YouTube video by TheLSIatUM

This article describes the transition of the Glass laboratory from X-ray crystallography to single-particle cryo-electron microscopy (cryo-EM) for structural studies of ATAD2B, a large AAA+ ATPase- and bromodomain-containing protein involved in chromatin regulation. It outlines practical strategies for protein expression, sample preparation, data processing and model building, offering a comprehensive workflow and troubleshooting guide for new cryo-EM users working with large, flexible macromolecular complexes.

YouTube video by TheLSIatUM

YouTube video by TheLSIatUM

LSI researchers have uncovered a clue explaining how woodrats have evolved potent immunity to rattlesnake bites.

Premarineosin A, a potent and selective antimalarial natural product, is a promising yet underexplored scaffold due to its limited availability and synthetic complexity. Here, the authors employ metab...

A new method for deracemization of atropisomers is described which leverages a P450 enzyme-mediated process involving bond rotation for enantioenrichment.

YouTube video by TheLSIatUM

Here the authors show that mutations in V-ATPase genes in follicular lymphoma trigger V-ATPase-dependent autophagy. This process, linked to tryptophan metabolism and ribosome biogenesis, may help tumor cells thrive under stress conditions.

Interactions between predators and prey are often characterized by strong selection pressures that shape extreme physiological adaptations. Venom resistance in large-bodied South American opossums (Cl...

Researchers at the University of Michigan have illuminated a complete sensory pathway showing how the skin communicates the temperature of its surroundings to the brain.

In the U.S., dietary obesity has a prevalence of 40% and obesity increases the risk of other chronic diseases such as heart disease and diabetes. Even though anorexia nervosa has a prevalence of 1%, i...

Until now the sensory neurons inside the tooth were primarily thought to send pain signals to the brain, but a new study shows those neurons are multitaskers that also trigger a jaw-opening reflex tha...

Even before many of the faculty lab spaces were occupied, the nascent Life Sciences Institute was investing in its scientific cores — research centers with specialized expertise and technologies that ...

Our fellowship program identifies exceptional postdoctoral researchers and empowers them to become independent leaders through financial support and dedicated mentorship.

Author summary Merkel cell polyomavirus (MCPyV) causes a rare but deadly form of skin cancer called Merkel cell carcinoma. However, many aspects of its infectious life cycle are unclear, including how...