iiinova — where your digital self keeps evolving

Allard van Renterghem @allardvanr.bsky.social · 27/01/2026

Thanks to all friends, collaborators and mentors involved in this project! @nkinl.bsky.social

Allard van Renterghem @allardvanr.bsky.social · 27/01/2026

In liver metastases, this circuit is shut down. IL-18–driven activation of liver Vδ1⁺ γδ T cells is actively suppressed by cancer cell-derived IL18BP, helping explain why liver metastases predict poor responses to immune checkpoint blockade.

120

Allard van Renterghem @allardvanr.bsky.social · 27/01/2026

Strikingly, we found that IL18 was able to activate liver-resident γδ T cells, whereas Vδ1⁺ γδ T cells from the intestines do not show this response. This shows are these cells not the same across organs and metastatic sites!

110

Allard van Renterghem @allardvanr.bsky.social · 27/01/2026

We identify in patients, IL-18 expression was associated with response to immune checkpoint blockade selectively in patients with liver metastases, highlighting it's importance in shaping liver-specific immunity (and potential as a target 💥1️⃣8️⃣💥)

110

Allard van Renterghem @allardvanr.bsky.social · 27/01/2026

We identify Vδ1⁺ γδ T cells as key tissue sentinels in the liver, capable of shifting the balance from tolerance to immunological control 🚨👮‍♀️. Vδ1⁺ γδ T cells are known to express PD-1, can act as effectors of ICB response in MMR-d cancers. The signals driving their activation are poorly understood.

100

Allard van Renterghem @allardvanr.bsky.social · 27/01/2026

Thanks to all friends, collaborators and mentors involved in this project! @nkinl.bsky.social

010

Allard van Renterghem @allardvanr.bsky.social · 27/01/2026

100

Allard van Renterghem @allardvanr.bsky.social · 27/01/2026

Strikingly, we found that IL18 was able to activate liver-resident Vδ1⁺ γδ T cells, whereas Vδ1⁺ γδ T cells from the intestines do not show this response. This shows γδ T cells that are not the same across organs.

100

Allard van Renterghem @allardvanr.bsky.social · 27/01/2026

110

Allard van Renterghem @allardvanr.bsky.social · 27/01/2026

We pinpoint Vδ1⁺ γδ T cells as key sentinels in the liver, capable of shifting the balance from tolerance to immunological control. γδ T cells are known to express PD-1, and can act as effectors of ICB response in MMR-d cancers. However te signals driving their activation are poorly understood.

100

Reposted by Allard van Renterghem

Waggoner Lab @labwaggoner.bsky.social · 26/01/2026

Liver metastases dampen IL18-driven γδ T cell activity and immunotherapy responsiveness in colorectal cancer @cp-cellrepmed.bsky.social www.cell.com/cell-reports...

062

Allard van Renterghem @allardvanr.bsky.social · 25/03/2025

What kind of policies and measures to promote diversity and equality are in place at your institutes? Would love to connect and happy to share some of the initiatives that help make the @nkinl.bsky.social an even better place :)

010

Allard van Renterghem @allardvanr.bsky.social · 25/03/2025

While awareness amongst healthcare professionals and researchers is a great start, there’s definitely a need to tackle discrimination on a policy and institutional level.

110

Allard van Renterghem @allardvanr.bsky.social · 25/03/2025

While diversity initiatives are under attack, at the netherlands cancer institute (@nkinl.bsky.social) we firmly believe in creating an inclusive & diverse environment! Together with Humanity in Action we hosted a workshop about recognizing and prevent discrimination in healthcare & academia

131

Reposted by Allard van Renterghem

Eric Topol @erictopol.bsky.social · 05/12/2024

The next frontier of T cell therapeutics when the T also stands for tissue-targeting, such as brain or local immune response, via synthetic gene circuits @science.org science.org/doi/10.1126/... science.org/doi/10.1126/... science.org/doi/10.1126/...

523053