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Ailith Ewing

@ailithewing.bsky.social
215 followers 185 following 1 posts

Chancellor's Fellow at Institute of Genetics and Cancer, Edinburgh. Chromosomal instability, dynamics of structural variation in tumours. Lead a statistical cancer genomics 🧬 group. Beaches, trees + mountains 🏝️🌲🏔️ Currently on maternity leave.

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Reposted by Ailith Ewing
Institute of Genetics and Cancer @uoe-igc.bsky.social · 02/07/2025
A study led by @ailithewing.bsky.social has gained new insights into how high grade serous ovarian cancer tumours emerge and grow, opening new avenues to develop better treatments: edin.ac/40vjn9a @natcomms.nature.com @cmvm-edinburghuni.bsky.social
edin.ac
New insights into high grade serous ovarian cancer tumour evolution | Institute of Genetics and Cancer | Institute of Genetics and Cancer
A study led by researchers at the Institute of Genetics and Cancer has gained new insights into how high grade serous ovarian cancer tumours emerge and grow, opening new avenues to develop better trea...
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Reposted by Ailith Ewing
Ronny Drapkin @rdrapkin8-penn.bsky.social · 27/03/2025
Surprising findings of BRCA mutations on the Fallopian tubes. Result of a tremendous team effort with @shenhui1986.bsky.social @vainstitute.bsky.social, Chuck Drescher @fredhutch.bsky.social, and Jarrod Marto @danafarber.bsky.social. @pennmedcso.bsky.social www.nature.com/articles/s41...
nature.com
Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube - Nature Communications
The human Fallopian tube (FT) is implicated as a site of origin for pelvic serous cancers. Here the authors conduct multi-omics analysis on over 100 FTs. The results challenge the assumption that BRCA...
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Reposted by Ailith Ewing
Trevor Graham @trevorgraham.bsky.social · 30/01/2025
Delighted our work using aneuploidy as a biomarker of colorectal cancer risk in inflammatory bowel disease is out: gut.bmj.com/content/earl... The initial reaction from patients&families has been overwhelming Led by Ibrahim AlBakir @yosoykit.bsky.social @cancerresearchuk.org @icrlondon.bsky.social
gut.bmj.com
Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis
Background The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and dif...
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Reposted by Ailith Ewing
Sarah Aitken @s-j-aitken.bsky.social · 15/01/2025
🌟NEW PREPRINT ALERT!🌟 We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution” www.biorxiv.org/content/10.1... 🧵[1/12]
biorxiv.org
Genetic background sets the trajectory of cancer evolution
Human cancers are heterogeneous. Their genomes evolve from genetically diverse germlines in complex and dynamic environments, including exposure to potential carcinogens. This heterogeneity of humans,...
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Reposted by Ailith Ewing
Trevor Graham @trevorgraham.bsky.social · 28/11/2024
We have an open #PhD #studentship as part of our "Black Leaders in Cancer" programme at @crukconvergence.bsky.social & @icrlondon.bsky.social. About computational modelling of T-cell evolution in cancer. www.findaphd.com/phds/project... I'm looking forward to meeting prospective students #CRUKfunded
findaphd.com
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Ailith Ewing @ailithewing.bsky.social · 27/11/2024
Well done Dr Jan! A PhD student with @mstaylor.bsky.social who passed his viva yesterday. We’ll miss having the indel expert in the building! 📷 artistic credit to Martin
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Reposted by Ailith Ewing
Barbara Marte @barbmarte.bsky.social · 20/11/2024
new out in Nature www.nature.com/articles/s41...
nature.com
Normal breast tissues harbour rare populations of aneuploid epithelial cells - Nature
Using single-cell DNA sequencing we show that most healthy women harbour rare populations of aneuploid epithelial cells with copy number alteration events in their breast tissue that expand and accumu...
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Reposted by Ailith Ewing
Samir Amin @samiramin.com · 19/11/2024
www.nature.com/articles/s41... #instability #evolution #cancer
nature.com
Chromothripsis in cancer - Nature Reviews Cancer
Chromothripsis is an extreme form of chromosome instability that causes the acquisition of multiple genomic aberrations. Simovic-Lorenz and Ernst discuss mechanistic models of chromothripsis and outli...
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Reposted by Ailith Ewing
Adrian Saurin @adesaurin.bsky.social · 19/11/2024
People working on the causes or consequences of #aneuploidy or #CIN. Reply if I missed you and you want adding to the list go.bsky.app/G8wHoXx
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Reposted by Ailith Ewing
King L Hung @kinglhung.bsky.social · 18/11/2024
Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/ www.nature.com/articles/s41...
nature.com
Coordinated inheritance of extrachromosomal DNAs in cancer cells - Nature
Cooperative species of extrachromosomal DNAs are coordinately inherited through mitotic co-segregation.
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Reposted by Ailith Ewing
Roel Verhaak @roelverhaak.bsky.social · 18/11/2024
Huge resource of MSK-IMPACT "genomes", what a treasure trove! Automated real-world data integration improves cancer outcome prediction www.nature.com/articles/s41...
nature.com
Automated real-world data integration improves cancer outcome prediction - Nature
A study generates a clinicogenomics dataset resource, MSK-CHORD, that combines natural language processing-derived clinical annotations with patient medical data from various sources to improve m...
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Reposted by Ailith Ewing
Oliver Hofmann @fiamh.bsky.social · 26/08/2024
We are happy to announce the release of a new #nf-core workflow -- #oncoanalyser performs an exhaustive analysis of single-patient cancer sequencing data using methods developed by the Hartwig Medical Foundation Australia. (1/5)
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Mcclelland lab @mcclellandlab.bsky.social · 15/11/2024
Tune in today at 2pm UK time for an online seminar explaining why our lab cares about Chromosomal Instability in cancer - as part of a wonderful lecture series on CIN
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