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Imogen Ramsden @imogen-ramsden.bsky.social · 02/07/2025

Back to back conferences - having wrapped up the Small G proteins meeting, landed in Istanbul heading to the 24th FEBS Young Scientists’ Forum ( #YSF2025 ) held in the stunning region of Sapança! Thanks to the FEBS for awarding me a YSF travel grant! @febspress.bsky.social #FEBS2025 #BiochemEvent

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Imogen Ramsden @imogen-ramsden.bsky.social · 27/06/2025

That’s a wrap on Small G Proteins Meeting 2025! 🌟 Highlights: 💡 Insightful talks given by students, postdocs and PIs ❓ Q&A from ECRs encouraged (thanks for my honourable mention for participation!) 🧫 Broad cell biology topics and methodology 💊 Clinical perspectives alongside fundamental research

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Imogen Ramsden @imogen-ramsden.bsky.social · 27/06/2025

Final Session 6 SGP2025: 🎯 Biomechanical signatures & potential targets in cancer 🧬 Rho and Cdc42 regulation via PTMs, localisation & degradation in cancer and immunodeficiencies ⚙️ Nuclear force feedback loops via Rnd3 modulate actomyosin tension @biochemsoc.bsky.social #BiochemEvent

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Imogen Ramsden @imogen-ramsden.bsky.social · 27/06/2025

Last day of the #SmallGproteins meeting, great evening last night meeting researchers in the field hearing about people’s journeys, and gave advice on expressing a phosphorylated GTPase. Looking forward to Session 6 kicked off by @vickysanzmoreno.bsky.social! @biochemsoc.bsky.social #BiochemEvent

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Imogen Ramsden @imogen-ramsden.bsky.social · 27/06/2025

SGP25 Sessions 4 & 5: 🧬 Lipid sensing, β-catenin, and phosphorylation reshape GTPase signalling ⚙️ Mechanical forces & trafficking: nuclear F-actin, actin-Rab27a, plexins, and COL1 ⚡️Cancer cell adaptation through RhoA/NFAT, Rac1 SUMOylation, and KRAS rewiring @biochemsoc.bsky.social #BiochemEvent

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Imogen Ramsden @imogen-ramsden.bsky.social · 25/06/2025

SGP25 Session 3: ⛓️ Tri-complex inhibitor as molecular glue for oncogenic RAS 💊 Combining inhibitors to combat KRAS-driven cancer 🎯 p120RasGAP molecular glue targeting RAS 🔢 Mathematical modelling to study RAS activity 🧐 RAS/RAL, Cdc42, RhoG, RAC1, EPAC2, RalGAP… @biochemsoc.bsky.social #BiochemEvent

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Imogen Ramsden @imogen-ramsden.bsky.social · 25/06/2025

SGP25 Session 2 (Part 2): 🧬 RAP1GDS1 isoform regulates KRAS signalling & lysosomal function in lung adenocarcinoma ❓Oncogenic KRAS may not alter Akt/ERK pathways ☠️ p190RhoGAP paralogs show synthetic lethality in endometrial cancer @biochemsoc.bsky.social #BiochemEvent

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Imogen Ramsden @imogen-ramsden.bsky.social · 25/06/2025

SGP25 Session 2 (Part 1): ⚙️ “Branchgetic” Ras mutations indicate effector selection 🔬 RAF biosensors to monitor acivity in live cells 💥 C2 domain boosts RasGAP activity 💊 RhoB-Ral complex a target for EGFR TK inhibition? @biochemsoc.bsky.social #BiochemEvent

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Reposted by Imogen Ramsden

Victoria Hart @vichart33.bsky.social · 25/06/2025

Day 2 of #SGP25 of to a great start with ✨ unpicking Ras effector binding in different tissues ✨ developing RAF based biosensors ✨ C2 domains and GAP functionality ✨ how RhoB and Ral affect EGFT therapy in lung cancer @Biochemsoc #BiochemEvent

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Imogen Ramsden @imogen-ramsden.bsky.social · 24/06/2025

SGP25 Session 1 (Part 2): 🧫 Overcoming RAS resistance: biobanking & precision medicine 💊 Adaptive immunity could enhance KRAS inhibitor activity 🔬 Organoids reveal allele-specific tumour growth 💥 Plus ARL15, RhoGDI1, RalGEF, SOS1/2 & proteomics pipelines @biochemsoc.bsky.social #BiochemEvent

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Imogen Ramsden @imogen-ramsden.bsky.social · 24/06/2025

SGP25 Session 1 (Part 1): ⛓️ Mapping KRAS interactomes in organoid models 🧬 Isoform-specific KRAS vulnerabilities: one mutation, big difference 🔬 Novel tool tracks Ras mutation dynamics in vivo ✨ And a reminder that clear science communication empowers patients! @biochemsoc.bsky.social #BiochemEvent

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Imogen Ramsden @imogen-ramsden.bsky.social · 24/06/2025

Just kicking off at the Small G Proteins Meeting 2025 after lunch meeting scientists from all over the world - Barcelona, Connecticut, New York - and it’s encouraging to see a programme with both early career researchers and group leaders presenting! @biochemsoc.bsky.social #BiochemEvent

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Imogen Ramsden @imogen-ramsden.bsky.social · 18/06/2025

Excited to be selected as one of the Social Media Contributors at the #BiochemEvent Small G Proteins Meeting next week, thanks to @biochemsoc.bsky.social. I look forward to hearing about and discussing the latest research in the area as well as presenting my own PhD work about Arf proteins!

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Imogen Ramsden @imogen-ramsden.bsky.social · 11/04/2025

Still thinking about my great experience at #Biologists100 — from my flash talk and poster, to the ECR session and insightful main talks, and all the chats in between! Big thanks to @biologists.bsky.social & @bscb-official.bsky.social for the opportunity! 📸 Full post and photos on my LinkedIn

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