.social · 10/02/2025
Please widely share our statement and advocacy letter template with your colleagues. @lolauic.bsky.social @orssociety.bsky.social @termisam.bsky.social @bmes-cmbe.bsky.social @aapmhq.bsky.social @ceschmidt2024.bsky.social @settonlab.bsky.social @tejaladesai.bsky.social @farsh-g.bsky.social
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Farshid Guilak @farsh-g.bsky.social · 07/02/2025
www.medscape.com/viewarticle/...
medscape.com
Could Gene Therapy for RA Soon Be Ready to ‘Take Off’?
Gene therapies to treat rheumatoid arthritis have evolved slowly, but one is ready to move into human trials and an osteoarthritis treatment in human trials may have potential for treating RA.
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Farshid Guilak @farsh-g.bsky.social · 14/01/2025
Congrats to Gabi Marushack and @alisavadipour.bsky.social & team for our latest @Guilak_Lab paper showing that polyunsaturated fatty acids alter cell membrane properties & inhibit chondrocyte #mechanotransduction by #Piezo1 and #TRPV4. faseb.onlinelibrary.wiley.com/doi/10.1096/...
faseb.onlinelibrary.wiley.com
Polyunsaturated fatty acids suppress PIEZO ion channel mechanotransduction in articular chondrocytes
Chondrocytes sense mechanical signals from their environment via ion channels such as TRPV4 and Piezo1. The mechanosensitivity of these channels is altered by the presence of polyunsaturated omega-3 ...
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Farshid Guilak @farsh-g.bsky.social · 14/01/2025
Huge congrats on an amazing dissertation and defense, Dr. Erica Ely! It's #Piezo month at @Guilak_lab
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