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JAMA @jama.com · 18/04/2026

Among adults with #AcuteSinusitis, standard-dose amoxicillin-clavulanate did not reduce treatment failure compared with amoxicillin, while overall failure and hospitalization rates were low in both groups. #ESCMIDGlobal2026 @escmid.bsky.social ja.ma/4mD2ymI

Cumulative incidence curves comparing amoxicillin-clavulanate to amoxicillin for acute sinusitis in adults. Graphs display treatment failure, new antibiotic use (with and without outpatient encounters), and antibiotic-associated adverse events over 14 days.

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amandagwee.bsky.social @amandagwee.bsky.social · 02/12/2025

We are hiring! Interested in being a research coordinator for paediatric antimicrobial trials @mcri.bsky.social? See career10.successfactors.com/sfcareer/job...

career10.successfactors.com

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amandagwee.bsky.social @amandagwee.bsky.social · 13/11/2025

Pkpd study in immunocompromised kids showing GCV AUC24 corresponding to 90% maximal suppression and elimination effects was approximately 40-100 mg/L·h. WCC significantly affected the viral decline rate. Time for routine tdm? bpspubs.onlinelibrary.wiley.com/doi/10.1002/... #cmv #pedsid #TxIDChat

bpspubs.onlinelibrary.wiley.com

BPS Publications

Aims Ganciclovir (GCV) is commonly used to treat cytomegalovirus (CMV) infections in immunocompromised children. Currently, the therapeutic target for effective treatment is unclear: Adult studies s...

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Michael Marks @drmichaelmarks.bsky.social · 13/04/2025

Vancomycin Taper trial presented by @dremilymcd.bsky.social #ESCMID2025. In people who get better by day 10 should we stop or give taper? Reduced recurrences by primary outcome timepoint but the KM suggests it may be just delaying rather than truly preventing recurrence? #IDSky

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amandagwee.bsky.social @amandagwee.bsky.social · 22/04/2025

All you need to know about vancomycin dosing in adults and kids led by @leggwamy.bsky.social and @tonylai.bsky.social

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amandagwee.bsky.social @amandagwee.bsky.social · 28/03/2025

Systematic review on posaconazole levels & clinical outcomes of IFI in kids. All but 1 breakthrough IFI occurred with serum levels ≤0.7mg/L. For IFI treatment, no association between trough >1.0mg/L & efficacy. Poor outcomes seen with levels between 0.2-4.8mg/L. pubmed.ncbi.nlm.nih.gov/40037294/

pubmed.ncbi.nlm.nih.gov

Relationship between posaconazole concentrations and clinical outcomes in paediatric cancer and haematopoietic stem cell transplant recipients - PubMed

This review supports current recommendations for posaconazole prophylaxis in paediatric oncology and HSCT recipients. The absence of a clear correlation found between serum trough concentrations and t...

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amandagwee.bsky.social @amandagwee.bsky.social · 28/03/2025

Reduction in sputum pseudomonas bacterial load (live and dead) associated with improvement in FEV1 in children with CF receiving antibiotics. No correlation between change in total sputum bacterial load and improvement in FEV1. #Idsky pubmed.ncbi.nlm.nih.gov/40090524/

pubmed.ncbi.nlm.nih.gov

Relationship between sputum bacterial load and lung function in children with cystic fibrosis receiving tobramycin - PubMed

A greater reduction in total sputum P. aeruginosa bacterial load (live + dead) was associated with improved lung function (FEV<sub>1</sub>) in children with CF receiving tobramycin.

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Nicole Messina @nicolemessina.bsky.social · 04/02/2025

📚 Our findings, along with our earlier study showing that #BCGvaccine increased risk of symptomatic [but not severe] #COVID-19, suggest that BCG vaccination does not enhance immunity to #SARSCoV2 or COVID-19 vaccines 🌍✨ #IDsky #Immunosky www.sciencedirect.com/science/arti...

sciencedirect.com

BCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial

Bacille Calmette-Guérin (BCG) vaccine has immunomodulatory effects that may provide protection against unrelated infectious diseases. We aimed to dete…

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BK. Titanji @boghuma.bsky.social · 01/02/2025

Vaccines and immunization fact sheets you can't find on CDC website anymore are archived at the link below. May be helpful to bookmark this for future reference. www.immunize.org/vaccines/vis...

immunize.org

Vaccine Information Statements (VISs) Overview | Immunize.org| Immunize.org

Find materials on legal requirements to give VISs to patients before vaccinating.

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José Molina @josemolinagb.bsky.social · 28/01/2025

In this table you can find a summary with different antimicrobials’ penetration into the bile (and the peritoneum). Hope you find it useful! 🙂 #AMSsky #IDOnc #IDSky

References:
2012 Surg Inf, Adnan
2016 J Chemotherapy, Mazzei
2017 WJES, Sartelli
2020 Pharmacotherapy, Thabit

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 31/12/2024

🆕💫Retrospective cohort study #CMI AKI is a frequent complication of S. aureus bacteraemia and is associated with 30-day mortality Not “a cute” complication: phenotypic analysis of acute kidney injury in S. aureus bacteraemia #idsky #EMIMCC www.clinicalmicrobiologyandinfection.com/article/S119...

clinicalmicrobiologyandinfection.com

DEFINE_ME

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Joseph Marcus @josephmarcusid.medsky.social · 23/12/2024

Reviews of antimicrobial dosing: 1. Anti-fungals: doi.org/10.1093/ofid... 2. All-antimicrobials: ccforum.biomedcentral.com/articles/10.... Systematic Reviews: 1. Definitions of ECMO infections: www.ajicjournal.org/article/S019... 2. Use of ppx antibiotics: journals.lww.com/asaiojournal...

doi.org

Antifungals in Patients With Extracorporeal Membrane Oxygenation: Clinical Implications

This review summarizes antifungal use in ECMO patients, exploring specific substances, dosing, TDM and ECMO-related factors from a clinical point of view.

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S. Evan Cooper 🦠 @scooper-id.bsky.social · 21/12/2024

Broad-Spectrum Antibiotics Linked To Increased Risk For Adverse Drug Events Among Outpatients With CAP #IDSky Antimicrobial stewardship efforts are needed to promote judicious use of antibiotics, and ultimately decrease antibiotic-related ADEs academic.oup.com/cid/advance-...

academic.oup.com

Comparative Safety of Different Antibiotic Regimens for the Treatment of Outpatient Community-Acquired Pneumonia Among Otherwise Healthy Adults

Among otherwise healthy, nonelderly adults treated for community-acquired pneumonia in the outpatient setting, each broad-spectrum antibiotic regimen was a

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 10/12/2024

Pharmacodynamic studies indicate that anaerobic killing is optimized when the plasma AUC) to MIC ratio is ≥70:1; the probability of achieving this target with 1000mg/d of metronidazole is > 99% against B. fragilis that exhibit MICs < 2mg/L #idsky #medsky #EMIMCC

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 10/12/2024

🔥The ADAPT-Sepsis RCT🔥 Daily PCT-guided protocol 🔽 total antibiotic duration & had noninferior all-cause mortality compared with standard care. No difference was found in total Abx duration between standard care & daily CRP-guided protocol CRP failure #idsky #EMIMCC jamanetwork.com/journals/jam...

jamanetwork.com

Biomarker-Guided Antibiotic Duration for Patients With Suspected Sepsis

This clinical trial assessed whether treatment protocols for monitoring C-reactive protein or procalcitonin safely reduced the amount of time critically ill adults with suspected sepsis received antib...

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 06/12/2024

🆕️✨️Retrospective cohort study Oral doxycycline for the treatment of ocular syphilis may be safe and effective as IV penicillin in a selected subset of patients who completed an extended oral antibiotic #idsky #medsky #AMSsky jamanetwork.com/journals/jam...

jamanetwork.com

Outpatient Oral Doxycycline Therapy for Ocular Syphilis

This cohort study compares the outcomes of oral doxycycline therapy with those of intravenous penicillin therapy among patients with ocular syphilis.

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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 21/11/2024

The standard four times daily cephalexin dose makes treatment adherence challenging 🆕️⚡️⚡️Retrospective #JAC Efficacy and tolerability of high-dose cefalexin 45 mg/kg/dose (maximum 1.5 g) three times daily in children with bone and joint infections #idsky academic.oup.com/jac/article-...

academic.oup.com

Efficacy and tolerability of high-dose cefalexin 45 mg/kg/dose (maximum 1.5 g) three times daily in children with bone and joint infections

AbstractBackground. Cefalexin, a first-generation cephalosporin, is commonly used as oral continuation therapy for paediatric bone and joint infections (BJ

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José Molina @josemolinagb.bsky.social · 17/11/2024

Struggling to keep up with the new (and upcoming) antibiotics for Gram-negatives? A quick reference guide! #AMSsky #IDSky

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