iiinova — where your digital self keeps evolving

allen institute @alleninstitute.org · 6h

Happy #FluorescenceFriday! Our #CellLineOfTheWeek is PCNA - illuminating a protein involved in DNA replication and repair! Our cell lines & plasmids are openly available to accelerate scientific discovery: bit.ly/3MRCl60 📦 @coriellinstitute.bsky.social and @addgene.bsky.social

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allen institute @alleninstitute.org · 22h

#openscience in action/ Using the Allen Brain Cell Atlas, Sora Mitamur is uncovering new insights into the cellular organization and gene expression patterns of the ventral striatum through computational analysis. Explore the ABC Atlas: brain-map.org/bkp/explore/abc-atlas

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allen institute @alleninstitute.org · 01/10/2026

"For me, biology is ultimately a design challenge." Sanjay Srivatsan, principal investigator of AI BioDesign, says new accelerator will use AI to understand biological patterns and use those patterns to find solutions to biological problems. Inside Precision Medicine reports: bit.ly/4yoOmm9

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allen institute @alleninstitute.org · 30/09/2026

How does a small pool of stem cells build a brain with hundreds of cell types, each in the right place? A new Nature paper from UCSF and the Allen Institute follows the forebrain's family tree to find out. Read the paper in Nature: go.nature.com/4hzn31v

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allen institute @alleninstitute.org · 29/09/2026

"An exciting opportunity to make fundamental discoveries." Applications for the Shanahan Foundation Fellowship at the Interface of Data and Neuroscience are now open! Experience in #neuroscience is not needed. Apply by Dec. 1: bit.ly/4h762LH

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allen institute @alleninstitute.org · 29/09/2026

Applications are open for the Studio D3 Fellowship at the Allen Institute! This 3-year fellowship empowers recent PhDs with quantitative backgrounds to apply computational and theoretical approaches to biology's most complex challenges. Apply by 12/1 alleninstitute.org/studio-d3/fe...

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allen institute @alleninstitute.org · 28/09/2026

"This is the best time in the history of humanity." AI BioDesign co-director Sanjay Srivatsan (@fredhutch) on why, via @KING5Seattle: AI is letting scientists design proteins nature never made, opening new paths to cancer therapies and vaccines. bit.ly/4yXZYfR

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allen institute @alleninstitute.org · 26/09/2026

Twenty years ago, on this day in 2006, Allen Institute for Brain Science announced the completion of our inaugural project: a web-based, 3D map of gene expression in the mouse brain providing scientists with a level of data previously not available. #openscience

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allen institute @alleninstitute.org · 25/09/2026

SON is our cell line of the week! SON and its associated plasmid illuminates nuclear speckles, a real science word for proteins in the nucleus involved in gene expression. Thanks to @coriellinstitute.bsky.social and @addgene.bsky.social for helping us make our cell lines and plasmids accessible.

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allen institute @alleninstitute.org · 24/09/2026

"What else is possible, and how can we test it?" David Baker on AI BioDesign — the new $95M Allen Institute, UW & Fred Hutch effort to design proteins nature never made, with all data shared freely.

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allen institute @alleninstitute.org · 23/09/2026

Could this new brain map help fight diseases like ALS and dementia? Our scientists and collaborators have created the most detailed map yet of the mouse motor cortex, identifying 16 distinct subregions with their own patterns of connections.

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allen institute @alleninstitute.org · 22/09/2026

Meet the 2026 cohort of Next Generation Leaders. This program recognizes emerging early career researchers in bioscience and is designed to foster community, exchange of ideas, innovation, and collaboration to make a broad, transformational impact on the future of science.

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allen institute @alleninstitute.org · 22/09/2026

Nature has been inventing proteins for billions of years, but it hasn't tried everything. David Baker co-leads AI BioDesign, our new accelerator in collaboration with @uwmedicine.bsky.social and @fredhutch.org, to design molecules that could break down plastic and target cancer with precision.

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allen institute @alleninstitute.org · 22/09/2026

A big thank you to @biolaminaab.bsky.social for sponsoring our Stem Cell and Developmental Biology Early Career Symposium! Support like this is what makes it possible to bring together the next generation of researchers to share their science, build connections, and launch what comes next.

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allen institute @alleninstitute.org · 21/09/2026

About 1 in 3 people lives with a neurological or brain condition such as Alzheimers, depression, or addiction. We need to speed up our understanding of how the human brain works to accelerate progress toward new treatments and therapies. We launched the Brain Health Accelerator to do just that.

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allen institute @alleninstitute.org · 18/09/2026

Explore the tiny structures that power life inside the human cell. #OpenScienceWeek.

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allen institute @alleninstitute.org · 18/09/2026

In the lab, we're all TFAM. Our #CellLineOfTheWeek is mitochondrial transcription factor A or TFAM! 🧫✨ This cell line and plasmid illuminates mitochondrial nucleoids - clusters of DNA within the mitochondria. 📦 @coriellinstitute.bsky.social & @addgene.bsky.social #FluorescenceFriday

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allen institute @alleninstitute.org · 17/09/2026

Deep in the brain’s “blue place,” our scientists found something surprising: a tiny brain region once thought to broadcast one signal actually sends targeted messages through distinct routes, including via the longest neuron ever measured in a mouse.

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allen institute @alleninstitute.org · 17/09/2026

“That’s a big proof of concept, saying it’s possible to create this kind of human-dominated cortex in a mouse.” Executive Vice President and Director of Brain Science, @hongkuizeng.bsky.social, weighs in on a new study by researchers at Stanford.

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allen institute @alleninstitute.org · 17/09/2026

23 years ago today on Sept 16, 2003, we set out to build an open map of the brain & give it away free. Today we span cell science, immunology, neural dynamics, synthetic biology, AI biodesign, and more. For #OpenScienceWeek today, we're taking you inside the moments that made us.

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allen institute @alleninstitute.org · 17/09/2026

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allen institute @alleninstitute.org · 15/09/2026

Applications are open for the Studio D3 Fellowship at the Allen Institute! This 3-year fellowship gives early-career scientists the freedom to pursue creative, high-impact ideas in biology alongside Institute scientists and Studio D3 Affiliates. 🌟Apply by Dec. 1: bit.ly/4rgbTmD

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allen institute @alleninstitute.org · 15/09/2026

"An exciting opportunity to make fundamental discoveries." The Shanahan Foundation Fellowship at the Interface of Data and Neuroscience. Experience in #neuroscience is not needed. 🌟Apply by Dec. 1: bit.ly/4h762LH

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allen institute @alleninstitute.org · 15/09/2026

Brain tissue processing consistency is critical to quality data. Learn more about our collaborative effort, supported by the Brain Initiative Cell Atlas Network (BICAN), to develop the most comprehensive cellular map of the human brain ever.

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allen institute @alleninstitute.org · 15/09/2026

The @rajlab.bsky.social at @ucsfimaging.bsky.social built a "Google Maps for tau" to predict how Alzheimer's spreads through the brain and found that both genetics and wiring drive the disease. The model was built using gene expression data from our Human Brain Atlas. 🔗 bit.ly/3Ul65vP

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allen institute @alleninstitute.org · 15/09/2026

What happens when access to training becomes a catalyst for something bigger? For Gideon Alex, a computational neuroscience workshop run by @trendcamina.bsky.social helped open the door to a network of students, faculty, and organizers working to expand scientific opportunity across Africa.

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allen institute @alleninstitute.org · 14/09/2026

It's #OpenScienceWeek! Research can be expensive, competitive, and surprisingly hard to share. Paywalls, data barriers, and the race to publish have historically kept discoveries locked away. Open science is the movement to change that.

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allen institute @alleninstitute.org · 10/09/2026

Exciting new updates to the Seattle Alzheimer’s Disease Brain Cell Atlas (SEA-AD)! Two new data sets are now available: SEA-AD Multiregion and SEA-AD CaH.

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allen institute @alleninstitute.org · 09/09/2026

Biology by design. AI BioDesign is here: a $95M initiative with @uwmedicine.bsky.social and @fredhutchprotons.bsky.social to design molecules that don't exist in nature, from cancer-fighting proteins to plastic eating enzymes: bit.ly/4gJZuDZ Via Christine Clarridge for @axios.com

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allen institute @alleninstitute.org · 04/09/2026

Happy #FluorescenceFriday! Our #CellLineOfTheWeek is our combo fibrillarin and nucleophosmin! 🧫 Our cell lines & plasmids are openly available to accelerate scientific discovery. 📦 Distributed by @coriellinstitute.bsky.social & @addgene.bsky.social

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allen institute @alleninstitute.org · 03/09/2026

AI BioDesign brings together complementary strengths from the Allen Institute, @uwmedicine.bsky.social, and @fredhutch.org with support from Fund for Science and Technology. Together, we aim to build a shared engine that learns from biology and turns that learning into design.

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allen institute @alleninstitute.org · 03/09/2026

The longer-term ambition reaches well beyond medicine. Biological tools could one day help digest plastics, break down persistent pollutants, power biological batteries, or compute with proteins using far less energy than silicon.

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allen institute @alleninstitute.org · 03/09/2026

The first outputs will be designed to be useful to researchers and clinicians, including precision protein binders, designer gene switches, proteome editors, and the models, reagents, datasets, and benchmarks that come from each flywheel.

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allen institute @alleninstitute.org · 03/09/2026

If the last century was about learning to compute, the next may be about learning to compose. Not just with code, but with life itself. AI BioDesign will explore the larger biological design space using AI and experiments together within a flywheel. alleninstitute.org/ai-biodesign

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allen institute @alleninstitute.org · 03/09/2026

What if the next breakthrough for human health, climate resilience, or clean energy isn’t waiting to be found in nature, but is waiting to be designed? Today, we’re launching AI BioDesign, a bold endeavor to explore the uncharted design space of life.

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allen institute @alleninstitute.org · 02/09/2026

Fentanyl is 100x stronger than morphine and it's reshaping the public health landscape. Dive into the neuroscience of addiction and the human stories behind the crisis: alleninstitute.org/news/lab-notes-t…

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allen institute @alleninstitute.org · 28/08/2026

Immune profiling of blood often requires cell isolation and cryopreservation, creating logistical challenges. Our Immunology team developed a spectral flow cytometry panels for deep immune profiling of fixed whole blood samples up to 2.5 years old. 🔗 bit.ly/4qHPxKx

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allen institute @alleninstitute.org · 28/08/2026

Our #CellLineOfTheWeek is FUS (RNA binding protein)! 🧫🧬 Our stem cell lines and plasmids – fluorescently-tagged to illuminate cellular structures – are openly available to accelerate scientific discovery. 📦 Distributed by @coriellinstitute.bsky.social and @addgene.bsky.social

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allen institute @alleninstitute.org · 27/08/2026

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allen institute @alleninstitute.org · 26/08/2026

Build your own brain cell model at Inside Open Science, our first-ever open house! 🗓️ Sept. 19, 10am-4pm 📍Allen Institute, South Lake Union 🎟️ Free, but registration required: alleninstitute.org/events/2026-insi…

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allen institute @alleninstitute.org · 22/08/2026

For the first time ever, we're opening our doors to the public! On Sept. 19, you're invited to get up close to our groundbreaking open science. Explore our building, look in our labs, and have fun at our activity stations. 🎟️ Free but RSVP is required: bit.ly/3U52zpb

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allen institute @alleninstitute.org · 21/08/2026

Our #CellLineOfTheWeek is Alpha Actinin 2! 🫀🧫 Our human iPS cell lines and plasmids – fluorescently-tagged to illuminate structures – are openly available to accelerate scientific discovery. 📦 Distributed by @coriellinstitute.bsky.social and @addgene.bsky.social #OpenScience

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allen institute @alleninstitute.org · 20/08/2026

Neurons don't connect randomly. In this video by our #ElectronMicroscopy team, a blue neuron's axon forms a connection to a far neuron. Along the way, it links to some neighbors while skipping thousands. Connectomics seeks to understand what makes those connections special.

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allen institute @alleninstitute.org · 20/08/2026

Jeff Carroll is fighting for his life. While serving in the military, he was tested for the gene linked to Huntington's disease, which was already impacting his mother. It came back positive. Since then, he's dedicated his life to fighting back: alleninstitute.org/articles/bat...

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allen institute @alleninstitute.org · 20/08/2026

DYK the Allen Cell Catalog now includes disease-specific cell line collections? 🧫✨ Each collection carries mutations associated with hypertrophic cardiomyopathy - the most common genetic heart condition in the world. Full catalog: bit.ly/4u00PtG @coriellinstitute.bsky.social

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allen institute @alleninstitute.org · 20/08/2026

DYK the Allen Cell Catalog includes disease-specific cell line collections? 🧫✨ Each collection carries mutations associated with hypertrophic cardiomyopathy - the most common genetic heart condition in the world. Browse our catalog: www.allencell.org/disease-collectio…

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allen institute @alleninstitute.org · 18/08/2026

We're taking open science to whole new level with an open house! Join us at Inside Open Science for hands-on activities for all ages, exclusive tours, and facetime with the scientists making history. Registration is free but required, so nab your spot today: bit.ly/3U52zpb

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allen institute @alleninstitute.org · 16/08/2026

Let us help you with your research! All of our neural dynamics tools, software, protocols, datasets, and even hardware plans are available in one convenient place. Check it out and let us know what you'd like to see next: www.allenneuraldynamics.org/tools

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allen institute @alleninstitute.org · 14/08/2026

Our #CellLineOfTheWeek is Nucleoporin Nup153! 🧫 Our human iPS cell lines & plasmids – fluorescently-tagged to illuminate structures – are openly available to support scientific discovery. 📦 Distributed by @coriellinstitute.bsky.social & @addgene.bsky.social

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allen institute @alleninstitute.org · 14/08/2026

Even in remission, multiple myeloma survivors often have weakened immune systems. With @fredhutch.org, we tracked patients for 2 years and found their flu vaccine response lagged, but their COVID vaccine response didn't. Could a change in formulation help survivors? 🔗 bit.ly/4bNbeTg

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