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Tom Hindmarsh Sten

@tshindmarsh.bsky.social
159 followers 181 following 7 posts

Circuit architectures, dynamics, and the evolution of behavior. Jane Coffin Childs-HHMI Fellow in the Luo lab at Stanford University | Previously Ruta lab at Rockefeller

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Reposted by Tom Hindmarsh Sten
Andres Bendesky @bendeskylab.com · 11/05/2026
California mice are paragons of monogamy. The neuronal bases of how they (or any other species) remember their partners is unknown. We found a surprisingly important role for hippocampal CA1 as the pair bond develops and a concomitantly diminishing role of CA2. www.biorxiv.org/content/10.6...
Pair of California mice taking care of their pups
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The Rockefeller University @rockefeller.edu · 28/04/2026
Rockefeller's Vanessa Ruta and Thomas Tuschl have been elected to the @nasonline.org! Congratulations 🎉 🔗: bit.ly/4vTZgQ8
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John Tuthill @tuthill.bsky.social · 24/03/2026
🧵 New preprint led by @bingbrunton.bsky.social, @elliottabe.bsky.social, @lawrencehu.bsky.social We gave a worm brain control of a fly body and it walked What did we learn? Nothing, other than deep reinforcement learning is effective We call it the digital sphinx www.biorxiv.org/content/10.6...
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Catherine Dulac @dulaclab.bsky.social · 13/12/2025
New paper alert!!...🤩 Led by @blogeman.bsky.social, we identify how cell type-specific hormonal responses in the hypothalamus tunes parenting behavior in males and females 🐭🧠🍼. Highlights in thread 👇 1/6 www.biorxiv.org/content/10.6...
biorxiv.org
Cell Type-Specific Hormonal Signaling Configures Hypothalamic Circuits for Parenting
Parenting behavior emerges from hormonally sensitive circuits, but how distinct circuit components are affected by, and contribute to, sex and state dependent changes in infant caregiving remains uncl...
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Nicholas Bellono @nbellono.bsky.social · 11/12/2025
Wendy Valencia-Montoya and team uncover thermal infrared as one of the most ancient pollination signals uniting plants and animals. From the field to single proteins. www.science.org/doi/10.1126/...
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Andrew Straw @andrewstraw.bsky.social · 06/12/2025
Have you ever wondered what you would find if you could keep your eyes on a bee for more than a few meters? Us, too! preprint (with videos!) + thread 🧵 Precise, individualized foraging flights in honey #bees 🐝 revealed by multicopter drone-based tracking www.biorxiv.org/content/10.6... 1/9
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Science Magazine @science.org · 30/10/2025
🎉 Cheng Lyu is the winner of the 2025 Eppendorf & Science Prize for Neurobiology for his work in understanding how neural circuits assemble with such remarkable precision during development. Learn more: scim.ag/4onaxEE
Cheng Lyu
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Philipp Brand @pbrand.bsky.social · 16/10/2025
Excited to share our new #biorxivpreprint We discovered that the fruit fly #drosophila erecta requires food odor to mate and arousal is further enhanced by social group motion. Cross-species analysis of brain activity reveals a novel gate evolved from within a conserved circuit shorturl.at/gGYm7
a group of Drosophila erecta fruit flies on a small food patch. flies on white background
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Philipp Brand @pbrand.bsky.social · 21/08/2025
Exciting new Ruta lab preprint by @annaryba.bsky.social et al. on the neural underpinnings of intraspecific behavioral variation: Strain variation identifies a neural substrate for behavioral evolution Drosophila www.biorxiv.org/content/10.1...
biorxiv.org
Strain variation identifies a neural substrate for behavioral evolution in Drosophila
Sexual selection acts on heritable differences within species, driving the parallel diversification of signal production in one sex and behavioral responses in the other. This coevolution implies that...
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Hannah Payne @hannahpayne.bsky.social · 11/06/2025
My latest Aronov lab paper is now published @Nature! When a chickadee looks at a distant location, the same place cells activate as if it were actually there 👁️ The hippocampus encodes where the bird is looking, AND what it expects to see next -- enabling spatial reasoning from afar bit.ly/3HvWSum
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Datta Lab @dattalab.bsky.social · 09/05/2025
Maps are everywhere in the brain...and finally we've discovered one in the nose! Led by @davidhbrann.bsky.social, we uncovered the logic that specifies the positions of each of the 1,000 sensory neuron subtypes in the nose and aligns their projections to the brain.👇👃see more details below👃👇
biorxiv.org
A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain
Although topographical maps organize many peripheral sensory systems, it remains unclear whether olfactory sensory neurons (OSNs) choose which of the ~1100 odor receptors (ORs) to express based upon t...
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Reposted by Tom Hindmarsh Sten
Matt Collie @mottcallie.bsky.social · 28/04/2025
Many animals use "adaptive control" to pursue moving objects, relying on flexible feedback loops to adjust their movement gain over time. But how do neural circuits actually implement this? Here, we show how adaptive control in Drosophila pursuit involves two specialized parallel feedback loops.
doi.org
Specialized parallel pathways for adaptive control of visual object pursuit
To pursue an unpredictably moving visual object, the brain must generate motor commands that continuously steer the object to the midline of the visual field via feedback. Behavior implies that visual...
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Tom Hindmarsh Sten @tshindmarsh.bsky.social · 14/02/2025
Thanks Navin!
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Tom Hindmarsh Sten @tshindmarsh.bsky.social · 14/02/2025
Tackar tackar! 🙏🏻
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Tom Hindmarsh Sten @tshindmarsh.bsky.social · 14/02/2025
Thanks so much!
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Tom Hindmarsh Sten @tshindmarsh.bsky.social · 14/02/2025
Thanks Katie!
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Tom Hindmarsh Sten @tshindmarsh.bsky.social · 14/02/2025
Excited see the final portion of my PhD work with Vanessa Ruta out today in @cellpress.bsky.social, in the midst of everything. In time for valentines day, @rufeili.bsky.social and I describe how competition between males sculpt mating decisions in 🪰🫶. www.cell.com/cell/fulltex...
cell.com
Male-male interactions shape mate selection in Drosophila
Male-male competition strongly influences mate selection in Drosophila, with males performing wing flicks to repel their rivals and jam a female’s perception of other potential mates. Recruitment of p...
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Tom Hindmarsh Sten @tshindmarsh.bsky.social · 09/01/2025
Huge congratulations Philipp!! So incredibly well deserved!! Can't wait to hear about all the cool stuff you find 🪰🪰🪰
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Catherine (Katie) Schretter @ceschretter.bsky.social · 12/12/2024
Excited to have this paper out (rdcu.be/d0T3Y)! In it, we focused on how flies know what to attend to in a complex environment (like below)? We uncovered neuronal pathways through which social states (like aggression 🥊) modulate visual processing in #Drosophila. #WomenInSTEM #neuroscience 🧪 1/
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Will Allen @weallen1.bsky.social · 21/11/2024
In collaboration with Reuben Saunders, @jswlab.bsky.social, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue. Check it out! www.biorxiv.org/content/10.1...
biorxiv.org
A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function
Organ function requires coordinated activities of thousands of genes in distinct, spatially organized cell types. Understanding the basis of emergent tissue function requires approaches to dissect the...
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Tom Hindmarsh Sten @tshindmarsh.bsky.social · 06/11/2023
Animals often congregate in large social groups to find mates. But how does an individual actually pick who to reproduce with? Incredibly excited to share the final piece of my graduate studies – a huge team effort to understand the logic of mate selection in Drosophila. bit.ly/flytriad
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