SUMMARYThe treatment and prevention of HIV have undergone significant transformations in the 16 years since the last major review of HIV therapeutics published in ASM’s Journal of Virology (A. M. N. T...

AbstractBackground. Despite advances in echocardiography, the definitive diagnosis of prosthetic valve endocarditis (PVE) has remained difficult. 18F-fluor

SUMMARYThe traditional landscape of dermatophyte infections has changed over the past decade. The emergence and global expansion of Trichophyton indotineae have highlighted the impact of irrational an...

Airborne mould spores, including those of the Aspergillus species, are ubiquitous both indoors and outdoors. While they are generally harmless, inhaled spores can cause severe infections, particularl...

Candida infections are a leading cause of invasive fungal disease (IFD), especially among critically ill and immunocompromised patients. Despite available pathogen-directed antifungal therapies, outcomes remain unsatisfactory with high associated morbidity and mortality rates. Increasing recognition of immune dysregulation of the host, including immunoparalysis and impaired antifungal effector responses, has driven interest in immunotherapeutic strategies as adjuncts to conventional treatment.

In an prospective observational study of patients with inflammatory bowel disease with oral thrush, the treatment of fluconazole (orogastrointestinal therapy), but not nystatin (oral therapy), led to ...

Nature Reviews Microbiology, Published online: 21 August 2026; doi:10.1038/s41579-026-01354-3In this Review, Schubert and Hardt explore the metabolic strategies that Enterobacteriaceae use to establish themselves in the gut, and how they adapt to inflammatory conditions in this environment.

Over the past several decades there have been significant advances in nucleos(t)ide analogue (NA) antiviral therapy for hepatitis B virus (HBV) and global expansion of primary prevention through imm.....

Abstract. Sepsis remains a leading cause of morbidity and mortality in US hospitals despite extensive efforts to improve early recognition and treatment, p

Fluconazole resistance has been documented in Candida albicans and Candida parapsilosis, both leading causes of invasive candidiasis, driven in part by mutations in MRR1 which encodes a transcription ...

AbstractBackground. The Infectious Diseases Society of America (IDSA) is committed to delivering timely, evidence-informed guidance on the management of an

Nature Microbiology, Published online: 30 July 2026; doi:10.1038/s41564-026-02409-0In a small case series, combined phage therapy and faecal microbiota transplantation was safe and led to sustained reductions in recurrence, severity and antibiotic use in women with recurrent urinary tract infections, even without complete eradication of Escherichia coli.

Abstract. MRSA remains a major global health challenge. Although its global prevalence has declined over the last decade, especially in high-income countri

Whether carbapenemase class independently influences prognosis in carbapenemase-producing Enterobacterales (CPE) infections remains uncertain.

Invasive fungal infections (IFI) are becoming more and more frequent in the intensive care unit (ICU), affecting not only immunocompromised patients. Invasive pulmonary aspergillosis, invasive cand...

This updated IDSA AMR Guidance document provides treatment suggestions for infections caused by extended-spectrum β-lactamase–producing Enterobacterales (ESBL-E), AmpC β-lactamase–producing Enterobact...

Beta-lactam antibiotics (beta-lactams) are first-line treatments for most major infectious syndromes in acutely ill patients, with in vitro activity against common pathogens, demonstrated efficacy in....

Antibiotic resistance has quietly become one of the greatest threats to global healthcare. Each year, drug-resistant bacteria claim lives by rendering once-reliable antibiotics ineffective, turning ro...

AbstractBackground. Treating Candida spp. urinary tract infections (UTIs) are challenging when isolates have reduced susceptibility to fluconazole. Voricon

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Nature Microbiology, Published online: 21 July 2026; doi:10.1038/s41564-026-02429-wClarifying objectives to strengthen wastewater-based AMR surveillance

The COVID-19 pandemic has exposed vulnerabilities in global health systems while accelerating the adoption of metagenomic next-generation sequencing (mNGS) a...

INTRODUCTION Metabolic syndrome (MetS) is associated with increased dementia risk, but its relationship with brain aging is unclear. METHODS The study included 27,375 UK Biobank participants aged 4...

In a multicenter cohort of 39,842 hospitalizations with suspected sepsis, including 19,121 among immunocompromised patients, delayed antibiotics were assoc