iiinova — where your digital self keeps evolving

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 15h

🍬 Sugar + Antibiotics = Gut Trouble? 🦠 Study in Nature tracked 9,419 meals across 173 patients and found a link: sweets at antibiotic treatment drives microbiome disruption. Mouse models confirmed sucrose fuels Enterococcus overgrowth. Source: www.nature.com/articles/s41586-026-…

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 01/09/2026

Translational science doesn’t just need newer models—it needs the comparative pathology expertise to interpret them correctly... Read the latest here: doi.org/10.1242/dmm.053172

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 14/08/2026

Robust biomedical research requires rigorous Genetic Quality Control. Learn how the MMRRC’s process validates alleles and characterizes genetic backgrounds to ensure the highest level of reproducibility in your experiments. 🔬 Watch the introductory webinar here: youtu.be/23ypdpILgok?si=h

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 08/07/2026

Dr. Stanley Gartler’s life was defined by unwavering integrity, analytical precision, and a profound commitment to scientific truth. His legacy lives on in every laboratory that values experimental reproducibility and curiosity-driven research. www.gs.washington.edu/stanley-gartl…

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 24/06/2026

A lot to look out for at BIO! From the regional pavilions (from Italy to Ohio), talks on NAM validation and function, and help with mouse model ideas (even finding the right mouse with the MMRRC!). Stop by booth 4121. convention.bio.org/landing

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 03/06/2026

All about the connection...The MMRRC has a great methbod to eliminate guesswork in experimental design via the Strain GQC Report to map genomic variations and find improved information from model selection. Read More Here: www.science.org/doi/10.1126/science…

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 26/05/2026

Allele in a day's work: A new MMRRC paper delivers a framework to optimize design and elevate reporting in mouse models. 🔬 Far from focusing on flawed models, the work is about supporting researchers and improving scientific rigor. 🔗 www.science.org/doi/10.1126/science…

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 24/04/2026

We are quite happy for Dr. Franklin on all his achievements, his mentorship, and his help with research the world over! For more info visit: cvm.missouri.edu/craig-franklin-rec…

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 21/04/2026

Who knew the YAK could hold the secret to healing the human brain? (Hint - gene is Retsat) Source: www.the-scientist.com/a-genetic-mut…

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 10/04/2026

A new Scn8a R1872W mouse model is paving the way for CRISPR-based epilepsy treatments. Source: www.jci.org/articles/view/196402

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 02/04/2026

New research explores a promising, low-toxicity transplant strategy for diabetes. Learn more: www.jci.org/articles/view/201105#SE… And to view diabetic specific models, visit: www.mmrrc.org/catalog/StrainCatalog…

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 17/03/2026

When global competitors are accelerating their investments in biomedical research, America cannot afford to fall behind...https://www.fiercebiotech.com/research/despite-delays-nih-grants-generated-250-return-366b-investment-2025-report?utm_medium=email&utm_source=nl&utm_campaign=LS-NL-FierceP

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 25/02/2026

Advances in organ and computer models are raising the prospect that some animal experiments could be eliminated. But there are still huge hurdles to overcome. Read More Here: postly.click/5vU

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 25/02/2026

The research landscape is approaching a turning point. Proposed cuts would weaken science—especially physiology—that drives medical breakthroughs. This overview sets the stage for a deeper look at what’s at stake and why this full report matters: www.physio

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 17/02/2026

Scientists, with initial mouse models findings, expand results in organoids to confirm nerve-repair treatment can trigger healing in human spinal tissue. Source: www.sciencealert.com/scientists-gre…

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 11/02/2026

🫱A new polymer delivery system may allow insulin to be absorbed through the skin and control blood sugar without injections, at least in animal studies! Source: www.nature.com/articles/s41586-025-…

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 27/01/2026

In vivo & in silico: Compounds linked to traditional medicine reduced anxiety-, depression-, and pain-related behaviors in mice. Computer modeling suggested key compounds and targets, while mouse studies showed how those predictions played out biologically: doi.org/10.100

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 18/01/2026

Turning Back Immune System Aging: A new method instructs liver to pump out specific proteins, effectively hitting the "reset" button on an aging immune system to restore youthful defense capabilities. Source: www.livescience.com/health/immun...

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 23/12/2025

📖 To celebrate the holidays, we've taken some of our strains to compose a seasonal story. Written version is below. Or spoken version here: youtu.be/xl-pHB0Y5bc . For the full "cast" see this link: postly.click/s61

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 15/12/2025

National Security Commission on Emerging Biotechnology warns U.S. science is getting outpaced: www.fiercebiotech.com/biotech/us-co…

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 01/12/2025

Scientists found that HSL not only breaks down fat but also works inside the nucleus of to keep adipose tissue healthy, explaining why people lacking HSL lose fat instead of becoming obese. scitechdaily.com/obesity-discovery-

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 18/11/2025

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 12/11/2025

The FDA has approved Kygevvi (doxecitine + doxribtimine) as the first-ever treatment for Thymidine Kinase 2 Deficiency (TK2d), offering hope to patients with this devastating mitochondrial disease. www.fda.gov/drugs/news-events-human…

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 10/11/2025

Scientists have made major progress in understanding and treating thymidine kinase 2 deficiency (TK2d), a rare genetic disorder that weakens muscles by disrupting mitochondrial DNA maintenance. postly.click/ABY

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 07/11/2025

James D. Watson, part of the team that uncovered the double-helix structure of DNA in 1953 with Francis Crick, Rosalind Franklin and Maurice Wilkins, has died at 97. His work marked a notable moment in biology. www.yahoo.com/news/articles/james-w…

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 07/11/2025

As oocytes grow, H2A.Z shifts from marking active genes to spreading across broader, silent DNA regions, working hand-in-hand with another modification to support healthy meiosis and prepare the egg’s epigenetic blueprint for early embryonic life. .nature.com/articles/s41594-025-01573-xMore Info:

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 30/10/2025

IMPC Strategic Conference ‘Insights from the Past, Shaping the Future’ Program and key information 👉 www.mousephenotype.org/news/2025-vi… Free Registration 👉https://tinyurl.com/yz7znkde

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 22/10/2025

🎉 Big congrats to Dr. Eric Green for receiving the American Society of Human Genetics Leadership Award — a standing ovation for visionary leadership in genomics! Read About it here: www.genengnews.com/topics/omics/eri…

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 20/10/2025

"Animal models provide insights that alternative approaches can’t. A heated debate about which method is better is distracting researchers from doing good science." EcKc5wILd4%3D

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 15/10/2025

MMRRC is in Boston at ASHG for the next 3 days - booth 1327! For more info: meetings.ashg.org/event/ASHG25/prog…

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 13/10/2025

What Baby KJ’s CRISPR Breakthrough Really Tells Us. Reflections on the balance between hope and realism — new therapies are exciting, but they’re not universal cures yet. Read More: www.statnews.com/2025/10/09/crispr-…

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 06/10/2025

Congratulations to Drs. Brunkow, Ramsdell, & Sakaguchi! For More information: postly.click/ECH

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 03/10/2025

“...the first step out of the maze for young men begins by reasserting to them the virtue of hard work — an often grueling but indispensable part of finding the right answers in science.” Read the essay with our gift article here: www.nytimes.com/2025/10/03/o...

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 16/09/2025

🌟 We’re proud to support the Rare Diseases Are Not Rare! Challenge—working together for faster treatments. With over 10,000 rare diseases, collaboration is key to speeding discovery and care. Learn more: www.challenge.gov/?challenge=rare-d…

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 02/09/2025

We're taking efforts to improve the information of new strains at the MMRRC, with our new Strain Quality Control. To view an example of one, visit this strain: www.mmrrc.org/catalog/sds.php?mmrrc…

mmrrc.org

MMRRC:075745-JAX

Strain Detail Sheet for C57BL/6-<i>Clptm1<sup>tm1a(KOMP)Wtsi</i></sup>/AmcrMmjax

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 17/07/2025

"To be clear, there is no replacement yet for animal research in biomedical science...it remains to be seen how faithfully these [stem cell] reprogrammed cells and organoids mimic various complex biological processes.

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 07/07/2025

Mice treated with a copper drug repaired faulty brain proteins, reversing Parkinson’s symptoms and offering new hope. Source: www.goodnewsnetwork.org/scientists-…

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 13/06/2025

What happens when lifesaving research quietly disappears? A look at critical NIH-funded projects lost to sudden budget cuts: projects.propublica.org/nih-cuts-res...

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 29/05/2025

Imagine a future where the smell of menthol could alleviate some of the worst symptoms of Alzheimer’s disease. Read More: theconversation.com/when-mice-with-…

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 20/05/2025

Scientists used gene-edited mice to test a custom therapy for a deadly infant liver disease—then saved a real child! (P.S., A MMRRC Center Director is an author on this paper!) Source: www.nejm.org/doi/full/10....

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 16/05/2025

Food for thought - "There’s no mystery to innovation and economic growth; the US must nurture its scientists or find out the hard way.

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 14/05/2025

Something different: 3D-printing inside a living mouse’s bladder using sound waves! No cuts. Just ultrasound. Curious? Find out in Science: www.science.org/doi/10.1126/...

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 07/05/2025

Scientists can now guide how cells self-organize using internal forces. Imagine using this to grow tissues in mice faster to test new therapies. Source: journals.aps.org/prl/abstract/10.1103/PhysRevLett.134.148301

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 28/04/2025

Mouse studies reveal gut viruses help antibiotics — without them, bacteria resist treatment. 🐭🦠Source: cell.com/cell-host-microbe/abstract/S1931-3128(25)00135-0

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 14/04/2025

Sweden launches PROMISE, a national initiative to integrate large-scale multi-omics data with healthcare and research. By bridging fragmented datasets and improving data access, Sweden aims to unlock the full potential of precision medicine.

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 11/04/2025

In an era where chronic illnesses are on the rise and research funding faces unprecedented challenges, the role of the MMRRC has never been more critical.

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 07/04/2025

A new webinar is coming regarding how ambient temperature affects metabolic rate, concepts of a thermoneutral zone vs thermoneutral points, and much more! physiology.org/detail/event/2025/05/06/default-calendar/understanding-body-temperature-and-energy-homeostasis-in-mice?SSO=Y&_zs=qQHNW&_zl=2imS4

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 03/04/2025

Sharing a message from the new NIH director regarding direction and aims. We hope to look at these goals to support researchers worldwide with the efforts we're known for and our desire to propel research forward.

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