The protein landscapes that underlie multicellular self-organization remain challenging to characterize across intact embryos at high spatial resolution. Here, the authors present 3D-4i, a high-throug...

Nature Biotechnology - A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.

A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.

A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.

A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.

Achieving uniform, isotropic sub-micrometer-resolution imaging at high speed across large, cleared tissues has been a major challenge for light-sheet microscopy. To address this, we developed a cost-e...

A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.

Modern biology increasingly depends on data-driven discovery, requiring scalable and affordable high-content 3D imaging across molecular to organ scales. Although tissue clearing, expansion microscopy...

We are pleased to announce the First Göttingen Cognition Forum: Curiosity & Interaction The conference brings together researchers from neuroscience, psychology, behavioral biology, computational scie...

In light-sheet fluorescence microscopy (LSFM), the axial resolution is governed by the illumination beam profile, motivating the development of advanced beam-shaping techniques to enhance imaging perf...

Light sheet microscopy is the ideal technique for multiscale imaging of large and cleared tissues, and it is desirable to achieve the highest possible isotropic resolution across the entire sample. Ho...