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Thomas Stehlé

@tstehle.bsky.social
905 followers 192 following 29 posts

Néphrologue HU Henri Mondor

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Reposted by Thomas Stehlé
Pierre Delanaye @delanaye.bsky.social · 03/09/2026
Challenges of kidney function evaluation in pregnancy academic.oup.com/joneph/artic... Estimating (but also measuring) GFR is particularly difficult during pregnancy. A few lines of thought. Thanks to @tstehle.bsky.social and all the merit to Stephanie Grosch
academic.oup.com
Challenges of kidney function evaluation in pregnancy
The kidney plays a central role in maintaining physiological homeostasis during pregnancy. Since the 1950s, it has been known that measured glomerular filt
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Reposted by Thomas Stehlé
American Journal of Kidney Diseases @ajkd.bsky.social · 24/08/2026
Distribution of GFR in Apparently Healthy Indians bit.ly/4qy4T4n
Measured glomerular filtration rate (mGFR) of apparently healthy Indian subjects is shown for various ages compared to the mGFR of apparently healthy individuals from the European population. Red lines: Median and 2.5th and 97.5th regression quantiles based on second-degree polynomials for Indian apparently healthy subjects.
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Thomas Stehlé @tstehle.bsky.social · 18/08/2026
Quelle histoire, et racontée de façon captivante. Bon rétablissement
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Reposted by Thomas Stehlé
The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 09/08/2026
#Semaglutide was effective in decreasing #CKD progression regardless of the administration route or indication (type 2 #diabetes or #obesity), adding to the evidence provided by FLOW in people with type 2 diabetes & CKD www.thelancet.com/journals/lan... #T2D #kidney #CVD #MedSky #RenalSky #CardioSky
Cumulative incidence plots showing time from randomisation to occurrence of first primary kidney composite event (A) and narrower secondary kidney composite event (B). Pooled data from the SELECT, FLOW, and SOUL trials, in the full analysis set. The primary kidney composite included onset of persistent ≥50% reduction in eGFR, kidney failure (persistent eGFR <15 mL/min per 1·73 m2 or initiation of kidney replacement therapy), kidney-related death, or cardiovascular-related death. Narrower secondary kidney composite included the above criteria, excluding cardiovascular-related death. eGFR=estimated glomerular filtration rate. HR=hazard ratio. IR=incidence rate (number of events per 100 years of observation).
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Reposted by Thomas Stehlé
Rolando Claure @runningkidneys.bsky.social · 29/07/2026
Urea may be a cost-effective alternative to tolvaptan for 🏥 SIADH patients. In a retrospective 📑 (n=537) both achieved similar correction of HypoNa (>130 mmol/L) while tolvaptan acted faster but caused more overcorrection & was substantially more 💵 🔗https://doi.org/10.1093/ndt/gfag165
doi.org
Urea vs. tolvaptan for hospitalized patients with SIADH
AbstractRationale. Hyponatremia is the most common electrolyte disorder found in hospitalized patients and is associated with an increased mortality. Urea
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Reposted by Thomas Stehlé
Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 09/07/2026
finally Health Canada wakes up recalls-rappels.canada.ca/en/alert-rec... Avacopan is dead -please stop using it, please stop anyone on it
recalls-rappels.canada.ca
TAVNEOS (avacopan) and Health Canada’s Review of Data Integrity Concerns - Canada.ca
Health Canada is reviewing significant concerns regarding the data integrity of the pivotal ADVOCATE trial, which served as the primary efficacy study supporting the authorization of TAVNEOS (avacopan...
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Reposted by Thomas Stehlé
JAMA @jama.com · 14/06/2026
In this observational study of adults in Stockholm, measured GFR (mGFR) values below 90 mL/min/1.73 m² were associated with progressively higher rates of #mortality, #kidney failure, #heart failure, acute kidney injury, and major #cardiovascular events. ja.ma/4aNjKky
JAMA logo. Title: Measured and Estimated Glomerular Filtration Rates and Risk of Adverse Health Outcomes. Figure 1 shows density and box plots of GFR distribution for mGFR, eGFRcr, eGFRcys, and eGFRcr-cys. All GFRs range from approx 15 to 120 mL/min/1.73 m² with varying peaks.
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Thomas Stehlé @tstehle.bsky.social · 06/06/2026
Completely agree. While the choice of tacrolimus as a comparator is understandable, this strategy is simply not acceptable.
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Reposted by Thomas Stehlé
Juan Carlos Q Vélez, MD @juancarlosqvelez.bsky.social · 29/05/2026
Helical RBC cast in a patient with atypical anti-GBM nephritis. #UrinarySediment #UrineMicroscopy
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Thomas Stehlé @tstehle.bsky.social · 24/05/2026
New publication on BIC/FTC/TAF in kidney transplant recipients living with HIV. doi.org/10.1093/jac/... Highly phenotyped patients with iohexol-measured GFR and tubular assessment showed no signal for kidney toxicity or clinically significant drug-drug interactions with immunosuppressants.
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Reposted by Thomas Stehlé
Pierre Delanaye @delanaye.bsky.social · 19/05/2026
academic.oup.com/ckj/article/... Congratulation to the Congolese team for this interesting publication about GFR etimation is patients with sickle cell disease! Special congratulations to Yannick Engole!
academic.oup.com
Performance of creatinine and cystatin C-based equations for estimating high levels of glomerular filtration rate in Congolese adults with sickle cell disease
ABSTRACTIntroduction. Sickle cell disease (SCD) carries a high risk of chronic kidney disease, necessitating accurate glomerular filtration rate (GFR) moni
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Reposted by Thomas Stehlé
ASN Publications @asnpublications.bsky.social · 14/05/2026
Multicenter study in #ASNJASN demonstrates that in ~30% of cases of patients undergoing allogeneic hematopoietic stem cell transplant (HSCT) or T-cell therapies, cystatin C revealed significantly lower kidney function than creatinine. kidney.pub/JASN1119
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Reposted by Thomas Stehlé
Brian Rifkin @brianrifkin.bsky.social · 02/05/2026
🚨A new KI Reports Community blog about Obinutuzumab. Wonderful review of how it differs from other anti-CD20 treatments, worth a read 📖 By Dr. Priyadarshini John #NephSky #MedSky www.kireportscommunity.org/post/beyond-...
kireportscommunity.org
Beyond Rituximab: Obinutuzumab Redefines Treatment in Resistant Membranous Nephropathy
Written by Priyadarshini John, DMPrimary membranous nephropathy (MN) is a prototypical autoimmune glomerular disease and one of the most common causes of nephrotic syndrome in adults. The discovery of...
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Thomas Stehlé @tstehle.bsky.social · 22/04/2026
Magnifique innovation !
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Reposted by Thomas Stehlé
NDT @ndt-era.bsky.social · 20/04/2026
Pregnancies in Living Kidney Donors doi.org/10.1093/ndt/...
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Reposted by Thomas Stehlé
Stéphane Burtey @sburtey.bsky.social · 03/04/2026
Quand tu ne fais plus de médecine et surtout ne lis plus depuis longtemps tu fais une loi sur le dépistage du risque cardiovasculaire qui n'inclut pas la maladie rénale chronique, ce qui traduit bien l'incompétence des gens qui ont porté ce texte... www.apmnews.com/story?objet=...
apmnews.com
Les députés favorables au renforcement du dépistage des risques et des pathologies cardiovasculaires
PARIS, 2 avril 2026 (APMnews) - La commission des affaires sociales de l'Assemblée nationale a adopté à l'unanimité mercredi, en première lecture, la proposition de loi de Yannick Neuder (DR, Isère) p...
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Reposted by Thomas Stehlé
Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 16/03/2026
From a large (almost 150,000) Fresenius cohort Association of dialysis time with survival 3 hours worse than longer www.kireports.org/article/S246... in KI Reports (Yes RCTs have failed to show benefit with longer)
Visual Abstract by Krishnam Penmatsa
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Reposted by Thomas Stehlé
Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 14/03/2026
Yet another ddAVP trial for kidney biopsies with neutral results academic.oup.com/ckj/advance-... In Clinical Kidney Journal Previous #NephJC discussion: www.nephjc.com/news/ddavp
academic.oup.com
Bleeding prevention with desmopressin for allograft kidney biopsies: a double-blind randomized study
AbstractBackground. Percutaneous kidney allograft biopsy is essential for evaluating graft dysfunction, but post-procedural bleeding remains the most frequ
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Reposted by Thomas Stehlé
Florian Buchkremer @swissnephro.bsky.social · 08/03/2026
The HIT (Hyponatremia Intervention Trial) is finally out! #hyponatremia #nephrology evidence.nejm.org/doi/10.1056/...
evidence.nejm.org
A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients
Chronic hyponatremia is associated with adverse outcomes, including falls, neurocognitive disorders, and mortality, but whether hyponatremia itself increases morbidity and mortality, or is simply a...
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Reposted by Thomas Stehlé
Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 07/03/2026
Very cool Enteric coated budesonide also reduces albuminuria, and GFR remains stable in #IgAN Single arm prospective study from India in KI Reports www.kireports.org/article/S246...
Graphical abstract
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Thomas Stehlé @tstehle.bsky.social · 20/02/2026
CT-based myosteatosis and muscle mass are increasingly studied in Nephrology How should these measures be interpreted? Physiological thresholds (age, sex, population) vs arbitrary historical cutoffs? This echoes the long-running debate on GFR thresholds to define CKD journals.lww.com/cjasn/citati...
journals.lww.com
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Reposted by Thomas Stehlé
American Journal of Kidney Diseases @ajkd.bsky.social · 17/02/2026
GFR Measured With Computerized Tomography Urography in Healthy Individuals and Patients With CKD bit.ly/3XsLlQY #OpenAccess
bit.ly
GFR Measured With Computerized Tomography Urography in Healthy Individuals and Patients With CKD
Opportunistic computed tomography (CT)-based screening is the practice of exploiting incidental imaging data for prevention, risk profiling, or presymptomatic detection of relevant disease unrelated…
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Reposted by Thomas Stehlé
Arkana Labs @arkanalabs.bsky.social · 11/02/2026
What happens when oxalate nephropathy & renal embolic disease interact? How does this interaction impact kidney function? Find out the answer in our latest #Collidescope episode! #renalpath #kidneypath #pathsky #renalsky
youtu.be
Oxalate Nephropathy & Renal Embolic Disease Collision Case | Collidescope Episode 10
Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
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Thomas Stehlé @tstehle.bsky.social · 22/01/2026
The article referred to seems to not be online yet. If the P30 of tGFR is 94%, this could be considered disappointing. An eGFRcr-cys with this level of accuracy is not uncommon. Comparing new mGFR methods with eGFRcr-cys is essential. This is what we did for CT-mGFR. www.ajkd.org/article/S027...
ajkd.org
GFR Measured With Computerized Tomography Urography in Healthy Individuals and Patients With CKD
Opportunistic computed tomography (CT)-based screening is the practice of exploiting incidental imaging data for prevention, risk profiling, or presymptomatic detection of relevant disease unrelated t...
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Reposted by Thomas Stehlé
Matthieu 💭 @matthieu910.eurosky.social · 10/01/2026
« [...]et il ne resterait d’autre solution pour les démocrates que de mourir. Notre sang tacherait l’histoire, la démocratie serait notre linceul et notre tombe.» legrandcontinent.eu/fr/2026/01/1...
legrandcontinent.eu
Résister à Trump au Groenland : la doctrine Muselier
Il existe un moyen de répondre à la nouvelle doctrine Monroe. Alors que les dirigeants européens hésitent à condamner le néo-impérialisme américain de peur de froisser l’allié militaire en Ukraine, l...
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Grace Choung, MD 박영이 @gracechoung.bsky.social · 26/12/2025
Kappa-type light chain proximal tubulopathy On EM, low mag shows membrane-bound crystalline-like cytoplasmic inclusions but up close has fibrillar appearance. 🔹Congo-red is negative 🔹Reported w/ MGUS, MM, & lymphoma 🔹Most had fanconi syndrome #MGRS #renalpath #pathsky #nephsky #nephrology (1/2)
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Kidney International @kidneyint.bsky.social · 10/12/2025
Nephrology Image Mesalazine crystalluria doi.org/10.1016/j.kint.2025.06.027 #MedSky #NephSky #lithiasis #mesalazine
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 19/11/2025
Urine crystals in a patient with Crohn’s Answer: www.kidney-international.org/article/S008... in @kidneyint.bsky.social #NephSky
Mesalazine crystals
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Reposted by Thomas Stehlé
American Journal of Kidney Diseases @ajkd.bsky.social · 13/11/2025
GFR Measured With Computerized Tomography Urography in Healthy Individuals and Patients With CKD bit.ly/3XsLlQY #OpenAccess
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Thomas Stehlé @tstehle.bsky.social · 12/11/2025
@hophenrimondor.bsky.social @ap-hp.bsky.social
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Thomas Stehlé @tstehle.bsky.social · 12/11/2025
- Hybrid GFR, defined as the mean between CT-mGFR and eGFRcr-cys would be even more accurate. These results open up new perspectives, particularly for patients with kidney cancer or urothelial carcinoma.
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Thomas Stehlé @tstehle.bsky.social · 12/11/2025
Measuring GFR using CT urography performed as part of routine care is possible not only in healthy individuals, but also in patients with CKD. In this study, we demonstrate that: - GFR measured by CT is more accurate than GFR estimated from creatinine, cystatin C, or both (eGFRcr-cys).
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Thomas Stehlé @tstehle.bsky.social · 12/11/2025
GFR Measured With Computerized Tomography Urography in Healthy Individuals and Patients With CKD - American Journal of Kidney Diseases www.ajkd.org/article/S027...
ajkd.org
GFR Measured With Computerized Tomography Urography in Healthy Individuals and Patients With CKD
Opportunistic CT-based screening is the practice of exploiting incidental imaging data for prevention, risk profiling, or presymptomatic detection of relevant disease unrelated to the purpose for whic...
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Reposted by Thomas Stehlé
kireports.bsky.social @kireports.bsky.social · 10/11/2025
#LiverCyst #Infection Outcomes in Patients With Autosomal Dominant Polycystic Kidney Disease #ADPKD #VisualAbstract by Kajaree www.kireports.org/article/S2468-024…
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Iain Bressendorff, MD PhD @ibressendorff.bsky.social · 27/09/2025
A little opinion piece on the relationship between serum calcification propensity (T50) and progressive CAC in kidney transplant recipients 🤓 www.kireports.org/article/S246...
kireports.org
T50 and Calcification Progression in Kidney Transplant Recipients: Does it have to be “bad” to be useful?
The increased risk of cardiovascular disease (CVD) among kidney transplant recipients (KTR)1 is challenging for the treating physician. For KTR, CVD risk remains higher than for individuals with simil...
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Pierre Delanaye @delanaye.bsky.social · 26/09/2025
www.jle.com/10.1684/ndt....
jle.com
JLE - Néphrologie & Thérapeutique - Il était une fois en néphrologie - Épisode 2. Une petite histoire du dosage de la créatinine
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KDIGO @kdigo.org · 25/09/2025
Check out the new KDIGO IgAN/IgAV Guideline Key Takeaways! IgAN: kdigo.co/KDIGO-IgAN-G... IgAV: kdigo.co/KDIGO-Guidel... These resources are designed to provide clinicians with quick and practical access to the most important points from the new KDIGO guideline on managing #IgAN and #IgAV.
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Thomas Stehlé @tstehle.bsky.social · 18/09/2025
Congratulations to Michael Moryoussef for this first original study, to Antoine Morel, the statistician in chief for this work ;-), and to all the co-authors.
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Thomas Stehlé @tstehle.bsky.social · 18/09/2025
In addition to diabetes and male gender, we identified myosteatosis and low muscle mass as predisposing factors. Visceral and subcutaneous fat mass were not determinants of the low ratio.
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Thomas Stehlé @tstehle.bsky.social · 18/09/2025
We show that a low eGFR ratio is associated with the occurrence of major cardiovascular events, whether using CKD-EPI or EKFC equations. The originality of this study also lies in our attempt to identify the determinants of such a low ratio by including body composition data in the analyses.
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Thomas Stehlé @tstehle.bsky.social · 18/09/2025
Very pleased to share this publication from @hophenrimondor.bsky.social . A low eGFRcys/eGFRcr ratio is increasingly recognized as a risk factor for morbidity and mortality, including CV events. However, there was little or no data available on kidney transplantation.
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Thomas Stehlé @tstehle.bsky.social · 18/09/2025
Low Cystatin C–to–Creatinine Estimated GFR Ratio Predicts Post–Kidney Transplant Cardiovascular Events - Kidney International Reports www.kireports.org/article/S246...
kireports.org
Low Cystatin C–to–Creatinine Estimated GFR Ratio Predicts Post–Kidney Transplant Cardiovascular Events
A low cystatin C–based to creatinine-based estimated glomerular filtration rate (eGFR) ratio (eGFRcys/eGFRcr) is associated with poor clinical outcomes, but data in kidney transplant recipients (KTRs)...
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 28/08/2025
Nice example of urate crystals in gouty tophi involving the medulla. Polarizable crystals can be see using unstained sections from the IF tissue. #renalpath #pathsky #nephsky
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Juan Carlos Q Vélez, MD @juancarlosqvelez.bsky.social · 28/07/2025
The Maltese Cross 🇲🇹🛡️sign is not unique to lipids, other structures can manifest it under polarized light (eg, starch, leucine crystals). Here, a rare sighting of a cast containing suspected ciprofloxacin crystals. #UrinarySediment #UrineMicroscopy #PisseProphet
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Thomas Stehlé @tstehle.bsky.social · 30/06/2025
Bravo Antoine pour cet édito avec deux co auteurs prestigieux !
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Hôpitaux Universitaires Henri-Mondor AP-HP @hophenrimondor.bsky.social · 23/06/2025
La coordination de prélèvement d’organes était hier au marché de Créteil pour la Journée Nationale Du Don d’organes. Rendez-vous ce mercredi 25 juin à l’hôpital Henri-Mondor, hall principal, de 9h à 16h30 pour en savoir plus et se sensibiliser ! @ap-hp.bsky.social
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ASN Publications @asnpublications.bsky.social · 05/06/2025
Needle selection in kidney biopsy requires balancing risk of complications with benefit of obtaining diagnostic tissue. Study shows that higher needle gauge provides more tissue for diagnosis but might be associated with greater risk of complications. bit.ly/KID0835 #ASNKidney360
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NEJM.org @nejm.org · 11/05/2025
Presented at #ECO2025: In the SURMOUNT-5 phase 3b trial involving adults with obesity without type 2 diabetes, tirzepatide was superior to semaglutide in reducing body weight and waist circumference. Full trial results: nej.md/44ZeMPz @easoobesity.bsky.social
The least-squares mean percent changes in body weight
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