Reposted by UNLEASHMichael LaFrance @mlafrance.bsky.social · 25/05/2026A livestream of a volcano in the Philippines captured a meteor crashing to Earth today. What are the odds? Mayon Volcano, Location: Albay, Luzon, Philippines 615288259435
Reposted by UNLEASHMolecular Cell @cp-molcell.bsky.social · 21/05/2026Online Now: Nitric oxide drives proteomic diversity through alternative splicing Online now:dlvr.itNitric oxide drives proteomic diversity through alternative splicingSchindler et al. report that RNA-binding proteins undergo widespread S-nitrosylation at evolutionarily conserved sites. S-nitrosylation of the master splicing regulator PTBP1 alters RNA-binding properties to reprogram the transcriptome and proteome. Nitric oxide thereby coordinates gene and protein regulation in cellular physiology and disease. 063
Reposted by UNLEASHDrug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 22/05/2026Happy Friday y'all! Hope you all had a good week. We've got some more #BookReviews for you for #WomensHealthMonth. This morning we are talking about "Invisible Women - Exposing data bias in a world designed for men" by @ccriadoperez.bsky.social #DDUat20 #HealthEquity #WomenInSTEM #InvisibleWomen 132
Reposted by UNLEASHDrug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 21/05/2026Morning skypals! Tea-break time seems like a good time for a book review - how about it? We will start with Medical Bondage, by Deirdre Cooper Owens, an American historian & reproductive rights activist #womenshealthmonth #DDUat20 #BookReview 131
UNLEASH @unleash-as.bsky.social · 18/05/2026Really feels like 'checking the LLM didn't hallucinate your references' should be the lowest conceivable bar. We would suggest 'have read the actual paper' is a preferable standard, but even 'have skimmed the abstract' seems like the minimum you would want to be able to honestly include a reference! 020
Reposted by UNLEASHThe Royal Society @royalsociety.org · 15/05/2026Mary Lyon FRS was born #OnThisDay in 1925. Lyon was the discoverer of X-chromosome inactivation, which the genetic process that leads to coloration like tortoiseshell cats. Read more about her discoveries in a @royalsocietypublishing.org biographical memoir. #WomenInSTEM bit.ly/4wutdqf 010029
UNLEASH @unleash-as.bsky.social · 13/05/2026You ever get the feeling that your sequence logo is talking about something other than base frequency.... #GTA #basefrequency #RNAsplicing #AccidentalGaming 120
Reposted by UNLEASHDigital Brain @yourdigitalbrain.bsky.social · 30/04/2026Did you know that the malaria parasite can deliver its RNA directly into immune cells, causing 94 changes in gene splicing? This clever tactic makes it harder for our defenses to fight back. How can we combat such a sneaky invader? 🦠sinapti.caThe malaria parasite infiltrates its RNA into immune cells to sabotage the body's defenses. - SinapticaResearchers from the Weizmann Institute of Science in Israel discovered that Plasmodium falciparum, the parasite responsible for the deadliest type of malaria, 033
Reposted by UNLEASHNature Reviews Genetics @natrevgenet.nature.com · 09/05/2026FYI: New online! Tools and tactics for studying alternative splicingdlvr.itTools and tactics for studying alternative splicingNature Reviews Genetics, Published online: 17 April 2026; doi:10.1038/s41576-026-00952-4In this Review, Sousa-Luís and Carmo-Fonseca discuss the various tools available to detect and quantify alternative splicing, functionally test splice isoforms and investigate the link between genetic variation, splicing and disease. 0187
Reposted by UNLEASHDrug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 12/05/2026Congratulations to Prof Doreen Cantrell on her election to US-based National Academy of Sciences @nasonline.org #WomenInScience www.biodundee.co.uk/science-city...biodundee.co.ukDundee scientist recognised with top international honour | Welcome to Bio-DundeeA pioneering University of Dundee academic has received international recognition after being elected to one of the world’s foremost scientific institutions. 022
Reposted by UNLEASHDrug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 12/05/2026In March 2025, we hosted an #Endometriosis Networking Workshop with experts from across the field. We’re excited to share the resulting white paper! A huge thanks to all who contributed to these vital discussions. Read here: www.linkedin.com/posts/possib... #DrugDiscovery #WomensHealth #DDUat20linkedin.comPossible Strategies for Drug Discovery for Endometriosis | Drug Discovery Unit, University of DundeeIn March 2025, we convened an Endometriosis Networking Workshop, bringing together academics, clinicians, industry leaders, and venture capitalists to collaboratively explore how we can advance drug d... 002
UNLEASH @unleash-as.bsky.social · 07/05/2026It's a beautiful day in Platja D'Arcy and we are inside hard at work talking about #alternativesplicing. #ScienceNeverStops 010
UNLEASH @unleash-as.bsky.social · 06/05/2026This is the best sparkling water in the world.....according to @biochemtrix.bsky.social at least! #consortiummeeting #splicingisthirstywork 010
Reposted by UNLEASHStephen Turner @stephenturner.us · 03/05/2026Free and open-source images, icons, and tools for creating scientific illustrations doi.org/10.59350/5zt... 🧪doi.orgFree and open-source images, icons, and tools for creating scientific illustrationsPhylopic, NIH Bioart, Bioicons, Scidraw, Open Science Art, Health Icons, Servier Medical Art, Biodiversity Heritage Library, the Noun Project, Segment Anything, Excalidraw, draw.io, Biographics 6406227
UNLEASH @unleash-as.bsky.social · 04/05/2026Our next Unleash meeting is on the horizon! Looking forward to Dundee, Munich and Barcelona getting together to talk about #Splicing! 000
Reposted by UNLEASHDrug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 04/05/2026Good morning sky-friends! We hope you are well on this lovely #mayday bank holiday! May is #WomensHealthMonth and we have lots of interesting things we want to talk about! 041
Reposted by UNLEASHbioRxivpreprint @biorxivpreprint.bsky.social · 14/01/2026Poly(A)-tail-length-dependent surveillance of viral RNA by PABPC1 orchestrates broad-spectrum antiviral defense www.biorxiv.org/content/10.64898/20… 011
Reposted by UNLEASHAging Journal @aging-us.bsky.social · 13/04/2026✅ Check out our #blog on: "A combination of differential expression and network connectivity analyses identifies a common set of RNA splicing and processing genes altered with age across human tissues." #Summary ⬇️ aging-us.org/2026/01/a-co... #agingaging-us.orgA Common Aging Pattern: Changes in RNA Splicing and Processing Across Human Tissues - Aging-US ResearchAs we age, every tissue in the body undergoes gradual molecular changes. A long-standing question in aging research is whether these changes follow common patterns across tissues or whether each tissu... 021
Reposted by UNLEASHProstate Cancer UK Professionals @prostateukprofs.bsky.social · 14/04/2026Could RNA-targeting identify drivers of AR-V7 linked #ProstateCancer? A team including Prof de Bono @icr.ac.uk, supported by our Movember London Centre of Excellence, share new findings as part of a @jci.org double-header. Grab a ☕ and read: bit.ly/4cjfadS 021
Reposted by UNLEASHSignal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 23/04/2026The cryptic lncRNA-encoded microprotein TPM3P9 promotes #ccRCC tumorigenesis by driving #Oncogenic RNA splicing, revealing a novel regulatory mechanism and potential #TherapeuticTarget in #RenalCancer. #STTT #OpenAccess: doi.org/10.1038/s413... 032
Reposted by UNLEASHDrug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 14/04/2026By bringing together expertise from DDU, @uofwa.uw.edu, & @dndi.org, we’re working to turn scientific potential into real progress against #ChagasDisease. Tackling #neglecteddiseases takes more than innovation—it takes #collaboration. #DrugDiscovery #GlobalHealth #WorldChagasday 042
Reposted by UNLEASHScottish Funding Council @scotfundcouncil.bsky.social · 14/04/2026World Chagas Disease Day acts as a reminder of a global health challenge that often goes unnoticed. In our latest blog, Manu De Rycker from the @dundee.ac.uk shares what his team are doing to combat this disease. #ChagasDisease www.sfc.ac.uk/inside-the-u...sfc.ac.ukInside the University of Dundee’s long‑term fight against Chagas disease - Scottish Funding CouncilWorld Chagas Disease Day acts as a reminder of a global health challenge that often goes unnoticed. Manu De Rycker shares what his team are doing to combat this disease. 065
Reposted by UNLEASHDrug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 30/01/2026Today is World Neglected Tropical Diseases Day. The Neglected Tropical Diseases (NTDs) are a group of diseases that affect >1 billion people worldwide (~1 in 8 people). Despite this number, treatments and diagnostics are often unsafe and unsuitable, if they even exist. www.who.int/health-topic...who.intNeglected tropical diseases -- GLOBALNeglected tropical diseases (NTDs) are a diverse group of 20 conditions that are mainly prevalent in tropical areas, where they mostly affect impoverished communities and disproportionately affect wo... 132
Reposted by UNLEASHDrug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 30/01/2026Want to see what we do up close? Sign up for the tour and networking event with us and #biodundee. See the link for details and tickets! #DDUat20 www.eventbrite.co.uk/e/drug-disco...eventbrite.co.ukDrug Discovery Unit Tour and NetworkingBioDundee is delighted to kick of the year of celebrations for #DDUat20 with Networking and a guided tour of the Drug Discovery Unit. 023
UNLEASH @unleash-as.bsky.social · 26/01/2026We feel that! How about you, bluesky? Does your data make sense this morning? #datawins 010
Reposted by UNLEASHDrug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 23/01/2026It's our Birthday!! 044
Reposted by UNLEASHNature @nature.com · 14/12/2025Sarah Tabrizi first saw the data her team had been chasing for decades: evidence that gene-targeted therapy could slow the progression of Huntington's disease She is part of Nature’s 10, a list of people who shaped science in 2025 go.nature.com/452HWfQgo.nature.com‘Giant step forward’ for Huntington’s — the scientist behind the first gene therapyNature - Sarah Tabrizi is part of Nature’s 10, a list of people who shaped science in 2025. 08821
UNLEASH @unleash-as.bsky.social · 13/12/2025Sharing this paper for all of us who pray over a thermal cycler late into the night... #PCR #qPCR #MolecularBiology www.immaterialscience.org/2025/pcr-dem...immaterialscience.orgOccultic Practices in qPCR — The Journal of Immaterial ScienceqPCR is a famously capricious and fiddly technique, bedevilled by poor reproducibility. When every other source of variation and contamination has been controlled, the only explanation is that the imp... 001
Reposted by UNLEASHCentre de Regulació Genòmica (CRG) @crg.eu · 13/11/2025En aquest diàleg, tres experts de referència respondran aquestes preguntes i compartiran la seva visió sobre les oportunitats i els reptes d’aquest camp emergent. Activitat gratuïta amb inscripció aquí: www.crg.eu/en/event/caf... 021
UNLEASH @unleash-as.bsky.social · 31/10/2025Happy #Halloween Bluesky! Hope y'all are having a spellbindingly good time! Our good friend Nicco is hard at work making witchy potions woooooo...... AKA growing up a biiiiiig batch of #HeLa cells to help study #splicing. What #spookyscience are you up to today? 030
UNLEASH @unleash-as.bsky.social · 23/10/2025Congratulations to @mdr-ddu.bsky.social for this amazing award, and to all the other winners 020
Reposted by UNLEASHDavid Baranger @davidbaranger.bsky.social · 25/09/2025Excited to share that I am officially recruiting a postdoc to study the neurobiology of addiction! Looking for someone who would be excited to lead current projects in the lab and develop new directions in related areas. More info: bearlab.science/opportunities/bearlab.scienceOpportunitiesInterested in the neuroscience of addiction? We are recruiting at all levels!! Reach out to Dr. Baranger – dbaranger@mcw.edu Postdoctoral fellows/Senior Scientists: Please send an email conta… 33113
Reposted by UNLEASHNature Portfolio @natureportfolio.nature.com · 25/09/2025Why do we still know so little about pregnancy? Claire Richards and Lana McClements write about their Nature Communications paper, explaining why sampling early placental tissue is risky, and how the world’s first bioprinted placenta organoids can help. #Academicsky 🧪 go.nature.comDesigner homes for mini-placentas: A bioprinted solutionMini placentas can be grown in the lab to study pregnancy and complications like preeclampsia. Using 3D printing technology, we have bioprinted the first placental organoids and studied the impact of their environment on cell behaviour. 0234
UNLEASH @unleash-as.bsky.social · 23/09/2025Morning sky-friends! We are delighted to share some ‘hot off the xray’ images from our talented scientists, Dr André Mourão & Ting Deng. They produced this beautiful diffraction of a compound bound to one of our protein targets whilst working with @esrf.fr 0104
Reposted by UNLEASHJCI insight @insight.jci.org · 14/09/2025ICYMI: Targeting RNA splicing as an alternative strategy in chronic lymphocytic leukemia? @prajishiyer.bsky.social & team find mutation in the RNA splicing factor SF3B1 activates the mTOR pathway to contribute to aggressive CLL: buff.ly/qkFAW4B 022
UNLEASH @unleash-as.bsky.social · 23/09/2025Good morning Bluesky! Are we feeling the Autumn chill yet? The #Dundee chapter of Unleash certainly are! 110
UNLEASH @unleash-as.bsky.social · 17/09/2025Good morning Bluesky! We have reached the end of our UNLEASH meeting and are all preparing to head home. We are full of enthusiasm and renewed purpose, and we look forward to keeping you all updated on our work! Tell us - what do you want to know about us? #SciComm #RNA #Splicing 032
UNLEASH @unleash-as.bsky.social · 16/09/2025Canvassing suggestions! What is the collective noun for a group of scientists on a hike? 🤔 100
UNLEASH @unleash-as.bsky.social · 16/09/2025Even during a break the #ScienceChat never stops! #Unleash #RNASplicing 010
UNLEASH @unleash-as.bsky.social · 16/09/2025It's day 2 of the UNLEASH meeting! We are in beautiful Bernried and looking forward to hearing more about the progress our members have made unpicking the details of #AlternativeSplicing! 010
Reposted by UNLEASHThe Helix Brief @helixbrief.bsky.social · 14/09/2025SpliceCoord is an R-based computational tool that analyzes long-read RNA sequencing data to identify coordinated exon splicing events. 121
UNLEASH @unleash-as.bsky.social · 15/09/2025We are all here in sunny Munich to talk about the progress we have all made UNLEASHing the secrets of #AlternativeSplicing Members of four different scientific groups across three different countries collaborating and sharing data. Follow us to see our progress too! 110