iiinova — where your digital self keeps evolving

Reposted by Aditi Gnanasekar

Guiping Wang @guipingwang.bsky.social · 24/05/2026

If you are intrigued by principles of gene regulation not only at the cellular level but also at the subcellular level... my lab at the CRUK Cambridge Institute is recruiting highly motivated PhD students with Jan 2027 start! 4-year fully funded, UK + intl welcome (1/5)

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Aditi Gnanasekar @agnanam.bsky.social · 17/04/2026

Incredible review by @ivywtl.bsky.social and team eDyNAmiC about how extrachromosomal DNA fuels several hallmarks of cancer. Read on!

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Aditi Gnanasekar @agnanam.bsky.social · 23/03/2026

Excited to share recent work from the Mischel and Chang labs in which we show functional heterogeneity arising from extrachromosomal (ecDNA) copy number heterogeneity. Preprint below! 1/13

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Reposted by Aditi Gnanasekar

Ivy Tsz-Lo Wong, PhD @ivywtl.bsky.social · 05/02/2026

I'm thrilled to start my first bluesky post by highlighting the review paper Hyerim and I have been working really hard together - published just yesterday on Nature Reviews Drug Discovery. In this review, we outlined the latest ecDNA biology and corresponding therapeutic vulnerabilities [1/2] -

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Aditi Gnanasekar @agnanam.bsky.social · 08/01/2026

Exciting work about oncogenic PVT1 fusions arising from extrachromosomal DNA!!! from the Mischel and Chang labs and more :)

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Aditi Gnanasekar @agnanam.bsky.social · 19/11/2025

so much fun working on this project with Venkat, King, Ivy, and team! Read on to learn about the retention elements critical for the tethering of extrachromosomal DNA to mitotic chromosomes in cancer cells.

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Reposted by Aditi Gnanasekar

King L Hung @kinglhung.bsky.social · 14/11/2025

Honored to receive the Science & SciLifeLab Prize! Very grateful to all my mentors and colleagues. I wrote an article in @science.org about my PhD thesis research on extrachromosomal DNA at Stanford @stanfordmedicine.bsky.social. www.science.org/doi/10.1126/...

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Reposted by Aditi Gnanasekar

Scripps Research @scripps.edu · 13/08/2025

Congrats to Benjamin Cravatt on receiving the 2025 Tetrahedron Prize for Creativity in Bioorganic & Medicinal Chemistry from @elsevierconnect.bsky.social, honoring his pioneering activity-based protein profiling (ABPP) to study and target disease-relevant proteins.

magazine.scripps.edu

Benjamin Cravatt awarded Tetrahedron Prize for Creativity - Scripps Research Magazine

Benjamin Cravatt, the Norton B. Gilula Chair in Biology and Chemistry at Scripps Research, will receive the 2025 Tetrahedron Prize for Creativity in Bioorganic and Medicinal Chemistry. Established in ...

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Aditi Gnanasekar @agnanam.bsky.social · 12/08/2025

Beautiful study by Vishnu who found elevated levels of oxidative damage in patients with ME/CFS, an understudied disease that lacks definitive diagnostic tests and effective treatments despite its enormous prevalence and incredible severity. Read more here www.pnas.org/doi/10.1073/...

pnas.org

Oxidative stress is a shared characteristic of ME/CFS and Long COVID | PNAS

Over 65 million individuals worldwide are estimated to have Long COVID (LC), a complex multisystemic condition marked by fatigue, post-exertional m...

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Lorenzo de la Rica @ldelarica.bsky.social · 27/04/2025

What a masterful #AACR25 Plenary talk by Paul Mischel @stanfordmedicine.bsky.social, #CancerGrandChallenges team eDyNAmiC lead) on the role of extrachromosomal DNAs (#ecDNAs) in cancer. As a funder, it’s incredible to see what we've enabled — in front of 21,000 cancer research leaders!

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bioRxivpreprint @biorxivpreprint.bsky.social · 03/04/2025

EcDNA-borne PVT1 fusion stabilizes oncogenic mRNAs www.biorxiv.org/content/10.1101/202…

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Reposted by Aditi Gnanasekar

Politico @politico.com · 27/03/2025

Exclusive: An ambitious California Democrat wants the state to create its own National Institutes of Health and vaccine program, saying California can’t rely on the Trump administration to support research and science.

politico.com

Fearing Trump cuts, California Democrat proposes creating state’s own NIH

The ambitious state lawmaker argues moves by Elon Musk and Robert F. Kennedy Jr. show the Golden State must “step up” as a global leader.

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Eric Topol @erictopol.bsky.social · 01/03/2025

3 points of progress vs pancreatic cancer! 1. Neoantigen vaccines www.nature.com/articles/s41... 2. KRAS drugs www.wsj.com/health/healt... 3. Early diagnosis www.science.org/doi/10.1126/...

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AndreaVentura @andreaventura.bsky.social · 18/12/2024

🧪1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇 www.nature.com/articles/s41...

nature.com

Engineered extrachromosomal oncogene amplifications promote tumorigenesis - Nature

Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...

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King L Hung @kinglhung.bsky.social · 18/11/2024

Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/ www.nature.com/articles/s41...

nature.com

Coordinated inheritance of extrachromosomal DNAs in cancer cells - Nature

Cooperative species of extrachromosomal DNAs are coordinately inherited through mitotic co-segregation.

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Eric Topol @erictopol.bsky.social · 10/11/2024

High-resolution of cancer. Unprecedented. A brief review of what we've just learned from 17 new papers in the latest edition of Ground Truths. It's free, open-access. erictopol.substack.com/p/cancer-sci...

erictopol.substack.com

Cancer Science in On a Tear

New insights on evolution, resistance, and therapies

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Magdalena Skipper @magdalenaskipper.bsky.social · 10/11/2024

This week in Nature - four papers probe the relationship between ecDNA & cancer * an atlas of ecDNA in cancer * ecDNA inheritance in cancer during cell division * a potential way to leverage ecDNA for treatment * ecDNA role in tumour evolution & therapy resistance www.nature.com/nature/volum...

nature.com

Nature - Outside influence

The cover shows circular extrachromosomal DNA (ecDNA) sitting next to a chromosome. ecDNA has a significant effect on the outcome of cancer treatment —...

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