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Stephan Uphoff

@uphoff.bsky.social
155 followers 108 following 3 posts

Professor of Physical Microbiology at Oxford University. Investigating bacterial DNA Repair and Mutagenesis. Imaging single molecules and single cells.

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Reposted by Stephan Uphoff
Grainger Lab @graingerlab.bsky.social · 21/08/2026
A new pre-print out - we show that promoters and terminators of transcription are frequently coupled, throughout the bacteria, and this is regulatory. www.biorxiv.org/content/10.6...
biorxiv.org
Widespread coupling of promoters and terminators of transcription in bacteria
Transcription underpins the expression of genetic information and is viewed as a series of independent initiation and termination events. In bacteria, promoters and terminators of transcription are th...
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Reposted by Stephan Uphoff
The Royal Society @royalsociety.org · 17/06/2026
Professor Colin Kleanthous FMedSci FRS is elected a Fellow of the Royal Society. He is a biochemist whose work has fundamentally changed our understanding of the outer membrane (OM) of Gram-negative bacteria. #RSFellows royalsociety.org/people/colin-klean…
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Reposted by Stephan Uphoff
Ashleigh Griffin @asgriffin.bsky.social · 27/04/2026
Big congratulations to @sarandavies.bsky.social on publishing this work from her DPhil. A dogged and determined and brilliant young scientist. And we couldn't have done it without our wonderful collaborator - @divyach.bsky.social from the @uphoff.bsky.social lab. Big team effort 🫶
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Reposted by Stephan Uphoff
Nathan Fraikin @nfrk92.bsky.social · 10/12/2025
academic.oup.com/nar/article/... Collaboration with Y. Yamaichi. Killing donor bacteria in conjugation mixes using water enables transcriptomic profiling of early plasmid genes ! Superb tool for studying zygotic induction of these early genes, which include anti-SOS and anti-RM factors. #microsky
academic.oup.com
Selective elimination of donor bacteria enables global profiling of plasmid gene expression at early stages of conjugation
Abstract. Conjugative plasmids are a major driving force for the dissemination of antimicrobial resistance. During conjugation, plasmid DNA is transferred
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Reposted by Stephan Uphoff
Tung Le @tunglejic.bsky.social · 03/10/2025
Independent research fellowships leading to tenured positions at the John Innes Centre. Repost = nice. Thank you very much!!!
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Reposted by Stephan Uphoff
Daniela Barillà @danielabarilla.bsky.social · 18/09/2025
With evidence attached 😊 #BioPhyChrom2025 @biochemsoc.bsky.social @biophychrom.bsky.social @damelab.bsky.social @vslioy.bsky.social @graingerlab.bsky.social @lauraspagnolo.bsky.social @tamarabasta.bsky.social
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Reposted by Stephan Uphoff
Vicky Lioy @vslioy.bsky.social · 09/09/2025
Next week, Biophychrom is happening and there’s still time to join us! 👇🏻
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Stephan Uphoff @uphoff.bsky.social · 09/07/2025
lister-institute.org.uk/how-to-apply/
lister-institute.org.uk
How to Apply – Lister Institute
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Reposted by Stephan Uphoff
Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 09/05/2025
I forgot to post about this recent paper - exciting work led by @michriscopy.bsky.social showing clearest evidence yet for transertion strongly tethering the bacterial nucleoid to the membrane during fast growth. It was a pleasure to contribute a little 🔬🦠🧫 www.nature.com/articles/s41...
nature.com
The nucleoid of rapidly growing Escherichia coli localizes close to the inner membrane and is organized by transcription, translation, and cell geometry - Nature Communications
The mechanisms underlying bacterial chromosome configuration are not fully understood. Here, Spahn et al. show that the Escherichia coli nucleoid adopts a condensed, membrane-proximal configuration du...
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Reposted by Stephan Uphoff
Emilia Dimitrova @edimitrova.bsky.social · 09/05/2025
An emotional day today @oxfordbiochemistry.bsky.social where leaders in the cell cycle field gathered to celebrate the life of Bela Novak and the huge impact he had on their work! www.bioch.ox.ac.uk/article/prof...
bioch.ox.ac.uk
Professor Bela Novak (1956–2025): A Life of Scientific Discovery in Numbers
It is with profound sorrow that we announce the passing of Professor Béla Novák
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