Preclinical models of SARS-CoV-2 vaccination revealed a targetable CXCL10–IFN-γ axis that drives cytokine-induced cardiac injury.

Efforts to shrink staff, budget, and focus have alarmed members of Congress

Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion micros...

Mitochondria, the dynamic orchestrators of cellular energy metabolism and signaling, are essential guardians of health. Dysfunction in these organelles underlies a diverse array of pathologies, rangin...

The chaos, conflicting information, firings, and hurtful rhetoric of the Trump administration’s approach to science over the past month are causing anxiety, grief, and concern for the scientific commu...

The chaos, conflicting information, firings, and hurtful rhetoric of the Trump administration’s approach to science over the past month are causing anxiety, grief, and concern for the scientific commu...

President of world's largest multidisciplinary scientific society warns that next month could be most important in history of US science

Research on science communication has largely focused on teaching scientists how to describe their studies in ways that interest the public while deepening their understanding of scientific exploratio...

As the calendar turns to 2025, the unflagging pace of advancement in science and technology promises to break new ground in areas as profound as humanity’s relationship with artificial intelligence (A...

Alzheimer’s disease (AD) and other age-related disorders associated with demyelination exhibit sex differences. In this work, we used single-nuclei transcriptomics to dissect the contributions of sex ...

Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...

Outdated gender stereotypes are influencing experimental design in laboratory animals

Loss-of-function mutations in LTBR result in a stromal defect, leading to dysfunctional secondary lymphoid organs and combined immunodeficiency in humans.

The Pew Research Center survey on trust in science and researchers is eagerly awaited every year by science policy experts and communicators. This year’s results, released last week, give a small, but...

Macrophages deliver polarizing messages to promote immune suppression in tumors

The tumor microenvironment (TME) contains a number of immune-suppressive cells such as T helper 1–polarized regulatory T cells (TH1-Treg cells). However, little is known about the mechanism behind the...

After recent changes to Elon Musk’s X, a gradual migration turns into a stampede

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