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Viktoria Brunner

@vbrunner.bsky.social
109 followers 129 following 14 posts

Bioinformatic Engineer interested in AMR diagnostics through WGS 🧬💊 | www.vbrunner.me 🌐 | PhD @ox.ac.uk @fowlerlab.org | MSc @ethz.ch

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Reposted by Viktoria Brunner
Sam Lipworth @samlipworth.bsky.social · 30/09/2026
Great new work from @dotnagy.bsky.social who has developed EpiSENTRY which performs sample size calculations for public health WGS surviellance studies. She applies to data from the NEKSUS study to estimate how much sequencing is enough for GNBSI surviellance in England. @modmedmicro.bsky.social
medrxiv.org
How much is enough? Optimising sampling frames for genomic surveillance of Escherichia coli and Klebsiella spp. bloodstream infections - a retrospective study
Background: Optimising sampling frames for genomic surveillance of E. coli and Klebsiella may support interventions to mitigate bloodstream infections (BSIs), but approaches to estimating sample size ...
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Viktoria Brunner @vbrunner.bsky.social · 01/06/2026
Loved this year's BRC showcase event, great work from everyone involved 👏 Now on to upgrading our DNA Detective game for the next outreach event! 🕵️‍♀️
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Reposted by Viktoria Brunner
TARGetAMR @target-amr.bsky.social · 14/05/2026
🌟Great start to #TARGetAMR26! 🎙️Today we heard an inspiring keynote, insightful talks and fantastic discussions on AMR genomics Plus our Co-Directors @wvschaik.bsky.social @ksbakes.bsky.social unveiled: 🚀Launch of our Flexible Funding Initiative 📚Debut of the TARGetAMR comic ⌛️We can't wait for Day 2!
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Reposted by Viktoria Brunner
Modernising Medical Microbiology @modmedmicro.bsky.social · 18/11/2025
For #WorldAntimicrobialAwarenessWeek, we introduce our recent paper on antibiotic-resistant subpopulations in TB. TB may be one of humanity’s oldest diseases, yet it still kills over 1M people yearly. As resistance spreads, knowing each patient’s resistance profile before treatment is vital. 🧬💊
academic.oup.com
Subpopulations in clinical samples of M. tuberculosis can give rise to rifampicin resistance and shed light on how resistance is acquired
AbstractObjectives. WGS has become a key tool for diagnosing Mycobacterium tuberculosis infections, but discrepancies between genotypic and phenotypic drug
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Reposted by Viktoria Brunner
JAC-AMR @jac-amr.bsky.social · 14/11/2025
Detecting minor resistance-associated variants in tuberculosis WGS samples improves the sensitivity of rifampicin resistance prediction: doi.org/10.1093/jaca... @philipwfowler.bsky.social @vbrunner.bsky.social #JACAMRNews #IDSky
doi.org
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Viktoria Brunner @vbrunner.bsky.social · 14/10/2025
Thanks Nicole! ☺️
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Viktoria Brunner @vbrunner.bsky.social · 13/10/2025
😷 We also investigated the source of resistance in samples with resistant subpopulations using within-sample diversity, which suggests secondary infection events in at least 28% of samples.
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Viktoria Brunner @vbrunner.bsky.social · 13/10/2025
⌛ Building on my previous work on compensatory mutations, we found that samples with resistant subpopulations were less likely to be compensated than homogeneous resistant samples, hinting at recent resistance acquisition.
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Viktoria Brunner @vbrunner.bsky.social · 13/10/2025
📈 Relaxing the read support threshold, for example, can increase the sensitivity of rifampicin resistance prediction to over 95%.
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Viktoria Brunner @vbrunner.bsky.social · 13/10/2025
Key take-aways: 🚧 In this work, we show that conservative parameters in bioinformatic pipelines can obscure resistant subpopulations in clinical samples of M. tb.
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Viktoria Brunner @vbrunner.bsky.social · 13/10/2025
Our recent paper on rifampicin resistant subpopulations in M. tuberculosis (M. tb) has been published at JAC-antimicrobial resistance. I am really happy to see this work published just hours before submitting my DPhil thesis! 🔗👇 doi.org/10.1093/jaca...
doi.org
Subpopulations in clinical samples of M. tuberculosis can give rise to rifampicin resistance and shed light on how resistance is acquired
AbstractObjectives. WGS has become a key tool for diagnosing Mycobacterium tuberculosis infections, but discrepancies between genotypic and phenotypic drug
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Reposted by Viktoria Brunner
Philip Fowler @philipwfowler.bsky.social · 25/06/2025
Come and work with me and use the 53,897 samples of M. tuberculosis we have collated to help tackle this important disease! We are part of the OxCoD4TB consortium that is developing new therapeutics for tuberculosis. Grade 7, funding until 28 Feb 2028, deadline noon Fri 4 July bit.ly/4ndKOhF
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Reposted by Viktoria Brunner
fowlerlab.org @fowlerlab.org · 23/06/2025
@vbrunner.bsky.social doing her pitch for her poster at #ESMyco! @modmedmicro.bsky.social
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Viktoria Brunner @vbrunner.bsky.social · 16/04/2025
Having often grappled with the limited translational aspect of my pre-PhD work, the real-world impact of the topics discussed in this session and at this conference was refreshing and motivating and will help me push my PhD at @modmedmicro.bsky.social over the finish line later this year!
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Viktoria Brunner @vbrunner.bsky.social · 16/04/2025
🚧 We showed that this issue can be easily mitigated by lowering the read support threshold required to call variants in whole-genome sequencing pipelines. This can lead to significantly increased sensitivity for rifampicin resistance prediction.
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Viktoria Brunner @vbrunner.bsky.social · 16/04/2025
🧬 The talk allowed me to raise a central issue in sequencing-based diagnostics for M. tuberculosis: they often fail to detect resistant subpopulations - something that can have serious clinical implications.
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Viktoria Brunner @vbrunner.bsky.social · 16/04/2025
Thrilled to have returned to the Congress of @escmid.bsky.social this year in the beautiful city of Vienna, and to have had the opportunity to present my latest work on rifampicin-resistant subpopulations in M. tuberculosis. 📋 Find all the details in our preprint: 🔗👇 www.biorxiv.org/content/10.1...
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Reposted by Viktoria Brunner
Modernising Medical Microbiology @modmedmicro.bsky.social · 14/04/2025
Another busy day at #ESCMIDGlobal! 0906 @vbrunner.bsky.social “RIF and subpopulations in TB” 0918 Ruan Spies “comparing TB pipelines" both in Hall 5 1000 Nicole Stoesser “plasmids & 1Health” in H2 1509 Jane Wei in Hall 2 “CAP and EHR” P1405 - Valentina Pennetta P2242 - Junko Takada
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Viktoria Brunner @vbrunner.bsky.social · 10/04/2025
😷In a third of our clinical samples with resistant subpopulations, resistance was likely caused by a secondary infection instead of within-host evolution. Hence the patient contracted an M. tuberculosis infection at least twice, independently.
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Viktoria Brunner @vbrunner.bsky.social · 10/04/2025
📈We managed to increase the sensitivity of rifampicin resistance prediction to over 95%, with no significant trade-off for specificity.
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Viktoria Brunner @vbrunner.bsky.social · 10/04/2025
📢 Our preprint on rifampicin resistant subpopulations in clinical samples of M. tuberculosis has just been uploaded. We show how detection of resistant subpopulations can significantly improve WGS-based resistance prediction, and how they can help identify the source of resistance.
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Reposted by Viktoria Brunner
Philip Fowler @philipwfowler.bsky.social · 10/04/2025
Check out @vbrunner.bsky.social latest work! Just in time for #ESCMIDGlobal and her talk next Monday morning.
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Reposted by Viktoria Brunner
NIHR Biomedical Research Centre: Oxford @oxfordbrc.bsky.social · 22/11/2024
Our amazing @modmedmicro.bsky.social team, who are leading our efforts to tackle antimicrobial resistance #AMR – in the lab, with data and in software - went blue for this picture for #WAAW2024. See more about our research at bashthebug.net
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Reposted by Viktoria Brunner
NIHR Biomedical Research Centre: Oxford @oxfordbrc.bsky.social · 22/11/2024
Researchers in @modmedmicro.bsky.social are studying the DNA of bacteria to understand the genes they carry and how they are related. This can help us detect outbreaks and track how antimicrobial resistance genes spread, so we can contain them better #WAAW2024
buff.ly
Putting 2 and 2 together: Using long-read bacterial genome assembly for public health surveillance
What is the problem? Studying the genetic code of bacteria (DNA) can give us vital information like the genes they carry and how they are related. This can help us detect outbreaks and track how an…
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Reposted by Viktoria Brunner
Modernising Medical Microbiology @modmedmicro.bsky.social · 26/11/2024
Come and work with us! Programme Manager is a key central role that sets large strategic objectives and manages practical issues across the MMM Unit. Grade 9, £55,636 - £64,228, deadline noon 6 Jan 25 bit.ly/4fGgnwv
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