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Adam Hockley

@adhockley.bsky.social
67 followers 120 following 14 posts

Research Scientist in the Hamm Lab at the Nathan Kline Institute. My general interests cover auditory neuroscience, neural circuits, predictive coding, schizophrenia, tinnitus and cycling

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Reposted by Adam Hockley
Fabian Schneider @fabianschneider.bsky.social · 12/01/2026
Same sound, different perception: Do expectations change what you hear?👂🧠 We paired faces w topics and played the same ambiguous speech w different faces. The brain sharpened sensory signals toward predictions and showed gated prediction errors at higher levels. Read @plosbiology.org. Blueprint👇
dx.plos.org
Sensory sharpening and semantic prediction errors unify competing models of predictive processing in human speech comprehension
Speech comprehension relies on predictive mechanisms, but models disagree on whether the brain prioritizes expected or unexpected information. This study shows that sharpening of sensory representatio...
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Reposted by Adam Hockley
PLOS Biology @plosbiology.org · 14/01/2026
In the #cochlear nucleus, the size of inputs from #auditory #nerve fibers is variable. This study shows that variable input strength enhances rate coding at the expense of temporal precision, potentially creating diverse information streams for #sensory encoding @plosbiology.org 🧪 plos.io/3YCaLMU
Synaptic input variation increases firing rates at the expense of temporal precision. Left: GBC identification based on morphological features. Top: Low-magnification image of cochlear nucleus parasagittal slice containing a biocytin-filled GBC near the AN root (arrow). AVCN, anteroventral cochlear nucleus; PVCN, posteroventral cochlear nucleus; DCN, dorsal cochlear nucleus; AN, auditory nerve. Bottom: High-magnification image of the same GBC, displaying its characteristic round soma and short dendrites. Right: Schematic of the experimental paradigm: Acoustic stimuli (top) were processed by an auditory nerve model to generate spike trains for 10 AN fibers (ANF1-10). These spike trains were convolved with the EPSC waveform to generate conductance templates with varying synaptic strengths, ranging from “no variation” (blue) to “high variation” (orange), and injected into GBCs.
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Adam Hockley @adhockley.bsky.social · 09/01/2026
It's been great working with the @your.neighborhoodscientist.org team on this article! YNS aim to improve public understanding of science, science policy and scientists, by fostering community conversations. If you can, help them out with a donation! neighborhoodscientist.org/donate.html
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Reposted by Adam Hockley
Alexandra Petri @petridishes.bsky.social · 08/01/2026
if you want a long read that involves udders, a hot air balloon, and some extremely dubious data on egg prices, the story I’ve been working on for the last few months where I tried to single-handedly take on every government function myself is now online! www.theatlantic.com/magazine/202...
theatlantic.com
I Tried to Be the Government. It Did Not Go Well.
My five-month quest to monitor the weather, track inflation, and inspect milk for harmful microorganisms
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Jordan Hamm @jordanhamm.bsky.social · 08/01/2026
Excited to share our preprint! We show that primary visual cortex is modulated by global predictability. This effect depended on higher level brain region (area ACa), and better explained classic oddball paradigms better than “local” context effects (i.e., recent stimulus history). 1/3
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Joel I Berger @joelberger.bsky.social · 11/12/2025
Our paper is out now in J Neuroscience (currently in "accepted paper" form). We directly record single neurons in human insula, as well as primary auditory cortex, while participants passively listen to simple sounds. @sfnjournals.bsky.social www.jneurosci.org/content/earl... (1/5) 🧠📈🧵👇
jneurosci.org
The human insula reimagined: Single neurons respond to simple sounds during passive listening
The insula is critical for integrating sensory information from the body with that arising from the environment. Although previous studies suggested that posterior insula is sensitive to sounds, these...
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Adam Hockley @adhockley.bsky.social · 07/01/2026
Our new preprint is out! We show that deviance detection in auditory cortex conveys the theorised comparison of internal prediction to sensory input. Our data confirm this key assumtion that links theoretical models of sensory processing to experimental data. www.biorxiv.org/content/10.6...
biorxiv.org
Cortical deviance detection represents a canonical difference signal
Context modulates neural processing of sensory stimuli. Neural responses are suppressed to stimuli that are typical in their context and augmented to stimuli that deviate from their context. The latte...
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Audrey Drotos, PhD 🧠 🔬 @audreydrotos.bsky.social · 29/12/2025
My nonprofit @your.neighborhoodscientist.org is looking for scientists to share their stories with us in 2026! Is your New Year's resolution to communicate & interface more with your community as a scientist? Send us a pitch at audrey@neighborhoodscientist.org ! 🧪🧠🇺🇸
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Reposted by Adam Hockley
Mark D Humphries @markdhumphries.bsky.social · 30/12/2025
Just published my review of neuroscience in 2025, on The Spike. The 10th of these, would you believe? This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more Enjoy! medium.com/the-spike/20...
medium.com
2025: A Review of the Year in Neuroscience
Enlightening the brain
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Reposted by Adam Hockley
Qingqing Zhang @qqzhang.bsky.social · 22/09/2025
Does predictive coding work in SPACE or in TIME? Most neuroscientists assume TIME, i.e. neurons predict their future sensory inputs. We show that in visual cortex predictive coding actually works across SPACE, just like the original Rao+Ballard theory #neuroscience www.biorxiv.org/cgi/content/...
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Sam Schwarzkopf @sampendu.bsky.social · 02/10/2025
Long time in the making: our preprint of survey study on the diversity with how people seem to experience #mentalimagery. Suggests #aphantasia should be redefined as absence of depictive thought, not merely "not seeing". Some more take home msg: #psychskysci #neuroscience doi.org/10.1101/2025...
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Adam Hockley @adhockley.bsky.social · 10/10/2025
"Silent neurons individually carry little information... however, we observed that combining the silence of one neuron with temporal firing patterns or firing rate of the other neuron in a pair led to comparable synergy to combining the spiking activity of both neurons" doi.org/10.1002/advs...
doi.org
Neural Response Reliability as a Marker of the Transition of Neural Codes along Auditory Pathways
Decoding sound from neural activity in mice reveals a striking shift in how the brain encodes sound: from precise but redundant timing codes in early auditory areas to efficient, synergistic rate-bas....
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Reposted by Adam Hockley
PLOS Biology @plosbiology.org · 08/09/2025
Early unilateral auditory deprivation can cause lasting spatial #hearing deficits. @anbuhlk.bsky.social &co show that unilateral #HearingLoss during development (but not adult-onset) impairs binaural #brainstem function & spatial hearing acuity in guinea pigs @plosbiology.org 🧪 plos.io/46njw1P
Transient conductive hearing loss (CHL) during development. Top left: Schematic of coronal section of a guinea pig skull (traced from high-resolution CT scan). A custom-made earplug is fitted within the cartilaginous ear canal (dotted line), a safe distance from the tympanic membrane (TM). Inset: View of external ear with earplug in place. Top right: Earplugs provide 10–35 dB SPL sound attenuation for frequencies >1 kHz. Bottom: Experimental timeline. Litters of newborn guinea pigs were divided into two groups at hearing onset (birth): pups that were raised with no earplug (littermate Controls) and pups that were raised with a unilateral earplug (“Early CHL”). Earplugs remained in place until adulthood (P56). Following earplug removal, animals were tested on: auditory brainstem responses (ABRs) including the binaural interaction component (BIC), a startle-based spatial discrimination task, and in vivo single-unit recordings in the auditory midbrain (i.e., inferior colliculus, IC). All testing was done within 1 week of earplug removal.
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Ben Hayden @benhayden.bsky.social · 04/09/2025
Sad day for peope who still believe brain areas are the primary organizational units of function in the brain. www.nature.com/articles/s41...
nature.com
A brain-wide map of neural activity during complex behaviour - Nature
The International Brain Laboratory presents a brain-wide electrophysiological map obtained from pooling data from 12 laboratories that performed the same standardized perceptual decision-making task i...
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samuel mehr @mehr.nz · 09/08/2025
music lessons don't make kids smarter, but many people have assumed that music lessons would have near-transfer effects, e.g. improving aspects of auditory perception big new study led by Andrew Oxenham says "nope". music lessons make kids better at music & that's good enough reason to do 'em !
nature.com
Large-scale multi-site study shows no association between musical training and early auditory neural sound encoding - Nature Communications
Widely cited studies have claimed that musical training is associated with enhanced neural encoding for sound at early stages of the auditory system. Results from this large-scale multisite study do n...
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Jordan Hamm @jordanhamm.bsky.social · 05/08/2025
First lab outing since the move to NYC.... feeling so lucky to have such a talented and fun group! with Lital Rachmany, @adhockley.bsky.social, me, Molly Hornick, Fumiyasu Imai, and @cgalli-io.bsky.social
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Claudia Clopath Lab @clopathlab.bsky.social · 02/07/2025
Are predictions computed hierarchically, or can they be computed locally? Check out our paper! Congrats, Toshitake Asabuki and @colleenjg.bsky.social ! www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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UCL Faculty of Brain Sciences @uclbrainscience.bsky.social · 29/06/2025
#ICYMI Areas of the brain that help a person differentiate between what is real and what is imaginary have been uncovered in a new study led by @uclpals.bsky.social‬ and @uclqsion.bsky.social‬ researchers.
buff.ly
Brain mechanisms that distinguish imagination from reality discovered
Areas of the brain that help a person differentiate between what is real and what is imaginary have been uncovered in a new study led by UCL researchers.
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Reposted by Adam Hockley
Poirazi Lab @dendritesgr.bsky.social · 03/07/2025
📣New study in Neuron, featuring modeling insights: "Cell-Specific Dendritic Integration in Cortical GABAergic Interneurons"! It reveals PV & SST interneurons compute differently. This highlights how distinct dendrites enable specialized brain computations! www.sciencedirect.com/science/arti...
sciencedirect.com
Distinct dendritic integration strategies control dynamics of inhibition in the neocortex
Dendrites critically influence single-neuron computations, but their role in neocortical GABAergic interneurons (INs) remains poorly understood. We fo…
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Adam Hockley @adhockley.bsky.social · 03/07/2025
Here's our new #preprint on triggering of cortical Up states by deviants in the auditory oddball paradigm. Up states are reliably evoked by deviants under anesthesia, explaining the long-latency deviant responses seen in previous studies. www.biorxiv.org/content/10.1...
biorxiv.org
Auditory deviants evoke cortical state changes under anesthesia
Context-dependent sensory processing within the predictive coding framework relies on detecting mismatches between incoming stimuli and internal predictive models. Sensory deviants elicit prediction e...
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Julie Fabre @juliefabre.bsky.social · 13/06/2025
🚀 We are excited to share that bombcell is now available in Python! 🐍 Automatically sort your units into good/MUA/noise/non-somatic using quality metrics and interpretable & adjustable classification thresholds. pip install and play around with our toy dataset: 🔗 github.com/Julie-Fabre/...
github.com
GitHub - Julie-Fabre/bombcell: Automated quality control, curation and neuron classification of spike-sorted electrophysiology data
Automated quality control, curation and neuron classification of spike-sorted electrophysiology data - Julie-Fabre/bombcell
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Adam Hockley @adhockley.bsky.social · 13/06/2025
A great catch up today in the Jono's @ Nottingham 🏰
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Adam Hockley @adhockley.bsky.social · 03/06/2025
My final day at the @incyl.bsky.social today! I've met so many amazing people here and I'll miss everyone so much 🩵 next step is back to UK for a month of hiking, cycling and camping, then heading to @jordanhamm.bsky.social lab soon! 🗽
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Reposted by Adam Hockley
Hayley Bounds @hayleybounds.bsky.social · 15/05/2025
Excited to share my PhD paper! In it, we use targeted 2-photon optogenetic stimulation to determine how V1 activity is read-out in a detection task. We found that network influence, not visual coding properties, predicted the impact of ensembles on behavior - contradicting our expectations (1/5).
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Alejandro Blenkmann @ablenkmann.bsky.social · 05/05/2025
1/ Excited to share our new paper just out in Scientific Reports! 🧠🎧 Using intracranial EEG, we show how the human brain automatically encodes patterns in random sounds– without attention or explicit awareness. 🔗 doi.org/10.1038/s415...
doi.org
Direct brain recordings reveal implicit encoding of structure in random auditory streams - Scientific Reports
Scientific Reports - Direct brain recordings reveal implicit encoding of structure in random auditory streams
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Adam Hockley @adhockley.bsky.social · 05/05/2025
Exciting work showing an objective test for tinnitus! www.science.org/doi/10.1126/...
science.org
Objective autonomic signatures of tinnitus and sound sensitivity disorders
Emotionally evocative sounds elicit pupil dilations and facial movements that index the severity of common hearing disorders.
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Reposted by Adam Hockley
Jérôme Lecoq @jeromelecoq.bsky.social · 15/04/2025
How does our brain predict the future? Our review of predictive processing + research program is now on arXiv arxiv.org/abs/2504.09614 50+ neuroscientists distributed across the world worked together to create this unique community project.
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Eliezyer de Oliveira @eliezyer.bsky.social · 18/04/2025
Does your research involve comparing experimental conditions? Then our latest publication is for you: We developed generalized contrastive PCA (gcPCA), a tool for comparing high-dimensional datasets. 🧠📊 doi.org/10.1371/journal.pcbi.1012747 This tool was born out of necessity, here is the story. 🧵 1/
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Brice Bathellier @bathellierlab.bsky.social · 21/04/2025
New preprint with systematic measurements of feature tuning in the mouse auditory system made with robust representation similarity analysis. Validates a range of earlier observations and generalizes beyond that. www.biorxiv.org/content/10.1...
biorxiv.org
Feature-dependent decorrelation of sound representations across the auditory pathway
Early studies on orientation selectivity in the visual cortex have suggested that sensory systems generate new feature representations at specific processing stages. Many observations challenge this v...
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Adam Hockley @adhockley.bsky.social · 22/04/2025
Thrilled to present our paper out today in @cp-cellreports.bsky.social We asked how prediction errors are generated in the auditory cortex during the oddball paradigm. When blocking top-down prediction signals from mPFC, we saw reduced prediction errors in A1. doi.org/10.1016/j.ce...
cell.com
Top-down prediction signals from the medial prefrontal cortex govern auditory cortex prediction errors
Hockley et al. investigate how the brain processes auditory stimuli based on predictability. The results show that predictions in the medial prefrontal cortex govern sensory information flow and modul...
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Kelsey Anbuhl @anbuhlk.bsky.social · 04/04/2025
Excited to share my latest work just out in @pnas.org! This NIH MOSAIC K99-funded project identifies a top-down cortical circuit—from cingulate to auditory cortex—that supports auditory perceptual performance in challenging listening conditions: www.pnas.org/doi/10.1073/...
pnas.org
The cingulate cortex facilitates auditory perception under challenging listening conditions | PNAS
We often exert greater cognitive resources (i.e., listening effort) to understand speech under challenging acoustic conditions. This mechanism can ...
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Adam Hockley @adhockley.bsky.social · 14/04/2025
Some really nice work on autonomic prediction errors in cortical circuits
nature.com
Ex vivo cortical circuits learn to predict and spontaneously replay temporal patterns - Nature Communications
Because the ability to tell time and make predictions anchor much of cognition, it has been proposed that they are computational primitives. Here, authors directly demonstrated that this is the case b...
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