Demo showcases new AI-powered tool of potential use in quantum computers

A sunlight-activated chemical spray increases wheat yield in field trials across rainfall conditions.

Necessity is the mother of invention. Most synthetic chemistry innovations are driven by our desire to make molecules. In the first half of the 20th century, much of this work was inspired by natural ...

Despite the abundance and non-toxic nature of sodium, organosodium reagents have rarely been used in organic synthesis. Now iron-catalysed homocoupling and C(sp2)–C(sp3) cross-coupling reactions of ar...

Serving the chemical, life science, and laboratory worlds

Spring is here, and daffodils are blooming. You might have some in your garden, or you might pick some up at a florist to put in a vase at home. If you do, it’s a good idea to place them in a…

A user-friendly, shelf-stable protonated betaine reagent (BEHT triflate), derived from Mitsunobu reagents, has been developed to enable the direct displacement of alcohols using primary and secondary...

For initial hit identification in fragment-based drug design, NMR is one of the preferred methods, with the well-established ligand screening experiments T1ρ, waterLOGSY and STD. Here, we present a n...

This report outlines an approach for preparing 5-color 3D printed plastic models of molecular orbitals and electron density surfaces using a hobby-grade 3D printer. Instructions are provided for prepa...

Physics Today the flagship publication of the American Institute of Physics is the most influential and closely followed physics magazine in the world.

Tiny genetic alterations could help the bird flu virus enter cells in the upper respiratory tract, the C.D.C. said. But there is no sign that mutations are widespread in nature.

A concise synthesis of the complex diterpene azorellolide, inspired by speculations on biosynthetic cationic cascades, is presented. The approach, guided by computation, relies on the intramolecular interception of a cyclopropylcarbinyl cation by an appended carboxylate. The successful execution of this strategy was achieved through acid-catalyzed isomerization of a β-lactone in competition with a type I dyotropic rearrangement.

A novel platform for the skeletal editing of single C–C bonds via a single-carbon insertion has been developed using diazirines. This strategy involves the photogeneration of arylchlorocarbenes as carbynoid species that undergo site-selective carbene insertion into tertiary C–H bonds and a subsequent Wagner–Meerwein rearrangement promoted by a silver salt. Our skeletal editing strategy based on a formal selective carbyne C–C bond insertion has been demonstrated in six core-to-core conversions, including linear and cyclic benzylic substrates, alkanes and late-stage functionalizations.