iiinova — where your digital self keeps evolving

Ivy Tsz-Lo Wong, PhD

@ivywtl.bsky.social

Postdoctoral Scholar at Stanford University, Department of Pathology and Sarafan ChEM-H | Molecular and cancer biologist | Studying ecDNA in human cancers at Mischel lab

Posts Replies Media

Reposted by Ivy Tsz-Lo Wong, PhD

Graham Erwin @grahamerwin.bsky.social · 18/08/2026

The Baylor College of Medicine Conference on Structural Variants and DNA Repeats is back, and this year it has a new home! Join us in person in Houston November 19th–20th. Or join online. Virtual registration is FREE! ErwinLab.org/svar-conference

168

Reposted by Ivy Tsz-Lo Wong, PhD

Cancer Grand Challenges @cancergrand.bsky.social · 16/04/2026

Team eDyNAmiC is proposing a more holistic perspective by integrating extrachromosomal DNA (ecDNA) into the broader Hallmarks of Cancer framework. Read why in a new review published today in @cellpress.bsky.social www.cell.com/cell/fulltex...

cell.com

A recipe for chaos: Extrachromosomal DNA and the hallmarks of cancer

When oncogenic genetic elements untether from chromosomes and no longer follow Mendelian inheritance, genomic chaos and accelerated evolution ensues. In this review, Wong et al. discuss the mechanisti...

012

Ivy Tsz-Lo Wong, PhD @ivywtl.bsky.social · 16/04/2026

The Hallmarks of Cancer series by Hanahan and Weinberg have been the guiding principles in how I come to understand and study cancer as a scientist. This year is the 25th anniversary of HoC since its first publication in 2020..!

100

Ivy Tsz-Lo Wong, PhD @ivywtl.bsky.social · 05/02/2026

We further laid out a roadmap to accelerate drug target discovery (esp. chemical proteomics approaches) and clinical deployment to actualize ecDNA-directed therapy. We hope this could be helpful for people who are interested in exploring the therapeutic space of ecDNA-driven cancers. [2/2]

100

Ivy Tsz-Lo Wong, PhD @ivywtl.bsky.social · 05/02/2026

I'm thrilled to start my first bluesky post by highlighting the review paper Hyerim and I have been working really hard together - published just yesterday on Nature Reviews Drug Discovery. In this review, we outlined the latest ecDNA biology and corresponding therapeutic vulnerabilities [1/2] -

085