Reposted by Yvann BourigaultCoralie Tesseur @coralietesseur.bsky.social · 09/07/2026So excited to share our new preprint! 🎉🤩 Check it out to discover how we investigated the role and spatiotemporal dynamics of an essential Tad nanomachine during the lifecycle of our favorite bacterial predator, B.bacteriovorus 🦠 Many thanks to everyone who made this work possible! 0166
Reposted by Yvann BourigaultGéraldine Laloux @lalouxlab.bsky.social · 09/07/2026New preprint! We show that the bacterial predator B. bacteriovorus deploys a unipolar Tad nanomachine for irreversible attachment to prey and invasion. @coralietesseur.bsky.social used CRISPRi+microfluidics to overcome barriers associated with essential systems in an obligate predatory lifestyle 🦠biorxiv.orgA polarity-controlled Tad nanomachine enables prey invasion in a bacterial predatorType IV pili are dynamic surface appendages assembled by envelope-spanning nanomachines that mediate diverse bacterial interactions, yet how these systems are adapted to predatory lifestyles remains p... 24717
Reposted by Yvann BourigaultGéraldine Laloux @lalouxlab.bsky.social · 05/03/2026#MicroSky Please RT @erc.europa.eu-funded postdoc position in my lab to identify the molecular basis of prey-predator interactions using our favorite micro-vampire Bdellovibrio exovorus as a model. Let's find what the bite is made of! 🧛 Flexible start date. Info: euraxess.ec.europa.eu/jobs/415877euraxess.ec.europa.euPostdoctoral researcher in molecular and cellular bacteriology - ERC CoG VAMPIREThe research group of Prof Géraldine Laloux at the de Duve Institute (UCLouvain) is looking for a highly motivated postdoc to elucidate the molecular factors underlying bacterial prey-predator interac... 02025
Reposted by Yvann Bourigaultdukasju.bsky.social @dukasju.bsky.social · 15/12/2025We propose immuno-centric view of secreted polymorphic toxin diversification and involvement of novel XPC systems in this process! Fantastic work of @jmartinkus.bsky.social with lab of @cascaleslab.bsky.social ! www.cell.com/current-biol...cell.comPoly-immunity arrays associated with Rhs toxins confer wide protection against competitorsMartinkus et al. show that Photorhabdus and Xenorhabdus species encode arrays of immunity genes whose protein products neutralize toxins secreted by competitors. These arrays, often linked to Xer pass... 077
Reposted by Yvann BourigaultCascales Lab @cascaleslab.bsky.social · 09/10/2025Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here: emploi.cnrs.fr/Offres/Docto...emploi.cnrs.fr Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F) 02535
Reposted by Yvann BourigaultCascales Lab @cascaleslab.bsky.social · 28/09/2025Happy to share our work on a T6SS effector with ADP ribose cyclase activity, published in JBC @asbmbjournals.bsky.social Great work of Julius Martinkus @jmartinkus.bsky.social and (always) great collaboration with @dukasju.bsky.social and @laurentterradot.bsky.social www.jbc.org/article/S002...jbc.orgWidespread deployment of the human CD38 ADP-ribosyl cyclase fold in antibacterial and anti-eukaryotic polymorphic toxinsBacterial polymorphic toxins are modular weapons that mediate inter-microbial competition and host interactions by delivering diverse cytotoxic domains through specialized secretion systems. Here, we ... 54012
Reposted by Yvann BourigaultGéraldine Laloux @lalouxlab.bsky.social · 25/09/2025📝New preprint! #MicroSky 🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy. 🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation. www.biorxiv.org/content/10.1...biorxiv.orgDynamics and interplay of gene expression and chromosome organization across a predatory lifecycleThe obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli... 16338
Reposted by Yvann BourigaultAgathe couturier @agathe-couturier.bsky.social · 17/09/2025Exclusion systems, far from slowing down plasmid spread, are in fact essential to preserve host cell viability and thereby ensure the successful dissemination of conjugative plasmids and antibiotic resistance genes. @nfrk92.bsky.social @narjournal.bsky.social academic.oup.com/nar/article/...academic.oup.comExclusion systems preserve host cell homeostasis and fitness, ensuring successful dissemination of conjugative plasmids and associated resistance genesAbstract. Plasmid conjugation is a major driver of antibiotic resistance dissemination in bacteria. In addition to genes required for transfer and maintena 13320
Reposted by Yvann BourigaultGéraldine Laloux @lalouxlab.bsky.social · 17/09/2025🚨New paper out! #MicroSky Studying obligate predators like Bdellovibrio bacteriovorus is tricky—essential genes for predation are also essential for survival. We expanded its genetic toolbox: 🧬promoters to fine-tune expression 🧬IPTG-inducible system 🧬CRISPRi for rapid knockdown bit.ly/46GUn2c 1/4academic.oup.comExpanding the genetic toolbox of the obligate predatory bacterium Bdellovibrio bacteriovorus with inducible gene expression and CRISPR interferenceInducible gene expression and CRISPR interference-mediated depletion in the predatory bacterium Bdellovibrio bacteriovorus. 25922
Reposted by Yvann BourigaultYoann Santin @ysantin.bsky.social · 11/09/2025I wrote a Preview in @cp-cellhostmicrobe.bsky.social ! A new study suggests that #curli may protect prey from bacterial predators like #Bdellovibrio. Really looking forward to seeing this model confirmed with live-cell imaging and specific reporters! www.cell.com/cell-host-mi...cell.comWhen predators meet the matrix: Natural resistance via amyloid fibersHow do bacteria protect themselves against predators? In a recent issue of Nature, Ledvina et al. reveal curli fibers as a genetically encoded defense against Bdellovibrio predation in wild E. coli st... 13311
Yvann Bourigault @yvannbglt.bsky.social · 02/09/2025Master 2 Internship-Microbiology-LBCM We are seeking a motivated Master 2 student for a research internship focusing on predatory bacteria for the biocontrol of pathogenic Vibrio species Application deadline: October 17, 2025 Contact: yvann.bourigault@univ-ubs.fr #biofilm #biocontrol #microsky 144
Reposted by Yvann BourigaultYoann Santin @ysantin.bsky.social · 25/07/2025Our review on contact-dependent #predation is now out ! We define predation processes and describe how predators kill and eat their prey 😈 Repost appreciated ❤️ 0167
Reposted by Yvann BourigaultGéraldine Laloux @lalouxlab.bsky.social · 25/07/2025#MicroSky Summer read! Predatory bacteria kill and eat other bacteria. Their deadly actions come in many flavors, often via direct physical contact between predator & prey 🧛 How do they do it? Our review 📖 @coralietesseur.bsky.social @ysantin.bsky.social www.sciencedirect.com/science/arti...sciencedirect.comStrategies and mechanisms of contact-dependent predation in bacteriaPredatory bacteria kill other bacteria to acquire nutrients. Among diverse strategies to kill and feed on prey, contact-dependent predation stands out… 25823
Reposted by Yvann BourigaultGéraldine Laloux @lalouxlab.bsky.social · 16/07/2025We wrote 2 📕 chapters with tips & tricks to identify protein-protein interactions in bacteria 🦠 1) In vivo proximity labeling with miniTurbo link.springer.com/protocol/10.... 2) An adapted polar recruitment assay feat. E. coli as a test tube link.springer.com/protocol/10..... Enjoy #MicroSky 🧪media.tenor.coma man wearing sunglasses and a white t-shirt is holding something in his hands .ALT: a man wearing sunglasses and a white t-shirt is holding something in his hands . 14015
Reposted by Yvann BourigaultCascales Lab @cascaleslab.bsky.social · 08/07/2025We have an open engineer position to work on type IX secretion (T9SS), under the supervision of @doan_thierry (collab with HP Fierobe & A. Tolonen). 1-year contract, renewable up to 3.5 years. Please apply here or forward to anyone potentially interested: emploi.cnrs.fr/Offres/CDD/U...emploi.cnrs.fr Portail Emploi CNRS - Offre d'emploi - Ingénieur d'Etude en Microbiologie (H/F) 02332