iiinova — where your digital self keeps evolving

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MwahahahahahadScientist @mads100tist.bsky.social · 25/09/2026

As Gregor Samsa awoke one morning from uneasy dreams he found himself transformed in his bed into a senior postdoc

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Nikolas Karalis @nikolaskaralis.bsky.social · 23/08/2026

Last week to apply for the Neuromodulation of Neuronal Circuits Conference & Workshop! Sept. 14 - 17, 2026, Paris Brain Institute Before the conference, we are hosting a two-day theoretical and hands-on workshop for selected early career researchers. Deadline: September 1 www.paris-circuits.eu

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Drew Schreiner @schreinerdrew.bsky.social · 28/07/2026

Psychology paper studying undergraduates: “We need to confront the fact that our subjects are WEIRD and results may not generalize” Systems Neuroscience paper studying one inbred mouse strain: “Here is how the mammalian brain works.”

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MwahahahahahadScientist @mads100tist.bsky.social · 27/07/2026

You have always been able to learn and use R, Python and Java. Some people are being kicked in the head with a bag of potatoes and are paying for it, and don't even want to acknowledge it 🧪

A user saying "i do think that computational capabilities will be greatly democratized with ai for biologists"

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Konrad Hinsen @khinsen.net · 06/07/2026

New blog post: "Conviviality in computational science" blog.khinsen.net/posts/2026/0... "Conviviality matters for science ... if you want to derive knowledge from your work, you need to know exactly what you are doing, and that includes a detailed understanding of your tools." 🧪 #metascience

blog.khinsen.net

Konrad Hinsen's blog

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Javier Alegre-Cortés @alegrecortes.bsky.social · 09/07/2026

I'm just a simple man, asking you to come to poster 613, say hi, and even discuss some cool science.

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Luis Guerra @luisguerra.bsky.social · 06/07/2026

Prebilaterian Origin of Monoaminergic Signalling is out! This paper represents four years of work, not only mine, but friends and colleagues. I am particularly grateful to Tatiana Mayorova; without her help, this paper would not have been nearly as complete. www.sciencedirect.com/science/arti...

sciencedirect.com

Prebilaterian origin of monoaminergic signaling

Monoamines such as serotonin, dopamine, and tyramine regulate physiological and behavioral processes in bilaterian animals, but the evolutionary origi…

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Nikolas Karalis @nikolaskaralis.bsky.social · 02/07/2026

Getting ready for #FENS2026 at Barcelona? Our lab will be there with 7 posters and a symposium. fens2026.neuronaldynamics.eu Come by our posters 611 - 617 on Thursday morning to learn the latest about neuromodulators and how they organize neural activity and computation. @fens.org

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Iris van Rooij 💭 @irisvanrooij.bsky.social · 04/07/2026

Cognition cannot be measured

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Javier Alegre-Cortés @alegrecortes.bsky.social · 02/07/2026

Are you attending #FENS2026 and interested in the interaction of Norepinephrine and Acetylcholine on sculpting neuronal firing? Spontaneous activity? Dynamical systems? Biophysics? Cellular heterogeneity? Find them all in one place! See you at poster 613 during Thursday's morning session PS05

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Javier Alegre-Cortés @alegrecortes.bsky.social · 30/06/2026

I've sent for printing not 1, but 2 posters 5 days ahead of a conference. Please applaud this uncommon achievement.

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Nikolas Karalis @nikolaskaralis.bsky.social · 22/06/2026

Registration is now open for the Paris Circuit Dynamics Conference & Workshop 2026! Neuromodulation of Neuronal Circuits: From Behavior to Computation Paris Brain Institute 16–17 September 2026 Registration is free (but required): www.paris-circuits.eu

paris-circuits.eu

Paris Circuit Dynamics

This conference will bring together leading experts to discuss how neuromodulatory systems shape neuronal circuit dynamics, behavior, and computation. The program will focus on how neuromodulators suc...

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Nikolas Karalis @nikolaskaralis.bsky.social · 11/06/2026

With #FENS2026 just around the corner, our unofficial @fens.org abstract explorer is back: fens2026.neuronaldynamics.eu • Search abstracts by author, keyword, affiliation, and more • Discover related work using abstract similarity • Save favorites, add notes and tags, and build your own itinerary

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Yogi Jaeger @yoginho.spore.social.ap.brid.gy · 02/06/2026

Online discussions about scientific concepts often bring out something that also runs deep in academia, but usually remains outside the spotlight of public discourse: the personal attachment of people to their ideas. Planck already said: science progresses one funeral at a time. What he meant […]

spore.social

Original post on spore.social

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Javier Alegre-Cortés @alegrecortes.bsky.social · 21/05/2026

"Explanatory power never resides in a concept, but always in the general laws in which it functions"

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Olivia Guest · Ολίβια Γκεστ @olivia.science · 07/05/2026

We end this very short paper on this point: > We should not [...] prioritize numerical correlation over explanation [because it risks] render[s] our fields closer to pseudoscience. Computational cognitive science in principle can and should do more than merely model data. doi.org/10.5281/zeno...

the less they can explain. Therefore, regardless of whether
there is a specific crisis in theory, blurring the meanings of
scientific terms like model and data is disruptive. Theoretical
and modelling work is possible only when the breadth of the
role that models play is recognized, understood, and nurtured.
The neuro-, psychological, and cognitive sciences, and
computational communities therein, should not be underes-
timated. We should not be content with theories and models
that prioritize numerical correlation over explanation that blur
their metatheoretical ties, and which render our fields closer to
pseudoscience. Computational cognitive science in principle
can and should do more than merely model data.

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Javier Alegre-Cortés @alegrecortes.bsky.social · 02/05/2026

Studies in the logic of explanation by Hempel and Oppenheim should be a mandatory read in grad school. Sharp and clearly written, fertile ground for though for any scientist

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Dan Quintana @dsquintana.bsky.social · 27/03/2026

Computationally formalising a verbal theory is an eye-opening experience because it forces you to openly state all the assumptions that the theory rest on

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Javier Alegre-Cortés @alegrecortes.bsky.social · 21/04/2026

Terms like "encode", "representation" or "manifold" are used with different meanings, often blurring the original definitions. This could be eased including a brief glossary section with operational definitions in papers, facilitating the communication and interpretation of scientific results.

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Tessa Montague @tessamontague.bsky.social · 19/04/2026

Excited to share a new review by @kocherlab.bsky.social and me: Nature-inspired neuroscience We discuss diverse sensory systems and behaviors across the animal kingdom and argue for their integration into neuroscience. New tools in diverse systems are making this possible ✨ tinyurl.com/y5y9du27

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Anna-Lena Eckert @eckertal.bsky.social · 15/04/2026

Sadly, applications to the Advanced Python summer school have dropped significantly over the past 2 years. Plus, there'll be no external funding for the 1st time in *17 years*. Likely all because of GenAI - but programming skills still matter🔥 Deadline May 3, please help by sharing: aspp.school

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andrea e. martin @andreaeyleen.eurosky.social · 13/04/2026

OPEN POSTDOC position (part of @erc.europa.eu Consolidator DYNALANG) We build math&comp models of neural dynamics using insights from formal linguistics + ML Seeking theory-driven researchers w/ interests in language, neural dynamics, & math/comp neuroscience. Apply here: tinyurl.com/55exdpse

tinyurl.com

Postdoctoral Position in the Cognitive Computational Neuroscience of Language | Max Planck Institute

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Joao Barbosa @jbarbosa.org · 03/04/2026

Wanna do neuroscience in Paris but can't find interesting lab? Want to come do a sabbatical but don't know who to collaborate? Check this webpage aggregating ~all the neuroscience labs (+200) in Paris. ⚠️only the information of 'verified' profiles is reliable⚠️ Please retweet 🙏 parisneuro.fr

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Javier Alegre-Cortés @alegrecortes.bsky.social · 25/03/2026

Looking forward to 45' with no distractions to fully enjoy @thedearhunter.bsky.social 's new album

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MwahahahahahadScientist @mads100tist.bsky.social · 20/03/2026

Let me post a spicy take here: most people don't read or cite other model organisms' work. Because of this, they keep rediscovering things and, most importantly, re-writing the timeline in favor of fewer and fewer models. That, plus an artificial limit of citations per paper equals this 🧪

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Javier Alegre-Cortés @alegrecortes.bsky.social · 16/03/2026

Science is about building and exploring new theories. We train people because they will be the future builders of theories that expand our knowledge, not because they are contingent labor. www.science.org/content/arti...

science.org

Why I may ‘hire’ AI instead of a graduate student

“It can competently perform a lot of the work I need immediately,” this professor writes

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Javier Alegre-Cortés @alegrecortes.bsky.social · 16/03/2026

Wtf Science is about building and exploring new theories. We train people because they will be the future builders of theories that will expand our knowledge, not because they are contingent labor. www.science.org/content/arti...

science.org

Why I may ‘hire’ AI instead of a graduate student

“It can competently perform a lot of the work I need immediately,” this professor writes

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Ted McCormick @tedmccormick.bsky.social · 13/03/2026

"I got my PhD by writing prompts instead of doing research, I'm winning" got some bad news, there still no jobs and now you also know nothing

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Javier Alegre-Cortés @alegrecortes.bsky.social · 12/03/2026

Mildly hot take: Not enough studies address neural dynamics from the perspective of the oscillatory properties of population firing rates

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Renato Duarte @rcfduarte.bsky.social · 11/03/2026

I tracked every keyword in 22 years of Cosyne abstracts to map how computational neuroscience evolved — from Bayesian brains to neural manifolds to LLMs — and where it's heading next.

open.substack.com

22 years of Brain Science: what CoSyNe tells us about the evolution of Neuroscience

Tracking the intellectual DNA of Computational and Systems Neuroscience through its flagship meeting

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Javier Alegre-Cortés @alegrecortes.bsky.social · 11/03/2026

Next week I'll attend #Systems-in-Action, at @neuroalc.bsky.social! Tired of just talking about glutamate and GABA? I will present my work on how the combination of neuromodulators shapes circuit activity and how biophysical models can explain their mechanisms of action and computational effects.

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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 07/03/2026

Evolutionarily conserved neural dynamics across mice, monkeys, and humans www.biorxiv.org/content/10.64898/20…

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Javier Alegre-Cortés @alegrecortes.bsky.social · 04/03/2026

Pepper update: Multiple varieties have germinated!

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Nikolas Karalis @nikolaskaralis.bsky.social · 01/03/2026

I’m building a foundational reading list for our lab (systems & circuit neuroscience, compneuro, modeling, neuromodulators, population coding etc.). I’d like to crowdsource recommendations. Which review(s) would you consider mandatory reading for the next generation of researchers?

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Mark Rubin @markrubin.bsky.social · 28/02/2026

“To develop, evaluate, and stress-test theories, we need theory-level constraints on and discussions about our science.” By @olivia.science & @andreaeyleen.bsky.social (2021): doi.org/10.1177/1745...

It is at the data and hypothesis levels that preregistration and similar methods attempt to constrain science to avoid QRPs (e.g., Flis, 2019; Szollosi et al., 2019). To ensure scientific quality, however, we propose that preregistration is not enough because it serves only to constrain the data and hypothesis spaces. Researchers who wish to develop their formal account of a capacity must ascend the path instead of, or in addition to, for example, preregistering analysis plans. Preregistration cannot on its own evaluate theories. We cannot coherently describe and thus cannot sensibly preregister what we do not yet (formally and computationally) understand. Indeed, theories can and should be computationally embodied and pitted against each other without gathering or analyzing any new data. To develop, evaluate, and stress-test theories, we need theory-level constraints on and discussions about our science. Figure 2 can serve as a first step in the right direction toward such an ideal.

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Javier Alegre-Cortés @alegrecortes.bsky.social · 28/02/2026

It's Saturday noon. I have no results for my Monday progress report, two liters of coffee and a great Spotify math-rock playlist...

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Natalie Schaworonkow @nschawor.bsky.social · 26/02/2026

I played around with building a bluesky labeler for neuroscience methods. subscribe to: neuromethods.bsky.social and like the corresponding post to have a shiny methods label appear in your profile.

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Berna Devezer @devezer.bsky.social · 23/02/2026

Fontana thinking his 6000+ experiments may not have been enough to feel confident in his conclusions in the 18th century while we expect our singular experiments and their standalone replications to do wonders some 250 years later... (excerpt from the intro of Jutta Schickore's About Experiment)

Toward the end of his two-volume Treatise on the Venom of the Viper, published in 1781, the Tuscan naturalist Deluxe Fontana declared: "I have made more than 6000 experiments; I have had more than 4000 animals bit; I have employed upwards of 3000 vipers and may have been deceived; some essential circumstance may have escaped me: I may have neglected some other, not thinking it necessary; my consequences may have been too general, my experiments too few in number. In a word, I may very easily have been mistaken, and it would be almost impossible that I should never have been so in a matter so difficult, so obscure, and likewise so new."

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Javier Alegre-Cortés @alegrecortes.bsky.social · 22/02/2026

Ironically or home in Paris has more sunlight that the ones where we used to live in Alicante, so let's see how it goes this time

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Javier Alegre-Cortés @alegrecortes.bsky.social · 21/02/2026

Celebrating the MSCA fellowship with a small homemade feast: ginger ribs, niratama, chinese style potato salad and grilled kushinsai

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Alina Studenova @studenova.bsky.social · 20/02/2026

The angle of the dipole obviously matters. If active dipoles in two conditions are slightly misaligned, a difference can be observed. However, this difference is not driven by differences in amplitudes, but only by differences in orientations. Here, I simulated such a scenario. #brainmovies

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Dan Levenstein @dlevenstein.bsky.social · 18/02/2026

With this one in print, I think I finally earned that PhD... 😅 Presented for the first time at the cosyne when the world ended (March 2020). I'll bring over a summary thread from twitter when it was still twitter... www.sciencedirect.com/science/arti...

sciencedirect.com

Neuronal spiking in the mammalian forebrain is dominated by a heterogeneous ground state

Neuronal firing patterns have significant spatiotemporal variability with no agreed-upon theoretical framework. Using a combined experimental and mode…

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Javier Alegre-Cortés @alegrecortes.bsky.social · 18/02/2026

Can anyone point me to works showing the evolution of monoaminergic signaling across the phylogenetic tree? Or how the molecules/peptides activating GPCRs may have changed in time?

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bioRxivpreprint @biorxivpreprint.bsky.social · 18/02/2026

An ancient monoaminergic signaling system coordinates contractility in a nerveless sponge www.biorxiv.org/content/10.64898/20…

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