van Renterghem et al. investigate the impact of liver metastases on immunity in MMR-d/MSI-hi patients treated with ICB. They show that IL18 activates liver-derived Vδ1+ T cells and predicts ICB benefi...

Tumor-induced systemic accumulation and polarization of neutrophils to an immunosuppressive phenotype is a potent driver of metastasis formation. Yet,…

Spatially resolved transcriptomic profiling of primary tumours and metastases from patients with pancreatic cancer provides insight into the evolutionary progression to metastasis, and the variation in clonal architecture within and between individuals.

Adipose manipulation transplantation can reduce tumor growth and proliferation in vitro and in mouse models.