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UNLEASH

@unleash-as.bsky.social
45 followers 92 following 28 posts

Social media account of the ERC SyG funded project UNLEASH. We will harness the splicing code for targeted control of gene expression using small molecules!

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Michael LaFrance @mlafrance.bsky.social · 25/05/2026
A livestream of a volcano in the Philippines captured a meteor crashing to Earth today. What are the odds? Mayon Volcano, Location: Albay, Luzon, Philippines
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UNLEASH @unleash-as.bsky.social · 26/05/2026
reading time!
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Molecular Cell @cp-molcell.bsky.social · 21/05/2026
Online Now: Nitric oxide drives proteomic diversity through alternative splicing Online now:
dlvr.it
Nitric oxide drives proteomic diversity through alternative splicing
Schindler et al. report that RNA-binding proteins undergo widespread S-nitrosylation at evolutionarily conserved sites. S-nitrosylation of the master splicing regulator PTBP1 alters RNA-binding properties to reprogram the transcriptome and proteome. Nitric oxide thereby coordinates gene and protein regulation in cellular physiology and disease.
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 22/05/2026
Happy Friday y'all! Hope you all had a good week. We've got some more #BookReviews for you for #WomensHealthMonth. This morning we are talking about "Invisible Women - Exposing data bias in a world designed for men" by @ccriadoperez.bsky.social #DDUat20 #HealthEquity #WomenInSTEM #InvisibleWomen
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 21/05/2026
Morning skypals! Tea-break time seems like a good time for a book review - how about it? We will start with Medical Bondage, by Deirdre Cooper Owens, an American historian & reproductive rights activist #womenshealthmonth #DDUat20 #BookReview
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UNLEASH @unleash-as.bsky.social · 18/05/2026
Really feels like 'checking the LLM didn't hallucinate your references' should be the lowest conceivable bar. We would suggest 'have read the actual paper' is a preferable standard, but even 'have skimmed the abstract' seems like the minimum you would want to be able to honestly include a reference!
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The Royal Society @royalsociety.org · 15/05/2026
Mary Lyon FRS was born #OnThisDay in 1925. Lyon was the discoverer of X-chromosome inactivation, which the genetic process that leads to coloration like tortoiseshell cats. Read more about her discoveries in a @royalsocietypublishing.org biographical memoir. #WomenInSTEM bit.ly/4wutdqf
A tortoiseshell cat with green eyes sitting on a rug against a white wall.A black and white photograph portrait of a woman with glasses. She's wearing a dark coat and a necklace is visible at her collar.
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UNLEASH @unleash-as.bsky.social · 13/05/2026
You ever get the feeling that your sequence logo is talking about something other than base frequency.... #GTA #basefrequency #RNAsplicing #AccidentalGaming
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Digital Brain @yourdigitalbrain.bsky.social · 30/04/2026
Did you know that the malaria parasite can deliver its RNA directly into immune cells, causing 94 changes in gene splicing? This clever tactic makes it harder for our defenses to fight back. How can we combat such a sneaky invader? 🦠
sinapti.ca
The malaria parasite infiltrates its RNA into immune cells to sabotage the body's defenses. - Sinaptica
Researchers from the Weizmann Institute of Science in Israel discovered that Plasmodium falciparum, the parasite responsible for the deadliest type of malaria,
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Nature Reviews Genetics @natrevgenet.nature.com · 09/05/2026
FYI: New online! Tools and tactics for studying alternative splicing
dlvr.it
Tools and tactics for studying alternative splicing
Nature Reviews Genetics, Published online: 17 April 2026; doi:10.1038/s41576-026-00952-4In this Review, Sousa-Luís and Carmo-Fonseca discuss the various tools available to detect and quantify alternative splicing, functionally test splice isoforms and investigate the link between genetic variation, splicing and disease.
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 12/05/2026
Congratulations to Prof Doreen Cantrell on her election to US-based National Academy of Sciences @nasonline.org #WomenInScience www.biodundee.co.uk/science-city...
biodundee.co.uk
Dundee scientist recognised with top international honour | Welcome to Bio-Dundee
A pioneering University of Dundee academic has received international recognition after being elected to one of the world’s foremost scientific institutions.
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 12/05/2026
In March 2025, we hosted an #Endometriosis Networking Workshop with experts from across the field. We’re excited to share the resulting white paper! A huge thanks to all who contributed to these vital discussions. Read here: www.linkedin.com/posts/possib... #DrugDiscovery #WomensHealth #DDUat20
linkedin.com
Possible Strategies for Drug Discovery for Endometriosis | Drug Discovery Unit, University of Dundee
In March 2025, we convened an Endometriosis Networking Workshop, bringing together academics, clinicians, industry leaders, and venture capitalists to collaboratively explore how we can advance drug d...
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UNLEASH @unleash-as.bsky.social · 07/05/2026
It's a beautiful day in Platja D'Arcy and we are inside hard at work talking about #alternativesplicing. #ScienceNeverStops
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UNLEASH @unleash-as.bsky.social · 06/05/2026
This is the best sparkling water in the world.....according to @biochemtrix.bsky.social at least! #consortiummeeting #splicingisthirstywork
Bottle of Vichy Catalan sparkling water on a table
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Stephen Turner @stephenturner.us · 03/05/2026
Free and open-source images, icons, and tools for creating scientific illustrations doi.org/10.59350/5zt... 🧪
doi.org
Free and open-source images, icons, and tools for creating scientific illustrations
Phylopic, NIH Bioart, Bioicons, Scidraw, Open Science Art, Health Icons, Servier Medical Art, Biodiversity Heritage Library, the Noun Project, Segment Anything, Excalidraw, draw.io, Biographics
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UNLEASH @unleash-as.bsky.social · 04/05/2026
Our next Unleash meeting is on the horizon! Looking forward to Dundee, Munich and Barcelona getting together to talk about #Splicing!
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 04/05/2026
Good morning sky-friends! We hope you are well on this lovely #mayday bank holiday! May is #WomensHealthMonth and we have lots of interesting things we want to talk about!
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bioRxivpreprint @biorxivpreprint.bsky.social · 14/01/2026
Poly(A)-tail-length-dependent surveillance of viral RNA by PABPC1 orchestrates broad-spectrum antiviral defense www.biorxiv.org/content/10.64898/20…
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Aging Journal @aging-us.bsky.social · 13/04/2026
✅ Check out our #blog on: "A combination of differential expression and network connectivity analyses identifies a common set of RNA splicing and processing genes altered with age across human tissues." #Summary ⬇️ aging-us.org/2026/01/a-co... #aging
aging-us.org
A Common Aging Pattern: Changes in RNA Splicing and Processing Across Human Tissues - Aging-US Research
As we age, every tissue in the body undergoes gradual molecular changes. A long-standing question in aging research is whether these changes follow common patterns across tissues or whether each tissu...
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Prostate Cancer UK Professionals @prostateukprofs.bsky.social · 14/04/2026
Could RNA-targeting identify drivers of AR-V7 linked #ProstateCancer? A team including Prof de Bono @icr.ac.uk, supported by our Movember London Centre of Excellence, share new findings as part of a @jci.org double-header. Grab a ☕ and read: bit.ly/4cjfadS
Graphic of a newly published research article published in The Journal of Clinical Investigation titled 'Splicing factor TRA2B enhances synthesis of androgen receptor variant AR-V7 in prostate cancer cells' by Brittain et al.
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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 23/04/2026
The cryptic lncRNA-encoded microprotein TPM3P9 promotes #ccRCC tumorigenesis by driving #Oncogenic RNA splicing, revealing a novel regulatory mechanism and potential #TherapeuticTarget in #RenalCancer. #STTT #OpenAccess: doi.org/10.1038/s413...
The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 14/04/2026
By bringing together expertise from DDU, @uofwa.uw.edu, & @dndi.org, we’re working to turn scientific potential into real progress against #ChagasDisease. Tackling #neglecteddiseases takes more than innovation—it takes #collaboration. #DrugDiscovery #GlobalHealth #WorldChagasday
One conversation. One shared goal.
 
From a conference in Bolivia to a global collaboration, teams at DDU, the University of Washington, and DNDi are working together to develop new treatments for Chagas disease.
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Scottish Funding Council @scotfundcouncil.bsky.social · 14/04/2026
World Chagas Disease Day acts as a reminder of a global health challenge that often goes unnoticed. In our latest blog, Manu De Rycker from the @dundee.ac.uk shares what his team are doing to combat this disease. #ChagasDisease www.sfc.ac.uk/inside-the-u...
sfc.ac.uk
Inside the University of Dundee’s long‑term fight against Chagas disease - Scottish Funding Council
World Chagas Disease Day acts as a reminder of a global health challenge that often goes unnoticed. Manu De Rycker shares what his team are doing to combat this disease.
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 30/01/2026
Today is World Neglected Tropical Diseases Day. The Neglected Tropical Diseases (NTDs) are a group of diseases that affect >1 billion people worldwide (~1 in 8 people). Despite this number, treatments and diagnostics are often unsafe and unsuitable, if they even exist. www.who.int/health-topic...
who.int
Neglected tropical diseases -- GLOBAL
Neglected tropical diseases (NTDs) are a diverse group of 20 conditions that are mainly prevalent in tropical areas, where they mostly affect impoverished communities and disproportionately affect wo...
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 30/01/2026
Want to see what we do up close? Sign up for the tour and networking event with us and #biodundee. See the link for details and tickets! #DDUat20 www.eventbrite.co.uk/e/drug-disco...
eventbrite.co.uk
Drug Discovery Unit Tour and Networking
BioDundee is delighted to kick of the year of celebrations for #DDUat20 with Networking and a guided tour of the Drug Discovery Unit.
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UNLEASH @unleash-as.bsky.social · 26/01/2026
We feel that! How about you, bluesky? Does your data make sense this morning? #datawins
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 23/01/2026
It's our Birthday!!
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Nature @nature.com · 14/12/2025
Sarah Tabrizi first saw the data her team had been chasing for decades: evidence that gene-targeted therapy could slow the progression of Huntington's disease She is part of Nature’s 10, a list of people who shaped science in 2025 go.nature.com/452HWfQ
go.nature.com
‘Giant step forward’ for Huntington’s — the scientist behind the first gene therapy
Nature - Sarah Tabrizi is part of Nature’s 10, a list of people who shaped science in 2025.
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UNLEASH @unleash-as.bsky.social · 13/12/2025
Sharing this paper for all of us who pray over a thermal cycler late into the night... #PCR #qPCR #MolecularBiology www.immaterialscience.org/2025/pcr-dem...
immaterialscience.org
Occultic Practices in qPCR — The Journal of Immaterial Science
qPCR is a famously capricious and fiddly technique, bedevilled by poor reproducibility. When every other source of variation and contamination has been controlled, the only explanation is that the imp...
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Centre de Regulació Genòmica (CRG) @crg.eu · 13/11/2025
En aquest diàleg, tres experts de referència respondran aquestes preguntes i compartiran la seva visió sobre les oportunitats i els reptes d’aquest camp emergent. Activitat gratuïta amb inscripció aquí: www.crg.eu/en/event/caf...
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UNLEASH @unleash-as.bsky.social · 31/10/2025
Happy #Halloween Bluesky! Hope y'all are having a spellbindingly good time! Our good friend Nicco is hard at work making witchy potions woooooo...... AKA growing up a biiiiiig batch of #HeLa cells to help study #splicing. What #spookyscience are you up to today?
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UNLEASH @unleash-as.bsky.social · 31/10/2025
We love some #oldschool slides! #splicing
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UNLEASH @unleash-as.bsky.social · 23/10/2025
Congratulations to @mdr-ddu.bsky.social for this amazing award, and to all the other winners
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David Baranger @davidbaranger.bsky.social · 25/09/2025
Excited to share that I am officially recruiting a postdoc to study the neurobiology of addiction! Looking for someone who would be excited to lead current projects in the lab and develop new directions in related areas. More info: bearlab.science/opportunities/
bearlab.science
Opportunities
Interested in the neuroscience of addiction? We are recruiting at all levels!! Reach out to Dr. Baranger – dbaranger@mcw.edu Postdoctoral fellows/Senior Scientists: Please send an email conta…
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Nature Portfolio @natureportfolio.nature.com · 25/09/2025
Why do we still know so little about pregnancy? Claire Richards and Lana McClements write about their Nature Communications paper, explaining why sampling early placental tissue is risky, and how the world’s first bioprinted placenta organoids can help. #Academicsky 🧪
go.nature.com
Designer homes for mini-placentas: A bioprinted solution
Mini placentas can be grown in the lab to study pregnancy and complications like preeclampsia. Using 3D printing technology, we have bioprinted the first placental organoids and studied the impact of their environment on cell behaviour.
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UNLEASH @unleash-as.bsky.social · 23/09/2025
Morning sky-friends! We are delighted to share some ‘hot off the xray’ images from our talented scientists, Dr André Mourão & Ting Deng. They produced this beautiful diffraction of a compound bound to one of our protein targets whilst working with @esrf.fr
on the left a picture of a crystal and on the right the xray diffraction of that crystal generated using a synchotron.
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JCI insight @insight.jci.org · 14/09/2025
ICYMI: Targeting RNA splicing as an alternative strategy in chronic lymphocytic leukemia? @prajishiyer.bsky.social & team find mutation in the RNA splicing factor SF3B1 activates the mTOR pathway to contribute to aggressive CLL: buff.ly/qkFAW4B
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UNLEASH @unleash-as.bsky.social · 23/09/2025
Good morning Bluesky! Are we feeling the Autumn chill yet? The #Dundee chapter of Unleash certainly are!
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UNLEASH @unleash-as.bsky.social · 17/09/2025
Good morning Bluesky! We have reached the end of our UNLEASH meeting and are all preparing to head home. We are full of enthusiasm and renewed purpose, and we look forward to keeping you all updated on our work! Tell us - what do you want to know about us? #SciComm #RNA #Splicing
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UNLEASH @unleash-as.bsky.social · 16/09/2025
Canvassing suggestions! What is the collective noun for a group of scientists on a hike? 🤔
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UNLEASH @unleash-as.bsky.social · 16/09/2025
Even during a break the #ScienceChat never stops! #Unleash #RNASplicing
A group of 9 scientists in casual dress standing having a discussion over cups of tea.
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UNLEASH @unleash-as.bsky.social · 16/09/2025
It's day 2 of the UNLEASH meeting! We are in beautiful Bernried and looking forward to hearing more about the progress our members have made unpicking the details of #AlternativeSplicing!
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The Helix Brief @helixbrief.bsky.social · 14/09/2025
SpliceCoord is an R-based computational tool that analyzes long-read RNA sequencing data to identify coordinated exon splicing events.
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UNLEASH @unleash-as.bsky.social · 15/09/2025
We are all here in sunny Munich to talk about the progress we have all made UNLEASHing the secrets of #AlternativeSplicing Members of four different scientific groups across three different countries collaborating and sharing data. Follow us to see our progress too!
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