Africa's top health agency says around 246 cases have been reported.

Scientific Reports - Endolysosomal trafficking regulator SH-BC-893 inhibits coronavirus entry in vitro and in vivo

Abstract. Pseudomonas aeruginosa (PA) is responsible for significant morbidity and mortality particularly in patients with chronic lung diseases such as ch

The fungal SND pathway inserts a wide range of proteins into the ER membrane. Here, SND3 is identified as a membrane insertase within a distinct SEC61 translocon complex, implying a role in co-transla...

Here the authors develop an assay capable of selecting Sec61 inhibitors by exploiting the inactivation of firefly luciferase, once translocated into the endoplasmic reticulum (ER), and the possibility of diverting and “re-lighting” luciferase into the cytosol by a Sec61 inhibitor.

Nature Communications - The Ebola and Marburg viruses use polymerase complexes to replicate and transcribe their genome. Here, the authors present cryo-EM structures of the polymerase complexes of...

Nature Communications - Sala et al. report the first structural snapshot of the Nipah virus RNA-dependent RNA polymerase in the actively elongating state, uncovering key mechanisms of RNA synthesis...

A phase 1 trial suggests safety, tolerability and immunogenicity of a candidate subunit vaccine against the deadly Nipah virus, for which countermeasures are urgently needed.

Highly contagious virus, which spreads from animals to humans, has a high fatality rate and there is no vaccine

Highly contagious virus, which spreads from animals to humans, has a high fatality rate and there is no vaccine

Have you ever been to a party where you sensed the messiness before it happened?

A 37-year-old man in Chad presented with a fever and a headache. An extensive evaluation identified a mammarenavirus, close to Lassa virus, in samples of cerebrospinal fluid.

The Highly Cited Researchers 2025 list identifies and celebrates individuals who have demonstrated significant and broad influence in their fields of research. Through rigorous selection criteria and ...

Structural studies of HSV-1 helicase-primase revealed how pritelivir and amenamevir bind and block its helicase activity.

Chikungunya cases break records in France; West Nile virus appears near Rome

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Ebola and Marburg virus (EBOV, MARV) cause severe disease and therapeutic options are urgently needed. The Sec61 translocon facilitates ER import of viral glycoproteins (GPs) and may represent a thera...