Mitochondria are not uniform organelles. Across the brain, they exhibit profound molecular, biochemical, and functional diversity shaped by cell type,…

In this issue of Cell Chemical Biology, Chandra and colleagues demonstrate that allosteric modulation of the mitochondrial protein Miro1 can selectively reprogram mitochondrial stress signaling. Chemical targeting of a single molecular hub can produce distinct responses in disease-relevant cell types, despite acting within a broadly conserved stress pathway.

Stunault et al. show that the ketogenic diet drives extensive transcriptional reprogramming of the hippocampus through histone post-translational modifications, leading to altered short-term plasticit...

Drugs targeting mitochondrial removal show unexpected mechanisms with implications for Parkinson’s therapeutics.

Author summary Mitochondria are essential cellular organelles that perform many important roles in regulating metabolism. They are dynamic in form, function and composition which is crucial to maintai...

The Stanford Biology Preview Program (BPP) aims to support scholars through the PhD application process. The Stanford BPP offers virtual workshops to provide insight into the Stanford Biology PhD Prog...

Mitochondrial diseases lead to chronic health impairment, aggravated by infections and other environmental exposures. Here authors show, in a mouse model of polymerase gamma (Polg)-related mitochondri...

Mitochondrial Ca2+ signaling regulates branched-chain amino acid catabolism in an adolescent liver cancer.

Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms u...

ARMC1 partitions between distinct outer mitochondrial membrane complexes and the cytosol to control mitochondrial distribution.

An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.

Nature Metabolism, Published online: 08 April 2025; doi:10.1038/s42255-025-01250-9Garbincius et al. show that the mitochondrial protein TMEM65 is required to mediate NCLX-dependent mitochondrial calcium efflux, thus fine-tuning mitochondrial function and cellular homeostasis

The brain is a high energy-demanding tissue with an heterogenous cellular composition. Most of the energy consumed is used for maintenance of neuronal synaptic transmission, and neurons almost exclus…