Proteasomal degradation is a fundamental process for all eukaryotic life. A protein destined for degradation is first tagged with a polyubiquitin chain, which is selected by the proteasome. Different ...

Focused ion beam (FIB)-milling has been adapted to thin frozen cells for visualization of macromolecular structures in situ with cryogenic electron microscopy. However, only a few large and abundant c...

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment has been the focus of a thirty-year research question. New work from the Cri...