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Vidhi Dholakia

@vidhid.bsky.social
111 followers 166 following 1 posts

Short human and cat enthusiast who studies viruses @ Laboratory of Environmental Virology, EPFL Previously @ Royal Veterinary College 🐈🦠🧬🧫

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Reposted by Vidhi Dholakia
Erseo05 🇪🇦 🇵🇸 @erseo05.bsky.social · 05/08/2026
New paper out! From my Postdoc at the Gresham Lab, @nyu.edu . Every cellular IAV infection is a small bottleneck. If 10 virions infect a cell, 1 or 2 replicates. Stochastic intracellular replication dynamics shape population-level evolution in Influenza A Virus academic.oup.com/ve/article/d...
academic.oup.com
Stochastic intracellular replication dynamics shape population-level evolution in Influenza A Virus
Abstract. Understanding the sources of genetic diversity in Influenza A Virus (IAV) infections is crucial for understanding the mechanisms of viral evoluti
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Ed Hutchinson @socialinfluenza.bsky.social · 23/07/2026
🚨New Pre-Print!🚨 Want to search for variation in influenza A virus sequences, but find the amount of data overwhelming? Wondering if new avian flu strains have signs of mammalian adaptation? The #Flu-MutationExplorer, a new online tool, can help (1/n) www.biorxiv.org/content/10.6...
An image in the style of an Andy Warhol screen print showing influenza virions in a variety of colours. (Image credit Ed Hutchinson and Naina Nair, MRC-University of Glasgow Centre for Virus Research)
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Thijs Kuiken @thijskuiken.bsky.social · 10/07/2026
Highly pathogenic avian influenza H5 detected in a greater crested tern at Robe, Limestone Coast, South Australia. All previous detections in Australia were in migratory birds that had likely brought the disease from the subantarctic, but the greater crested tern is a resident seabird in Australia.
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Madhu Pai, MD, PhD @madhupai.bsky.social · 29/05/2026
With Ebola impacting parts of Africa, and all the travel bans, I can already see stigmatizing language in the media Journalists must do better and this essay offers some tips (with Annalisa Merelli) 10 best practices for equitable global health journalism qz.com/10-best-prac...
qz.com
10 best practices for equitable global health journalism
If journalists want to help make global health more inclusive, they can start with these guidelines
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Ed Hutchinson @socialinfluenza.bsky.social · 18/05/2026
Why do influenza viruses make ludicrously long filamentous virions? Probably lots of reasons, but in a new study Lu Liu et al. provide evidence for an appealing hypothesis: filaments are more stable in acidic solutions and hence survive for longer in aerosols www.nature.com/articles/s41...
Electron micrographs showing influenza virions of varying morphologies, from spheres to filaments
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Ed Hutchinson @socialinfluenza.bsky.social · 07/05/2026
🚨New paper!🚨 Our study showing that H5N1 influenza viruses can remain infectious in unpasteurised milk for, basically, as long as you are likely to encounter that milk has now been published: www.microbiologyresearch.org/content/jour...
A drawing of a Fresian cow whose markings resemble influenza viruses (image: Ed Hutchinson, 2025)
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Ed Hutchinson @socialinfluenza.bsky.social · 17/04/2026
🚨New pre-print!🚨 Influenza viruses need proteases to become infectious. Here, we identify the proteases needed for influenza D virus entry, and show that proteases in the human airway are more than capable of activating this non-human virus www.biorxiv.org/content/10.6...
A woodcut of a highland cow peering through a square frame (image credit Ed Hutchinson)
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Ed Hutchinson @socialinfluenza.bsky.social · 17/04/2026
🚨New pre-print!🚨 Using a panel of different H5N1 clade 2.3.4.4b viruses and human seasonal influenza, and mammary explants from common beef and dairy cattle breeds, we add to the growing data showing that H5N1 spillovers into cattle should be seen as an ongoing risk www.biorxiv.org/content/10.6...
A panel of immunohistochemistry images showing infection of a panel of IAV viruses (as 6:2 reassortants on a PR8 backbone) in epithelia from the teat and gland cisterns of Aberdeen Angus, Limousin and Holstein Friesian cattle
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Ed Hutchinson @socialinfluenza.bsky.social · 17/04/2026
🚨New pre-print!🚨 Because influenza virions are highly variable in form no single method can show their molecular architecture in detail. Here, we integrate multiple structural and compositional approaches to identify new features of these beautiful virus particles www.biorxiv.org/content/10.6...
An illustration of an apical region of an animal cell in cross section, shown crowded with individual molecules. The plasma membrane is densely occupied by influenza virus glycoproteins, and from the surface bud influenza virions with different morphologies (L-R): spherical, bacilliform, filamentous with a genome, filamentous and empty, filamentous with a helical inner layer, and filamentous with a cofilactin cytoskeleton.
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Tom Peacock @peacockflu.bsky.social · 14/04/2026
Excited to advertise a fully funded PhD with @socialinfluenza.bsky.social investigating how influenza virus evolution differs between different avian hosts (and how this impacts pandemic potential). Joint between @pirbrightinst.bsky.social + @cvrinfo.bsky.social www.findaphd.com/phds/project...
findaphd.com
FULLY FUNDED PhD - Visualising avian influenza virus tropism and co-infection in avian hosts at University of Glasgow on FindAPhD.com
PhD Project - FULLY FUNDED PhD - Visualising avian influenza virus tropism and co-infection in avian hosts at University of Glasgow, listed on FindAPhD.com
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Angie Rasmussen @angierasmussen.bsky.social · 03/04/2026
So pleased to contribute to this preprint on H5N1 spillover from birds to dairy cattle from the Moo Flu Crew, led by the excellent @jevp.bsky.social. We traced both B3.13 in Texas and D1.1 in Nevada and Arizona to look at how the virus evolves and what changed👇 www.biorxiv.org/content/10.6...
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Tom Peacock @peacockflu.bsky.social · 06/04/2026
Really excited to be able to share our latest preprint, describing how during its evolution in cattle, H5N1 has got better at using a type of alternative receptor that's abundant in cows, but not found in humans and birds. www.biorxiv.org/content/10.6...
Graph of receptor binding curves showing an ancestral and recent H5N1. The ancestral virus does not bind NeuGc receptor well, whereas the recent virus birds NeuGc and NeuAc containing receptors equally.
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Ed Hutchinson @socialinfluenza.bsky.social · 27/03/2026
www.euronews.com/health/2026/...
euronews.com
Italy confirms first European human H9N2 avian flu case
The first human case of H9N2 avian flu in Europe has been detected in Italy in a person who travelled from outside the continent.
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Ed Hutchinson @socialinfluenza.bsky.social · 05/03/2026
🚨New Influenza Tool🚨 Interested in IAV mutations? Looking for markers of mammalian adaptation? Frustrated by converting between IAV numbering systems? The #Flu-MutationExplorer, a new tool from @cvrbioinfo.bsky.social and @royalvetcollege.bsky.social, is here to help: flu-gdb.cvr.gla.ac.uk (1/n)
A 3x3 grid of coloured images of influenza virus particles in the style of an Andy Warhol screen print. Image credit Naina Nair / Ed Hutchinson (MRC-University of Glasgow Centre for Virus Research)
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Ervin Fodor @efodor.bsky.social · 24/01/2026
Cryo-EM structure reveals how influenza A virus NEP binds the viral polymerase at a regulatory hotspot, coordinating RNA synthesis and nuclear export. Fantastic collaboration with @loiccarrique.bsky.social and Jon Grimes. www.science.org/doi/10.1126/...
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Thijs Kuiken @thijskuiken.bsky.social · 23/01/2026
First evidence in Europe of highly pathogenic avian influenza virus H5N1 infection in a dairy cow. Antibodies against H5N1 detected in a cow with mastitis and respiratory signs on a Dutch dairy farm at the end of December. A cat on that farm had died from H5N1. www.tweedekamer.nl/downloads/do...
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Tom Peacock @peacockflu.bsky.social · 20/01/2026
Really excited our paper about how H5N1 rapidly adapted to cattle (and how these adaptations also increased its ability to infect cells from the human respiratory tract) is now published! www.nature.com/articles/s41...
nature.com
Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammals - Nature Communications
Avian influenza jumped from wild birds into dairy cattle. Here, the authors report that two mutations in the viral polymerase helped the virus to quickly adapt to cattle. Mutations increased the polym...
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PLOS Biology @plosbiology.org · 09/12/2025
Spillover of #influenza A viruses from animals to humans represents a threat to our health. In this Perspective, Silke Stertz @virology.uzh.ch discusses emerging research that suggests some influenza A viruses can enter host cells via MHC-II receptors across species 🧪 #virology
plos.io
A new path to spillover: MHC-II entry of influenza A viruses
Spillover of influenza A viruses from animals to humans represents a threat to our health. This Perspective discusses emerging research that suggests some influenza A viruses can enter host cells via…
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Ed Hutchinson @socialinfluenza.bsky.social · 28/11/2025
🚨New Paper!🚨 Some like it hot: Matt Turnbull and @samjwilsonphd.bsky.social collaborated with groups from @cvrinfo.bsky.social, @cam.ac.uk and beyond to show that, while our fevers are hot enough to control human flu, they don't protect against avian influenzas adaptd to the hotter bodies of birds
science.org
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...
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Ed Hutchinson @socialinfluenza.bsky.social · 26/11/2025
H5N1 in bats - what should we think about this? @itingtu.bsky.social explains her recent preprint (a collaboration with multiple @cvrinfo.bsky.social groups) in a really nice interview with @science.org www.science.org/content/arti...
science.org
Vampire bats may have contracted H5N1 bird flu in Peru, raising worries about further spread
Bats could form a bridge between marine and terrestrial mammals, scientists say
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Ed Hutchinson @socialinfluenza.bsky.social · 17/11/2025
On the first day of Christmas, a virus gave to me...
A paper design for cutting out some sort of snowflake
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Daniel Goldhill @influenzal.bsky.social · 04/11/2025
If you are looking for a PhD in the UK, please check out the LIDo program - www.lido-dtp.ac.uk/apply. If you are interested in viruses and making genetically edited salmon, please look up my icase project. International students are welcome to apply! Please reach out if you have questions.
A diagram depicting a PhD project whereby editing salmon cells or ova leads to viral resistance from ISAV.
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Tom Peacock @peacockflu.bsky.social · 21/08/2025
Really excited to have been a part of this study, lead by @willharv.bsky.social on how reassortment of H5N1 in birds has lead to a 'specialist' genotype that thrives in seabirds and drives summer/spring (rather than winter) waves of poultry outbreaks www.biorxiv.org/content/10.1...
biorxiv.org
Genetic reassortment and diversification of host specificity have driven evolutionary trajectories of lineages of panzootic H5N1 influenza
Since 2021, subclade 2.3.4.4b A(H5N1) high pathogenicity avian influenza (HPAI) viruses have undergone changes in ecology and epidemiology, causing a panzootic of unprecedented scale in wild and domes...
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Tamar Kohn @viralexplorers.bsky.social · 11/08/2025
Want to move to Switzerland? We are looking for a postdoc to study airborne viruses: careers.epfl.ch/job/Lausanne... @linseymarr.bsky.social @lakdawalalab.bsky.social @corsiaq.bsky.social @influenzal.bsky.social @chuckhaas.bsky.social
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Vidhi Dholakia @vidhid.bsky.social · 11/08/2025
Our lab is looking for a post-doc to investigate the effect of air composition on respiratory virus transmission! If you're someone with experience in virus inactivation, cryo-EM and fluorescence microscopy, and/or aerosol science, apply here: careers.epfl.ch/job/Lausanne...
careers.epfl.ch
Postdoc to investigate the effect of air composition on the respiratory virus transmission chain 1
Postdoc to investigate the effect of air composition on the respiratory virus transmission chain 1
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Daniel Goldhill @influenzal.bsky.social · 08/07/2025
Something a little different. If you're looking for interesting science to engage with older school children, I would like to plug my students' work on cow flu - where it came from and what risk it might pose. doi.org/10.1042/bio_... PS> Not peer reviewed but was fun to help write!
doi.org
Cross-species concerns: how worried should you be about cow flu?
In 2024, H5N1 avian flu jumped from birds into cows for the first time. Replicating in cow udders and spreading via milk, the virus rapidly infected dairy cows across the USA. The flu virus also manag...
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Daniel Goldhill @influenzal.bsky.social · 10/06/2025
Excited to present the first review from my lab! Which mutations allow H5 influenza to jump into humans or other mammals? How close is H5 to a pandemic? This review has the answers and explains the molecular mechanism behind the mutations. Led by @fcapelastegui.bsky.social. doi.org/10.1099/jgv....
A beautiful figure.
Global detections of A(H5N1) clade 2.3.4.4b in mammalian species, split by sporadic detections (black) and detections which are associated with an outbreak (orange) alongside key mammalian adaptive mutations. 
Taken from Capelastegui & Goldhill 2025.
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Daniel Weir @danielweiriav.bsky.social · 06/06/2025
🚨🔎 Out now in PLOS Pathogens ! 🔎🚨 This project has taken us @cvrinfo.bsky.social @uofgmvls.bsky.social on a wild and wonderful journey. I am excited to share our story of how influenza A viruses (IAVs) exploit cell death to facilitate its covert spread. N/1 journals.plos.org/plospathogen...
journals.plos.org
Induction of tunnelling nanotube-like structures by influenza A viruses requires the onset of apoptosis
Author summary Influenza A viruses (IAVs) spread efficiently through the respiratory tract in the form of extracellular virus particles, but can be restricted by neutralising antibodies and antiviral ...
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Tom Peacock @peacockflu.bsky.social · 24/02/2025
Our analysis of the second incursion of H5N1 viruses (genotype D1.1) into dairy cattle in the US is now posted to virological virological.org/t/timing-and...
virological.org
Timing and molecular characterisation of the transmission to cattle of H5N1 influenza A virus genotype D1.1, clade 2.3.4.4b
Jonathan E. Pekar, Institute of Ecology and Evolution, University of Edinburgh, Edinburgh, UK Thomas P. Peacock, The Pirbright Institute, Woking, UK, GU24 0NF; Department of Infectious Disease, Imper...
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Theo Sanderson @theo.io · 22/01/2025
🎺 PhD studentship available at @lshtm.bsky.social and RVC! @influenzal.bsky.social and I are advertising for a project to investigate the unexpected phenomenon that mutagenic antiviral drugs can give rise to viruses with hundreds of mutations which are still viable. 🧵 www.lshtm.ac.uk/study/fees-a...
lshtm.ac.uk
2025-26 Bloomsbury Colleges PhD Studentships | LSHTM
The Bloomsbury Colleges group was set up in 2004 and consists of five institutions: Birkbeck, London School of Hygiene & Tropical Medicine (LSHTM), the Royal Veterinary College (RVC), the School of Or...
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Tom Peacock @peacockflu.bsky.social · 06/02/2025
Just out: PhD opportunity with Dr Marie Di Placido, Dr Stephen Dunham, Prof Munir Iqbal, Prof. Janet Daley and myself looking at how different livestock species make antibody responses to H5N1. www.findaphd.com/phds/project...
findaphd.com
Deepening our understanding of cross-species antibody responses to H5Nx influenza viruses at The Pirbright Institute on FindAPhD.com
PhD Project - Deepening our understanding of cross-species antibody responses to H5Nx influenza viruses at The Pirbright Institute, listed on FindAPhD.com
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Ed Hutchinson @socialinfluenza.bsky.social · 31/01/2025
Why can't these viruses be friends? During her PhD, Anna Sims showed that influenza viruses segregate into genetically-distinct lesion through a process called superinfection exclusion. In a new preprint, she shows that the same process also applies for SARS-CoV-2 www.biorxiv.org/content/10.1...
A region of purple cells and a region of green cells, touching but not overlapping
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Ed Hutchinson @socialinfluenza.bsky.social · 30/01/2025
Our study on pasteurising influenza viruses in milk is now out! It's a nice simple story: influenza viruses (including H5N1) are killed really effectively by pasteurisation, but in raw milk they stay infectious - obvious public health implications of both points... (1/2) rdcu.be/d73te
A picture of a Fresian cow whose markings resemble influenza viruses
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Jayna Raghwani @jraghwani.bsky.social · 10/01/2025
Please share widely! We are recruiting a 3-year postdoc at the RVC to develop new methodology to infer epidemic dynamics from wild animal viromes sampled across changeable environments. Further details: jobs.rvc.ac.uk/vacancy.aspx... Feel free to reach out with any questions. Deadline Feb 9th
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bioRxivpreprint @biorxivpreprint.bsky.social · 07/01/2025
Polymerase mutations underlie adaptation of H5N1 influenza virus to dairy cattle and other mammals. www.biorxiv.org/content/10.1101/202…
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Tom Peacock @peacockflu.bsky.social · 07/01/2025
Really proud to share our preprint describing early adaptation of H5N1 to US dairy cattle, and showing how these mutations enhance the ability of the virus to infect other mammals, such as pigs and humans. With @influenzal.bsky.social @vidhid.bsky.social @drclairesmith.bsky.social and many more!
biorxiv.org
Polymerase mutations underlie adaptation of H5N1 influenza virus to dairy cattle and other mammals.
In early 2024, an unprecedented outbreak of H5N1 high pathogenicity avian influenza was detected in dairy cattle in the USA. The epidemic remains uncontrolled, with spillbacks into poultry, wild birds...
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