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Xiaojun Tian

@xiaojuntian.bsky.social
94 followers 58 following 9 posts

Associate Professor at @ASU, systems biology, synthetic biology, #NSFCareer 2022 Awardee, #NIH MIRA 2021 Awardee,

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Reposted by Xiaojun Tian
Kevin Bonham @kevinbonham.com · 17/01/2026
Been hearing some horrifying chatter about dealing with the new #NIH common form and #ScienCV system, so I put together a short video with some tricks for mitigating some of those pain points. Hope it helps? 🧪 open.substack.com/pub/emptymod...
open.substack.com
Dealing with ScienCV formatting
Some tips for composing and making your new NIH biosketch not look like garbage
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Xiaojun Tian @xiaojuntian.bsky.social · 11/11/2025
Check out the ASU News story highlighting our Cell paper, Using nature’s playbook to keep engineered cells on script news.asu.edu/20251110-sci...
news.asu.edu
Using nature’s playbook to keep engineered cells on script | ASU News
When it comes to organization, even cells have their own preferred system.While genetic engineers can design and assemble sophisticated gene circuits to program cells with new functions, as these cell...
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Xiaojun Tian @xiaojuntian.bsky.social · 07/11/2025
Excited to share our new Cell paper! Liquid–liquid phase separation (LLPS) provides a powerful way to stabilize synthetic gene circuits by buffering growth-mediated dilution—adding a spatial layer of control beyond network design. Grateful to all collaborators! www.cell.com/cell/fulltex...
cell.com
Phase separation to buffer growth-mediated dilution in synthetic circuits
Phase separation stabilizes synthetic gene circuits and boosts production under dynamic growth conditions. By locally concentrating transcription factors at promoters, it protects gene expression from...
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Xiaojun Tian @xiaojuntian.bsky.social · 24/10/2025
We’re Hiring Professor (all ranks) in Synthetic Biology and AI-Enabled Biodesign at the School of Biological and Health Systems Engineering, Arizona State University.📍 Tempe, Arizona Apply here: apply.interfolio.com/175856
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Xiaojun Tian @xiaojuntian.bsky.social · 29/09/2025
Our new NAR paper is out! We turned a recombinase-based negative feedback circuit into a combined feedback+feedforward controller with one promoter flip—tunable resource decoupling achieved. Congrats to our 3rd-year PhD student 🎉 academic.oup.com/nar/article/... academic.oup.com/nar/article/...
academic.oup.com
Integrating recombinase-based feedback and feedforward control for optimal resource decoupling
Abstract. Resource competition disrupts circuit modularity by introducing unintended coupling between otherwise independent gene modules, thereby compromis
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Xiaojun Tian @xiaojuntian.bsky.social · 23/09/2025
Now this is out at @ACS Synthetic Biology pubs.acs.org/doi/full/10....
pubs.acs.org
CRISPRi-Linked Multimodule Negative Feedback Loops to Address Winner-Take-All Resource Competition
Cellular resource limitations create unintended interactions among synthetic gene circuit modules, compromising circuit modularity. This challenge is particularly pronounced in circuits with positive ...
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Xiaojun Tian @xiaojuntian.bsky.social · 18/05/2025
🆕 Another preprint! CRISPRi-linked multi-module negative feedback loops to combat winner-take-all dynamics from resource competition in gene circuits. 📄 www.biorxiv.org/content/10.1... #SynBio #CRISPRi #GeneCircuits #ResourceCompetition
biorxiv.org
CRISPRi-Linked Multi-Module Negative Feedback Loops to Address Winner-Take-All Resource Competition
Cellular resource limitations create unintended interactions among synthetic gene circuit modules, compromising circuit modularity. This challenge is particularly pronounced in circuits with positive ...
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Xiaojun Tian @xiaojuntian.bsky.social · 16/05/2025
🚨 New preprint! We present Re-NF-FF-Controller—a compact strategy that integrates negative feedback and feedforward control via a single promoter flip to optimally decouple resource competition. 📄 www.biorxiv.org/content/10.1... #SynBio #GeneCircuits #ResourceCompetition
biorxiv.org
Integrating Recombinase-Based Feedback and Feedforward Control for Optimal Resource Decoupling
Resource competition disrupts circuit modularity by introducing unintended coupling between otherwise independent gene modules, thereby compromising genetic circuit function. While various control str...
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Reposted by Xiaojun Tian
Drug Monkey @drugmonkey.bsky.social · 22/01/2025
Latest report from a highly credible source. An SRO issuing study section guidance to not address the Diversity Plan or include it in the impact score for a mechanism that required the plan to be included.
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Reposted by Xiaojun Tian
Amy Feldman @amyfeldman7.bsky.social · 22/01/2025
If you’ve been directly impacted by a pause or cancellation of an NIH study session, we @forbes.com would like to talk to you
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Reposted by Xiaojun Tian
Elisa Franco @francolab.bsky.social · 07/01/2025
#UCLA QCbio qcb.ucla.edu is looking for a new director! recruit.apo.ucla.edu/JPF10007 Please share
recruit.apo.ucla.edu
Director, Institute for Quantitative and Computational Biosciences
University of California, Los Angeles is hiring. Apply now!
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Reposted by Xiaojun Tian
Francesca Ceroni @ceronifranci.bsky.social · 13/11/2024
Exciting post doc opportunity: we are seeking a post doc to work with us and @ProfTomEllis on large DNA engineering in mammalian cells funded by @ChanZuckerberg. Come and join us at @ImperialChemEng! Apply at the link below: www.imperial.ac.uk/jobs/search-...
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Xiaojun Tian @xiaojuntian.bsky.social · 15/01/2024
Our new work demonstrated the idea of using a supplementary repressive link to enhance the synthetic gene circuit stability under growth feedback. academic.oup.com/nar/advance-...
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Reposted by Xiaojun Tian
Jose Jimenez @jjimenez.bsky.social · 26/10/2023
Open position for a molecular biologist in a brand new sequencing lab at Achilles Therapeutics, a London-based biotech SME working on cancer immune therapies. If interested please get in touch! 👇 apply.workable.com/achilles-the...
apply.workable.com
Research Associate/ Senior Research Associate - Sequencing - Achilles Therapeutics
Achilles is a fast paced, trail blazing company focused on the development of the next generation of personalised T cell therapies to treat cancer. We are breaking new ground with our science - there...
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Reposted by Xiaojun Tian
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 25/10/2023
Light-driven synchronization of optogenetic clocks www.biorxiv.org/content/10.1101/202…
biorxiv.org
Light-driven synchronization of optogenetic clocks https://www.biorxiv.org/content/10.1101/2023.10.24.563722v1
Synthetic genetic oscillators can serve as internal clocks within engineered cells to program period
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Reposted by Xiaojun Tian
Tom Ellis @proftomellis.bsky.social · 23/10/2023
Our Holobiont Research centre has 2 bioengineering postdoc places on offer, inc. a synthetic biology one in my group. Interested in engineering microbes to live within native communities and sense and record inputs? Then this job could be for you👇 www.jobs.ac.uk/job/DDO637/r...
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Reposted by Xiaojun Tian
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · 20/10/2023
A three-node Turing gene circuit forms periodic spatial patterns in bacteria www.biorxiv.org/content/10.1101/202…
biorxiv.org
A three-node Turing gene circuit forms periodic spatial patterns in bacteria https://www.biorxiv.org/content/10.1101/2023.10.19.563112v1
Turing patterns1 are well-known self-organising systems that can form spots, stripes, or labyrinths.
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