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Adam Butterworth

@aidanbutty.bsky.social
112 followers 105 following 2 posts

Professor of Molecular Epidemiology in Cambridge (UK)

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Reposted by Adam Butterworth
Mike Inouye @mikeinouye.bsky.social · 18/06/2026
Review from the lab just out in Cell Genomics: Translating genome-wide association studies at multiple scales: Drug target prioritization, cellular architectures, and organ imaging www.cell.com/cell-genomic... Co-led by fab PhD students Benedetta Felici and Siyuan Chen!
cell.com
Translating genome-wide association studies at multiple scales: Drug target prioritization, cellular architectures, and organ imaging
This review covers how the results of genome-wide association studies are now utilized at multiple scales, informing our etiological understanding at the levels of molecules, cells, and organs. It cov...
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Reposted by Adam Butterworth
Mike Inouye @mikeinouye.bsky.social · 16/04/2026
📣 New preprint: Plasma proteomics improves prediction of recurrent cardiovascular events www.medrxiv.org/content/10.6... Wonderful work with Yang Liu, @sritchie73.bsky.social, and many at @cambridge-ceu.bsky.social
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Reposted by Adam Butterworth
Stephen Burgess @stevesphd.bsky.social · 19/01/2026
New paper "Variant selection to maximize variance explained in cis-Mendelian randomization" led by @AngZhou3 and published at @HGGAdvances: pubmed.ncbi.nlm.nih.gov/41548043/, with contribution from @vkarhune.bsky.social, Haodong, Janne, Ash, and Eric. Brief thread:
pubmed.ncbi.nlm.nih.gov
Variant selection to maximize variance explained in cis-Mendelian randomization - PubMed
Optimal selection of instrumental variables (IVs) from a single gene region in cis-Mendelian randomization is challenging as variants are highly correlated due to linkage disequilibrium (LD). Using only the lead variant is convenient but may not achieve full statistical power if multiple signals exi …
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Reposted by Adam Butterworth
Mike Inouye @mikeinouye.bsky.social · 12/01/2026
ICYMI in the mad rush before the winter holidays, we published a paper looking at integrated risk prediction of cardiovascular disease and modelling both targeted and population-wide intervention in the UK. I was honestly surprised at the potential benefits 👇
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Reposted by Adam Butterworth
Helle Jørgensen @hellefjorgensen.bsky.social · 05/01/2026
Happy New Year! We are looking for a postdoc with computational expertise to join our group. Deadline for application is 13th January. www.cam.ac.uk/jobs/researc... #newjob #postdoc #vascularbiology #atherosclerosis #cellplasticitycontrol #functionalgenomics #cellheterogeneity
cam.ac.uk
Research Associate (Fixed Term)
Postdoctoral Research Associate in vascular cell plasticity and translation (single-cell and omics) (Fixed Term) We invite applicants for a postdoc position (Research Associate) for a project in Dr
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Reposted by Adam Butterworth
Charlotte Summers @charlottesummers.bsky.social · 16/12/2025
Are you an emerging clinical academic leader in respiratory medicine? Come and join @vpd-hlri.bsky.social and @royalpapworth.bsky.social and build your career! Get in touch if you’d like to discuss. www.cam.ac.uk/jobs/assista...
cam.ac.uk
Assistant/Associate Professor in Respiratory Medicine (Honorary Consultant) (Fixed Term)
An exciting opportunity has arisen for a new University of Cambridge-Royal Papworth Hospital NHS Foundation Trust Assistant/Associate Professor in Respiratory Medicine. We are seeking applications
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Reposted by Adam Butterworth
Charlotte Summers @charlottesummers.bsky.social · 16/12/2025
🚨Wanted…emerging clinical academic leader in cardiology to join @vpd-hlri.bsky.social and @royalpapworth.bsky.social. Get in touch if you’d like to discuss the role. We’d love to hear from you! www.cam.ac.uk/jobs/assista...
cam.ac.uk
Assistant/Associate Professor in Cardiology (Honorary Consultant) (Fixed Term)
An exciting opportunity has arisen for a new University of Cambridge - Royal Papworth Hospital NHS Foundation Trust Assistant/Associate Professor in Cardiology. We are seeking expressions of interest
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Reposted by Adam Butterworth
Mike Inouye @mikeinouye.bsky.social · 15/12/2025
Just published @ Eur Heart J: Combined clinical, metabolomic, and polygenic scores for cardiovascular risk prediction academic.oup.com/eurheartj/ad... tl;dr these next-gen risk factors could boost the number of CVD events prevented by +80% while keeping treatment efficiency (NNT) the same.
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Reposted by Adam Butterworth
BHF Cardiovascular Epidemiology Unit at Cambridge @cambridge-ceu.bsky.social · 15/12/2025
New paper alert! @sritchie73.bsky.social @mikeinouye.bsky.social & team found integrating genetic & metabolic blood tests with existing clinical data could enhance how doctors identify people at high risk of heart disease, leading to earlier prevention strategies Read more tinyurl.com/bp5tjck2
tinyurl.com
Combined clinical, metabolomic, and polygenic scores for cardiovascular risk prediction
AbstractBackground and Aims. Clinical biomarkers, nuclear magnetic resonance (NMR) metabolomics biomarker scores, and polygenic risk scores (PRS) have show
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