iiinova — where your digital self keeps evolving

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Suzanne C. Jansen @suzannejansen.bsky.social · 19/09/2026

Excited to share our latest preprint! Oftentimes, interesting stories start as a puzzling observation in the lab, and that was definitely the case here. We combined kinetic analysis, mass spectrometry, and computational modeling to solve this mystery! Grateful for the collaboration!

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Roelfes Group @roelfesgroup.bsky.social · 16/07/2026

Is was our absolute pleasure to help organise the @eurobic18.bsky.social together with Sylvestre Bonnet @unileiden.bsky.social. Special thanks to @wesleybrowne.bsky.social and everyone from @stratinghinst.bsky.social @rug.nl who contributed to a very successful and stimulating week at #EuroBIC18!

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Bratislav Dačević @hemadzer.bsky.social · 16/07/2026

A fantastic week at @eurobic18.bsky.social in Groningen! It was a great pleasure to present my latest research and also to help behind the scenes as part of the conference support team. This was also a very good opportunity to reconnect with friends, collaborators, and colleagues.

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MüllerLab @mueller-lab.bsky.social · 14/07/2026

Happy and honored to present our work on metal-modified nucleic acids in a plenary lecture at @eurobic18.bsky.social in wonderful Groningen. A big thank you to @roelfesgroup.bsky.social and @sylvestrebonnet.bsky.social for organizing this great conference! 🧬

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EuroBIC 18 Conference @eurobic18.bsky.social · 12/07/2026

Welcome to EuroBIC 18! We wish everyone an inspiring week of science, stimulating discussions, and new connections here in Groningen. 🇳🇱🧪

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Marcel Swart @marcelswart.bsky.social · 06/07/2026

Next week: @eurobic18.bsky.social Groningen 🇳🇱, July 12-17 eurobic18.eu/page/plenary...

eurobic18.eu

EuroBIC 18

EuroBIC 18th Conference Website

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Bratislav Dačević @hemadzer.bsky.social · 06/07/2026

See you at #EuroBIC18 next week in Groningen! I’ll be presenting my latest research on Wednesday morning. Looking forward to a great week of bioinorganic chemistry and catching up with colleagues!

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EuroBIC 18 Conference @eurobic18.bsky.social · 06/07/2026

Welcome to the official BS page of the 18th European Biological Inorganic Chemistry Conference (EuroBIC 18), taking place in Groningen, the Netherlands 🇳🇱, from July 12–16, 2026. See you next week! Visit eurobic18.eu for the full programme, schedule, travel information, and other practical details.

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Roelfes Group @roelfesgroup.bsky.social · 30/06/2026

Strong presence of our current and former group members at GCEBio (Genetic Code Expansion in Biotechnology) 2026 in Amsterdam. We’d like to spotlight our postdoc @valeriapoggetti.bsky.social and her work on nucleophilic catalysis in thiophenol-based artificial enzymes. Brava Valeria!

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Bart Brouwer @brouwerb.bsky.social · 30/04/2026

Proud to share that another one of my main PhD projects has now been published! The manuscript entitled "Exploring PadR Proteins for Artificial Enzyme Design" is now available online in #ChemBioChem. Keep readin below or check out the full paper here: doi.org/10.1002/cbic... Thread ⬇️

doi.org

Exploring PadR Proteins for Artificial Enzyme Design

Inspired by the Lactococcal multidrug resistance regulator (LmrR) protein scaffold, new phenolic acid decarboxylase transcriptional regulator (PadR) proteins were identified and evaluated as scaffold...

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Roelfes Group @roelfesgroup.bsky.social · 11/03/2026

⏰ Deadline approaching! The 15 March deadline for submitting abstracts for oral communications to EuroBIC18 is fast approaching! We are excited to announce an outstanding lineup of plenary and keynote speakers – check them out on our website: 🌐 eurobic18.eu

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Bratislav Dačević @hemadzer.bsky.social · 09/03/2026

Last week I had the pleasure of attending the Netherlands’ Catalysis and Chemistry Conference (NCCC), where I presented my research on photobiocatalytic atroposelective biaryl coupling. I’m excited to share that I was awarded the Royal Society of Chemistry @rsc.org EES Catalysis Best Talk Prize!

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ETOC Symposium @etoc-symposium.bsky.social · 04/02/2026

📣 Thrilled to announce our incredible speaker lineup for the 2026 edition of #ETOC Online Symposium on April 29-30th.🗓️ Join us by registering today and to stay up-to-date! : tinyurl.com/ETOC2026-reg... (1/3)

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Roelfes Group @roelfesgroup.bsky.social · 12/12/2025

Season’s greetings from the Roelfes and Mayer groups! 🎉🎄 Warm wishes to our colleagues, collaborators, and friends across the community for a joyful holiday season and an inspiring New Year ahead. ✨🧪

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Roelfes Group @roelfesgroup.bsky.social · 02/12/2025

Our postdoc Valeria Poggetti @valeriapoggetti.bsky.social presented her work on Nucleophilic Catalysis in Thiophenol-Based Designer Enzymes at #NWOChains @stratinghinst.bsky.social @rug.nl

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Fabrizio Casilli @fabricas.bsky.social · 11/11/2025

Last week I have defended my PhD in the beautiful Aula of the @rug.nl with a thesis entitled "Mapping the Sequence Landscape of an Artificial Enzyme". Such a huge diploma is proportionate to the immensely beautiful experience behind a PhD in the @roelfesgroup.bsky.social. Thank you very much to all!

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Felix Kaspar @chemzymes.bsky.social · 15/10/2025

I am looking for a PhD student interested in enzymes! For the full annoucement: www.chemzymes.com

Upper half of a PhD position accountment in the field of biochemistry.

Lower half of a PhD position accountment in the field of biochemistry.

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Fabrizio Casilli @fabricas.bsky.social · 08/08/2025

📢📢 New paper out! AI and networks can be used to predict distal mutations in proteins, even in artificial enzymes! Check out the article here ----‐> doi.org/10.1016/j.ij... Thread 1/5 🧵

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Clemens @mayerlab.bsky.social · 17/07/2025

With #PFAS and other organofluorides wreaking havoc, we set out to engineer natural defluorinases for man-made organofluorides. All credit goes to the amazing @suzannejansen.bsky.social, who has outdone herself in this project! (1/5) www.biorxiv.org/content/10.1...

biorxiv.org

Engineering fluoroacetate dehalogenase by growth-based selections to degrade non-natural organofluorides

The widespread use of organofluorides in modern society has inadvertently led to the bioaccumulation of harmful pollutants, most prominently per- and polyfluorinated alkyl substances (PFAS). In princi...

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Roelfes Group @roelfesgroup.bsky.social · 01/07/2025

Our postdoc @francdefel.bsky.social just gave a fantastic talk on gold-based artificial metalloenzymes for asymmetric catalysis. #Biotrans2025 @stratinghinst.bsky.social @rug.nl

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Roelfes Group @roelfesgroup.bsky.social · 01/07/2025

#Biotrans2025 Gerard just gave an overview on recent advances in non-canonical amino acids application for novel artificial (metallo)enzymes from our group.

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Roelfes Group @roelfesgroup.bsky.social · 27/06/2025

#RepArtZymes pre-conference in Basel also brought together some of our old and current group members. @zhizhou1619.bsky.social @reubenlg.bsky.social

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Roelfes Group @roelfesgroup.bsky.social · 26/06/2025

Our group members are attending #RepArtZymes Biotrans 2025 pre-conference. Gerard just presented our work on Artificial Metalloenzymes Featuring Thiol-Based Amino Acids. Compliments to the organisers #WardGroup for the fantastic program and a great get-together of the key players in our field.

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Franco Della Felice @francdefel.bsky.social · 26/06/2025

Great experience at the Green Chemistry & Engineering Conference! Amazing time around a neat program. Extremely grateful for giving me the chance to share my work in an environment that pushes towards sustainable research #GreenChemistry #MSCA @acsgci.bsky.social @roelfesgroup.bsky.social

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Roelfes Group @roelfesgroup.bsky.social · 12/05/2025

📢📢📢 PhD Opportunity! Join our research group at RUG! We're seeking a motivated PhD student for a project on biocatalytic cascade processes combining natural and designer enzymes, supported by machine learning. Click below to learn more — and feel free to share! sites.google.com/rug.nl/roelf...

sites.google.com

Roelfes group - Open Positions

PhD position on Hybrid biocatalytic cascades aided by Machine learning (1.0 FTE)

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Bart Brouwer @brouwerb.bsky.social · 23/04/2025

Very proud to share that one of my main PhD projects has been published in @chemicalscience.rsc.org, and that it has been selected as a #ChemSciPicks of the week paper! Keep reading below for more details, or check out the full paper for free online: doi.org/10.1039/D5SC... Thread ⬇️

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Chemical Science @chemicalscience.rsc.org · 23/04/2025

Check out this week’s #ChemSciPicks from Gerard Roelfes (@roelfesgroup.bsky.social, @stratinghinst.bsky.social) et al.! ‘Genetically Encoded 3-Aminotyrosine as Catalytic Residue in a Designer Friedel-Crafts Alkylase’ Read it here for free: doi.org/10.1039/D5SC... #ChemSky 🧪

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Franco Della Felice @francdefel.bsky.social · 27/03/2025

Had an amazing week at #ACSSpring2025! It was an intense but incredibly rewarding experience with top speakers and insightful discussions. I'm grateful for the opportunity to present my research in the biocatalysis session - awesome interaction! #MSCA @roelfesgroup.bsky.social

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Bratislav Dačević @hemadzer.bsky.social · 22/03/2025

Had an amazing week at the MetRaZymes @metrazymes.bsky.social Winter School in Hirschegg, Austria! It was a pleasure to learn, share, and connect with fellow researchers in our doctoral network. We organized and attended insightful lectures and workshops on ⬇️🧵

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Diethard Mattanovich @dmattanovich.bsky.social · 10/03/2025

We are announcing about 30 PhD positions in the @fwf-at.bsky.social Cluster of Excellence Circular Bioengineering www.circularbioengineering.at/jobs 9 projects open in Progamme 2 (Self-Sustainable Microbial Systems) in 4 Austrian Universities

A spaceship as an allegory to an independent, self recycling system.

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Roelfes Group @roelfesgroup.bsky.social · 12/03/2025

Huge congratulations to our former PhD student Reuben @reubenlg.bsky.social on winning the KNCV-DCS Thesis Award from the Dutch Catalysis Society for his outstanding PhD research in our group! A well-deserved recognition of his hard work and dedication. 🎉

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Roelfes Group @roelfesgroup.bsky.social · 11/03/2025

Our group members Tanja and Franco @francdefel.bsky.social presented their exciting research at NCCC this week. Franco talked about his work on asymmetric catalysis in gold-based artificial metalloenzymes.

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Roelfes Group @roelfesgroup.bsky.social · 14/02/2025

Our latest publication is out in @angewandtechemie.bsky.social! We generated and engineered a novel artificial metalloenzyme for the enantioselective synthesis of a panel of γ-nitro-carbonyl compounds on a preparative scale.

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Franco Della Felice @francdefel.bsky.social · 12/02/2025

Grateful to be part of this awesome project lead by @brouwerb.bsky.social. Take a look to our preprint about unlocking iminium ion catalysis when using amino-tyrosine as a genetically encoded amino acid! 🤓 #MSCA @roelfesgroup.bsky.social

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Bart Brouwer @brouwerb.bsky.social · 11/02/2025

Check out our latest preprint, in which we demonstrate the first example of using noncanonical 3-aminotyrosine (aY) as a catalytic residue for iminium activation in a designer enzyme! Thread ⬇️

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Roelfes Group @roelfesgroup.bsky.social · 13/01/2025

Check out our latest work where we combined mutagenesis, crystallography, and computational approaches to uncover the evolutionary specialization of a promiscuous designer enzyme. Kudos to @reubenlg.bsky.social and the entire team! Find more details in the thread below:

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Roelfes Group @roelfesgroup.bsky.social · 06/01/2025

Fantastic start of 2025 for the group. Our own Lars Longwitz won the @unigroningen.bsky.social FSE Postdoc prize for 2024. This prize celebrates his excellence in research and great potential of becoming a scientific leader. Well well deserved Lars! 👏 @stratinghinst.bsky.social

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Roelfes Group @roelfesgroup.bsky.social · 23/12/2024

Season's greetings from Roelfes and Mayer groups! Wishing our colleagues, collaborators, and the entire community a joyful holiday season and a prosperous New Year ahead! 🎉🎄✨🧪

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Roelfes Group @roelfesgroup.bsky.social · 06/12/2024

We are thrilled to share our new noble-metal enzyme design approach. We used the in-vivo incorporation of a noble-metal-binding ligand for ArM design to bridge the versatility of noble metals with the catalytic power of enzymes. Thread ⬇️

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Roelfes Group @roelfesgroup.bsky.social · 05/12/2024

We are delighted to introduce our new Boron Designer Enzyme for the kinetic resolution of α-hydroxythioesters. For this activity, the noncanonical amino acid and a natural lysine residue have to work together to form a Hybrid Catalytic Dyad!

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